{"id":"https://openalex.org/W2252374439","doi":"https://doi.org/10.1152/ajpheart.2002.282.1.h58","title":"Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy","display_name":"Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2252374439","doi":"https://doi.org/10.1152/ajpheart.2002.282.1.h58","mag":"2252374439","pmid":"https://pubmed.ncbi.nlm.nih.gov/11748047"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.2002.282.1.h58","doi":"https://doi.org/10.1152/ajpheart.2002.282.1.h58","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2002.282.1.h58","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071223454","display_name":"James R. Klinger","orcid":"https://orcid.org/0000-0003-2997-5955","observed_orcids":["https://orcid.org/0000-0003-2997-5955"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Klinger","raw_affiliation_strings":["Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017877969","display_name":"Rod R. Warburton","orcid":"https://orcid.org/0000-0001-9381-8722","observed_orcids":["https://orcid.org/0000-0001-9381-8722"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rod R. Warburton","raw_affiliation_strings":["Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024645392","display_name":"Linda A. Pietras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Pietras","raw_affiliation_strings":["Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111725362","display_name":"Paula M. Oliver","orcid":"https://orcid.org/0000-0002-0455-3767","observed_orcids":["https://orcid.org/0000-0002-0455-3767","https://orcid.org/0000-0002-3110-4131"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Oliver","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112759007","display_name":"Jennifer E. Fox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Fox","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070335657","display_name":"Oliver Smithies","orcid":"https://orcid.org/0000-0002-4934-3931","observed_orcids":["https://orcid.org/0000-0002-4934-3931"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver Smithies","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067984012","display_name":"Nicholas S. Hill","orcid":"https://orcid.org/0000-0002-8242-8339","observed_orcids":["https://orcid.org/0000-0002-8242-8339"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas S. Hill","raw_affiliation_strings":["Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903; and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5491,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.92786938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"282","issue":"1","first_page":"H58","last_page":"H65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/npr-a","display_name":"natriuretic peptide receptor A","score":0.9850000143051147},{"id":"https://openalex.org/keywords/npr1-gene","display_name":"NPR1 gene","score":0.6520000100135803},{"id":"https://openalex.org/keywords/hypobaric-hypoxia","display_name":"hypobaric hypoxia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7839999794960022},{"id":"https://openalex.org/keywords/right-ventricular-hypertrophy","display_name":"right ventricular hypertrophy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.734000027179718},{"id":"https://openalex.org/keywords/ventricular-pressure","display_name":"ventricular pressure","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.6240000128746033},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.787925124168396},{"id":"https://openalex.org/C2779376020","wikidata":"https://www.wikidata.org/wiki/Q2014808","display_name":"Right ventricular hypertrophy","level":3,"score":0.7725011110305786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6529747843742371},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6416528224945068},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5805092453956604},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.4864661395549774},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.47520074248313904},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.46149951219558716},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.424895703792572},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4228541851043701},{"id":"https://openalex.org/C26635844","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular pressure","level":3,"score":0.41030603647232056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4054126441478729},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.3749232292175293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33511048555374146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3196033835411072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2770722508430481},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2733125686645508},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.23350417613983154},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2061612606048584},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.09507527947425842},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06376448273658752},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006909","descriptor_name":"Hydroxyproline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016278","descriptor_name":"Ventricular Function, Right","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017461","descriptor_name":"Receptors, Atrial Natriuretic Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017461","descriptor_name":"Receptors, Atrial Natriuretic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017461","descriptor_name":"Receptors, Atrial Natriuretic Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.2002.282.1.h58","doi":"https://doi.org/10.1152/ajpheart.2002.282.1.h58","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2002.282.1.h58","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:11748047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11748047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3076182424","display_name":null,"funder_award_id":"HL-40505","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G786011568","display_name":"MECHANISMS OF CARDIAC NATRIURETIC PEPTIDE SYNTHESIS","funder_award_id":"5k08hl002613-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G814011042","display_name":null,"funder_award_id":"HL-02613","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1491464210","https://openalex.org/W1574842592","https://openalex.org/W1960406067","https://openalex.org/W1964541624","https://openalex.org/W1970407496","https://openalex.org/W1973644408","https://openalex.org/W1984893737","https://openalex.org/W2001314044","https://openalex.org/W2003232973","https://openalex.org/W2006950308","https://openalex.org/W2015996457","https://openalex.org/W2030165232","https://openalex.org/W2044813579","https://openalex.org/W2051222628","https://openalex.org/W2054649519","https://openalex.org/W2059535615","https://openalex.org/W2067196589","https://openalex.org/W2069190401","https://openalex.org/W2072859275","https://openalex.org/W2075973145","https://openalex.org/W2103751591","https://openalex.org/W2106000728","https://openalex.org/W2107821473","https://openalex.org/W2114425457","https://openalex.org/W2120553703","https://openalex.org/W2121434292","https://openalex.org/W2154616804","https://openalex.org/W2158344911","https://openalex.org/W2181526959","https://openalex.org/W2185549840","https://openalex.org/W2188364927","https://openalex.org/W2188943974","https://openalex.org/W2191613235","https://openalex.org/W2263809318","https://openalex.org/W2266319099","https://openalex.org/W2278085417","https://openalex.org/W2302856137","https://openalex.org/W2334806207","https://openalex.org/W2335533066","https://openalex.org/W2404915920","https://openalex.org/W2416661914"],"related_works":["https://openalex.org/W2001314044","https://openalex.org/W1960406067","https://openalex.org/W2077018497","https://openalex.org/W2188364927","https://openalex.org/W7443638","https://openalex.org/W2401529483","https://openalex.org/W2274490421","https://openalex.org/W1984893737","https://openalex.org/W1964333435","https://openalex.org/W2411142581"],"abstract_inverted_index":{"Targeted":[0],"disruption":[1],"of":[2,36,39,62,136,233],"the":[3,34,64,158],"gene":[4,65],"for":[5,68],"natriuretic":[6],"peptide":[7],"receptor-A":[8],"(NPR-A)":[9],"worsens":[10,235],"pulmonary":[11,251],"hypertension":[12],"and":[13,26,46,50,119,140,207,239],"right":[14,45,75,127,236],"ventricular":[15,24,48,76,102,128,237,242],"hypertrophy":[16,238,243],"during":[17,244],"hypoxia,":[18],"but":[19,89,157,219],"its":[20],"effect":[21,35,201,210],"on":[22,44,202],"left":[23,47,101,241],"mass":[25,51],"systemic":[27,253],"pressures":[28],"is":[29],"not":[30,209],"known.":[31],"We":[32,228],"examined":[33],"3":[37],"wk":[38],"hypobaric":[40],"hypoxia":[41,137,198,248],"(0.5":[42],"atm)":[43],"pressure":[49,78,255],"in":[52,70,82,85,95,112,115,143,148,152,161,170,175,204,213,224],"mice":[53,118,173,178],"with":[54],"2":[55,86,116,176,216],"(wild":[56],"type),":[57],"1,":[58],"or":[59,215,252],"0":[60,83,113,171,225],"copies":[61],"Npr1,":[63],"that":[66,230],"encodes":[67],"NPR-A":[69,234],"mice.":[71,227],"Under":[72],"normoxic":[73],"conditions,":[74],"peak":[77],"(RVPP)":[79],"was":[80,110,121,150,164],"greater":[81,111,126],"than":[84,114,166,174],"copy":[87,117,172,177,217,226],"mice,":[88,218],"there":[90,120],"were":[91],"no":[92,200],"genotype-related":[93],"differences":[94],"carotid":[96],"artery":[97],"PP":[98],"(CAPP).":[99],"The":[100,146],"free":[103],"wall":[104],"weight-to-body":[105,129],"weight":[106,130],"(LV/body":[107],"wt)":[108,132],"ratio":[109],"a":[122,125],"trend":[123],"toward":[124],"(RV/body":[131],"ratio.":[133],"Three":[134],"weeks":[135],"increased":[138,220],"RVPP":[139,149],"RV/body":[141,162],"wt":[142,163,212,222],"all":[144,153],"genotypes.":[145],"increase":[147,160],"similar":[151],"genotypes":[154],"(11-14":[155],"mmHg),":[156],"hypoxia-induced":[159],"more":[165],"twice":[167],"as":[168],"great":[169],"(1.11":[179],"+/-":[180,184,188,192],"0.06":[181],"to":[182,190,246],"2.65":[183],"0.46":[185],"vs.":[186],"0.96":[187],"0.04":[189],"1.4":[191],"0.09,":[193],"P":[194],"<":[195],"0.05).":[196],"Chronic":[197],"had":[199],"CAPP":[203],"any":[205],"genotype":[206],"did":[208],"LV/body":[211,221],"1":[214],"41%":[223],"conclude":[229],"absent":[231],"expression":[232],"causes":[240],"exposure":[245],"chronic":[247],"without":[249],"increasing":[250],"arterial":[254],"responses.":[256]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}