{"id":"https://openalex.org/W2251362463","doi":"https://doi.org/10.1016/j.neuroscience.2016.01.026","title":"Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro","display_name":"Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2251362463","doi":"https://doi.org/10.1016/j.neuroscience.2016.01.026","mag":"2251362463","pmid":"https://pubmed.ncbi.nlm.nih.gov/26820594"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2016.01.026","doi":"https://doi.org/10.1016/j.neuroscience.2016.01.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2016.01.026","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050936474","display_name":"H.E. Barratt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.E. Barratt","raw_affiliation_strings":["Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043956593","display_name":"Hailey C. Budnick","orcid":"https://orcid.org/0009-0000-8125-1175","observed_orcids":["https://orcid.org/0009-0000-8125-1175"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.C. Budnick","raw_affiliation_strings":["Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Parra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Parra","raw_affiliation_strings":["Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001970259","display_name":"Russell James Lolley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.J. Lolley","raw_affiliation_strings":["Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053999451","display_name":"Cynthia N. Perry","orcid":"https://orcid.org/0000-0001-6005-9301","observed_orcids":["https://orcid.org/0000-0001-6005-9301"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.N. Perry","raw_affiliation_strings":["Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":null,"display_name":"O. Nesic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. Nesic","raw_affiliation_strings":["Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States; Department of Biomedical Sciences, Virginia Tech Carilion School of Medicine; Virginia Tech Carilion Research Institute, Roanoke, VA 24016, United States. Electronic address: olnesic@vt.edu","Department of Biomedical Sciences, Virginia Tech Carilion School of Medicine","Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","Virginia Tech Carilion Research Institute, Roanoke, VA 24016, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States; Department of Biomedical Sciences, Virginia Tech Carilion School of Medicine; Virginia Tech Carilion Research Institute, Roanoke, VA 24016, United States. Electronic address: olnesic@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Virginia Tech Carilion School of Medicine","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Medical Education, Texas Tech University Health Sciences Center El Paso: Paul L. Foster School of Medicine, United States","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"Virginia Tech Carilion Research Institute, Roanoke, VA 24016, United States","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.3636,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.75850104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"319","issue":null,"first_page":"146","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.06390000134706497,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":1.0},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.9570000171661377},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tamoxifen-citrate","display_name":"tamoxifen citrate","score":0.7630000114440918},{"id":"https://openalex.org/keywords/4-hydroxytamoxifen","display_name":"4-hydroxytamoxifen","score":0.9589999914169312},{"id":"https://openalex.org/keywords/endoxifen","display_name":"endoxifen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/astrogliogenesis","display_name":"astrogliogenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cnpase","display_name":"CNPase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.805005669593811},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.6888887882232666},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5420907139778137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49580058455467224},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.4755396842956543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47384363412857056},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.471076637506485},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.43762046098709106},{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.4375873804092407},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3745134472846985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3171674311161041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3169250190258026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23572105169296265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16896405816078186},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10793420672416687}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroscience.2016.01.026","doi":"https://doi.org/10.1016/j.neuroscience.2016.01.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2016.01.026","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:26820594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26820594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:ecommons.aku.edu:bmi-1162","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.aku.edu/bmi/170","pdf_url":null,"source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain and Mind Institute","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1900556344","https://openalex.org/W1901604477","https://openalex.org/W1917367513","https://openalex.org/W1935820490","https://openalex.org/W1964416005","https://openalex.org/W1965292592","https://openalex.org/W1965323887","https://openalex.org/W1965335984","https://openalex.org/W1970531647","https://openalex.org/W1970747178","https://openalex.org/W1974352283","https://openalex.org/W1976053967","https://openalex.org/W1978361606","https://openalex.org/W1981125500","https://openalex.org/W2003807965","https://openalex.org/W2010391061","https://openalex.org/W2012710587","https://openalex.org/W2013479777","https://openalex.org/W2026122266","https://openalex.org/W2027434771","https://openalex.org/W2045072541","https://openalex.org/W2048082433","https://openalex.org/W2048944834","https://openalex.org/W2049116118","https://openalex.org/W2049834865","https://openalex.org/W2051262966","https://openalex.org/W2056677926","https://openalex.org/W2059137890","https://openalex.org/W2065970275","https://openalex.org/W2069025840","https://openalex.org/W2069648734","https://openalex.org/W2078140574","https://openalex.org/W2078482008","https://openalex.org/W2080141893","https://openalex.org/W2081870563","https://openalex.org/W2090181747","https://openalex.org/W2095831706","https://openalex.org/W2097635139","https://openalex.org/W2101738855","https://openalex.org/W2101833345","https://openalex.org/W2104447446","https://openalex.org/W2115516116","https://openalex.org/W2127744082","https://openalex.org/W2132670847","https://openalex.org/W2133016564","https://openalex.org/W2134798433","https://openalex.org/W2135805788","https://openalex.org/W2139422964","https://openalex.org/W2141254780","https://openalex.org/W2147352258","https://openalex.org/W2156455256","https://openalex.org/W2160618408","https://openalex.org/W2162631676","https://openalex.org/W2170664539","https://openalex.org/W2396827053","https://openalex.org/W2402754272","https://openalex.org/W6713477460"],"related_works":["https://openalex.org/W2513554498","https://openalex.org/W4415310496","https://openalex.org/W4394806417","https://openalex.org/W2030126638","https://openalex.org/W4386697707","https://openalex.org/W1965292592","https://openalex.org/W3205717969","https://openalex.org/W2155841310","https://openalex.org/W3173413363","https://openalex.org/W2788339791"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}