{"id":"https://openalex.org/W2251291005","doi":null,"title":"The analysis of human serum lipoprotein distributions.","display_name":"The analysis of human serum lipoprotein distributions.","publication_year":1965,"publication_date":"1965-01-01","ids":{"openalex":"https://openalex.org/W2251291005","mag":"2251291005","pmid":"https://pubmed.ncbi.nlm.nih.gov/5331622"},"language":"en","primary_location":{"id":"pmid:5331622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5331622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in lipid research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054113385","display_name":"A. M. Ewing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Ewing","raw_affiliation_strings":["Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California Berkeley, California","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053255238","display_name":"NORMAN K. FREEMAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N K Freeman","raw_affiliation_strings":["Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California Berkeley, California","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111423854","display_name":"Frank T. Lindgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F T Lindgren","raw_affiliation_strings":["Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California Berkeley, California","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":6.8055,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.96565015,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"25","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-lipoproteins","display_name":"serum lipoproteins","score":0.9070000052452087},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.8360000252723694},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hdl2-cholesterol","display_name":"HDL2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hdl3","display_name":"HDL3","score":1.0},{"id":"https://openalex.org/keywords/analytical-ultracentrifugation","display_name":"analytical ultracentrifugation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lipoprotein-subfractions","display_name":"lipoprotein subfractions","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5883371829986572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5353489518165588},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3430442214012146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3369755148887634},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33568936586380005},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3201519548892975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27510613203048706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23734524846076965}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:5331622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5331622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in lipid research","raw_type":"Journal Article"},{"id":"mag:2251291005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5331622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W14642818","https://openalex.org/W593265407","https://openalex.org/W1531181853","https://openalex.org/W1567811966","https://openalex.org/W1584531376","https://openalex.org/W1589517411","https://openalex.org/W1670866707","https://openalex.org/W1965790678","https://openalex.org/W1972683001","https://openalex.org/W1976747807","https://openalex.org/W2015862620","https://openalex.org/W2016102080","https://openalex.org/W2020470831","https://openalex.org/W2027770928","https://openalex.org/W2031391456","https://openalex.org/W2032771951","https://openalex.org/W2048445863","https://openalex.org/W2060369320","https://openalex.org/W2077157113","https://openalex.org/W2093349432","https://openalex.org/W2168644924","https://openalex.org/W2181699429","https://openalex.org/W2205913049","https://openalex.org/W2325495394","https://openalex.org/W2336794324","https://openalex.org/W2343473386","https://openalex.org/W2394848232","https://openalex.org/W2397880752","https://openalex.org/W2404388068"],"related_works":["https://openalex.org/W4323284558","https://openalex.org/W2135503869","https://openalex.org/W2090435112","https://openalex.org/W6962843106","https://openalex.org/W2000362074","https://openalex.org/W119636521","https://openalex.org/W832404989","https://openalex.org/W2465238358","https://openalex.org/W2132344399","https://openalex.org/W2185919342"],"abstract_inverted_index":{"Publisher":[0],"Summary":[1],"This":[4],"chapter":[5],"reviews":[6],"distributions":[7,13],"of":[8,48,61,71,77,91,98,117,139,150],"human":[9,17,49],"serum":[10],"lipoproteins.":[11],"Macromolecular":[12],"such":[14,72],"as":[15],"the":[16,28,42,52,62,92,96,99,115,140],"lipoprotein":[18,46,84,101,104,129],"system":[19],"have":[20],"for":[21,66,83,147],"many":[22],"years":[23],"been":[24,107,156],"analyzed":[25],"by":[26],"utilizing":[27],"analytical":[29,53],"ultracentrifuge.":[30],"A":[31],"biochemically":[32],"important":[33],"macromolecular":[34,73],"system,":[35],"exhibiting":[36],"these":[37],"special":[38],"physical":[39],"characteristics,":[40],"is":[41],"low-":[43],"and":[44,121,133,143],"high-density":[45,100,128],"spectrum":[47],"sera.":[50],"Although":[51],"difficulties":[54],"are":[55],"considerable,":[56],"ultracentrifugal":[57,81],"analysis":[58,70,85],"provides":[59],"one":[60],"few":[63],"available":[64],"approaches":[65],"an":[67],"extensive":[68],"quantitative":[69],"distributions.":[74],"Largely":[75],"because":[76],"technical":[78],"limitations,":[79],"previous":[80],"methodology":[82],"has":[86,106,154],"considered":[87],"only":[88],"broad":[89],"subtractions":[90],"low-density":[93],"spectra.":[94],"In":[95],"case":[97],"spectrum,":[102],"this":[103,148,165],"distribution":[105],"divided":[108],"essentially":[109],"into":[110],"two":[111],"main":[112],"classes":[113],"on":[114],"basis":[116],"hydrated":[118],"density":[119],"below":[120],"above":[122],"approximately":[123],"1.125":[124],"gm/ml,":[125],"corresponding":[126],"to":[127,158,163],"HDL":[130,134],"2":[131],"3":[135],",":[136],"respectively.":[137],"Because":[138],"elaborate":[141],"calculations":[142],"data":[144],"processing":[145],"required":[146],"kind":[149],"mathematical":[151],"analysis,":[152],"it":[153],"not":[155],"feasible":[157],"consider":[159],"potentially":[160],"useful":[161],"techniques":[162],"accomplish":[164],"task":[166],"manually.":[167]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}