{"id":"https://openalex.org/W2250124751","doi":null,"title":"Estudo dos mecanismos de resist\u00eancia e virul\u00eancia de isolados de Cryptococcus neoformans e Cryptococcus gattii e quantifica\u00e7\u00e3o de genes de bomba de efluxo p\u00f3s tratamento com Galatos de Alquila","display_name":"Estudo dos mecanismos de resist\u00eancia e virul\u00eancia de isolados de Cryptococcus neoformans e Cryptococcus gattii e quantifica\u00e7\u00e3o de genes de bomba de efluxo p\u00f3s tratamento com Galatos de Alquila","publication_year":2014,"publication_date":"2014-11-28","ids":{"openalex":"https://openalex.org/W2250124751","mag":"2250124751"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:2157702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/132188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/132188","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045610665","display_name":"Su\u00e9len Andreia Rossi","orcid":"https://orcid.org/0000-0003-4128-6909","observed_orcids":["https://orcid.org/0000-0003-4128-6909"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Su\u00e9len Andreia Rossi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4128-6909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045610665"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.08100000023841858,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":1.0},{"id":"https://openalex.org/keywords/cryptococcus-gattii","display_name":"Cryptococcus gattii","score":1.0},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7490000128746033},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.8320000171661377},{"id":"https://openalex.org/keywords/alkyl-gallates","display_name":"alkyl gallates","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.777999997138977},{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.7910000085830688},{"id":"https://openalex.org/keywords/erg11","display_name":"ERG11","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/galleria-mellonella","display_name":"Galleria mellonella","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cryptococcosis","display_name":"cryptococcosis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.4970000088214874},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5249999761581421},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.7067170739173889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6382884979248047},{"id":"https://openalex.org/C2779286289","wikidata":"https://www.wikidata.org/wiki/Q149791","display_name":"Cryptococcus gattii","level":3,"score":0.5558185577392578},{"id":"https://openalex.org/C2778952914","wikidata":"https://www.wikidata.org/wiki/Q309498","display_name":"Cryptococcus","level":2,"score":0.5403698682785034},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3227364718914032}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:2157702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/132188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.unesp.br:11449/132188","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/132188","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:acervodigital.unesp.br:11449/132188","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/132188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400256","display_name":"Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115194","host_organization_name":"Funda\u00e7\u00e3o para o Desenvolvimento da UNESP","host_organization_lineage":["https://openalex.org/I4210115194"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"outro"},{"id":"mag:2250124751","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.unesp.br/handle/11449/132188","pdf_url":null,"source":{"id":"https://openalex.org/S4210186100","display_name":"Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences","issn_l":"2639-6440","issn":["2639-6440","2639-6459"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:2157702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/132188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W793882887","https://openalex.org/W2188048436","https://openalex.org/W2125789219","https://openalex.org/W2279648668","https://openalex.org/W2132853100","https://openalex.org/W4293537965","https://openalex.org/W2043524178","https://openalex.org/W2791761451","https://openalex.org/W2152033992","https://openalex.org/W2157318380"],"abstract_inverted_index":{"The":[0,18,170,211,233],"increase":[1],"of":[2,8,29,49,74,79,84,93,127,135],"invasive":[3],"mycoses":[4],"and":[5,24,26,98,106,155,158,165,174,182,198,243,248],"the":[6,27,33,45,58,65,72,91,120,125,132,144,159,166,230,249,269],"development":[7],"antifungal":[9,19,30,204],"resistance":[10,31],"by":[11,109],"some":[12],"fungi":[13,38],"species":[14],"have":[15],"been":[16],"worrying.":[17],"treatment":[20],"is":[21],"usually":[22],"aggressive":[23],"inefficient,":[25],"emergence":[28],"increases":[32],"difficulties":[34],"in":[35,103,124,140,224],"treating":[36],"these":[37,118,255],"infections.Cryptococcus":[39],"neoformans":[40],"e":[41,209],"Cryptococcus":[42],"gattii":[43,184],"are":[44,101],"main":[46],"etiologic":[47],"agents":[48],"cryptococcosis":[50],"andespecially":[51],"affect":[52],"immunocompromised":[53],"patients.":[54],"In":[55,87],"this":[56,259],"work":[57],"Galleria":[59],"mellonella,":[60],"was":[61,89,215,251,272],"used":[62,123],"to":[63,130,217,253],"perform":[64],"morphologic":[66],"characterization":[67],"as":[68,70,149],"well":[69],"determine":[71],"virulence":[73,266],"three":[75],"sequential":[76],"clinical":[77],"isolates":[78,121,146,240],"C.":[80,85,160,183],"neoformansand":[81],"twoisolates":[82],"environmental":[83],"gattii.":[86],"addition,":[88],"held":[90],"analysis":[92],"genes":[94,256],"expressions":[95],"(MDR1,":[96],"ERG11":[97],"AFR1),":[99],"that":[100,238],"involved":[102],"efflux":[104,246],"pumps":[105],"ergosterol":[107],"synthesis,":[108],"real":[110],"time":[111],"PCR":[112],"(polimerase":[113],"chain":[114],"reaction)":[115],"assay.":[116],"After":[117,138],"characterizations":[119],"were":[122,147,162,178,188],"prospecting":[126],"synthetic":[128,176],"molecules":[129,173],"verify":[131],"inhibitory":[133],"activity":[134,223],"selected":[136],"genes.":[137],"incubation":[139],"vitro":[141],"with":[142,227],"fluconazole":[143],"C.neoformans":[145,181],"classified":[148],"sensitive":[150,168],"(26S),":[151],"intermediate":[152],"sensitivity":[153],"(27I)":[154],"resistant":[156,163],"(30R),":[157],"gattiiisolates":[161],"(118R)":[164],"other":[167],"(LC).":[169],"galic":[171],"acid":[172],"their":[175],"derivatives":[177],"tests":[179,219],"against":[180],"isolates.The":[185],"best":[186],"results":[187],"obtained":[189],"from":[190],"alkyl":[191],"gallates":[192],"G11,":[193],"G12,":[194],"G14,":[195,207],"G15,":[196],"G16":[197,208,250],"G17":[199],"which":[200,257],"shows":[201,237],"a":[202],"great":[203],"activity,":[205],"especially":[206],"G17.":[210],"gallate":[212],"n-dodecyl":[213],"(G16),":[214],"select":[216],"others":[218],"once":[220],"presented":[221],"additive":[222],"synergism":[225],"test":[226],"fluconazole,":[228],"decreasing":[229],"MIC":[231],"values.":[232],"gene":[234],"expression":[235],"assay":[236],"both":[239],"expressed":[241],"MDR1":[242],"AFR1":[244],"(encoding":[245],"pumps),":[247],"capable":[252],"inhibit":[254],"makes":[258],"molecule":[260],"promising":[261],"for":[262],"inhibiting":[263],"efflux.":[264],"With":[265],"assays":[267],"using":[268],"G.":[270],"mellonella":[271],"possible":[273],"...":[274]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}