{"id":"https://openalex.org/W2249670160","doi":"https://doi.org/10.1182/blood.v116.21.3289.3289","title":"Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo","display_name":"Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2249670160","doi":"https://doi.org/10.1182/blood.v116.21.3289.3289","mag":"2249670160"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.3289.3289","doi":"https://doi.org/10.1182/blood.v116.21.3289.3289","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.3289.3289","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035808651","display_name":"Andrew S. Moore","orcid":"https://orcid.org/0000-0001-8062-1779","observed_orcids":["https://orcid.org/0000-0001-8062-1779"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew S Moore","raw_affiliation_strings":["Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087031667","display_name":"Amir Faisal","orcid":"https://orcid.org/0000-0002-7376-8286","observed_orcids":["https://orcid.org/0000-0002-7376-8286"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Amir Faisal","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036587927","display_name":"Vassilios Bavetsias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Vassilios Bavetsias","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008308657","display_name":"Chongbo Sun","orcid":"https://orcid.org/0009-0006-1040-7682","observed_orcids":["https://orcid.org/0009-0006-1040-7682"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Chongbo Sun","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050713768","display_name":"Butrus Atrash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Butrus Atrash","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089603827","display_name":"Melanie R. Valenti","orcid":"https://orcid.org/0000-0001-7610-1375","observed_orcids":["https://orcid.org/0000-0001-7610-1375"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Melanie Valenti","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904367","display_name":"Alexis de Haven Brandon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexis de Haven Brandon","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055603007","display_name":"Sian Avery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sian Avery","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058014829","display_name":"Florence I. Raynaud","orcid":"https://orcid.org/0000-0003-0957-6279","observed_orcids":["https://orcid.org/0000-0003-0957-6279"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Florence I Raynaud","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003965204","display_name":"Paul Workman","orcid":"https://orcid.org/0000-0003-1659-3034","observed_orcids":["https://orcid.org/0000-0003-1659-3034"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul Workman","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052706160","display_name":"Andrew D.J. Pearson","orcid":"https://orcid.org/0000-0002-8738-5913","observed_orcids":["https://orcid.org/0000-0002-8738-5913"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew DJ Pearson","raw_affiliation_strings":["Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055979646","display_name":"Julian Blagg","orcid":"https://orcid.org/0000-0002-7409-0323","observed_orcids":["https://orcid.org/0000-0002-7409-0323"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julian Blagg","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110523635","display_name":"Suzanne A. Eccles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Suzanne A Eccles","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052675504","display_name":"Spiros Linardopoulos","orcid":"https://orcid.org/0000-0002-6600-400X","observed_orcids":["https://orcid.org/0000-0002-6600-400X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Spiros Linardopoulos","raw_affiliation_strings":["Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003965204","https://openalex.org/A5008308657","https://openalex.org/A5035808651","https://openalex.org/A5036587927","https://openalex.org/A5050713768","https://openalex.org/A5052675504","https://openalex.org/A5052706160","https://openalex.org/A5055603007","https://openalex.org/A5055979646","https://openalex.org/A5058014829","https://openalex.org/A5087031667","https://openalex.org/A5089603827","https://openalex.org/A5110523635","https://openalex.org/A5112904367"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.1997,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62483635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"116","issue":"21","first_page":"3289","last_page":"3289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.7559999823570251},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/aurora-kinase-inhibitors","display_name":"Aurora kinase inhibitors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dual-kinase-inhibition","display_name":"dual kinase inhibition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/imidazo-4-5-b-pyridine","display_name":"imidazo[4,5-b]pyridine","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.625},{"id":"https://openalex.org/keywords/mv4-11-cells","display_name":"MV4-11 cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9729999899864197},{"id":"https://openalex.org/keywords/stat5-phosphorylation","display_name":"STAT5 phosphorylation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C20552341","wikidata":"https://www.wikidata.org/wiki/Q4822632","display_name":"Aurora inhibitor","level":4,"score":0.8764711618423462},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7627655863761902},{"id":"https://openalex.org/C2780808130","wikidata":"https://www.wikidata.org/wiki/Q24745285","display_name":"Aurora kinase","level":4,"score":0.7574153542518616},{"id":"https://openalex.org/C141937037","wikidata":"https://www.wikidata.org/wiki/Q14911664","display_name":"Aurora B kinase","level":5,"score":0.6464113593101501},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.5672184824943542},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.5551669597625732},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4696708619594574},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46600064635276794},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4584150016307831},{"id":"https://openalex.org/C2779425043","wikidata":"https://www.wikidata.org/wiki/Q14905704","display_name":"Aurora A kinase","level":3,"score":0.4559441804885864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42563366889953613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3270135521888733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3217392563819885},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.316165953874588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2395249307155609},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.19062674045562744},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17598006129264832},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.14977651834487915},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.11017552018165588},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.09990954399108887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06202855706214905}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.3289.3289","doi":"https://doi.org/10.1182/blood.v116.21.3289.3289","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.3289.3289","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042636485","https://openalex.org/W2081888424","https://openalex.org/W1994026326","https://openalex.org/W2553470673","https://openalex.org/W4239446831","https://openalex.org/W2586769142","https://openalex.org/W2005499874","https://openalex.org/W3193559035","https://openalex.org/W3015749894","https://openalex.org/W2020481917"],"abstract_inverted_index":{"Abstract":[0,1],"3289":[2],"The":[3,315,355,361],"Aurora":[4,23,35,91,95,99,177,179,182,194,217,302],"kinases":[5,11,24,184,220,305],"are":[6,38,159,379],"a":[7,29,52,190,232,368,382,392],"family":[8],"of":[9,19,22,31,46,54,143,176,187,193,201,205,216,267,277,281,301,319,330,341,347,357,363,400,406,412,418,424,432,438,444,450,456,462,468,474],"serine-threonine":[10],"that":[12,172,298,332,394],"play":[13],"key":[14],"roles":[15],"in":[16,28,43,59,110,113,116,137,140,145,221,231,240,249,321,343,371],"different":[17],"stages":[18],"mitosis.":[20],"Over-expression":[21],"has":[25,367],"been":[26],"demonstrated":[27],"range":[30],"malignancies":[32],"including":[33],"leukemia.":[34],"kinase":[36,337],"inhibitors":[37,338],"emerging":[39],"as":[40],"promising":[41],"agents":[42],"the":[44,136,151,265,292,327,344],"treatment":[45],"acute":[47],"myeloid":[48],"leukemia":[49],"(AML)":[50],"with":[51,85,162,225,237,246,271,288,349],"number":[53],"compounds":[55],"currently":[56],"being":[57],"assessed":[58],"clinical":[60],"trials":[61],"(Moore":[62],"AS":[63],"et":[64,127],"al,":[65,128],"Leukemia":[66],"2010).":[67,132],"CCT137690,":[68],"an":[69,77],"imidazo[4,5-b]pyridine":[70],"derivative":[71],"discovered":[72],"at":[73],"our":[74],"Institute,":[75],"is":[76,395],"orally":[78,254],"bioavailable,":[79],"potent,":[80],"pan-Aurora":[81,334],"and":[82,103,112,122,139,157,181,185,203,210,218,229,262,303,335],"FLT3":[83,104,202,219,244,294,304,312,336],"inhibitor":[84,295],"low":[86],"nanomolar":[87],"IC50":[88],"values":[89,164],"against":[90],"A":[92],"(15":[93],"nM),":[94,98,102],"B":[96,180,195],"(25":[97],"C":[100,183],"(19":[101],"(<0.5":[105],"nM)":[106],"kinases.":[107],"CCT137690":[108,144,173,197,226,258,289,320],"showed":[109],"vitro":[111,138],"vivo":[114,141],"activity":[115,142,318],"human":[117],"colon":[118],"cancer":[119],"cell":[120,154,234],"lines":[121,155],"xenograft":[123,283],"models":[124,325],"(Bavetsias":[125],"V":[126],"J":[129],"Med":[130],"Chem":[131],"Here":[133],"we":[134],"report":[135],"FLT3-ITD":[146,152,222,322,350],"positive":[147,153,223,323,351],"AML.":[148,352],"In":[149],"vitro,":[150],"MV-4-11":[156],"MOLM-13":[158,269,282],"particularly":[160],"sensitive":[161],"GI50":[163],"less":[165],"than":[166],"50":[167],"nM.":[168],"Cellular":[169],"assays":[170],"demonstrate":[171],"inhibits":[174,199],"autophosphorylation":[175,200],"A,":[178],"phosphorylation":[186,204],"histone":[188],"H3,":[189],"direct":[191],"target":[192,260],"kinase.":[196],"also":[198],"its":[206],"downstream":[207],"targets":[208],"STAT5":[209],"p44/42":[211],"MAPK":[212],"(Erk1/2).":[213],"Dual":[214],"inhibition":[215,245,300,313],"AML":[224,324],"induces":[227],"apoptosis":[228],"results":[230],"unique":[233],"cycle":[235],"profile":[236],"cells":[238],"accumulating":[239],"G2/M,":[241],"whilst":[242],"selective":[243,293,311],"MLN518":[247],"resulted":[248],"G1/S":[250],"arrest.":[251],"When":[252],"given":[253],"to":[255,291,310,381,384,391],"athymic":[256],"mice,":[257],"achieved":[259],"modulation":[261],"potently":[263],"inhibited":[264],"growth":[266,284],"subcutaneous":[268],"xenografts,":[270],"no":[272],"obvious":[273],"toxicity":[274],"or":[275],"loss":[276],"body":[278,329],"weight.":[279],"Inhibition":[280],"was":[285],"more":[286],"pronounced":[287],"compared":[290,309],"MLN518,":[296],"suggesting":[297],"dual":[299,333],"may":[306,339,388],"have":[307],"advantages":[308],"alone.":[314],"potent":[316],"preclinical":[317],"supports":[326],"growing":[328],"evidence":[331],"be":[340],"benefit":[342],"high-risk":[345],"group":[346],"patients":[348],"Disclosures:":[353],"Moore:":[354],"Institute":[356,362,399,405,411,417,423,431,437,443,449,455,461,467,473],"Cancer":[358,364,401,407,413,419,425,433,439,445,451,457,463,469,475],"Research:":[359,402,408,414,420,426,434,440,446,452,458,464,470,476],"Employment,":[360],"Research":[365],"(ICR)":[366],"commercial":[369],"interest":[370],"drug":[372],"development":[373],"programs.":[374],"Authors":[375],"employed":[376],"by":[377],"ICR":[378],"subject":[380],"Rewards":[383],"Inventors":[385],"Scheme,":[386],"which":[387],"reward":[389],"contributors":[390],"program":[393],"subsequently":[396],"licensed.":[397],"Faisal:The":[398],"Employment.":[403,409,415,421,427,435,441,447,453,459,465,471,477],"Bavetsias:The":[404],"Sun:The":[410],"Atrash:The":[416],"Valenti:The":[422],"de":[428],"Haven":[429],"Brandon:The":[430],"Avery:The":[436],"Raynaud:The":[442],"Workman:The":[448],"Pearson:The":[454],"Blagg:The":[460],"Eccles:The":[466],"Linardopoulos:The":[472]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}