{"id":"https://openalex.org/W2249553571","doi":null,"title":"Do Glucocorticoids Hold Promise as a Treatment for PTSD","display_name":"Do Glucocorticoids Hold Promise as a Treatment for PTSD","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2249553571","mag":"2249553571"},"language":"en","primary_location":{"id":"mag:2249553571","doi":null,"is_oa":false,"landing_page_url":"https://www.questia.com/library/journal/1G1-344842908/do-glucocorticoids-hold-promise-as-a-treatment-for","pdf_url":null,"source":{"id":"https://openalex.org/S2764520953","display_name":"Current psychiatry","issn_l":"1537-8276","issn":["1537-8276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322696809","host_organization_name":"Frontline Medical Communications","host_organization_lineage":["https://openalex.org/P4322696809"],"host_organization_lineage_names":["Frontline Medical Communications"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current psychiatry","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071886352","display_name":"Farha B. Motiwala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farha Motiwala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060107642","display_name":"Michele Morals","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Morals","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017484966","display_name":"Saurabh B. Bhardwaj","orcid":"https://orcid.org/0000-0002-8845-0182","observed_orcids":["https://orcid.org/0000-0002-8845-0182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saurabh Bhardwaj","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8845-0182","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018430748","display_name":"Steven Lippmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Lippmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.27313813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"12","issue":"9","first_page":"57","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8840000033378601},{"id":"https://openalex.org/keywords/startle-response","display_name":"startle response","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hyperarousal","display_name":"hyperarousal","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fear-memory-consolidation","display_name":"fear memory consolidation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dexamethasone-suppression-test","display_name":"dexamethasone suppression test","score":0.765999972820282},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.6650000214576721},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.4269999861717224},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.5559999942779541},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.5339999794960022},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777845764","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle response","level":2,"score":0.6734572649002075},{"id":"https://openalex.org/C2779354879","wikidata":"https://www.wikidata.org/wiki/Q1641161","display_name":"Hypervigilance","level":3,"score":0.6644814014434814},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6580783128738403},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5746505260467529},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5413082242012024},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.4614151418209076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4545457065105438},{"id":"https://openalex.org/C62913699","wikidata":"https://www.wikidata.org/wiki/Q5173333","display_name":"Cortisol awakening response","level":3,"score":0.45258814096450806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4516597390174866},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4315107464790344},{"id":"https://openalex.org/C2909172351","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle reaction","level":3,"score":0.4292522668838501},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40809041261672974},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.30554836988449097},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.2210133969783783},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19592714309692383},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.10236859321594238}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2249553571","doi":null,"is_oa":false,"landing_page_url":"https://www.questia.com/library/journal/1G1-344842908/do-glucocorticoids-hold-promise-as-a-treatment-for","pdf_url":null,"source":{"id":"https://openalex.org/S2764520953","display_name":"Current psychiatry","issn_l":"1537-8276","issn":["1537-8276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322696809","host_organization_name":"Frontline Medical Communications","host_organization_lineage":["https://openalex.org/P4322696809"],"host_organization_lineage_names":["Frontline Medical Communications"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current psychiatry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1593827333","https://openalex.org/W2093376597","https://openalex.org/W2131975102","https://openalex.org/W2080519369","https://openalex.org/W4309438086","https://openalex.org/W2588982525","https://openalex.org/W6986383270","https://openalex.org/W4414130677","https://openalex.org/W2894784196","https://openalex.org/W2804739651"],"abstract_inverted_index":{"As":[0],"symptoms":[1,50],"of":[2,37,51,68,88,118,148,176,183,197,204,263,271,276,284,342,346,349],"posttrauma":[3],"tic":[4],"stress":[132],"disorder":[6],"(PTSD)":[7],"progress,":[8],"the":[9,65,210,238,251,260,318],"involved":[10],"person's":[11],"physical":[12],"and":[13,58,187,213,231,265,296,312,323,331],"mental":[14],"health":[15],"deteriorates.":[16],"(1)":[17,202],"This":[18,82,179],"sparks":[19],"lifestyle":[20],"changes":[21],"that":[22,45,115,279],"allow":[23],"them":[24,109],"to":[25,28,84,97,129,155,299],"avoid":[26,98],"re-exposure":[27],"triggering":[29],"stimuli;":[30],"however,":[31],"it":[32],"also":[33,124],"increases":[34],"their":[35],"risk":[36],"social":[38],"isolation.":[39],"Early":[40],"clinical":[41],"investigation":[42],"has":[43,250],"found":[44],"patients":[46,244],"who":[47],"experience":[48],"hyperarousal":[49],"overt":[52],"PTSD--difficulty":[53],"sleeping,":[54],"emotional":[55,136],"dyscontrol,":[56],"hypervigilance,":[57],"an":[59,232,256],"enhanced":[60,184],"startle":[61,235,240,266,338],"response--could":[62],"benefit":[63],"from":[64],"stress-reducing":[66],"capacity":[67],"glucocorticoids.":[69],"Decreased":[70],"glucocorticoids":[71],"After":[72],"a":[73,85,103,113,131,139,152,181,335,343],"distressing":[74],"situation,":[75],"norepinephrine":[76],"levels":[77,175,216,230],"rise":[78],"acutely.":[79],"(2),":[80,121,287,325],"(3)":[81,122,162,288,301,326],"contributes":[83],"protective":[86],"retention":[87],"potentially":[89],"threatening":[90],"memories,":[91],"which":[92,192],"is":[93,127,180,193,255],"how":[94],"people":[95,157],"learn":[96],"danger.":[99],"Glucocorticoid":[100,292],"secretion":[101],"enhances":[102],"patient's":[104],"coping":[105],"mechanisms":[106],"by":[107,195,307,315],"helping":[108],"process":[110],"information":[111],"in":[112,173,209,220,234,243,281,290,337],"way":[114],"diminishes":[116,144],"retrieval":[117,147],"fear-evoking":[119],"memories.":[120,286],"Glucocorticoid,":[123],"called":[125],"cortisol,":[126],"referred":[128],"as":[130,151],"hormone.":[133],"Cortisol":[134],"promotes":[135,274],"adaptability":[137],"following":[138],"traumatic":[140,285],"event;":[141],"this":[142],"action":[143],"future,":[145],"inappropriate":[146],"frightening":[149,277],"memories":[150],"physiologic":[153],"mechanism":[154],"help":[156],"cope":[158],"with":[159,245,309,330],"upsetting":[160],"situations.":[161],"PTSD":[163,221,291,333],"pathogenesis":[164],"involves":[165],"altered":[166],"hypothalamic-pituitary-adrenal":[167],"axis":[168],"function;":[169],"sustained":[170],"results":[172,196,280],"decreased":[174],"circulating":[177,248,272],"glucocorticoid.":[178],"consequence":[182],"negative":[185],"feedback":[186],"increased":[188,214],"glucocorticoid":[189,249,264,273,303],"receptor":[190],"sensitivity,":[191],"evidenced":[194],"abnormal":[198],"dexamethasone":[199],"suppression":[200],"tests.":[201],"Downregulation":[203],"corticotropin-releasing":[205],"hormone":[206],"(CRH)":[207],"receptors":[208],"pituitary":[211],"glands":[212],"CRH":[215,229],"have":[217],"been":[218],"documented":[219],"patients.":[222],"(1),":[223],"(4)":[224],"An":[225],"association":[226],"between":[227,259],"high":[228],"increase":[233],"response":[236,241,339],"explains":[237],"exaggerated":[239],"observed":[242],"PTSD.":[246],"Higher":[247],"opposite":[252],"effect;":[253],"there":[254],"inverse":[257],"relationship":[258],"daily":[261],"level":[262,270],"amplitude.":[267],"A":[268],"low":[269],"recall":[275],"events":[278],"persistent":[282],"re-experiencing":[283],"Glucocorticoids":[289],"administration":[293,304,341],"reduces":[294],"psychological":[295],"physiological":[297],"responses":[298],"stress.":[300],"Exogenous":[302],"affects":[305],"cognition":[306],"interacting":[308],"serotonin,":[310],"dopamine,":[311],"[gamma]-aminobutyric":[313],"acid":[314],"actions":[316],"on":[317],"amygdala,":[319],"medial":[320],"prefrontal":[321],"cortex,":[322],"hippocampus.":[324],"Research":[327],"among":[328],"veterans":[329],"without":[332],"recorded":[334],"decrease":[336],"after":[340],"single":[344],"dose":[345],"20":[347],"mg":[348],"hydrocortisone.":[350],"\u2026":[351]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}