{"id":"https://openalex.org/W2249448335","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.14059","title":"Phase 1, pharmacokinetic (PK) and pharmacodynamic (PD) study of oral alvespimycin (A; KOS-1022; 17-DMAG): Two different schedules in patients with advanced malignancies","display_name":"Phase 1, pharmacokinetic (PK) and pharmacodynamic (PD) study of oral alvespimycin (A; KOS-1022; 17-DMAG): Two different schedules in patients with advanced malignancies","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2249448335","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.14059","mag":"2249448335"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.14059","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.14059","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.14059","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055358118","display_name":"K. T. Flaherty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. T. Flaherty","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037169725","display_name":"Lia Gore","orcid":"https://orcid.org/0000-0002-2546-4616","observed_orcids":["https://orcid.org/0000-0002-2546-4616"]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Gore","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066015282","display_name":"Anjali Narayan Avadhani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Avadhani","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Leong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Leong","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071388496","display_name":"Kathleen Harlacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Harlacker","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008892178","display_name":"Ziyang Zhong","orcid":"https://orcid.org/0009-0006-4206-5728","observed_orcids":["https://orcid.org/0009-0006-4206-5728"]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Zhong","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010393631","display_name":"Robert G. Johnson","orcid":"https://orcid.org/0000-0003-3271-4916","observed_orcids":["https://orcid.org/0000-0003-3271-4916"]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. G. Johnson","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089364285","display_name":"Alison L. Hannah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. L. Hannah","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. O\u2019Dwyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. O\u2019Dwyer","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048907012","display_name":"S. Gail Eckhardt","orcid":"https://orcid.org/0000-0002-8103-1620","observed_orcids":["https://orcid.org/0000-0002-8103-1620"]},"institutions":[{"id":"https://openalex.org/I4387153735","display_name":"Kosan Biosciences (United States)","ror":"https://ror.org/02a00xk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387153735"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. G. Eckhardt","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA; Univ of Colorado at Denver and Health Science Cntr, Aurora, CO; Kosan Biosciences, Hayward, CA","institution_ids":["https://openalex.org/I4387153735","https://openalex.org/I79576946","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"14059","last_page":"14059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/17-dmag","display_name":"17-DMAG","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9629999995231628},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7649999856948853},{"id":"https://openalex.org/keywords/recommended-phase-ii-dose","display_name":"recommended phase 2 dose","score":0.7699999809265137},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6990000009536743},{"id":"https://openalex.org/keywords/peripheral-edema","display_name":"peripheral edema","score":0.7870000004768372},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.5170000195503235},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.6629999876022339},{"id":"https://openalex.org/keywords/absolute-bioavailability","display_name":"absolute bioavailability","score":0.640999972820282},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.5839999914169312},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.828000009059906},{"id":"https://openalex.org/keywords/hsp90alpha","display_name":"HSP90\u03b1","score":0.3310000002384186},{"id":"https://openalex.org/keywords/hsp90beta","display_name":"HSP90\u03b2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.5090000033378601},{"id":"https://openalex.org/keywords/hsp40","display_name":"Hsp40","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9188715219497681},{"id":"https://openalex.org/C2777482430","wikidata":"https://www.wikidata.org/wiki/Q7168709","display_name":"Peripheral edema","level":3,"score":0.7798213958740234},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6753528118133545},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6318135261535645},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6156041026115417},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5982876420021057},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5650972127914429},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.549141526222229},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5114361047744751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4676342308521271},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4635089933872223},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.40035849809646606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.14059","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.14059","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.14059","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2590538210","https://openalex.org/W2594218231","https://openalex.org/W2043832565","https://openalex.org/W2266076711","https://openalex.org/W2247627085","https://openalex.org/W1970460458","https://openalex.org/W2006598126","https://openalex.org/W7222525826","https://openalex.org/W2249199963","https://openalex.org/W2595746152"],"abstract_inverted_index":{"14059":[0],"Background:":[1],"A":[2,70,80],"is":[3,31,38,379],"\u223c3\u20135":[4],"fold":[5],"more":[6],"potent":[7],"compared":[8],"to":[9,15,56,105,126,222,272,374],"17-AAG":[10],"(the":[11],"first":[12],"Hsp90":[13],"inhibitor":[14],"enter":[16],"clinical":[17],"testing),":[18],"based":[19],"on":[20,84,153,176,256,299,355,369],"in":[21,27,36,43,71,129,240,288,314,317,344,372],"vitro":[22],"cytotoxicity":[23],"or":[24,91],"the":[25,44,58,113,154,177,270,315,318,347],"MTD":[26],"toxicology":[28],"studies;":[29],"it":[30],"water-soluble;":[32],"and":[33,49,67,118,137,143,168,187,211,218,242,254,259,261,280,293,338],"oral":[34,121],"bioavailability":[35,251],"dogs":[37],"estimated":[39],"at":[40,139,157,324,346,361],"40%.":[41],"Toxicity":[42,378],"dog":[45],"included":[46,233],"kidney,":[47],"intestinal":[48],"liver":[50],"findings.":[51],"This":[52],"study":[53],"was":[54,103,110,262,352],"conducted":[55],"determine":[57],"toxicity,":[59],"MTD,":[60],"recommended":[61],"phase":[62],"2":[63,85],"dose":[64,102,295,350],"(RP2D),":[65],"PK":[66,109,248],"PD":[68],"of":[69,79,96,120,159,383],"pts":[72,149,173,245,328],"with":[73,246,285,306,320,329,358],"solid":[74],"tumors.":[75],"Methods:":[76],"Escalating":[77],"doses":[78,158],"were":[81,124,150,181],"given":[82,104],"PO":[83],"different":[86],"schedules:":[87],"every":[88],"other":[89],"day":[90],"daily":[92],"for":[93,269],"4":[94,172],"out":[95],"6":[97],"weeks.":[98],"An":[99],"initial":[100],"IV":[101,114],"calculate":[106],"absolute":[107],"bioavailability.":[108],"evaluated":[111],"after":[112],"dose,":[115],"Day":[116,257,266,291,356],"1":[117,136,258,292],"21":[119,138,267,294,357],"dosing.":[122],"PBLs":[123],"collected":[125],"investigate":[127],"changes":[128,313],"intracellular":[130],"signaling":[131],"proteins":[132],"by":[133],"immunoblot":[134],"(Days":[135],"1,":[140],"3,":[141],"24":[142,152,362],"48":[144],"hours":[145,363],"post-dose).":[146],"Results:":[147],"28":[148],"enrolled:":[151],"QOD":[155],"schedule":[156],"5":[160,271],"(n=4),":[161,163],"10":[162],"20":[164],"(n=8),":[165],"30":[166,273,348],"(n=5)":[167],"40":[169],"mg":[170,349],"(n=3);":[171],"received":[174],"10mg":[175],"QD":[178],"schedule.":[179],"50%":[180],"male,":[182],"median":[183,189],"age/ECOG":[184],"PS":[185],"55":[186],"0;":[188],"prior":[190,309],"regimen":[191],"3.":[192],"DLT":[193],"has":[194],"not":[195,263],"yet":[196],"been":[197,297,386],"observed.":[198,387],"Common":[199],"drug-related":[200],"toxicities":[201],"(n=23):":[202],"fatigue":[203,217],"43%,":[204],"nausea":[205],"24%,":[206],"anorexia":[207],"19%,":[208,210],"proteinuria":[209],"peripheral":[212,219,236],"edema":[213,220],"14%.":[214],"Of":[215],"these,":[216],"appear":[221],"be":[223],"possibly":[224],"dose-related.":[225],"Drug-related":[226],"Grade":[227],"3\u20134":[228],"toxicity":[229],"(one":[230],"patient":[231],"each)":[232],"anemia,":[234],"neutropenia,":[235],"edema,":[237],"hypokalemia,":[238],"pain":[239],"extremity":[241],"hypoxia.":[243],"For":[244],"full":[247],"data":[249],"(n=14),":[250],"equaled":[252,276],"51%":[253],"49%":[255],"21,":[260],"dose-dependent.":[264],"Mean":[265],"AUCinf":[268,289],"mg/m2":[274],"levels":[275],"91,":[277],"166,":[278],"542":[279],"1889":[281],"ng*h/mL.":[282],"One":[283,304],"pt":[284,305],"3-fold":[286],"increase":[287],"comparing":[290],"had":[296,311],"started":[298],"dronabinol,":[300],"a":[301,376],"CYP2C9":[302],"inhibitor.":[303],"fibrosarcoma":[307],"(4":[308],"regimens)":[310],"necrotic":[312],"tumor":[316],"axilla":[319],"improved":[321],"symptoms":[322],"(active":[323],"5+":[325],"months).":[326,342],"Additional":[327],"SD":[330],"include":[331],"hemangioendothelioma":[332],"(7":[333],"months),":[334,337],"melanoma":[335],"(6+":[336],"renal":[339],"cell":[340],"(5":[341],"Induction":[343],"Hsp70":[345],"level":[351],"seen":[353],"pre-dose":[354],"maximal":[359],"induction":[360],"post-dose.":[364],"Conclusions:":[365],"Dose":[366],"escalation":[367],"continues":[368],"both":[370],"schedules":[371],"order":[373],"define":[375],"RP2D.":[377],"acceptable.":[380],"Early":[381],"signs":[382],"activity":[384],"have":[385],"[Table:":[388],"see":[389],"text]":[390]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}