{"id":"https://openalex.org/W2249244150","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.9519","title":"Sunitinib treatment of pediatric metastatic GIST after failure of imatinib","display_name":"Sunitinib treatment of pediatric metastatic GIST after failure of imatinib","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2249244150","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.9519","mag":"2249244150"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.9519","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.9519","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.9519","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056053037","display_name":"Katherine A. Janeway","orcid":"https://orcid.org/0000-0001-6000-3594","observed_orcids":["https://orcid.org/0000-0001-6000-3594"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. A. Janeway","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020991267","display_name":"Don Matthews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. C. Matthews","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087253387","display_name":"James Edward Butrynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. E. Butrynski","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041323342","display_name":"Gina Z. D\u2019Amato","orcid":"https://orcid.org/0000-0001-6981-7527","observed_orcids":["https://orcid.org/0000-0001-6981-7527"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Z. D\u2019Amato","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108263966","display_name":"S. Agresta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Agresta","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086094365","display_name":"Christopher R. Garrett","orcid":"https://orcid.org/0000-0003-2564-7882","observed_orcids":["https://orcid.org/0000-0003-2564-7882"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Garrett","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026593581","display_name":"Christopher L. Corless","orcid":"https://orcid.org/0000-0003-4871-8364","observed_orcids":["https://orcid.org/0000-0003-4871-8364"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. L. Corless","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003791140","display_name":"Karen H. Albritton","orcid":"https://orcid.org/0000-0002-4427-5634","observed_orcids":["https://orcid.org/0000-0002-4427-5634"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. H. Albritton","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035376959","display_name":"George D. Demetri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. D. Demetri","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; University of Washington School of Medicine, Seattle, WA; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Oregon Health & Science University Cancer Institute, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I3019308854","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"9519","last_page":"9519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metastatic-gist","display_name":"metastatic GIST","score":0.9330000281333923},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/wild-type-gist","display_name":"wild-type GIST","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.953000009059906},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/retroperitoneal-metastasis","display_name":"retroperitoneal metastasis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gastric-gist","display_name":"gastric GIST","score":0.7110000252723694},{"id":"https://openalex.org/keywords/adjuvant-imatinib","display_name":"adjuvant imatinib","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.414000004529953},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/expanded-access-protocol","display_name":"expanded access protocol","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9400433301925659},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.9394207000732422},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.8829816579818726},{"id":"https://openalex.org/C2908861226","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib malate","level":4,"score":0.8009341955184937},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6191936135292053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5162577629089355},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5090877413749695},{"id":"https://openalex.org/C2777007597","wikidata":"https://www.wikidata.org/wiki/Q16869243","display_name":"Stromal tumor","level":3,"score":0.48600706458091736},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4731113612651825},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4716711938381195},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4047406315803528},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3318285346031189},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31815633177757263},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.15282517671585083},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.9519","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.9519","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.9519","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2278655168","https://openalex.org/W3028750840","https://openalex.org/W3141547332","https://openalex.org/W2129878459","https://openalex.org/W2498546831","https://openalex.org/W2039155298","https://openalex.org/W2075255927","https://openalex.org/W2067449025","https://openalex.org/W2491750779","https://openalex.org/W2006210684"],"abstract_inverted_index":{"9519":[0],"Background:":[1],"The":[2],"genotype":[3],"of":[4,75,107,117,146,221,233,267,284,355],"most":[5],"GIST":[6,82,99,173,196,270,359],"in":[7,54,199,246,276,288,294,300,321,327,335,344,357],"pediatric":[8,77,345,358],"patients":[9],"(pts)":[10],"is":[11,236,360],"\u201cwild":[12],"type\u201d":[13],"(WT-GIST),":[14],"with":[15,23,38,48,65,79,94,131,169,208,219,281,309,347],"no":[16],"detectable":[17],"KIT":[18],"or":[19,274],"PDGFR-\u03b1":[20],"mutations.":[21],"Adults":[22],"metastatic":[24,81,195],"WT-GIST":[25],"often":[26],"have":[27,263,272,311],"suboptimal":[28],"results":[29,53],"and":[30,50,86,97,104,120,159,174,181,202,227,318,330],"primary":[31],"resistance":[32],"to":[33,115],"imatinib":[34],"(IM)":[35],"therapy.":[36],"Treatment":[37],"sunitinib":[39,310,356],"malate":[40],"(SU11248),":[41],"an":[42,132,241],"oral,":[43],"multitargeted":[44],"tyrosine":[45],"kinase":[46],"inhibitor":[47],"antiangiogenic":[49],"antitumor":[51,342],"activities,":[52],"significant":[55,298],"clinical":[56],"benefit,":[57],"such":[58],"as":[59],"improved":[60],"survival,":[61],"for":[62,186,211,251],"adult":[63],"pts":[64,78,262,296,346],"IM-resistant":[66,348],"GIST,":[67,135],"including":[68,314],"WT-GIST.":[69],"We":[70],"report":[71],"here":[72],"the":[73,200,222],"treatment":[74],"3":[76,164,235,325,332],"IM-resistant,":[80],"using":[83],"sunitinib.":[84,268],"Methods":[85],"Patients:":[87],"Pt":[88,125,163,234,289],"1":[89,212,226],"presented":[90,127,165],"at":[91,128,166,303],"age":[92,129,167],"17":[93],"numerous":[95],"abdominal":[96],"hepatic":[98,123,216],"metastases.":[100,162],"Following":[101],"surgical":[102],"debulking":[103],"6":[105],"wks":[106,253,257],"IM":[108,141,185,204],"treatment,":[109],"objective":[110],"progression":[111,220],"was":[112,197,206,244],"noted":[113,198],"due":[114],"growth":[116],"omental":[118],"masses":[119],"a":[121,147,170,175],"new":[122,215],"lesion.":[124],"2":[126,155,228,256,285,295,316,329],"8":[130],"isolated":[133],"gastric":[134,172],"fully":[136,179],"resected,":[137],"followed":[138,182,254],"by":[139,183,255,278],"adjuvant":[140,184],"that":[142],"continued":[143],"until":[144],"resection":[145],"local":[148,157],"recurrence":[149],"14":[150],"mos":[151,190],"later.":[152],"She":[153],"had":[154,229],"more":[156],"recurrences":[158],"developed":[160],"lung":[161,286],"13":[168],"large":[171],"retroperitoneal":[176,223],"metastasis,":[177],"both":[178],"resected":[180],"18":[187],"mos.":[188],"Six":[189],"after":[191],"discontinuing":[192],"IM,":[193],"recurrent":[194],"liver":[201],"retroperitoneum;":[203],"therapy":[205],"resumed":[207],"stable":[209],"disease":[210,305],"yr":[213],"when":[214],"lesions":[217,271],"appeared":[218],"mass.":[224],"Pts":[225],"WT-GIST,":[230],"while":[231],"genotyping":[232],"pending.":[237],"Sunitinib,":[238],"obtained":[239,293],"via":[240],"expanded-access":[242],"protocol,":[243],"administered":[245],"6-wk":[247],"cycles,":[248],"orally":[249],"QD":[250],"4":[252],"off":[258],"dosing.":[259],"Results:":[260],"All":[261,269],"received":[264],"5":[265],"cycles":[266],"stabilized":[273],"decreased":[275],"size":[277],"CT":[279],"imaging,":[280],"complete":[282],"regression":[283],"nodules":[287],"2.":[290],"18FDG-PET":[291],"imaging":[292],"showed":[297],"decreases":[299],"tumor-associated":[301],"activity":[302,343],"all":[304],"sites.":[306],"Side":[307],"effects":[308],"been":[312],"manageable,":[313],"grade":[315,324,331],"GI":[317],"hematologic":[319,333],"toxicities":[320],"pt":[322,328,336],"1,":[323],"fatigue":[326],"toxicity":[334],"3.":[337],"Conclusions:":[338],"Sunitinib":[339],"shows":[340],"important":[341],"GIST.":[349],"An":[350],"expanded":[351],"phase":[352],"I/II":[353],"trial":[354],"warranted.":[361],"[Table:":[362],"see":[363],"text]":[364]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
