{"id":"https://openalex.org/W2249163471","doi":"https://doi.org/10.1242/dev.127068","title":"An Nfic-hedgehog signaling cascade regulates tooth root development","display_name":"An Nfic-hedgehog signaling cascade regulates tooth root development","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2249163471","doi":"https://doi.org/10.1242/dev.127068","mag":"2249163471","pmid":"https://pubmed.ncbi.nlm.nih.gov/26293299","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4631759"},"language":"en","primary_location":{"id":"doi:10.1242/dev.127068","doi":"https://doi.org/10.1242/dev.127068","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.127068","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4631759","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100781635","display_name":"Liu Yang","orcid":"https://orcid.org/0000-0002-6498-4702","observed_orcids":["https://orcid.org/0000-0002-6498-4702"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","Department of Prosthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PRC","Department of Prosthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PRC","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"Department of Prosthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, People's Republic of China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087033025","display_name":"Jifan Feng","orcid":"https://orcid.org/0000-0002-9944-2604","observed_orcids":["https://orcid.org/0000-0002-9944-2604"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jifan Feng","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601055","display_name":"Jingyuan Li","orcid":"https://orcid.org/0000-0003-2926-1864","observed_orcids":["https://orcid.org/0000-0003-2926-1864"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jingyuan Li","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, PRC","Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, PRC","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042903123","display_name":"Hu Zhao","orcid":"https://orcid.org/0000-0002-2961-0086","observed_orcids":["https://orcid.org/0000-0002-2961-0086"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hu Zhao","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077274349","display_name":"Thach\u2010Vu Ho","orcid":"https://orcid.org/0000-0001-6293-4739","observed_orcids":["https://orcid.org/0000-0001-6293-4739"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thach-Vu Ho","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yang Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Chai","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":2.6033,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.90645712,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"142","issue":"19","first_page":"3374","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tooth-root-formation","display_name":"tooth root development","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nfic","display_name":"NFIC","score":0.984000027179718},{"id":"https://openalex.org/keywords/hhip","display_name":"HHIP","score":0.8619999885559082},{"id":"https://openalex.org/keywords/apical-papilla","display_name":"apical papilla","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hertwig-s-epithelial-root-sheath","display_name":"Hertwig's epithelial root sheath","score":0.9980000257492065},{"id":"https://openalex.org/keywords/molar-roots","display_name":"molar roots","score":0.7739999890327454},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/root-defects","display_name":"root defects","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7004371881484985},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6887786388397217},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6041382551193237},{"id":"https://openalex.org/C56302369","wikidata":"https://www.wikidata.org/wiki/Q189341","display_name":"Cementoblast","level":4,"score":0.5677533745765686},{"id":"https://openalex.org/C72041822","wikidata":"https://www.wikidata.org/wiki/Q3362895","display_name":"Dental papilla","level":4,"score":0.4959906041622162},{"id":"https://openalex.org/C2520015","wikidata":"https://www.wikidata.org/wiki/Q853338","display_name":"Odontoblast","level":3,"score":0.46176499128341675},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.4481469988822937},{"id":"https://openalex.org/C2777894202","wikidata":"https://www.wikidata.org/wiki/Q848382","display_name":"Cementum","level":3,"score":0.4073767066001892},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3827209770679474},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3822551965713501},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19280606508255005},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.13631048798561096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008963","descriptor_name":"Molar","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014092","descriptor_name":"Tooth Root","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051839","descriptor_name":"NFI Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.127068","doi":"https://doi.org/10.1242/dev.127068","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.127068","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4631759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4631759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:26293299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26293299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4631759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4631759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.41999998688697815,"display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5377049682","display_name":"TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS","funder_award_id":"R37DE012711","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G689494279","display_name":"INTEGRATED RESEARCH OF FUNCTIONAL GENOMICS AND CRANIOFACIAL MORPHOGENESIS","funder_award_id":"U01DE024421","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000859648","display_name":"The Molecular Regulatory Mechanism of Tooth Root Development","funder_award_id":"R01DE022503","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1585922331","https://openalex.org/W1658177695","https://openalex.org/W1750014769","https://openalex.org/W1963936348","https://openalex.org/W1976155294","https://openalex.org/W1980543551","https://openalex.org/W1982460275","https://openalex.org/W1984967831","https://openalex.org/W2011143314","https://openalex.org/W2021447561","https://openalex.org/W2027654288","https://openalex.org/W2035228968","https://openalex.org/W2040285649","https://openalex.org/W2040387337","https://openalex.org/W2040816841","https://openalex.org/W2043384567","https://openalex.org/W2045728629","https://openalex.org/W2048666625","https://openalex.org/W2050107109","https://openalex.org/W2054611625","https://openalex.org/W2075839182","https://openalex.org/W2075994912","https://openalex.org/W2088342479","https://openalex.org/W2091275560","https://openalex.org/W2094957942","https://openalex.org/W2096148741","https://openalex.org/W2096823486","https://openalex.org/W2097044981","https://openalex.org/W2097803027","https://openalex.org/W2104602416","https://openalex.org/W2106462858","https://openalex.org/W2110167181","https://openalex.org/W2110844256","https://openalex.org/W2115321640","https://openalex.org/W2116102471","https://openalex.org/W2120977933","https://openalex.org/W2121678464","https://openalex.org/W2123728260","https://openalex.org/W2125012054","https://openalex.org/W2125846051","https://openalex.org/W2126693515","https://openalex.org/W2134438979","https://openalex.org/W2137455986","https://openalex.org/W2138800234","https://openalex.org/W2145538381","https://openalex.org/W2147822820","https://openalex.org/W2149879796","https://openalex.org/W2154330374","https://openalex.org/W2155943585","https://openalex.org/W2157569342","https://openalex.org/W2161282017","https://openalex.org/W2169019243"],"related_works":["https://openalex.org/W7098635685","https://openalex.org/W2075886882","https://openalex.org/W1963936348","https://openalex.org/W2219350855","https://openalex.org/W7098797560","https://openalex.org/W2021447561","https://openalex.org/W2347394756","https://openalex.org/W2288946891","https://openalex.org/W2347876079","https://openalex.org/W2724386338"],"abstract_inverted_index":{"Coordination":[0],"between":[1],"the":[2,70,86,91,118,144,159,205],"Hertwig's":[3],"epithelial":[4],"root":[5,17,31,49,67,132,178,198,210],"sheath":[6],"(HERS)":[7],"and":[8,24,56,65,72,120,138,151,177,196],"apical":[9,193],"papilla":[10,194],"(AP)":[11],"is":[12,62,88,126,148,190],"crucial":[13,89,191],"for":[14,90,192],"proper":[15,79,197],"tooth":[16,30,209],"development.":[18,179,211],"The":[19,78],"hedgehog":[20],"(Hh)":[21],"signaling":[22,61,83,108,188],"pathway":[23,189],"Nfic":[25,156],"are":[26],"both":[27],"involved":[28],"in":[29,69,85,110,117,128,139],"development;":[32],"however,":[33],"their":[34],"relationship":[35],"has":[36],"yet":[37],"to":[38,114,158],"be":[39],"elucidated.":[40],"Here,":[41],"we":[42,57],"establish":[43],"a":[44,131],"timecourse":[45],"of":[46,54,81,93,106,162,165],"mouse":[47],"molar":[48],"development":[50,68],"by":[51],"histological":[52],"staining":[53],"sections,":[55],"demonstrate":[58,184],"that":[59,143,155,185],"Hh":[60,82,101,107,124,145,169],"active":[63],"before":[64],"during":[66],"AP":[71,87,119,175],"HERS":[73],"using":[74],"Gli1":[75],"reporter":[76],"mice.":[77],"pattern":[80],"activity":[84,109,125],"proliferation":[92,116],"dental":[94],"mesenchymal":[95],"cells,":[96],"because":[97],"either":[98],"inhibition":[99],"with":[100,168],"inhibitors":[102],"or":[103],"constitutive":[104],"activation":[105],"transgenic":[111],"mice":[112,167],"leads":[113],"decreased":[115],"shorter":[121],"roots.":[122],"Moreover,":[123],"elevated":[127],"Nfic(-/-)":[129,166],"mice,":[130],"defect":[133],"model,":[134],"whereas":[135],"RNA":[136],"sequencing":[137],"situ":[140],"hybridization":[141],"show":[142],"attenuator":[146],"Hhip":[147],"downregulated.":[149],"ChIP":[150],"RNAscope":[152],"analyses":[153],"suggest":[154],"binds":[157],"promoter":[160],"region":[161],"Hhip.":[163],"Treatment":[164],"inhibitor":[170],"partially":[171],"restores":[172],"cell":[173],"proliferation,":[174],"growth":[176,195],"Taken":[180],"together,":[181],"our":[182],"results":[183],"an":[186],"Nfic-Hhip-Hh":[187],"formation.":[199],"This":[200],"discovery":[201],"provides":[202],"insight":[203],"into":[204],"molecular":[206],"mechanisms":[207],"regulating":[208]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}