{"id":"https://openalex.org/W2248796441","doi":"https://doi.org/10.1212/nxi.0000000000000110","title":"Aquaporin-4 autoimmunity","display_name":"Aquaporin-4 autoimmunity","publication_year":2015,"publication_date":"2015-05-22","ids":{"openalex":"https://openalex.org/W2248796441","doi":"https://doi.org/10.1212/nxi.0000000000000110","mag":"2248796441","pmid":"https://pubmed.ncbi.nlm.nih.gov/26185772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4442096"},"language":"en","primary_location":{"id":"doi:10.1212/nxi.0000000000000110","doi":"https://doi.org/10.1212/nxi.0000000000000110","is_oa":true,"landing_page_url":"https://doi.org/10.1212/nxi.0000000000000110","pdf_url":"https://nn.neurology.org/content/nnn/2/4/e110.full.pdf","source":{"id":"https://openalex.org/S2764892302","display_name":"Neurology Neuroimmunology & Neuroinflammation","issn_l":"2332-7812","issn":["2332-7812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Neuroimmunology &amp; Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://nn.neurology.org/content/nnn/2/4/e110.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028503045","display_name":"\u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u0396\u03b5\u03ba\u03b5\u03c1\u03af\u03b4\u03bf\u03c5","orcid":"https://orcid.org/0000-0002-1960-9065","observed_orcids":["https://orcid.org/0000-0002-1960-9065"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia Zekeridou","raw_affiliation_strings":["From the Departments of Laboratory Medicine and Pathology (A.Z., V.A.L.), Neurology (V.A.L.), and Immunology (V.A.L.), Neuroimmunology Laboratory, Mayo Clinic College of Medicine, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Laboratory Medicine and Pathology (A.Z., V.A.L.), Neurology (V.A.L.), and Immunology (V.A.L.), Neuroimmunology Laboratory, Mayo Clinic College of Medicine, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055122406","display_name":"Vanda A. Lennon","orcid":"https://orcid.org/0000-0003-1910-1576","observed_orcids":["https://orcid.org/0000-0003-1910-1576"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vanda A. Lennon","raw_affiliation_strings":["From the Departments of Laboratory Medicine and Pathology (A.Z., V.A.L.), Neurology (V.A.L.), and Immunology (V.A.L.), Neuroimmunology Laboratory, Mayo Clinic College of Medicine, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Laboratory Medicine and Pathology (A.Z., V.A.L.), Neurology (V.A.L.), and Immunology (V.A.L.), Neuroimmunology Laboratory, Mayo Clinic College of Medicine, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055122406"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":3.7085,"has_fulltext":true,"cited_by_count":212,"citation_normalized_percentile":{"value":0.96558442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"2","issue":"4","first_page":"e110","last_page":"e110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromyelitis-optica","display_name":"neuromyelitis optica","score":0.9380000233650208},{"id":"https://openalex.org/keywords/aquaporin-4-antibodies","display_name":"aquaporin-4 antibodies","score":0.8500000238418579},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.6230000257492065},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7179999947547913},{"id":"https://openalex.org/keywords/longitudinally-extensive-transverse-myelitis","display_name":"longitudinally extensive transverse myelitis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/optic-neuritis","display_name":"optic neuritis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/circumventricular-organs","display_name":"circumventricular organs","score":0.765999972820282},{"id":"https://openalex.org/keywords/skeletal-muscle-injury","display_name":"skeletal muscle injury","score":0.7540000081062317},{"id":"https://openalex.org/keywords/paraneoplastic-syndrome","display_name":"paraneoplastic syndrome","score":0.8370000123977661},{"id":"https://openalex.org/keywords/autoimmune-comorbidity","display_name":"autoimmune disease comorbidity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.6769999861717224},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.6129999756813049},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2781137167","wikidata":"https://www.wikidata.org/wiki/Q611458","display_name":"Neuromyelitis optica","level":3,"score":0.9276241064071655},{"id":"https://openalex.org/C2779357208","wikidata":"https://www.wikidata.org/wiki/Q6947292","display_name":"Myelin oligodendrocyte glycoprotein","level":4,"score":0.8066754341125488},{"id":"https://openalex.org/C2777185649","wikidata":"https://www.wikidata.org/wiki/Q202217","display_name":"Transverse myelitis","level":3,"score":0.7536120414733887},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.751705527305603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7270362377166748},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6817224025726318},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6274325847625732},{"id":"https://openalex.org/C2776572573","wikidata":"https://www.wikidata.org/wiki/Q972514","display_name":"Optic neuritis","level":3,"score":0.5241209268569946},{"id":"https://openalex.org/C15755913","wikidata":"https://www.wikidata.org/wiki/Q14902502","display_name":"Aquaporin 4","level":2,"score":0.46628615260124207},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4635865390300751},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44475460052490234},{"id":"https://openalex.org/C2777704947","wikidata":"https://www.wikidata.org/wiki/Q551085","display_name":"Myelitis","level":3,"score":0.4307713806629181},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3974335789680481},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3345193862915039},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.2379070520401001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1373932659626007},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.07818645238876343},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1212/nxi.0000000000000110","doi":"https://doi.org/10.1212/nxi.0000000000000110","is_oa":true,"landing_page_url":"https://doi.org/10.1212/nxi.0000000000000110","pdf_url":"https://nn.neurology.org/content/nnn/2/4/e110.full.pdf","source":{"id":"https://openalex.org/S2764892302","display_name":"Neurology Neuroimmunology & Neuroinflammation","issn_l":"2332-7812","issn":["2332-7812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Neuroimmunology &amp; Neuroinflammation","raw_type":"journal-article"},{"id":"pmid:26185772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26185772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology(R) neuroimmunology & neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4442096","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4442096/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurol Neuroimmunol Neuroinflamm","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1212/nxi.0000000000000110","doi":"https://doi.org/10.1212/nxi.0000000000000110","is_oa":true,"landing_page_url":"https://doi.org/10.1212/nxi.0000000000000110","pdf_url":"https://nn.neurology.org/content/nnn/2/4/e110.full.pdf","source":{"id":"https://openalex.org/S2764892302","display_name":"Neurology Neuroimmunology & Neuroinflammation","issn_l":"2332-7812","issn":["2332-7812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Neuroimmunology &amp; Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2248796441.pdf","grobid_xml":"https://content.openalex.org/works/W2248796441.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1482033427","https://openalex.org/W1950288943","https://openalex.org/W1967548317","https://openalex.org/W1968076673","https://openalex.org/W1975595956","https://openalex.org/W1978928514","https://openalex.org/W1987830245","https://openalex.org/W1993868490","https://openalex.org/W1996023281","https://openalex.org/W1998908782","https://openalex.org/W2000027714","https://openalex.org/W2007502293","https://openalex.org/W2008212836","https://openalex.org/W2018737593","https://openalex.org/W2019074756","https://openalex.org/W2019076400","https://openalex.org/W2022538673","https://openalex.org/W2024996035","https://openalex.org/W2025101687","https://openalex.org/W2035237217","https://openalex.org/W2041820375","https://openalex.org/W2043256608","https://openalex.org/W2052652578","https://openalex.org/W2053472907","https://openalex.org/W2058153911","https://openalex.org/W2061740460","https://openalex.org/W2062104733","https://openalex.org/W2065005202","https://openalex.org/W2067782280","https://openalex.org/W2072799381","https://openalex.org/W2079123351","https://openalex.org/W2080225371","https://openalex.org/W2081358645","https://openalex.org/W2082646193","https://openalex.org/W2084145298","https://openalex.org/W2087498644","https://openalex.org/W2089237405","https://openalex.org/W2090209691","https://openalex.org/W2103812851","https://openalex.org/W2104448214","https://openalex.org/W2107941546","https://openalex.org/W2114414511","https://openalex.org/W2120238028","https://openalex.org/W2120949412","https://openalex.org/W2124851812","https://openalex.org/W2130830366","https://openalex.org/W2133031405","https://openalex.org/W2134211282","https://openalex.org/W2136132690","https://openalex.org/W2137385534","https://openalex.org/W2140073882","https://openalex.org/W2140729341","https://openalex.org/W2144469764","https://openalex.org/W2151592237","https://openalex.org/W2152156112","https://openalex.org/W2154982729","https://openalex.org/W2155112931","https://openalex.org/W2162576364","https://openalex.org/W2171164054","https://openalex.org/W2587498331","https://openalex.org/W2771158131"],"related_works":["https://openalex.org/W1976144584","https://openalex.org/W2463681628","https://openalex.org/W4224087418","https://openalex.org/W2623764732","https://openalex.org/W2488375096","https://openalex.org/W2016374711","https://openalex.org/W2055857874","https://openalex.org/W4283691211","https://openalex.org/W2143195034","https://openalex.org/W2320796795"],"abstract_inverted_index":{"Neuromyelitis":[0],"optica":[1],"(NMO)":[2],"and":[3,42,58,72,92,97,117],"a":[4,16,76,147,153],"related":[5],"spectrum":[6,159],"of":[7,15,37,50,55,81,103,136,146,155,167],"inflammatory":[8],"CNS":[9],"disorders":[10],"are":[11,39,83],"unified":[12],"by":[13,68],"detection":[14,113],"serum":[17],"autoantibody":[18,151],"specific":[19],"for":[20],"the":[21,89],"aquaporin-4":[22],"(AQP4)":[23],"water":[24],"channel,":[25],"which":[26],"is":[27,62,65],"abundant":[28],"in":[29,75,88,118,152],"astrocytic":[30],"foot":[31],"processes.":[32],"The":[33,79,100],"classic":[34],"clinical":[35,140],"manifestations":[36,49],"NMO":[38,61,127,158],"optic":[40],"neuritis":[41],"longitudinally":[43],"extensive":[44],"transverse":[45],"myelitis.":[46],"Newly":[47],"recognized":[48],"AQP4":[51,104],"autoimmunity":[52],"include":[53],"lesions":[54],"circumventricular":[56],"organs":[57],"skeletal":[59],"muscle.":[60],"commonly":[63],"relapsing,":[64],"frequently":[66],"accompanied":[67],"other":[69],"autoimmune":[70],"disorders,":[71],"sometimes":[73],"occurs":[74],"paraneoplastic":[77],"context.":[78],"goals":[80],"treatment":[82],"to":[84,94,126,142],"minimize":[85],"neurologic":[86],"disability":[87],"acute":[90],"attack":[91],"thereafter":[93],"prevent":[95],"relapses":[96],"cumulative":[98],"disability.":[99],"disease":[101,170],"specificity":[102],"immunoglobulin":[105],"(Ig)":[106],"G":[107],"approaches":[108],"100%":[109],"using":[110],"optimized":[111],"molecular-based":[112],"assays.":[114],"Clinical,":[115],"immunohistopathologic,":[116],"vitro":[119],"evidence":[120],"support":[121],"this":[122],"antibody":[123],"being":[124],"central":[125],"pathogenesis.":[128],"Current":[129],"animal":[130],"models":[131],"yield":[132],"limited":[133],"histopathologic":[134],"characteristics":[135],"NMO,":[137],"with":[138,157],"no":[139],"deficits":[141],"date.":[143],"Recent":[144],"descriptions":[145],"myelin":[148],"oligodendrocyte":[149],"glycoprotein":[150],"minority":[154],"patients":[156],"phenotype":[160],"who":[161],"lack":[162],"AQP4-IgG":[163],"predict":[164],"serologic":[165],"delineation":[166],"additional":[168],"distinctive":[169],"entities.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
