{"id":"https://openalex.org/W2248631347","doi":null,"title":"An\u00e1lise da express\u00e3o de HLA-G em carcinomas ductais infiltrantes mam\u00e1rios","display_name":"An\u00e1lise da express\u00e3o de HLA-G em carcinomas ductais infiltrantes mam\u00e1rios","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2248631347","mag":"2248631347"},"language":"pt","primary_location":{"id":"pmh:oai:acervodigital.ufpr.br:1884/36078","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1884/36078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFPR","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1884/36078","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066353291","display_name":"F. S. C. Breginski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Breginski, Fernanda Santos Cavalcanti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066353291"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-g","display_name":"HLA-G","score":0.9350000023841858},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7639999985694885},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hla-g-expression","display_name":"HLA-G expression","score":0.6290000081062317},{"id":"https://openalex.org/keywords/breast-tissue","display_name":"breast tissue","score":0.335999995470047},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.421999990940094},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.33762484788894653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2472076714038849},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08946439623832703},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.08673033118247986}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:acervodigital.ufpr.br:1884/36078","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1884/36078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFPR","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:acervodigital.ufpr.br:1884/36078","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1884/36078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFPR","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320335303","display_name":"Funda\u00e7\u00e3o da Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W159376627","https://openalex.org/W575389344","https://openalex.org/W1481140172","https://openalex.org/W1519441922","https://openalex.org/W1546709038","https://openalex.org/W1561153455","https://openalex.org/W1575587378","https://openalex.org/W1586884884","https://openalex.org/W1603593764","https://openalex.org/W1882502102","https://openalex.org/W1949237903","https://openalex.org/W1952428126","https://openalex.org/W1965156081","https://openalex.org/W1965780550","https://openalex.org/W1967186439","https://openalex.org/W1967263426","https://openalex.org/W1970604482","https://openalex.org/W1972258248","https://openalex.org/W1977295091","https://openalex.org/W1979727824","https://openalex.org/W1981566776","https://openalex.org/W1981754119","https://openalex.org/W1986672594","https://openalex.org/W1988941398","https://openalex.org/W1989313702","https://openalex.org/W1990757073","https://openalex.org/W1991787903","https://openalex.org/W1992010653","https://openalex.org/W1993480429","https://openalex.org/W1996451338","https://openalex.org/W1998666960","https://openalex.org/W2000844161","https://openalex.org/W2001656603","https://openalex.org/W2002804691","https://openalex.org/W2007627967","https://openalex.org/W2010969591","https://openalex.org/W2011244916","https://openalex.org/W2013143312","https://openalex.org/W2014546230","https://openalex.org/W2017983971","https://openalex.org/W2020830322","https://openalex.org/W2021582501","https://openalex.org/W2024533943","https://openalex.org/W2028355522","https://openalex.org/W2030274612","https://openalex.org/W2032233271","https://openalex.org/W2032491410","https://openalex.org/W2034003932","https://openalex.org/W2039339794","https://openalex.org/W2042461504","https://openalex.org/W2046972425","https://openalex.org/W2047298978","https://openalex.org/W2048939997","https://openalex.org/W2055437708","https://openalex.org/W2056828169","https://openalex.org/W2057589452","https://openalex.org/W2062163694","https://openalex.org/W2063023195","https://openalex.org/W2066969492","https://openalex.org/W2069197942","https://openalex.org/W2069307120","https://openalex.org/W2072772580","https://openalex.org/W2078740176","https://openalex.org/W2080512953","https://openalex.org/W2082980147","https://openalex.org/W2084652933","https://openalex.org/W2088779353","https://openalex.org/W2089595068","https://openalex.org/W2091961739","https://openalex.org/W2097255042","https://openalex.org/W2098178477","https://openalex.org/W2098677755","https://openalex.org/W2098924171","https://openalex.org/W2100325546","https://openalex.org/W2101103478","https://openalex.org/W2102217018","https://openalex.org/W2104912399","https://openalex.org/W2106181427","https://openalex.org/W2106292881","https://openalex.org/W2106860115","https://openalex.org/W2107277218","https://openalex.org/W2110439344","https://openalex.org/W2110578052","https://openalex.org/W2113633750","https://openalex.org/W2115321397","https://openalex.org/W2121426439","https://openalex.org/W2121626779","https://openalex.org/W2123820095","https://openalex.org/W2125785648","https://openalex.org/W2128449615","https://openalex.org/W2128605357","https://openalex.org/W2129129053","https://openalex.org/W2130900820","https://openalex.org/W2131702935","https://openalex.org/W2131994307","https://openalex.org/W2133185366","https://openalex.org/W2135548733","https://openalex.org/W2135936056","https://openalex.org/W2136143495","https://openalex.org/W2137853125","https://openalex.org/W2144022436","https://openalex.org/W2145716461","https://openalex.org/W2147153911","https://openalex.org/W2147343434","https://openalex.org/W2153505850","https://openalex.org/W2153577115","https://openalex.org/W2158997529","https://openalex.org/W2160048269","https://openalex.org/W2160928966","https://openalex.org/W2161710954","https://openalex.org/W2162344195","https://openalex.org/W2162584202","https://openalex.org/W2165693726","https://openalex.org/W2165788766","https://openalex.org/W2167577087","https://openalex.org/W2170825753","https://openalex.org/W2184152595","https://openalex.org/W2188370736","https://openalex.org/W2330826514","https://openalex.org/W2772971838"],"related_works":["https://openalex.org/W7045696739","https://openalex.org/W7103468003","https://openalex.org/W7120848010","https://openalex.org/W3088641413","https://openalex.org/W3196046677","https://openalex.org/W2352165256","https://openalex.org/W2057589452","https://openalex.org/W2289160626","https://openalex.org/W2246503841","https://openalex.org/W1920744841"],"abstract_inverted_index":{"Resumo:":[0],"A":[1,24],"descoberta":[2],"de":[3,14,21,29,46,64,70,87,94,102,147,197,210,228,257,269,285,292,307,312,315,341,354],"novos":[4],"marcadores":[5],"moleculares":[6],"como":[7,67,327],"ferramentas":[8],"no":[9,68,297,332,335,339],"diagn\u00f3stico,":[10],"progn\u00f3stico":[11,336],"e":[12,39,56,75,105,118,201,232,337,345,356],"tratamento":[13,340],"diversas":[15],"doen\u00e7as,":[16],"incluindo":[17],"o":[18,217,244,325],"c\u00e2ncer,":[19],"\u00e9":[20,246],"extrema":[22],"import\u00e2ncia.":[23],"prote\u00edna":[25],"HLA-G":[26,52,88,154,177,191,245,279,286,316,326],"apresenta":[27],"fun\u00e7\u00e3o":[28],"imunotoler\u00e2ncia,":[30],"auxiliando":[31,331],"as":[32],"c\u00e9lulas":[33],"tumorais":[34],"a":[35,85,184,206,263,305],"escaparem":[36],"do":[37,48,50,233,265,352],"reconhecimento":[38],"destrui\u00e7\u00e3o":[40],"pelo":[41],"sistema":[42],"imune.":[43],"N\u00edveis":[44],"aumentados":[45],"express\u00e3o":[47,86,313],"produto":[49],"gene":[51,218,234],"j\u00e1":[53],"foram":[54,121,204],"identificados":[55],"associados":[57],"com":[58,224,343,349],"piores":[59],"progn\u00f3sticos":[60],"em":[61,97,111,126,220,249,287,317],"diversos":[62],"tipos":[63],"neoplasias":[65],"malignas":[66],"c\u00e2ncer":[69],"pulm\u00e3o,":[71],"colo-retal,":[72],"mama,":[73],"melanomas":[74],"leucemias,":[76],"sendo,":[77],"portanto":[78],"considerado,":[79],"um":[80,328],"potencial":[81,329],"marcador.":[82],"Neste":[83],"estudo":[84,299,323],"foi":[89,271],"analisada":[90],"atrav\u00e9s":[91,351],"da":[92],"t\u00e9cnica":[93],"imunoistoqu\u00edmica":[95],"(IHQ)":[96],"202":[98,131,167],"carcinomas":[99],"ductais":[100],"infiltrantes":[101],"mama":[103],"(IDC)":[104],"104":[106,145],"tecidos":[107,250],"mam\u00e1rios":[108,251],"normais":[109,120,203],"emblocados":[110],"parafina.":[112],"Dentre":[113],"estas":[114],"amostras,":[115],"64":[116,180,195],"IDC":[117,181],"14":[119,202],"avaliados":[122],"por":[123],"PCR":[124],"quantitativa":[125],"tempo":[127],"real":[128],"(RT-qPCR).":[129],"Dos":[130,179],"IDC,":[132,168,344],"38":[133],"(18,8%)":[134],"coraram":[135,174],"positivamente":[136,152,175],"para":[137,153,176,183,190,216,262,278,304],"HLA-G.":[138],"Diferentemente":[139],"destes,":[140],"somente":[141,274],"uma":[142,207,301],"(0,9%)":[143],"das":[144,222,226,289],"amostras":[146,196,223,227,260,276,291],"tecido":[148,198,293],"n\u00e3o":[149,213],"tumoral":[150,200],"corou":[151],"(p<0,0001).":[155],"Os":[156,320],"tumores":[157,318],"triplo":[158],"negativos":[159],"(TNBC),":[160],"geralmente":[161],"mais":[162,346],"agressivos,":[163],"representavam":[164],"37":[165],"dos":[166],"sendo":[169],"que":[170,243,253],"destes":[171],"13":[172],"(35,1%)":[173],"(p<0,01).":[178],"utilizados":[182],"RT-qPCR,":[185],"11":[186,290],"(17,2%)":[187],"eram":[188],"positivos":[189],"na":[192,239,280,283,310],"IHQ.":[193],"As":[194],"mam\u00e1rio":[199,294],"submetidas":[205],"primeira":[208,240],"rodada":[209],"amplifica\u00e7\u00e3o,":[211],"onde":[212],"houve":[214],"amplifica\u00e7\u00e3o":[215,241,284],"HLA-G,":[219],"nenhuma":[221],"exce\u00e7\u00e3o":[225],"placenta":[229],"(controle":[230],"positivo)":[231],"ACTB":[235],"(refer\u00eancia).":[236],"Esta":[237],"falha":[238],"sugere":[242],"pouco":[247],"expresso":[248],"e/ou":[252],"havia":[254],"pouca":[255],"quantidade":[256],"RNA":[258],"nas":[259,275],"utilizadas":[261],"sensibilidade":[264],"m\u00e9todo.":[266],"Uma":[267],"rea\u00e7\u00e3o":[268],"reamplifica\u00e7\u00e3o":[270],"ent\u00e3o":[272],"realizada":[273],"positivas":[277],"IHQ,":[281],"resultando":[282],"nove":[288],"tumoral.":[295],"Portanto,":[296],"presente":[298],"sugere-se":[300],"nova":[302],"padroniza\u00e7\u00e3o":[303],"utiliza\u00e7\u00e3o":[306],"blocos":[308],"histol\u00f3gicos":[309],"avalia\u00e7\u00e3o":[311],"g\u00eanica":[314],"mam\u00e1rios.":[319],"achados":[321],"deste":[322],"sugerem":[324],"marcador":[330],"diagn\u00f3stico":[333],"diferencial,":[334],"talvez":[338],"pacientes":[342],"especificamente":[347],"naqueles":[348],"TNBC,":[350],"uso":[353],"IHQ":[355],"possivelmente":[357],"RT-qPCR.":[358]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}