{"id":"https://openalex.org/W224760654","doi":null,"title":"Role of Neurogranin in the regulation of calcium binding to Calmodulin","display_name":"Role of Neurogranin in the regulation of calcium binding to Calmodulin","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W224760654","mag":"224760654"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1407","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044136951","display_name":"Anuja Chandrasekar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anuja Chandrasekar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044136951"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07249999791383743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurogranin","display_name":"neurogranin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rc3","display_name":"RC3","score":0.8479999899864197},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.8930000066757202},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6990000009536743},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.828000009059906},{"id":"https://openalex.org/keywords/calcium-binding-kinetics","display_name":"calcium binding kinetics","score":0.656000018119812},{"id":"https://openalex.org/keywords/calcium-buffering","display_name":"calcium buffering","score":0.5059999823570251},{"id":"https://openalex.org/keywords/target-specificity","display_name":"target specificity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.5149999856948853},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.7591321468353271},{"id":"https://openalex.org/C2780748493","wikidata":"https://www.wikidata.org/wiki/Q22676708","display_name":"Neurogranin","level":4,"score":0.7310488224029541},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.561946451663971},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.5238583087921143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4957481324672699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38331732153892517},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36850398778915405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3135242462158203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23184561729431152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20928484201431274},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17801633477210999},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1407","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:224760654","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1407&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1407","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/373","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W224760654.pdf","grobid_xml":"https://content.openalex.org/works/W224760654.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W47365113","https://openalex.org/W90454921","https://openalex.org/W625010509","https://openalex.org/W1506911550","https://openalex.org/W1509876279","https://openalex.org/W1519525270","https://openalex.org/W1545633418","https://openalex.org/W1565248232","https://openalex.org/W1567413936","https://openalex.org/W1575693343","https://openalex.org/W1589645365","https://openalex.org/W1592692300","https://openalex.org/W1628979938","https://openalex.org/W1814732951","https://openalex.org/W1842081459","https://openalex.org/W1871052754","https://openalex.org/W1917062983","https://openalex.org/W1965611215","https://openalex.org/W1969903567","https://openalex.org/W1978964592","https://openalex.org/W1981195606","https://openalex.org/W1981358116","https://openalex.org/W1981611790","https://openalex.org/W1984028758","https://openalex.org/W1985587671","https://openalex.org/W1985655894","https://openalex.org/W1994021526","https://openalex.org/W1994207775","https://openalex.org/W1997297151","https://openalex.org/W1998492592","https://openalex.org/W2003138178","https://openalex.org/W2003782121","https://openalex.org/W2007413897","https://openalex.org/W2009064225","https://openalex.org/W2013739995","https://openalex.org/W2017842551","https://openalex.org/W2017927790","https://openalex.org/W2019123717","https://openalex.org/W2019651649","https://openalex.org/W2021300391","https://openalex.org/W2021996506","https://openalex.org/W2022286642","https://openalex.org/W2023458956","https://openalex.org/W2027749211","https://openalex.org/W2031811477","https://openalex.org/W2033982127","https://openalex.org/W2034513993","https://openalex.org/W2037710668","https://openalex.org/W2041165019","https://openalex.org/W2041505869","https://openalex.org/W2042312855","https://openalex.org/W2042407765","https://openalex.org/W2042663951","https://openalex.org/W2043935934","https://openalex.org/W2046868190","https://openalex.org/W2052177331","https://openalex.org/W2053591536","https://openalex.org/W2054328794","https://openalex.org/W2055568369","https://openalex.org/W2056183361","https://openalex.org/W2057406592","https://openalex.org/W2059338140","https://openalex.org/W2061609689","https://openalex.org/W2062090669","https://openalex.org/W2066044909","https://openalex.org/W2067238658","https://openalex.org/W2069111868","https://openalex.org/W2071076794","https://openalex.org/W2074855486","https://openalex.org/W2076718555","https://openalex.org/W2077906120","https://openalex.org/W2078850134","https://openalex.org/W2079496755","https://openalex.org/W2082566419","https://openalex.org/W2084336840","https://openalex.org/W2086922020","https://openalex.org/W2087062865","https://openalex.org/W2100814575","https://openalex.org/W2101978320","https://openalex.org/W2103071749","https://openalex.org/W2104274727","https://openalex.org/W2114321498","https://openalex.org/W2120142493","https://openalex.org/W2131624747","https://openalex.org/W2133667940","https://openalex.org/W2139183106","https://openalex.org/W2406291111","https://openalex.org/W4214891130"],"related_works":["https://openalex.org/W2155291552","https://openalex.org/W2103071749","https://openalex.org/W1545633418","https://openalex.org/W2054856526","https://openalex.org/W200341172","https://openalex.org/W4396888650","https://openalex.org/W2609438140","https://openalex.org/W4407430989","https://openalex.org/W1998160424","https://openalex.org/W2042407765"],"abstract_inverted_index":{"Role":[0],"of":[1,6,22,31,47,87,105,147,150,173,212,220,229,261],"Neurogranin":[2],"in":[3,64,76,108,114,125,182,197],"the":[4,33,213,218,236,259],"regulation":[5],"calcium":[7,71,97,106,129,136,171,221],"binding":[8,98,137,222],"to":[9,26,60,127,161,225],"Calmodulin":[10],"Anuja":[11],"Chandrasekar,":[12],"B.S":[13],"Advisor:":[14],"M.":[15],"Neal":[16],"Waxham,":[17],"Ph.D":[18],"The":[19],"overall":[20],"goal":[21],"my":[23,251],"project":[24],"was":[25,158],"gain":[27],"a":[28,44,70,102,118,128,145,148,163,170,193,203,227],"quantitative":[29],"understanding":[30],"how":[32],"interaction":[34,237],"between":[35,238],"two":[36],"proteins":[37,132,156,214],"neurogranin":[38,209,240,256],"(RC3)":[39],"and":[40,78,84,241,247,264],"calmodulin":[41],"(CaM)":[42],"alters":[43],"fundamental":[45],"property":[46],"CaM.":[48],"CaM,":[49,93,239],"has":[50],"been":[51],"extensively":[52],"studied":[53],"for":[54],"more":[55,194],"than":[56,199],"four":[57,96],"decades":[58],"due":[59],"its":[61,95,135],"seminal":[62],"role":[63,116,165,196],"almost":[65],"all":[66],"biological":[67],"functions":[68],"as":[69,101,117,142,202],"signal":[72],"transducer.":[73],"Calcium":[74],"signals":[75,230],"cardiac":[77],"neuronal":[79,152],"cells":[80],"are":[81],"exquisitely":[82],"precise":[83],"enable":[85],"activation":[86],"some":[88],"processes":[89],"while":[90],"down-regulating":[91],"others.":[92],"with":[94,231],"sites,":[99],"serves":[100],"central":[103],"component":[104],"signaling":[107],"these":[109],"cells.":[110],"It":[111],"is":[112,144,210],"aided":[113],"this":[115,190],"regulatory":[119],"hub":[120],"that":[121,133,157,189,208,255],"differentially":[122],"activates":[123],"targets":[124],"response":[126],"flux":[130],"by":[131,166,216],"alter":[134],"properties.":[138],"Neurogranin,":[139],"also":[140],"known":[141],"RC3,":[143],"member":[146],"family":[149],"small":[151],"IQ":[153],"(SNIQ)":[154],"domain":[155],"originally":[159],"thought":[160],"play":[162],"\u2018capacitive\u2019":[164],"sequestering":[167],"CaM":[168,204,224,263],"until":[169],"influx":[172],"sufficient":[174],"intensity":[175],"arrived.":[176],"However,":[177],"based":[178],"on":[179,185],"earlier":[180],"work":[181],"our":[183],"lab":[184],"neurogranin,":[186],"we":[187],"believe":[188,207],"protein":[191],"plays":[192],"nuanced":[195],"neurons":[198],"simply":[200],"acting":[201],"buffer.":[205],"We":[206],"one":[211],"which,":[215],"altering":[217],"kinetics":[219],"allow":[223],"decode":[226],"variety":[228],"fine":[232],"precision.":[233],"To":[234],"quantify":[235],"calcium,":[242],"I":[243,253],"used":[244],"biophysical":[245],"techniques":[246],"computational":[248],"simulations.":[249],"From":[250],"results,":[252],"conclude":[254],"finely":[257],"regulates":[258],"proportion":[260],"calcium-saturated":[262],"thereby":[265],"directs":[266],"CaM\u2019s":[267],"target":[268],"specificity.":[269]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}