{"id":"https://openalex.org/W2247228522","doi":"https://doi.org/10.1152/ajprenal.1996.270.1.f164","title":"Glucocorticoids regulate NHE-3 transcription in OKP cells","display_name":"Glucocorticoids regulate NHE-3 transcription in OKP cells","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2247228522","doi":"https://doi.org/10.1152/ajprenal.1996.270.1.f164","mag":"2247228522","pmid":"https://pubmed.ncbi.nlm.nih.gov/8769835"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1996.270.1.f164","doi":"https://doi.org/10.1152/ajprenal.1996.270.1.f164","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1996.270.1.f164","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080913812","display_name":"Michel G. Baum","orcid":"https://orcid.org/0000-0002-2015-5996","observed_orcids":["https://orcid.org/0000-0002-2015-5996"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Baum","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066258545","display_name":"Morimasa Amemiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Amemiya","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104440236","display_name":"Vangipuram N. Dwarakanath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Dwarakanath","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035732349","display_name":"Robert J. Alpern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Alpern","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023488815","display_name":"Orson W. Moe","orcid":"https://orcid.org/0000-0001-9176-3414","observed_orcids":["https://orcid.org/0000-0001-9176-3414"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. W. Moe","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.8835,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.7336787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"270","issue":"1","first_page":"F164","last_page":"F169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nhe3","display_name":"NHE3","score":0.9629999995231628},{"id":"https://openalex.org/keywords/na-h-antiporter","display_name":"Na+/H+ antiporter","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mrna-half-life","display_name":"mRNA half-life","score":0.7229999899864197},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.8960000276565552},{"id":"https://openalex.org/keywords/renal-tubular-ion-transport","display_name":"renal tubular ion transport","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C57181701","wikidata":"https://www.wikidata.org/wiki/Q2853339","display_name":"Antiporter","level":3,"score":0.9025441408157349},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.7528762817382812},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6554210782051086},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6482250094413757},{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.5895848274230957},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5412975549697876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5161601305007935},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4898788332939148},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4441635310649872},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4434281289577484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44222667813301086},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3971337378025055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38823631405830383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3410094380378723},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2310471534729004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2205185890197754},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.1778867244720459},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1397571563720703},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009893","descriptor_name":"Opossums","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.1996.270.1.f164","doi":"https://doi.org/10.1152/ajprenal.1996.270.1.f164","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1996.270.1.f164","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:8769835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8769835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2305158576","display_name":null,"funder_award_id":"DK 48482","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2608043130","display_name":null,"funder_award_id":"DK-41612","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G405449878","display_name":null,"funder_award_id":"DK 39298","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5476319931","display_name":"Neonatal Proximal Tubule Acidification","funder_award_id":"R01DK041612","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418414302","https://openalex.org/W2143058708","https://openalex.org/W2460497802","https://openalex.org/W2399511611","https://openalex.org/W2121875250","https://openalex.org/W2093238419","https://openalex.org/W2013425658","https://openalex.org/W2099542398","https://openalex.org/W2054462203","https://openalex.org/W2463522734"],"abstract_inverted_index":{"OKP":[0,32,62,144],"cells":[1,33,63,145],"express":[2],"NHE-3,":[3],"an":[4,11,27,164],"amiloride-resistant":[5,28],"Na+/H+":[6,29,57,98,158],"antiporter,":[7],"which":[8],"is":[9,34,161],"likely":[10],"isoform":[12],"responsible":[13],"for":[14,52,97,105],"apical":[15],"proton":[16],"secretion":[17],"by":[18,36],"the":[19,44,50,53,103,106,154],"proximal":[20],"tubule.":[21],"We":[22],"have":[23],"previously":[24],"shown":[25],"that":[26,95,153],"antiporter":[30,58,99,159],"in":[31,56,69,75,108,115,129,137,157,166],"regulated":[35],"dexamethasone,":[37,89],"a":[38,70,90,124],"synthetic":[39],"glucocorticoid.":[40],"The":[41,134],"purpose":[42],"of":[43,61,86,126,136],"present":[45],"study":[46],"was":[47,81,140],"to":[48,72,94,163],"examine":[49,102],"mechanism":[51,104],"glucocorticoid-mediated":[54,155],"increase":[55,74,80,107,156,165],"activity.":[59,100],"Incubation":[60],"with":[64,88,148],"10(-6)":[65],"M":[66],"dexamethasone":[67],"resulted":[68],"two-":[71],"threefold":[73],"NHE-3":[76,109,121,167],"mRNA":[77,110,112,122],"abundance.":[78],"This":[79],"seen":[82],"after":[83],"4":[84],"h":[85,128],"incubation":[87],"time":[91],"course":[92],"similar":[93],"found":[96],"To":[101],"abundance,":[111],"half-life":[113,125],"and":[114,131],"vitro":[116,138],"transcription":[117,139],"experiments":[118],"were":[119,146],"performed.":[120],"had":[123],"8":[127],"control":[130],"dexamethasone-treated":[132],"cells.":[133],"rate":[135],"1.8-fold":[141],"greater":[142],"when":[143],"treated":[147],"dexamethasone.":[149],"These":[150],"data":[151],"suggest":[152],"activity":[160],"due":[162],"gene":[168],"transcription.":[169]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
