{"id":"https://openalex.org/W2247201217","doi":"https://doi.org/10.1038/nchembio.2010","title":"The many genes of drug mechanism","display_name":"The many genes of drug mechanism","publication_year":2016,"publication_date":"2016-01-19","ids":{"openalex":"https://openalex.org/W2247201217","doi":"https://doi.org/10.1038/nchembio.2010","mag":"2247201217","pmid":"https://pubmed.ncbi.nlm.nih.gov/26784844"},"language":"en","primary_location":{"id":"doi:10.1038/nchembio.2010","doi":"https://doi.org/10.1038/nchembio.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nchembio.2010","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049302160","display_name":"Adam Christopher Palmer","orcid":"https://orcid.org/0000-0001-5028-7028","observed_orcids":["https://orcid.org/0000-0001-5028-7028"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU","US"],"is_corresponding":true,"raw_author_name":"Adam C Palmer","raw_affiliation_strings":["Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA, and the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia","Adam Palmer is in the Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA, and the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.,"],"raw_orcid":"https://orcid.org/0000-0001-5028-7028","affiliations":[{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA, and the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I31746571"]},{"raw_affiliation_string":"Adam Palmer is in the Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA, and the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049302160"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I31746571"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":0.5903,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69084557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"12","issue":"2","first_page":"57","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7099999785423279},{"id":"https://openalex.org/keywords/human-cell-lines","display_name":"human cell lines","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gene-products","display_name":"gene products","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6835086345672607},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5842322111129761},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5435296297073364},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5407088398933411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.50197434425354},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48817139863967896},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4655720889568329},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44042131304740906},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.43868914246559143},{"id":"https://openalex.org/C2993684226","wikidata":"https://www.wikidata.org/wiki/Q2662727","display_name":"Human cell","level":3,"score":0.4305903911590576},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4206072688102722},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3531288504600525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33887428045272827},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20927992463111877},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2003142237663269},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12462899088859558},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001686","descriptor_name":"Biological Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001686","descriptor_name":"Biological Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001686","descriptor_name":"Biological Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nchembio.2010","doi":"https://doi.org/10.1038/nchembio.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nchembio.2010","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},{"id":"pmid:26784844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26784844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature chemical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2008345619","https://openalex.org/W2035270506","https://openalex.org/W2038252445","https://openalex.org/W2043398720","https://openalex.org/W2115835385","https://openalex.org/W2125789330","https://openalex.org/W2152883907","https://openalex.org/W2175970000","https://openalex.org/W2220553089","https://openalex.org/W2273218209"],"related_works":["https://openalex.org/W2031410708","https://openalex.org/W580785917","https://openalex.org/W2080670791","https://openalex.org/W1981786601","https://openalex.org/W2788776141","https://openalex.org/W2949580896","https://openalex.org/W2509888465","https://openalex.org/W2006222270","https://openalex.org/W2066626586","https://openalex.org/W1539847635","https://openalex.org/W2078190029","https://openalex.org/W1595865635","https://openalex.org/W2988423625","https://openalex.org/W3043489078","https://openalex.org/W2137462664","https://openalex.org/W2765760205","https://openalex.org/W2982314070","https://openalex.org/W2081365810","https://openalex.org/W3200479133","https://openalex.org/W2040185733"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
