{"id":"https://openalex.org/W2245844780","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3632","title":"An open-label, phase I study of cetuximab to assess the safety, efficacy and pharmacokinetics (PK) of different cetuximab regimens in patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC)","display_name":"An open-label, phase I study of cetuximab to assess the safety, efficacy and pharmacokinetics (PK) of different cetuximab regimens in patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC)","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2245844780","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3632","mag":"2245844780"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2005.23.16_suppl.3632","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3632","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.3632","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111976804","display_name":"Yves Humblet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"Y. Humblet","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024390084","display_name":"Marc Peeters","orcid":"https://orcid.org/0000-0003-4969-2303","observed_orcids":["https://orcid.org/0000-0003-4969-2303"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"M. Peeters","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028299314","display_name":"Harry Bleiberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"H. Bleiberg","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053052330","display_name":"Roger Stupp","orcid":"https://orcid.org/0000-0002-5483-3118","observed_orcids":["https://orcid.org/0000-0002-5483-3118"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"R. Stupp","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086081284","display_name":"Cristiana Sessa","orcid":"https://orcid.org/0000-0001-8132-2527","observed_orcids":["https://orcid.org/0000-0001-8132-2527"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"C. Sessa","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"A. Roth","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080338388","display_name":"Johannes Nippgen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"J. Nippgen","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064306189","display_name":"Arno Nolting","orcid":"https://orcid.org/0009-0000-3590-0584","observed_orcids":["https://orcid.org/0009-0000-3590-0584"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"A. Nolting","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Stuart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"P. Stuart","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022063365","display_name":"Giuseppe Giaccone","orcid":"https://orcid.org/0000-0002-7392-1965","observed_orcids":["https://orcid.org/0000-0002-7392-1965","https://orcid.org/0000-0002-5023-7562"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["BE","CH","DE","NL"],"is_corresponding":false,"raw_author_name":"G. Giaccone","raw_affiliation_strings":["Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clin Univ St. Luc, Brussels, Belgium; Univ Ziekenhuis Gent, Gent, Belgium; Inst J. Bordet, Bruxelles, Belgium; Ctr Hospitalier Univ Vaudois, Lausanne, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; H\u00f4pital Cantonal, Gen\u00e8ve, Switzerland; Merck KGaA, Darmstadt, Germany; Merck KGaA, Darmstadt, Germany; Merck BV, Amsterdam, The Netherlands; VU Medisch Centrum, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I2801227569","https://openalex.org/I2801838318","https://openalex.org/I2802229882","https://openalex.org/I4404532900","https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"16_suppl","first_page":"3632","last_page":"3632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.5770000219345093},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8809999823570251},{"id":"https://openalex.org/keywords/skin-toxicity","display_name":"skin toxicity","score":0.5320000052452087},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.6940000057220459},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.7979999780654907},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7319999933242798},{"id":"https://openalex.org/keywords/safety-profile","display_name":"safety profile","score":0.4339999854564667},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5429999828338623},{"id":"https://openalex.org/keywords/monoclonal-antibody-therapy","display_name":"monoclonal antibody therapy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/irinotecan-based-chemotherapy","display_name":"irinotecan-based chemotherapy","score":0.5699999928474426},{"id":"https://openalex.org/keywords/ecog-performance-status","display_name":"ECOG performance status","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9435544610023499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8859384059906006},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.7971018552780151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6032847166061401},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6018269062042236},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.583476185798645},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.561091959476471},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5428206920623779},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5000755786895752},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4784643352031708},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.46824538707733154},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4625380039215088},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4338432550430298},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38211825489997864},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36592501401901245},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3633093237876892},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32919394969940186},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.2005.23.16_suppl.3632","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3632","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.3632","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:archive.ugent.be:318663","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/318663","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0732-183X","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:dial.uclouvain.be:boreal:60906","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/60906","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, Vol. 23, no. 16, p. 279S-279S (2005)","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2266631974","https://openalex.org/W2018048717","https://openalex.org/W2245406219","https://openalex.org/W2243164797","https://openalex.org/W2344396584","https://openalex.org/W1775605021","https://openalex.org/W3201757330","https://openalex.org/W2146100972","https://openalex.org/W2264142765","https://openalex.org/W2414046499"],"abstract_inverted_index":{"3632":[0],"Background:":[1],"Cetuximab":[2,14,254],"(Erbitux)":[3],"is":[4,325],"an":[5],"IgG1":[6],"monoclonal":[7],"antibody":[8],"that":[9,181],"targets":[10],"the":[11,49,57,113,186,197,260,263,269,276,295],"human":[12],"EGFR.":[13],"has":[15],"been":[16,252],"shown":[17],"to":[18,27,47,108,268,317],"be":[19,315],"active":[20],"in":[21,98,144,153,204,231,237,319],"patients":[22,99,118,133],"with":[23,38,100,112,147,275],"advanced":[24],"CRC":[25],"refractory":[26,102],"irinotecan-based":[28],"chemotherapy,":[29],"both":[30],"as":[31],"a":[32,94,122,208],"single":[33],"agent":[34],"and":[35,52,74,125,129,131,155,164,172,259,291,299,312],"when":[36],"combined":[37],"irinotecan.":[39],"Methods:":[40],"The":[41,167,188,211,221,242,289,307],"purpose":[42],"of":[43,54,64,71,80,162,185,262,280,294,322],"this":[44],"study":[45],"was":[46,193,229,249,256],"characterize":[48],"safety,":[50],"efficacy":[51],"PK":[53,138,168,290],"cetuximab":[55,297,302],"following":[56,159],"approved":[58],"regimen":[59,298],"(Group":[60,83,88],"A)":[61],"(initial":[62],"dose":[63],"400":[65],"mg/m2,":[66],"followed":[67],"by":[68,93],"weekly":[69,160],"doses":[70,79,161],"250":[72,81,163],"mg/m2)":[73],"two":[75],"exploratory":[76,301],"regimens":[77,303],"(weekly":[78],"mg/m2":[82,87],"B)":[84],"or":[85,272,330,333],"350":[86,165],"C)":[89],"respectively":[90],"not":[91,194,250],"preceded":[92],"higher":[95],"initial":[96],"dose)":[97],"EGFR-expressing,":[101],"mCRC.":[103],"Skin":[104],"biopsies":[105,324],"were":[106,119,134,143,157,174,183,215,225,266,273,304],"taken":[107],"correlate":[109],"biological":[110],"activity":[111],"different":[114],"schedules.":[115],"Results:":[116],"49":[117],"enrolled":[120],"on":[121],"sequential":[123],"basis":[124],"evaluated":[126,135],"for":[127,136,140,217,246],"safety":[128,278,292],"efficacy,":[130],"45":[132],"PK.":[137],"parameters":[139,169],"Group":[141],"A":[142,239,311],"good":[145],"agreement":[146],"historical":[148],"data.":[149],"Dose-related,":[150],"predictable":[151],"increases":[152],"Cmax":[154],"AUC\u03c4":[156],"observed":[158],"mg/m2.":[166],"t1/2,":[170],"CLss":[171],"Vss":[173],"similar":[175],"across":[176,196],"all":[177],"treatment":[178],"groups,":[179],"indicating":[180],"they":[182],"independent":[184],"dose.":[187],"ECOG":[189],"performance":[190],"status":[191],"(PS)":[192],"balanced":[195],"groups":[198],"(ECOG":[199],"2:":[200],"A:35%/B11%/C:0).":[201],"One":[202],"patient,":[203],"group":[205,232,238,247],"B,":[206],"achieved":[207],"complete":[209],"response.":[210],"objective":[212],"response":[213],"rates":[214,224],"7.1%/22.2%/17.7%":[216],"arms":[218],"A/B/C":[219],"respectively.":[220],"disease":[222,271],"control":[223],"7.1%/27.8%/23.5%.":[226],"Median":[227],"survival":[228,244],"greater":[230],"B":[233,313],"(8.3":[234],"months)":[235],"than":[236],"(3.6":[240],"months).":[241],"median":[243],"time":[245],"C":[248],"yet":[251],"reached.":[253],"therapy":[255],"well":[257],"tolerated":[258],"majority":[261],"adverse":[264],"events":[265],"due":[267],"underlying":[270],"consistent":[274],"known":[277],"profile":[279],"cetuximab.":[281],"No":[282],"Grade":[283],"3/4":[284],"skin":[285,323],"toxicity":[286],"occurred.":[287],"Conclusions:":[288],"profiles":[293],"standard":[296],"2":[300],"within":[305],"expectation.":[306],"differences":[308,318],"between":[309],"Groups":[310],"can":[314],"attributed":[316],"PS.":[320],"Evaluation":[321],"ongoing.":[326],"Author":[327],"Disclosure":[328],"Employment":[329],"Leadership":[331],"Consultant":[332],"Advisory":[334],"Role":[335],"Stock":[336],"Ownership":[337],"Honoraria":[338],"Research":[339],"Funding":[340],"Expert":[341],"Testimony":[342],"Other":[343],"Remuneration":[344],"Merck":[345,352],"KGaA":[346],"AstraZeneca,":[347,358,365],"Bristol-Myers":[348,360],"Squibb,":[349,361],"H3,":[350],"Merck,":[351],"KGaA,":[353],"Pfizer,":[354,362],"Pharmachemic,":[355],"Roche,":[356,363],"Threshold":[357],"Aventis,":[359,368],"Sanofi":[364,367,369],"Roche":[366]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}