{"id":"https://openalex.org/W2245632002","doi":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","title":"Effect of Nigella sativa on hemodynamics, hemoglobin, and blood coagulation in patients with type 2 diabetes","display_name":"Effect of Nigella sativa on hemodynamics, hemoglobin, and blood coagulation in patients with type 2 diabetes","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2245632002","doi":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","mag":"2245632002"},"language":"en","primary_location":{"id":"doi:10.7123/01.ejh.0000415060.42791.a6","doi":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","is_oa":true,"landing_page_url":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","pdf_url":null,"source":{"id":"https://openalex.org/S4210180515","display_name":"The Egyptian Journal of Haematology","issn_l":"1110-1067","issn":["1110-1067","2090-9268"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076573768","display_name":"Abdullah Omar Bamosa","orcid":"https://orcid.org/0000-0001-5941-4353","observed_orcids":["https://orcid.org/0000-0001-5941-4353"]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"AbdullahO. Bamosa","raw_affiliation_strings":["Department of Physiology, College of Medicine, Dammam University, Dammam, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, Dammam University, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096756780","display_name":"FatmaM. Lebda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"FatmaM. Lebda","raw_affiliation_strings":["Department of Physiology, College of Medicine, Dammam University, Dammam, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, Dammam University, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063920974","display_name":"Huda Kaatabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Huda Kaatabi","raw_affiliation_strings":["Department of Physiology, College of Medicine, Dammam University, Dammam, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, Dammam University, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066164653","display_name":"Abdulmohsen H. Al Elq","orcid":"https://orcid.org/0000-0002-3906-0188","observed_orcids":["https://orcid.org/0000-0002-3906-0188"]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdulmohsen Al Elq","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Dammam University, Dammam, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Dammam University, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108483294","display_name":"Ali Ibrahim Al\u2010Sultan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ali Al-Sultan","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Dammam University, Dammam, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Dammam University, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76571253"],"apc_list":null,"apc_paid":null,"fwci":0.714,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81647683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"37","issue":"2","first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nigella-sativa","display_name":"Nigella sativa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nigella-sativa-seeds","display_name":"black cumin seed","score":0.7459999918937683},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.8920000195503235},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9100000262260437},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.9259999990463257},{"id":"https://openalex.org/keywords/rate-pressure-product","display_name":"rate-pressure product","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.8410000205039978},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9010000228881836},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"prothrombin time","score":0.949999988079071},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8370000123977661},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.574999988079071},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.8436036705970764},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7873949408531189},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7816185355186462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7245250940322876},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6460403203964233},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5671522617340088},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.5570138692855835},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.46647578477859497},{"id":"https://openalex.org/C2993714443","wikidata":"https://www.wikidata.org/wiki/Q160575","display_name":"Nigella sativa","level":2,"score":0.4362591803073883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43495696783065796},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.42067328095436096},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3837004005908966},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3599163293838501},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.33125728368759155},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2833791673183441},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.08947306871414185}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7123/01.ejh.0000415060.42791.a6","doi":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","is_oa":true,"landing_page_url":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","pdf_url":null,"source":{"id":"https://openalex.org/S4210180515","display_name":"The Egyptian Journal of Haematology","issn_l":"1110-1067","issn":["1110-1067","2090-9268"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Haematology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7123/01.ejh.0000415060.42791.a6","doi":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","is_oa":true,"landing_page_url":"https://doi.org/10.7123/01.ejh.0000415060.42791.a6","pdf_url":null,"source":{"id":"https://openalex.org/S4210180515","display_name":"The Egyptian Journal of Haematology","issn_l":"1110-1067","issn":["1110-1067","2090-9268"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W22189248","https://openalex.org/W43218661","https://openalex.org/W258541089","https://openalex.org/W1253076899","https://openalex.org/W1497388823","https://openalex.org/W1504565165","https://openalex.org/W1513622810","https://openalex.org/W1968094414","https://openalex.org/W1970469091","https://openalex.org/W1981373280","https://openalex.org/W1993456360","https://openalex.org/W1995444152","https://openalex.org/W1997457584","https://openalex.org/W2005998137","https://openalex.org/W2016903551","https://openalex.org/W2018070208","https://openalex.org/W2025057319","https://openalex.org/W2054500920","https://openalex.org/W2057393088","https://openalex.org/W2082724449","https://openalex.org/W2086378871","https://openalex.org/W2087387943","https://openalex.org/W2099471833","https://openalex.org/W2115800727","https://openalex.org/W2115812939","https://openalex.org/W2125985137","https://openalex.org/W2149674228","https://openalex.org/W2152688067","https://openalex.org/W2154604904","https://openalex.org/W2172124430","https://openalex.org/W2185461071","https://openalex.org/W2220211413"],"related_works":["https://openalex.org/W2811413127","https://openalex.org/W2110223924","https://openalex.org/W2029341269","https://openalex.org/W4211117411","https://openalex.org/W2035952571","https://openalex.org/W2359135438","https://openalex.org/W2356362309","https://openalex.org/W107393773","https://openalex.org/W2074772071","https://openalex.org/W2326821580"],"abstract_inverted_index":{"Objectives":[0],"This":[1,32],"study":[2,33],"aimed":[3],"to":[4,174],"determine":[5],"the":[6,67,128,148,165,171,181,186,198,212,215,228,232,244,262],"efficacy":[7],"of":[8,55,137,214,249],"a":[9,53,135,144,205,219,258],"Nigella":[10],"sativa":[11],"(NS)":[12],"seed":[13],"supplement":[14,136],"on":[15,180,188,261],"hemodynamics,":[16],"hemoglobin":[17],"(Hb)":[18],"levels,":[19,88,98],"and":[20,58,82,89,99,106,110,159,184,218,225,240],"blood":[21,71,74,150,153,182],"coagulation":[22,90],"in":[23,127,147,170,197,208,222,237,272],"patients":[24,36,132,274],"with":[25,164,243,270,275],"type":[26],"2":[27,138,210,239,250],"diabetes":[28],"mellitus.":[29],"Study":[30],"design":[31],"included":[34],"94":[35],"who":[37,133],"were":[38,49,102],"divided":[39],"randomly":[40],"into":[41],"three":[42,199],"dose":[43,54,173],"groups.":[44,200],"Capsules":[45],"containing":[46],"NS":[47,118,140,172,252,266],"seeds":[48,253],"administered":[50,269],"orally":[51],"at":[52,211],"1,":[56],"2,":[57],"3":[59,175,226,241],"g/day":[60,117,139,176,251],"for":[61,119,254],"12":[62,111,120,255],"weeks.":[63,112],"In":[64],"all":[65],"patients,":[66],"hemodynamic":[68,129,263],"markers":[69,91],"[systolic":[70],"pressure,":[72,75,78,151,154,157],"diastolic":[73,152],"mean":[76,155],"arterial":[77,156],"heart":[79],"rate":[80,83,160],"(HR),":[81],"pressure":[84,161,183],"product":[85],"(RPP)],":[86],"Hb":[87,191],"(prothrombin":[92],"time,":[93,96],"partial":[94],"thromboplastin":[95,202],"fibrinogen":[97,233],"platelet":[100],"count)":[101],"determined":[103],"before":[104],"treatment":[105,216,229],"after":[107],"4,":[108],"8,":[109],"Results":[113],"Patients":[114],"receiving":[115],"1":[116,224],"weeks":[121,256],"(group":[122,141],"1)":[123],"showed":[124,143,204],"nonsignificant":[125,220],"changes":[126],"parameters,":[130],"whereas":[131],"received":[134],"2)":[142],"significant":[145,206],"reduction":[146],"systolic":[149],"HR,":[158],"product,":[162],"compared":[163,242],"baseline":[166,245],"values.":[167,246],"An":[168],"increase":[169,207,221],"exerted":[177,257],"less":[178],"effect":[179,187],"reversed":[185],"HR.":[189],"The":[190],"levels":[192,234],"decreased":[193],"slightly,":[194],"but":[195],"significantly":[196,236],"Partial":[201],"time":[203],"group":[209],"end":[213],"period":[217],"groups":[223,238],"throughout":[227],"period.":[230],"However,":[231,265],"increased":[235],"Conclusion":[247],"Ingestion":[248],"favorable":[259],"impact":[260],"parameters.":[264],"should":[267],"be":[268],"caution":[271],"diabetic":[273],"anemia.":[276]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}