{"id":"https://openalex.org/W2245492872","doi":"https://doi.org/10.6028/jres.093.136","title":"Applications of lasers in bioanalytical chemistry","display_name":"Applications of lasers in bioanalytical chemistry","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2245492872","doi":"https://doi.org/10.6028/jres.093.136","mag":"2245492872"},"language":"en","primary_location":{"id":"doi:10.6028/jres.093.136","doi":"https://doi.org/10.6028/jres.093.136","is_oa":true,"landing_page_url":"https://doi.org/10.6028/jres.093.136","pdf_url":"https://doi.org/10.6028/jres.093.136","source":{"id":"https://openalex.org/S4210205825","display_name":"Journal of Research of the National Bureau of Standards","issn_l":"0160-1741","issn":["0160-1741","2376-5259"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316732","host_organization_name":"The National Institute of Standards and Technology","host_organization_lineage":["https://openalex.org/P4310316732"],"host_organization_lineage_names":["The National Institute of Standards and Technology"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research of the National Bureau of Standards","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.6028/jres.093.136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061282830","display_name":"Edward S. Yeung","orcid":"https://orcid.org/0000-0003-0919-6700","observed_orcids":["https://orcid.org/0000-0003-0919-6700"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E.S. Yeung","raw_affiliation_strings":["Department of Chemistry, Iowa State University, Ames, IA 50011","Iowa State University\u2028"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Iowa State University, Ames, IA 50011","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Iowa State University\u2028","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061282830"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.20626151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"93","issue":"3","first_page":"502","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.15929999947547913,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasers","display_name":"lasers","score":0.6200000047683716},{"id":"https://openalex.org/keywords/laser-induced-fluorescence","display_name":"laser-induced fluorescence","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bioanalytical-instrumentation","display_name":"bioanalytical instrumentation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.6959999799728394},{"id":"https://openalex.org/keywords/chromosome-mapping","display_name":"chromosome mapping","score":0.7400000095367432},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6010000109672546},{"id":"https://openalex.org/keywords/enzyme-heterogeneity","display_name":"enzyme heterogeneity","score":0.718999981880188},{"id":"https://openalex.org/keywords/antigen-detection","display_name":"antigen detection","score":0.7599999904632568},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.6899887919425964},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6382066011428833},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.5861247777938843},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5118802785873413},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45758500695228577},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4413357973098755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4145646095275879},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37694939970970154},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3669828772544861},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30142366886138916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2258661687374115},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13130009174346924},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1212766170501709},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08665701746940613},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.6028/jres.093.136","doi":"https://doi.org/10.6028/jres.093.136","is_oa":true,"landing_page_url":"https://doi.org/10.6028/jres.093.136","pdf_url":"https://doi.org/10.6028/jres.093.136","source":{"id":"https://openalex.org/S4210205825","display_name":"Journal of Research of the National Bureau of Standards","issn_l":"0160-1741","issn":["0160-1741","2376-5259"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316732","host_organization_name":"The National Institute of Standards and Technology","host_organization_lineage":["https://openalex.org/P4310316732"],"host_organization_lineage_names":["The National Institute of Standards and Technology"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research of the National Bureau of Standards","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5181979","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5181979","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Res Natl Bur Stand (1977)","raw_type":"Text"},{"id":"pmh:oai:cdm16009.contentdm.oclc.org:p16009coll6/71871","doi":null,"is_oa":true,"landing_page_url":"http://cdm16009.contentdm.oclc.org/u?/p16009coll6,71871","pdf_url":null,"source":{"id":"https://openalex.org/S7407052254","display_name":"National Institute of Standards and Technology (NIST)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Research of the National Bureau of Standards","raw_type":null},{"id":"mag:2245492872","doi":null,"is_oa":false,"landing_page_url":"https://www.osapublishing.org/abstract.cfm?URI=CLEO-1995-JTuF1","pdf_url":null,"source":{"id":"https://openalex.org/S4306418073","display_name":"Conference on Lasers and Electro-Optics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Conference on Lasers and Electro-Optics","raw_type":null}],"best_oa_location":{"id":"doi:10.6028/jres.093.136","doi":"https://doi.org/10.6028/jres.093.136","is_oa":true,"landing_page_url":"https://doi.org/10.6028/jres.093.136","pdf_url":"https://doi.org/10.6028/jres.093.136","source":{"id":"https://openalex.org/S4210205825","display_name":"Journal of Research of the National Bureau of Standards","issn_l":"0160-1741","issn":["0160-1741","2376-5259"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316732","host_organization_name":"The National Institute of Standards and Technology","host_organization_lineage":["https://openalex.org/P4310316732"],"host_organization_lineage_names":["The National Institute of Standards and Technology"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research of the National Bureau of Standards","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2245492872.pdf","grobid_xml":"https://content.openalex.org/works/W2245492872.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7132058606","https://openalex.org/W7163925112","https://openalex.org/W4402378949","https://openalex.org/W2030395042","https://openalex.org/W44659403","https://openalex.org/W4410213002","https://openalex.org/W4252813341","https://openalex.org/W2968879449","https://openalex.org/W2996503971","https://openalex.org/W2252988931"],"abstract_inverted_index":{"Lasers":[0],"have":[1,177],"grown":[2],"from":[3],"being":[4],"an":[5,14],"exotic":[6],"device":[7],"in":[8,33,97,154,164],"the":[9,28,49,52,76,85,91,107,132,140,149],"research":[10],"laboratory":[11],"to":[12,39,62,121,158],"become":[13],"important":[15],"part":[16],"of":[17,30,43,56,93,109,127,134,137,145,151,169],"practical":[18],"bioanalytical":[19],"instrumentation.":[20],"Laser-excited":[21],"fluorescence":[22],"offers":[23],"extremely":[24],"high":[25],"sensitivity":[26],"for":[27,48,142,161,172],"detection":[29,92],"trace":[31,152],"components":[32],"ultramicro":[34],"environments.":[35],"This":[36],"has":[37],"led":[38],"a":[40,125],"new":[41,159],"generation":[42],"cellular":[44],"and":[45,51,64,73,83,104,117,147],"subcellular":[46],"probes":[47],"biochemical":[50],"clinical":[53],"laboratory.":[54],"Examples":[55],"upcoming":[57],"technologies":[58],"that":[59],"are":[60,66],"relevant":[61],"medicine":[63],"biotechnology":[65],"presented,":[67],"including":[68],"(1)":[69],"high-speed":[70],"DNA":[71],"mapping":[72],"sequencing,":[74],"where":[75,84],"analysis":[77],"time":[78],"is":[79,87],"decreased":[80],"by":[81],"1000\u00d7":[82],"accuracy":[86],"improved":[88],"substantially;":[89],"(2)":[90],"various":[94],"intracellullar":[95],"enzymes":[96],"blood":[98],"cells,":[99],"providing":[100],"information":[101],"about":[102],"aging":[103],"carcinogenesis;":[105],"(3)":[106],"characterization":[108],"individual":[110],"enzyme":[111],"molecules,":[112],"showing":[113],"how":[114],"protein":[115],"folding":[116],"refolding":[118],"can":[119],"lead":[120],"different":[122],"activities":[123],"among":[124],"population":[126],"otherwise":[128],"identical":[129],"molecules;":[130],"(4)":[131],"measurement":[133],"zeptomole":[135],"quantities":[136],"antigens,":[138],"paving":[139],"way":[141],"early":[143],"diagnosis":[144],"diseases;":[146],"(5)":[148],"monitoring":[150],"impurities":[153],"biopharmaceuticals,":[155],"potentially":[156],"leading":[157],"standards":[160],"quality":[162],"control":[163],"their":[165],"production.":[166],"New":[167],"types":[168],"lasers":[170],"optimized":[171],"these":[173],"applications":[174],"will":[175],"therefore":[176],"significant":[178],"market":[179],"potential.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}