{"id":"https://openalex.org/W2245408106","doi":null,"title":"Etude de la pr\u00e9sence et du r\u00f4le des lymphocytes Th17 dans le micro-environnement des lymphomes B murins","display_name":"Etude de la pr\u00e9sence et du r\u00f4le des lymphocytes Th17 dans le micro-environnement des lymphomes B murins","publication_year":2011,"publication_date":"2011-11-18","ids":{"openalex":"https://openalex.org/W2245408106","mag":"2245408106"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/870208","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/870208","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00650093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027729714","display_name":"Claire Galand","orcid":"https://orcid.org/0000-0001-8005-4831","observed_orcids":["https://orcid.org/0000-0001-8005-4831"]},"institutions":[{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"C Galand","raw_affiliation_strings":["Centre de Recherche des Cordeliers"],"raw_orcid":"https://orcid.org/0000-0001-8005-4831","affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers","institution_ids":["https://openalex.org/I4210092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027729714"],"corresponding_institution_ids":["https://openalex.org/I4210092322"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6890000104904175},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immunologically-privileged-sites","display_name":"immunologically privileged sites","score":0.5740000009536743},{"id":"https://openalex.org/keywords/intraocular-lymphoma","display_name":"intraocular lymphoma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.8610000014305115},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anti-tumoral-immune-response","display_name":"anti-tumoral immune response","score":0.6899999976158142},{"id":"https://openalex.org/keywords/murine-lymphoma-model","display_name":"murine lymphoma model","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6529838442802429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3504880666732788}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/870208","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/870208","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00650093v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00650093","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunologie. Universit\u00e9 Pierre et Marie Curie - Paris VI, 2011. Fran\u00e7ais. &#x27E8;NNT : &#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2245408106","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00650093","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-00650093v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00650093","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunologie. Universit\u00e9 Pierre et Marie Curie - Paris VI, 2011. Fran\u00e7ais. &#x27E8;NNT : &#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":200,"referenced_works":["https://openalex.org/W84406250","https://openalex.org/W151635657","https://openalex.org/W229616345","https://openalex.org/W580494680","https://openalex.org/W1493816460","https://openalex.org/W1497578010","https://openalex.org/W1510081630","https://openalex.org/W1518549789","https://openalex.org/W1533029876","https://openalex.org/W1543653831","https://openalex.org/W1554419904","https://openalex.org/W1555526178","https://openalex.org/W1558285676","https://openalex.org/W1560891208","https://openalex.org/W1627612497","https://openalex.org/W1642873092","https://openalex.org/W1663740629","https://openalex.org/W1825388809","https://openalex.org/W1883217637","https://openalex.org/W1893048570","https://openalex.org/W1935309503","https://openalex.org/W1949104013","https://openalex.org/W1960035134","https://openalex.org/W1966239676","https://openalex.org/W1966768211","https://openalex.org/W1967261754","https://openalex.org/W1967476755","https://openalex.org/W1967824941","https://openalex.org/W1971790974","https://openalex.org/W1976591271","https://openalex.org/W1977093012","https://openalex.org/W1977604451","https://openalex.org/W1979439341","https://openalex.org/W1982425751","https://openalex.org/W1984202589","https://openalex.org/W1987200981","https://openalex.org/W1987375206","https://openalex.org/W1987680648","https://openalex.org/W1988703453","https://openalex.org/W1991873176","https://openalex.org/W1992750664","https://openalex.org/W1995663931","https://openalex.org/W1996080482","https://openalex.org/W1996614926","https://openalex.org/W1996807539","https://openalex.org/W1997275623","https://openalex.org/W1998000193","https://openalex.org/W1998444876","https://openalex.org/W1999080103","https://openalex.org/W1999629342","https://openalex.org/W1999786927","https://openalex.org/W2000102677","https://openalex.org/W2000767839","https://openalex.org/W2001717792","https://openalex.org/W2002157461","https://openalex.org/W2002409863","https://openalex.org/W2004186675","https://openalex.org/W2006249161","https://openalex.org/W2006252261","https://openalex.org/W2006428939","https://openalex.org/W2010310014","https://openalex.org/W2010459522","https://openalex.org/W2011957759","https://openalex.org/W2013038914","https://openalex.org/W2013548919","https://openalex.org/W2014750930","https://openalex.org/W2016488838","https://openalex.org/W2017893786","https://openalex.org/W2018206879","https://openalex.org/W2018224938","https://openalex.org/W2019433245","https://openalex.org/W2019490105","https://openalex.org/W2020145270","https://openalex.org/W2021355464","https://openalex.org/W2023962763","https://openalex.org/W2027646748","https://openalex.org/W2027699993","https://openalex.org/W2027949856","https://openalex.org/W2029695719","https://openalex.org/W2032596171","https://openalex.org/W2032704882","https://openalex.org/W2034368187","https://openalex.org/W2034453891","https://openalex.org/W2034949380","https://openalex.org/W2034977063","https://openalex.org/W2035600340","https://openalex.org/W2036383793","https://openalex.org/W2036489358","https://openalex.org/W2039130367","https://openalex.org/W2040113238","https://openalex.org/W2040770569","https://openalex.org/W2043641165","https://openalex.org/W2043901139","https://openalex.org/W2047299887","https://openalex.org/W2048102361","https://openalex.org/W2049094526","https://openalex.org/W2049426330","https://openalex.org/W2049910239","https://openalex.org/W2050558522","https://openalex.org/W2054163626","https://openalex.org/W2055022115","https://openalex.org/W2058587420","https://openalex.org/W2059043985","https://openalex.org/W2059130119","https://openalex.org/W2059191664","https://openalex.org/W2060410377","https://openalex.org/W2060456703","https://openalex.org/W2060874030","https://openalex.org/W2061217789","https://openalex.org/W2064912737","https://openalex.org/W2065136791","https://openalex.org/W2068119757","https://openalex.org/W2070079904","https://openalex.org/W2076293675","https://openalex.org/W2076889715","https://openalex.org/W2077204887","https://openalex.org/W2081496541","https://openalex.org/W2082237689","https://openalex.org/W2085257327","https://openalex.org/W2085356010","https://openalex.org/W2086539844","https://openalex.org/W2086551636","https://openalex.org/W2087482409","https://openalex.org/W2090428008","https://openalex.org/W2091787066","https://openalex.org/W2091953646","https://openalex.org/W2092289533","https://openalex.org/W2093897672","https://openalex.org/W2096367348","https://openalex.org/W2097672049","https://openalex.org/W2098005365","https://openalex.org/W2099113429","https://openalex.org/W2100991714","https://openalex.org/W2105484520","https://openalex.org/W2106481577","https://openalex.org/W2107235439","https://openalex.org/W2107587037","https://openalex.org/W2107830035","https://openalex.org/W2110228704","https://openalex.org/W2110252240","https://openalex.org/W2111500154","https://openalex.org/W2111988435","https://openalex.org/W2113030185","https://openalex.org/W2114027214","https://openalex.org/W2114140047","https://openalex.org/W2114300975","https://openalex.org/W2114307334","https://openalex.org/W2115073769","https://openalex.org/W2115483836","https://openalex.org/W2115919961","https://openalex.org/W2117692326","https://openalex.org/W2123497942","https://openalex.org/W2123589978","https://openalex.org/W2125170171","https://openalex.org/W2126456833","https://openalex.org/W2127946706","https://openalex.org/W2130401210","https://openalex.org/W2132598458","https://openalex.org/W2134365788","https://openalex.org/W2136360293","https://openalex.org/W2136757803","https://openalex.org/W2137712039","https://openalex.org/W2137914700","https://openalex.org/W2138402519","https://openalex.org/W2138733343","https://openalex.org/W2139605769","https://openalex.org/W2140683554","https://openalex.org/W2141628791","https://openalex.org/W2144441835","https://openalex.org/W2147246240","https://openalex.org/W2147350757","https://openalex.org/W2149003918","https://openalex.org/W2149915530","https://openalex.org/W2150213518","https://openalex.org/W2151055438","https://openalex.org/W2152009414","https://openalex.org/W2152118650","https://openalex.org/W2153389047","https://openalex.org/W2155013311","https://openalex.org/W2156451877","https://openalex.org/W2157072818","https://openalex.org/W2157485001","https://openalex.org/W2157824068","https://openalex.org/W2157837362","https://openalex.org/W2158550612","https://openalex.org/W2159252214","https://openalex.org/W2159511210","https://openalex.org/W2161132784","https://openalex.org/W2163828646","https://openalex.org/W2165403621","https://openalex.org/W2167799732","https://openalex.org/W2169542066","https://openalex.org/W2170888044","https://openalex.org/W2171775292","https://openalex.org/W2172466148","https://openalex.org/W2236375555","https://openalex.org/W2419177274","https://openalex.org/W2772222670","https://openalex.org/W4251630365","https://openalex.org/W4313308282"],"related_works":["https://openalex.org/W4392489986","https://openalex.org/W7070514379","https://openalex.org/W7151901715","https://openalex.org/W7061752658","https://openalex.org/W7147113469","https://openalex.org/W2990803152","https://openalex.org/W2091787066","https://openalex.org/W7152119502","https://openalex.org/W7099648732","https://openalex.org/W4394692126"],"abstract_inverted_index":{"Le":[0,48],"principal":[1],"cancer":[2],"h\u00e9matologique":[3],"est":[4,16,191,196],"le":[5,17,32,65,153,222,234,270],"lymphome":[6,18,154,239],"B":[7,19,101,123,240],"non-hodgkinien":[8],"(LNH)":[9],"dont":[10,56],"la":[11,13,193,208,211,266],"forme":[12],"plus":[14],"courante":[15],"diffus":[20],"\u00e0":[21,41,81,103,241,254],"grande":[22],"cellule":[23],"(DLBCL).":[24],"La":[25],"pr\u00e9sence":[26],"d'un":[27,34],"infiltrat":[28],"lymphocytaire":[29,133],"T":[30,116,201],"dans":[31,53,87,140,152,170,216,221,233,246],"micro-environnement":[33],"LNH-B":[35,49],"nodal":[36],"a":[37,79],"\u00e9t\u00e9":[38],"clairement":[39],"associ\u00e9e":[40],"un":[42],"bon":[43],"pronostic":[44],"vital":[45],"des":[46,88,164,180,186,230,272],"patients.":[47],"peut":[50],"se":[51],"d\u00e9velopper":[52],"divers":[54],"tissus":[55],"certains":[57],"organes":[58,172],"immunologiquement":[59,173,249],"privil\u00e9gi\u00e9s,":[60],"comme":[61],"les":[62,68,83,96,121,141,167,171,214,219,247,259],"yeux":[63],"et":[64,108,145,182,198,218],"cerveau,":[66],"o\u00f9":[67],"r\u00e9ponses":[69],"immunitaires":[70,98],"sont":[71,138,203],"inhib\u00e9es":[72],"ou":[73],"retard\u00e9es.":[74],"Mon":[75],"projet":[76],"de":[77,90,99,136,207,210,225,257,265],"th\u00e8se":[78],"consist\u00e9":[80],"\u00e9tudier":[82],"interactions":[84],"tumeur-micro-environnement":[85],"immunitaire":[86],"sites":[89,143,248],"privil\u00e8ge":[91],"immunitaire.":[92],"Nous":[93],"avons":[94,147,158],"compar\u00e9":[95],"infiltrats":[97],"lymphomes":[100,122],"murins":[102],"grandes":[104,242],"cellules":[105,243],"intra-spl\u00e9nique,":[106],"intra-c\u00e9r\u00e9bral":[107],"intra-oculaire":[109],"par":[110,176],"cytom\u00e9trie":[111],"en":[112,160,205,262],"flux.":[113],"Les":[114,129],"lymphocytes":[115],"(LT),":[117],"majoritairement":[118],"CD4+,":[119],"infiltrent":[120],"quelles":[124],"que":[125],"soient":[126],"leurs":[127],"localisations.":[128],"Th17,":[130],"une":[131],"sous-population":[132],"CD4+":[134,202],"produisant":[135],"l'IL-17,":[137],"pr\u00e9sents":[139],"3":[142],"tumoraux":[144],"nous":[146,157],"d\u00e9montr\u00e9":[148],"leur":[149],"r\u00f4le":[150],"anti-tumoral":[151],"intra-oculaire.":[155],"Cependant,":[156],"mis":[159],"\u00e9vidence":[161],"l'impact":[162],"suppresseur":[163],"Treg":[165],"sur":[166],"LT":[168,181,231,260],"effecteurs":[169,232,261],"privil\u00e9gi\u00e9s":[174],"uniquement,":[175],"stimulation":[177],"ex":[178],"vivo":[179,185],"d\u00e9pl\u00e9tion":[183],"in":[184],"Treg.":[187],"Lorsque":[188],"cette":[189],"inhibition":[190],"lev\u00e9e,":[192],"progression":[194],"tumorale":[195],"ralentie":[197],"d'autres":[199],"sous-populations":[200],"favoris\u00e9es":[204],"fonction":[206],"localisation":[209,267],"tumeur":[212],":":[213],"Th2":[215],"l'\u0153il":[217],"Th17":[220],"cerveau.":[223],"L'ensemble":[224],"ces":[226],"donn\u00e9es":[227],"montre":[228],"l'importance":[229],"contr\u00f4le":[235],"du":[236,238],"d\u00e9veloppement":[237],"y":[244],"compris":[245],"privil\u00e9gi\u00e9s.":[250],"Une":[251],"piste":[252],"importante":[253],"explorer":[255],"serait":[256],"stimuler":[258],"tenant":[263],"compte":[264],"pour":[268],"am\u00e9liorer":[269],"traitement":[271],"DLBCL.":[273]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
