{"id":"https://openalex.org/W2245294536","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.22020","title":"Inter-observer reliability for the diagnosis of lung cancer in a clinical cohort using the WHO classification system, version","display_name":"Inter-observer reliability for the diagnosis of lung cancer in a clinical cohort using the WHO classification system, version","publication_year":2008,"publication_date":"2008-05-20","ids":{"openalex":"https://openalex.org/W2245294536","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.22020","mag":"2245294536"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.26.15_suppl.22020","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.22020","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.22020","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059915005","display_name":"Juneko E. Grilley\u2010Olson","orcid":"https://orcid.org/0000-0002-1896-7020","observed_orcids":["https://orcid.org/0000-0002-1896-7020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. E. Grilley-Olson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068906036","display_name":"David Neil Hayes","orcid":"https://orcid.org/0000-0001-6203-7771","observed_orcids":["https://orcid.org/0000-0001-6203-7771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. N. Hayes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015876455","display_name":"R. D. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. D. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078629724","display_name":"Mark A. Socinski","orcid":"https://orcid.org/0000-0003-2915-9325","observed_orcids":["https://orcid.org/0000-0003-2915-9325","https://orcid.org/0000-0002-8213-0137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. A. Socinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014554706","display_name":"Thomas E. Stinchcombe","orcid":"https://orcid.org/0000-0002-3595-8011","observed_orcids":["https://orcid.org/0000-0002-3595-8011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. E. Stinchcombe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032699241","display_name":"Michele C. Hayward","orcid":"https://orcid.org/0000-0003-0921-1368","observed_orcids":["https://orcid.org/0000-0003-0921-1368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hayward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082974900","display_name":"Bahjat F. Qaqish","orcid":"https://orcid.org/0000-0002-5154-2059","observed_orcids":["https://orcid.org/0000-0002-5154-2059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. F. Qaqish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106628122","display_name":"Dominic T. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. T. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044894170","display_name":"William K. Funkhouser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. K. Funkhouser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"15_suppl","first_page":"22020","last_page":"22020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.2020999938249588,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/inter-rater-reliability","display_name":"inter-rater reliability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/histological-classification","display_name":"histological classification","score":0.7009999752044678},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7049999833106995},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/large-cell-carcinoma","display_name":"large cell carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/kappa-statistic","display_name":"kappa statistic","score":0.656000018119812},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"digital pathology","score":0.7039999961853027},{"id":"https://openalex.org/keywords/virtual-slides","display_name":"virtual slides","score":0.6079999804496765},{"id":"https://openalex.org/keywords/pathologist-agreement","display_name":"pathologist agreement","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9007807970046997},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6762731671333313},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6189223527908325},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.5176682472229004},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4902699291706085},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46934211254119873},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3888430595397949},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3377547264099121},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33562642335891724},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.33253538608551025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3108365535736084}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2008.26.15_suppl.22020","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.22020","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.22020","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2162141568","https://openalex.org/W1966567342","https://openalex.org/W2328479653","https://openalex.org/W2472415808","https://openalex.org/W2945429077","https://openalex.org/W4410855774","https://openalex.org/W2108302629","https://openalex.org/W4389804560","https://openalex.org/W2058206917","https://openalex.org/W4308402150"],"abstract_inverted_index":{"22020":[0],"Background:":[1],"Personalized":[2],"medicine":[3],"implies":[4],"correlation":[5],"of":[6,26,46,64,78,175,190,243,276,291,297,310],"patients/tumors/diagnoses":[7],"with":[8,108,217,246],"therapies.":[9],"In":[10],"parallel,":[11],"precise":[12],"pathologic":[13],"classification":[14],"permits":[15],"more":[16],"meaningful":[17],"phenotype-outcome":[18],"associations.":[19],"A":[20,199],"current":[21,48],"morphologic":[22],"standard":[23,154],"for":[24,128,151,221,226,230,271,304],"diagnosis":[25,201,296],"lung":[27,57,80,116,179,298],"cancer":[28,58,81],"is":[29,40],"the":[30,47,62,65,103,138,159,168,191,211,244,247,258,283,289,292,295,308],"World":[31],"Health":[32],"Organization":[33],"classification,":[34],"version":[35,49],"3":[36],"(WHOC).":[37],"This":[38],"system":[39],"based":[41,95],"on":[42,96,171],"expert":[43,185],"consensus;":[44],"validation":[45],"has":[50],"not":[51,203,294],"been":[52],"well":[53],"described.":[54],"Using":[55],"a":[56,88,123,302],"cohort,":[59],"we":[60],"estimate":[61],"reliability":[63,249,290],"WHOC":[66],"to":[67,158,167,257,269,317],"be":[68,267],"only":[69],"moderately":[70],"precise.":[71],"Methods:":[72],"We":[73,140,234],"generated":[74],"an":[75],"incident":[76],"cohort":[77],"96":[79],"patients":[82],"treated":[83],"at":[84],"our":[85],"institution":[86],"over":[87],"10":[89],"year":[90],"period.":[91],"Sample":[92],"selection":[93],"was":[94,119,161,202,208],"surgical":[97],"resection,":[98],"frozen":[99],"samples":[100],"available":[101],"from":[102],"same":[104],"patient":[105],"(to":[106],"correlate":[107],"future":[109],"molecular":[110,311],"analyses),":[111],"satisfactory":[112],"H&E":[113],"stains,":[114],"primary":[115],"tumor.":[117],"Viewing":[118],"standardized":[120],"by":[121],"creating":[122],"single":[124],"representative":[125],"virtual":[126],"slide":[127],"each":[129,148],"tumor,":[130],"using":[131,137],"Aperio":[132],"Scanscope.":[133],"Pathologists":[134],"classified":[135],"tumors":[136],"WHOC.":[139],"determined":[141],"that":[142],"24":[143,146],"pathologists":[144],"reviewing":[145],"slides":[147,193,280],"would":[149],"allow":[150],"kappa(K)=0.7":[152],"and":[153,183,228,239,278],"error(SE)=0.09.":[155],"Results:":[156],"Response":[157],"survey":[160],"generally":[162],"positive.":[163],"One":[164],"pathologist":[165],"objected":[166],"technology.":[169],"Based":[170],"participant":[172],"self-identification,":[173],"25%":[174,184],"participants":[176],"were":[177,194],"\u201cexpert\u201d":[178],"pathologists,":[180],"50%":[181],"generalist,":[182],"in":[186,205,210,240,250],"another":[187],"area.":[188],"1%":[189],"digital":[192],"self":[195],"reported":[196],"as":[197,307],"\u201cuninterpertable.\u201d":[198],"specific":[200],"made":[204],"4%":[206],"but":[207],"reached":[209],"remaining":[212],"95%.":[213],"The":[214],"overall":[215,238],"K=0.36":[216],"SE=0.07,":[218],"K=":[219],"0.33":[220],"squamous":[222],"cell":[223],"carcinoma,":[224],"0.58":[225],"adenocarcinoma,":[227],"0.21":[229],"large":[231],"cell.":[232],"Conclusions:":[233],"demonstrated":[235],"fair":[236],"agreement":[237],"many":[241],"subclassifications":[242],"WHOC,":[245,293],"best":[248],"adenocarcinoma.":[251],"Infrequently":[252],"used":[253],"categories":[254],"likely":[255],"contributed":[256],"relatively":[259],"poor":[260],"inter-observer":[261],"agreement,":[262],"suggesting":[263],"this":[264,286],"schema":[265],"may":[266,281],"difficult":[268],"implement":[270],"clinical":[272],"diagnostic":[273],"purposes.":[274],"Use":[275],"immunohistochemicals":[277],"multiple":[279],"increase":[282],"K.":[284],"Although":[285],"model":[287],"assesses":[288],"cancer,":[299],"it":[300],"provides":[301],"baseline":[303],"improvements":[305],"such":[306],"addition":[309],"markers.":[312],"No":[313],"significant":[314],"financial":[315],"relationships":[316],"disclose.":[318]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}