{"id":"https://openalex.org/W2245165785","doi":"https://doi.org/10.1152/japplphysiol.00131.2003","title":"Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide","display_name":"Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2245165785","doi":"https://doi.org/10.1152/japplphysiol.00131.2003","mag":"2245165785","pmid":"https://pubmed.ncbi.nlm.nih.gov/12665533"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00131.2003","doi":"https://doi.org/10.1152/japplphysiol.00131.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00131.2003","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sang-jin Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang-jin Shin","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111823579","display_name":"Beverley Fermor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beverley Fermor","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102751703","display_name":"Joe Brice Weinberg","orcid":"https://orcid.org/0000-0003-4052-5576","observed_orcids":["https://orcid.org/0000-0003-4052-5576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Brice Weinberg","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015062757","display_name":"David S. Pisetsky","orcid":"https://orcid.org/0000-0002-3539-5351","observed_orcids":["https://orcid.org/0000-0002-3539-5351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David S. Pisetsky","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090627153","display_name":"Farshid Guilak","orcid":"https://orcid.org/0000-0001-7380-0330","observed_orcids":["https://orcid.org/0000-0001-7380-0330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farshid Guilak","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4436,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.88549946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"1","first_page":"308","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meniscus","display_name":"meniscus","score":0.996999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix-turnover","display_name":"extracellular matrix turnover","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.9240000247955322},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-2","display_name":"nitric oxide synthase 2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/proteoglycan-synthesis","display_name":"proteoglycan synthesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/proteoglycan-release","display_name":"proteoglycan release","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dynamic-compression","display_name":"dynamic compression","score":0.8820000290870667},{"id":"https://openalex.org/keywords/knee-biomechanics","display_name":"knee biomechanics","score":0.5630000233650208},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7853876352310181},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.7483790516853333},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6835168600082397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5533556342124939},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5369422435760498},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.515842616558075},{"id":"https://openalex.org/C189178095","wikidata":"https://www.wikidata.org/wiki/Q15834833","display_name":"Meniscus","level":3,"score":0.4121791422367096},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38264933228492737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3799149692058563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2718583941459656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18630951642990112},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007596","descriptor_name":"Joints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013462","descriptor_name":"Sulfur Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/japplphysiol.00131.2003","doi":"https://doi.org/10.1152/japplphysiol.00131.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00131.2003","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:12665533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12665533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.860.7156","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.860.7156","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jap.physiology.org/content/jap/95/1/308.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1413923409","display_name":"MECHANICAL STRESS AND PROSTAGLANDINS IN CARTILAGE","funder_award_id":"R03AR047920","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6454837097","display_name":"Viscoelastic Properties of Normal and OA Chondrons","funder_award_id":"R01AG015768","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7633619524","display_name":"Mechanical and Osmotic Signaling in Chondrocytes","funder_award_id":"R01AR048182","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W49808031","https://openalex.org/W123183995","https://openalex.org/W124081177","https://openalex.org/W298340976","https://openalex.org/W1544116994","https://openalex.org/W1584548942","https://openalex.org/W1928968758","https://openalex.org/W1963813826","https://openalex.org/W1964038634","https://openalex.org/W1964836517","https://openalex.org/W1964979213","https://openalex.org/W1965282306","https://openalex.org/W1967357201","https://openalex.org/W1968659828","https://openalex.org/W1969937820","https://openalex.org/W1971407952","https://openalex.org/W1972426221","https://openalex.org/W1979915035","https://openalex.org/W1987004514","https://openalex.org/W1990278546","https://openalex.org/W1991987132","https://openalex.org/W1992036838","https://openalex.org/W1992750250","https://openalex.org/W1998785004","https://openalex.org/W1999893828","https://openalex.org/W2003678590","https://openalex.org/W2009350275","https://openalex.org/W2010313836","https://openalex.org/W2010335941","https://openalex.org/W2015007716","https://openalex.org/W2020787517","https://openalex.org/W2022086692","https://openalex.org/W2026420278","https://openalex.org/W2027404394","https://openalex.org/W2042994078","https://openalex.org/W2055150344","https://openalex.org/W2057575379","https://openalex.org/W2057635936","https://openalex.org/W2058396041","https://openalex.org/W2063139074","https://openalex.org/W2076472900","https://openalex.org/W2080272899","https://openalex.org/W2087669457","https://openalex.org/W2095186645","https://openalex.org/W2095485275","https://openalex.org/W2105601013","https://openalex.org/W2106498077","https://openalex.org/W2115021310","https://openalex.org/W2121801199","https://openalex.org/W2122500510","https://openalex.org/W2136152329","https://openalex.org/W2155873300","https://openalex.org/W2164933897","https://openalex.org/W2167031471","https://openalex.org/W2261237464","https://openalex.org/W2337019382","https://openalex.org/W2343137005","https://openalex.org/W2400107839","https://openalex.org/W6636129110"],"related_works":["https://openalex.org/W2022086692","https://openalex.org/W2084919270","https://openalex.org/W2009895803","https://openalex.org/W2781785618","https://openalex.org/W2051822687","https://openalex.org/W1987001055","https://openalex.org/W2042994078","https://openalex.org/W2808315264","https://openalex.org/W2095186645","https://openalex.org/W4415656898"],"abstract_inverted_index":{"The":[0,42,113],"meniscus":[1,20,60],"is":[2,221],"an":[3],"intra-articular":[4],"fibrocartilaginous":[5],"structure":[6],"that":[7,33,204,220],"serves":[8],"essential":[9],"biomechanical":[10,31],"roles":[11],"in":[12,27,58,61,76,187],"the":[13,19,37,50,59,62,70,103,151,166,197,208],"knee.":[14],"With":[15],"injury":[16],"or":[17,172],"arthritis,":[18],"may":[21,206],"be":[22],"exposed":[23],"to":[24,36,48,68,85,189],"significant":[25],"changes":[26],"its":[28],"biochemical":[29],"and":[30,67,102,109,130,135,175,180],"environments":[32],"likely":[34],"contribute":[35],"progression":[38],"of":[39,44,52,64,72,80,105,115,145,153,163,184,196,199,210],"joint":[40],"disease.":[41],"goal":[43],"this":[45],"study":[46],"was":[47,111,148,156,168,191],"examine":[49],"influence":[51],"mechanical":[53,146,173,211],"stress":[54,147,212],"on":[55,193,213,223],"matrix":[56,215],"turnover":[57,216],"presence":[63,152,198],"interleukin-1":[65],"(IL-1)":[66],"determine":[69],"role":[71],"nitric":[73,117],"oxide":[74,118],"(NO)":[75],"these":[77],"processes.":[78],"Explants":[79],"porcine":[81],"menisci":[82],"were":[83,123],"subjected":[84],"dynamic":[86],"compressive":[87],"stresses":[88],"at":[89,95],"0.1":[90],"MPa":[91],"for":[92],"24":[93],"h":[94],"0.5":[96],"Hz":[97],"with":[98,139],"1":[99],"ng/ml":[100],"IL-1,":[101],"synthesis":[104,132],"total":[106],"protein,":[107],"proteoglycan,":[108],"NO":[110],"measured.":[112],"effects":[114,209],"a":[116,218],"synthase":[119],"2":[120],"(NOS2)":[121],"inhibitor":[122],"determined.":[124],"Dynamic":[125],"compression":[126,174,181,190],"significantly":[127],"increased":[128,169],"protein":[129],"proteoglycan":[131,185],"by":[133,150,158,170,178],"68":[134],"58%,":[136],"respectively,":[137],"compared":[138],"uncompressed":[140],"explants.":[141],"This":[142],"stimulatory":[143],"effect":[144],"prevented":[149],"IL-1":[154,171,179,205],"but":[155],"restored":[157],"specifically":[159],"inhibiting":[160],"NOS2.":[161],"Release":[162],"proteoglycans":[164],"into":[165],"medium":[167],"further":[176],"enhanced":[177],"together.":[182],"Stimulation":[183],"release":[186],"response":[188],"dependent":[192,222],"NOS2":[194],"regardless":[195],"IL-1.":[200],"These":[201],"finding":[202],"suggest":[203],"modulate":[207],"extracellular":[214],"through":[217],"pathway":[219],"NO.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
