{"id":"https://openalex.org/W2244778660","doi":null,"title":"Characterization of signalling pathways in cardiac hypertrophic response","display_name":"Characterization of signalling pathways in cardiac hypertrophic response","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2244778660","mag":"2244778660"},"language":"en","primary_location":{"id":"mag:2244778660","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9789514294617.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Elina Koivisto","orcid":"https://orcid.org/0009-0003-8480-8751","observed_orcids":["https://orcid.org/0009-0003-8480-8751"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elina Koivisto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-8480-8751","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2877,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.81394621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.11110000312328339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiomyocyte-stretch","display_name":"cardiomyocyte stretch","score":0.7329999804496765},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.781000018119812},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8709999918937683},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tef-1","display_name":"TEF-1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/atf3","display_name":"ATF3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gata4","display_name":"GATA4","score":1.0},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nkx2-5","display_name":"Nkx2.5","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3529999852180481},{"id":"https://openalex.org/keywords/cardiomyocyte-survival","display_name":"cardiomyocyte survival","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5679756999015808},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5679689049720764},{"id":"https://openalex.org/C157880135","wikidata":"https://www.wikidata.org/wiki/Q17832633","display_name":"ATF3","level":5,"score":0.5202490091323853},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4993560314178467},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49645453691482544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48612141609191895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4688265025615692},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4511231780052185},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.4396209418773651},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.43659836053848267},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4214032292366028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38631051778793335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.341076523065567},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2704456150531769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.243000328540802},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.13770005106925964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10659733414649963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09110915660858154},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06560596823692322}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2244778660","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9789514294617.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":382,"referenced_works":["https://openalex.org/W197144613","https://openalex.org/W203470123","https://openalex.org/W1479831323","https://openalex.org/W1488252766","https://openalex.org/W1488424161","https://openalex.org/W1513067957","https://openalex.org/W1522471368","https://openalex.org/W1544768460","https://openalex.org/W1553668020","https://openalex.org/W1559777116","https://openalex.org/W1560653098","https://openalex.org/W1568842777","https://openalex.org/W1576399086","https://openalex.org/W1576457818","https://openalex.org/W1577233398","https://openalex.org/W1583270829","https://openalex.org/W1584351787","https://openalex.org/W1588725890","https://openalex.org/W1593273547","https://openalex.org/W1597808722","https://openalex.org/W1599556324","https://openalex.org/W1602267436","https://openalex.org/W1775898306","https://openalex.org/W1862499115","https://openalex.org/W1869555064","https://openalex.org/W1889002087","https://openalex.org/W1911477298","https://openalex.org/W1963513641","https://openalex.org/W1964292925","https://openalex.org/W1964436833","https://openalex.org/W1965389732","https://openalex.org/W1965559802","https://openalex.org/W1965993201","https://openalex.org/W1967412797","https://openalex.org/W1967465122","https://openalex.org/W1967688761","https://openalex.org/W1968672667","https://openalex.org/W1969281472","https://openalex.org/W1969347062","https://openalex.org/W1969963271","https://openalex.org/W1970546329","https://openalex.org/W1971599917","https://openalex.org/W1972558433","https://openalex.org/W1973460380","https://openalex.org/W1974684787","https://openalex.org/W1974768008","https://openalex.org/W1976462601","https://openalex.org/W1976690335","https://openalex.org/W1977277617","https://openalex.org/W1977314462","https://openalex.org/W1977385412","https://openalex.org/W1978038902","https://openalex.org/W1978162225","https://openalex.org/W1979285069","https://openalex.org/W1979740950","https://openalex.org/W1980156049","https://openalex.org/W1980831535","https://openalex.org/W1981229396","https://openalex.org/W1981438457","https://openalex.org/W1982051116","https://openalex.org/W1982785554","https://openalex.org/W1983207595","https://openalex.org/W1983692570","https://openalex.org/W1985130075","https://openalex.org/W1985358659","https://openalex.org/W1986060421","https://openalex.org/W1986094670","https://openalex.org/W1986772902","https://openalex.org/W1987453246","https://openalex.org/W1988718032","https://openalex.org/W1988887575","https://openalex.org/W1989355270","https://openalex.org/W1989950796","https://openalex.org/W1990543022","https://openalex.org/W1991047915","https://openalex.org/W1991545343","https://openalex.org/W1992834760","https://openalex.org/W1994219871","https://openalex.org/W1994545438","https://openalex.org/W1994794191","https://openalex.org/W1994970453","https://openalex.org/W1996405087","https://openalex.org/W1997271589","https://openalex.org/W1998487776","https://openalex.org/W1999158663","https://openalex.org/W1999437232","https://openalex.org/W2000722663","https://openalex.org/W2000974608","https://openalex.org/W2001333805","https://openalex.org/W2001399809","https://openalex.org/W2001637044","https://openalex.org/W2002416384","https://openalex.org/W2002564316","https://openalex.org/W2003234142","https://openalex.org/W2005874915","https://openalex.org/W2006316667","https://openalex.org/W2006739286","https://openalex.org/W2007974580","https://openalex.org/W2009338965","https://openalex.org/W2009797078","https://openalex.org/W2009884615","https://openalex.org/W2011048353","https://openalex.org/W2011936496","https://openalex.org/W2012041356","https://openalex.org/W2012156030","https://openalex.org/W2014434817","https://openalex.org/W2014943313","https://openalex.org/W2015162349","https://openalex.org/W2015615030","https://openalex.org/W2016730049","https://openalex.org/W2017557087","https://openalex.org/W2018769945","https://openalex.org/W2018773000","https://openalex.org/W2019599792","https://openalex.org/W2019831571","https://openalex.org/W2020208784","https://openalex.org/W2020760006","https://openalex.org/W2021028340","https://openalex.org/W2021216564","https://openalex.org/W2021387138","https://openalex.org/W2025252445","https://openalex.org/W2025857838","https://openalex.org/W2026398626","https://openalex.org/W2026472826","https://openalex.org/W2026789574","https://openalex.org/W2027288608","https://openalex.org/W2028373562","https://openalex.org/W2030768343","https://openalex.org/W2030900078","https://openalex.org/W2031662595","https://openalex.org/W2032327430","https://openalex.org/W2032666422","https://openalex.org/W2036956062","https://openalex.org/W2037199313","https://openalex.org/W2037957201","https://openalex.org/W2038392876","https://openalex.org/W2041538521","https://openalex.org/W2041550708","https://openalex.org/W2043075037","https://openalex.org/W2043359085","https://openalex.org/W2043477713","https://openalex.org/W2043659211","https://openalex.org/W2046146856","https://openalex.org/W2047067372","https://openalex.org/W2047866697","https://openalex.org/W2048020247","https://openalex.org/W2048404789","https://openalex.org/W2048443661","https://openalex.org/W2048605672","https://openalex.org/W2049370164","https://openalex.org/W2049793557","https://openalex.org/W2050162178","https://openalex.org/W2050251634","https://openalex.org/W2050346306","https://openalex.org/W2050690958","https://openalex.org/W2050744280","https://openalex.org/W2052097767","https://openalex.org/W2052137719","https://openalex.org/W2052397527","https://openalex.org/W2052780003","https://openalex.org/W2053329983","https://openalex.org/W2054096312","https://openalex.org/W2054588120","https://openalex.org/W2054723192","https://openalex.org/W2055217734","https://openalex.org/W2055469901","https://openalex.org/W2055545648","https://openalex.org/W2056028095","https://openalex.org/W2056099499","https://openalex.org/W2056311227","https://openalex.org/W2057386289","https://openalex.org/W2058490849","https://openalex.org/W2058956794","https://openalex.org/W2059190844","https://openalex.org/W2060018075","https://openalex.org/W2060049476","https://openalex.org/W2060333964","https://openalex.org/W2060394697","https://openalex.org/W2061459977","https://openalex.org/W2062255318","https://openalex.org/W2062856841","https://openalex.org/W2063346793","https://openalex.org/W2063654473","https://openalex.org/W2063812215","https://openalex.org/W2063831467","https://openalex.org/W2065329924","https://openalex.org/W2066675672","https://openalex.org/W2066695771","https://openalex.org/W2067450773","https://openalex.org/W2067837253","https://openalex.org/W2067893274","https://openalex.org/W2068905608","https://openalex.org/W2070341655","https://openalex.org/W2072319964","https://openalex.org/W2072410510","https://openalex.org/W2073597339","https://openalex.org/W2074187803","https://openalex.org/W2074800090","https://openalex.org/W2075809778","https://openalex.org/W2075907691","https://openalex.org/W2076071130","https://openalex.org/W2076485183","https://openalex.org/W2076810768","https://openalex.org/W2077469001","https://openalex.org/W2077880395","https://openalex.org/W2078593992","https://openalex.org/W2081079039","https://openalex.org/W2081088335","https://openalex.org/W2081874080","https://openalex.org/W2081878872","https://openalex.org/W2082090096","https://openalex.org/W2082209421","https://openalex.org/W2082824461","https://openalex.org/W2084037169","https://openalex.org/W2085039460","https://openalex.org/W2086041680","https://openalex.org/W2086525709","https://openalex.org/W2088749722","https://openalex.org/W2088764696","https://openalex.org/W2088918935","https://openalex.org/W2088923697","https://openalex.org/W2090281182","https://openalex.org/W2091592969","https://openalex.org/W2093801383","https://openalex.org/W2094580473","https://openalex.org/W2094871761","https://openalex.org/W2095224095","https://openalex.org/W2096379722","https://openalex.org/W2096847688","https://openalex.org/W2097011926","https://openalex.org/W2098255687","https://openalex.org/W2098296304","https://openalex.org/W2098719212","https://openalex.org/W2098881788","https://openalex.org/W2099093659","https://openalex.org/W2100846311","https://openalex.org/W2102987687","https://openalex.org/W2103751591","https://openalex.org/W2104483699","https://openalex.org/W2105502622","https://openalex.org/W2105657039","https://openalex.org/W2107651170","https://openalex.org/W2108083474","https://openalex.org/W2109399660","https://openalex.org/W2109686719","https://openalex.org/W2109838780","https://openalex.org/W2109970232","https://openalex.org/W2111428392","https://openalex.org/W2111692340","https://openalex.org/W2111951034","https://openalex.org/W2112081943","https://openalex.org/W2112481821","https://openalex.org/W2112958265","https://openalex.org/W2112976261","https://openalex.org/W2113849978","https://openalex.org/W2115166724","https://openalex.org/W2117798803","https://openalex.org/W2118152368","https://openalex.org/W2118212225","https://openalex.org/W2118634133","https://openalex.org/W2118722072","https://openalex.org/W2119241703","https://openalex.org/W2119370228","https://openalex.org/W2120553703","https://openalex.org/W2120955132","https://openalex.org/W2121185454","https://openalex.org/W2121342790","https://openalex.org/W2122057254","https://openalex.org/W2122950102","https://openalex.org/W2124968202","https://openalex.org/W2126196465","https://openalex.org/W2126352334","https://openalex.org/W2126636055","https://openalex.org/W2128445285","https://openalex.org/W2128725121","https://openalex.org/W2129328611","https://openalex.org/W2129686252","https://openalex.org/W2129860928","https://openalex.org/W2130678592","https://openalex.org/W2131162745","https://openalex.org/W2131901675","https://openalex.org/W2132106701","https://openalex.org/W2133396714","https://openalex.org/W2133759908","https://openalex.org/W2134686559","https://openalex.org/W2135417344","https://openalex.org/W2135960088","https://openalex.org/W2136541388","https://openalex.org/W2137137048","https://openalex.org/W2138363901","https://openalex.org/W2138459630","https://openalex.org/W2139689863","https://openalex.org/W2140017673","https://openalex.org/W2140641001","https://openalex.org/W2140665358","https://openalex.org/W2142638534","https://openalex.org/W2142737651","https://openalex.org/W2143339726","https://openalex.org/W2144099695","https://openalex.org/W2145221987","https://openalex.org/W2145852350","https://openalex.org/W2146471966","https://openalex.org/W2146993974","https://openalex.org/W2147005862","https://openalex.org/W2147103035","https://openalex.org/W2147883257","https://openalex.org/W2148149979","https://openalex.org/W2148304011","https://openalex.org/W2148475161","https://openalex.org/W2148889365","https://openalex.org/W2149474631","https://openalex.org/W2149818824","https://openalex.org/W2149970887","https://openalex.org/W2150192232","https://openalex.org/W2150200572","https://openalex.org/W2150278759","https://openalex.org/W2151120515","https://openalex.org/W2152090961","https://openalex.org/W2152665674","https://openalex.org/W2153610363","https://openalex.org/W2153819921","https://openalex.org/W2153981371","https://openalex.org/W2154201149","https://openalex.org/W2154901227","https://openalex.org/W2155365737","https://openalex.org/W2155433363","https://openalex.org/W2155591792","https://openalex.org/W2160738020","https://openalex.org/W2160767270","https://openalex.org/W2160979402","https://openalex.org/W2161550086","https://openalex.org/W2162182552","https://openalex.org/W2162644348","https://openalex.org/W2162804111","https://openalex.org/W2164160223","https://openalex.org/W2164313332","https://openalex.org/W2164900052","https://openalex.org/W2166068071","https://openalex.org/W2166410110","https://openalex.org/W2166444451","https://openalex.org/W2166527628","https://openalex.org/W2166744427","https://openalex.org/W2166781034","https://openalex.org/W2167646683","https://openalex.org/W2167689189","https://openalex.org/W2168444218","https://openalex.org/W2169054761","https://openalex.org/W2169187666","https://openalex.org/W2169804106","https://openalex.org/W2170015173","https://openalex.org/W2170149212","https://openalex.org/W2170738063","https://openalex.org/W2171515161","https://openalex.org/W2174542542","https://openalex.org/W2183826319","https://openalex.org/W2216105551","https://openalex.org/W2226163352","https://openalex.org/W2228392371","https://openalex.org/W2230408202","https://openalex.org/W2234198186","https://openalex.org/W2236970829","https://openalex.org/W2237051785","https://openalex.org/W2240094846","https://openalex.org/W2242796412","https://openalex.org/W2243688815","https://openalex.org/W2245853588","https://openalex.org/W2246886221","https://openalex.org/W2261795007","https://openalex.org/W2262449009","https://openalex.org/W2271504979","https://openalex.org/W2274188306","https://openalex.org/W2287460756","https://openalex.org/W2313149031","https://openalex.org/W2322523258","https://openalex.org/W2329404090","https://openalex.org/W2340214166","https://openalex.org/W2414518450","https://openalex.org/W2416228519","https://openalex.org/W2428721686","https://openalex.org/W2792980560","https://openalex.org/W2913008332","https://openalex.org/W3141289570"],"related_works":["https://openalex.org/W2061865489","https://openalex.org/W1955797432","https://openalex.org/W2727960146","https://openalex.org/W2499386740","https://openalex.org/W2130678592","https://openalex.org/W2112484130","https://openalex.org/W2001333805","https://openalex.org/W2094914396","https://openalex.org/W2113238955","https://openalex.org/W2040888486"],"abstract_inverted_index":{"Intracellular":[0],"signalling":[1,65,100,269],"cascades":[2,101],"regulate":[3],"cardiomyocyte":[4],"hypertrophic":[5,33,73,96,274],"response.":[6,74],"Initially":[7],"hypertrophy":[8],"of":[9,50,55,62,70,77,94,159,220,230,240,267,286],"individual":[10],"myocytes":[11],"occurs":[12],"as":[13],"an":[14],"adaptive":[15],"response":[16],"to":[17,44,59,134],"increased":[18],"demands":[19],"for":[20,190,205,213,253,281],"cardiac":[21,72,231,273],"work,":[22],"e.g.":[23],"during":[24,127],"hypertension":[25],"or":[26],"after":[27],"myocardial":[28],"infarction,":[29],"but":[30],"a":[31,91,210,250],"prolonged":[32],"response,":[34,97],"accompanied":[35],"by":[36,137,147,155,198],"accelerated":[37],"fibrosis":[38],"and":[39,47,106,119,129,165,209,224,236,238,243,276,284],"apoptosis,":[40],"predisposes":[41],"the":[42,48,63,71,85,95,156,160,206,214,256,265,282],"heart":[43,51,287],"impaired":[45],"performance":[46],"syndrome":[49],"failure.":[52,288],"The":[53,149],"goal":[54],"this":[56,259],"work":[57],"was":[58,132,145,152,172,195],"elucidate":[60],"some":[61],"main":[64],"pathways":[66],"in":[67,82,167,222,225,228,255,272],"experimental":[68],"models":[69],"Mechanical":[75],"stretching":[76],"cultured":[78],"neonatal":[79],"rat":[80],"cardiomyocytes":[81],"vitro":[83,223],"activates":[84],"B-type":[86],"natriuretic":[87],"peptide":[88],"(BNP)":[89],"gene,":[90],"well-established":[92],"marker":[93],"through":[98,174,183],"intracellular":[99],"mitogen-activated":[102],"protein":[103,107],"kinases":[104],"(MAPKs)":[105],"kinase":[108,140],"A":[109],"(PKA)":[110],"-pathway.":[111],"Further,":[112],"transcription":[113,121,182],"factors":[114,233],"transcriptional":[115],"enhancer":[116],"factor-1":[117],"(TEF-1)":[118],"activating":[120],"factor":[122],"3":[123],"(ATF3)":[124],"were":[125],"induced":[126],"stretch,":[128],"TEF-1":[130],"activation":[131,144,171,229],"shown":[133],"be":[135],"regulated":[136],"extracellular":[138],"signal-regulated":[139],"(ERK),":[141],"while":[142,178],"ATF3":[143,221,254],"modulated":[146],"PKA.":[148],"BNP":[150,181],"gene":[151],"also":[153],"activated":[154],"adenoviral":[157,218],"overexpression":[158,219],"p38":[161,192],"MAPK":[162],"isoforms":[163],"p38\u03b1":[164,207],"p38\u03b2":[166,179,215],"vitro.":[168],"Importantly,":[169],"p38\u03b1\u2013induced":[170],"mediated":[173,180],"activator":[175],"protein-1":[176],"(AP-1)":[177],"GATA-4,":[184],"which":[185,201],"suggests":[186,277],"distinct":[187],"physiological":[188],"roles":[189],"different":[191],"isoforms.":[193],"This":[194],"further":[196],"confirmed":[197],"quantitative":[199],"PCR,":[200],"demonstrated":[202],"pro-fibrotic":[203,244],"role":[204,212,252,266],"isoform":[208],"prohypertrophic":[211],"isoform.":[216],"Finally,":[217],"vivo":[226],"resulted":[227],"survival":[232],"nuclear":[234],"factor-\u03ba\u0412":[235],"Nkx-2.5,":[237],"attenuation":[239],"central":[241],"pro-inflammatory":[242],"mediators.":[245],"Together":[246],"these":[247],"data":[248],"suggest":[249],"protective":[251],"heart.":[257],"Overall":[258],"study":[260],"provides":[261],"new":[262],"insights":[263],"into":[264],"several":[268],"molecules":[270],"involved":[271],"process":[275],"potential":[278],"therapeutic":[279],"strategies":[280],"diagnosis":[283],"treatment":[285]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
