{"id":"https://openalex.org/W2243833711","doi":null,"title":"RIBOFLAVIN LOWERS BLOOD PRESSURE: A REVIEW OF A NOVEL GENE-NUTRIENT INTERACTION (REVIEW ARTICLE)","display_name":"RIBOFLAVIN LOWERS BLOOD PRESSURE: A REVIEW OF A NOVEL GENE-NUTRIENT INTERACTION (REVIEW ARTICLE)","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2243833711","mag":"2243833711"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:openaire/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","doi":null,"is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strain, JJ, Hughes, CF, McNulty, H & Ward, M 2015, 'Riboflavin lowers blood pressure: a review of a novel gene-nutrient interaction', Nutrition and Food Sciences Research, vol. 2, no. 2, pp. 3-6.","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.ulster.ac.uk/en/publications/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059126202","display_name":"JJ Strain","orcid":"https://orcid.org/0000-0002-1633-2873","observed_orcids":["https://orcid.org/0000-0002-1633-2873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JJ Strain","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1633-2873","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047453700","display_name":"Falade Catherine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Falade Catherine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084898155","display_name":"Helene McNulty","orcid":"https://orcid.org/0000-0002-4366-6457","observed_orcids":["https://orcid.org/0000-0002-4366-6457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mcnulty Helene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024129666","display_name":"Ward Mary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ward Mary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4456,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.8091432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"2","first_page":"3","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.996999979019165},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gene-nutrient-interactions","display_name":"gene-nutrient interactions","score":0.9570000171661377},{"id":"https://openalex.org/keywords/flavin-adenine-dinucleotide","display_name":"flavin adenine dinucleotide","score":0.8899999856948853},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8759999871253967},{"id":"https://openalex.org/keywords/personalized-nutrition","display_name":"personalized nutrition","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.6551287770271301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44293463230133057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34609484672546387},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3005681335926056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23202896118164062}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pure.atira.dk:openaire/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","doi":null,"is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strain, JJ, Hughes, CF, McNulty, H & Ward, M 2015, 'Riboflavin lowers blood pressure: a review of a novel gene-nutrient interaction', Nutrition and Food Sciences Research, vol. 2, no. 2, pp. 3-6.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:04858919fe404fa89b500f4ba37d60ae","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/04858919fe404fa89b500f4ba37d60ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrition and Food Sciences Research, Vol 2, Iss 2, Pp 3-6 (2015)","raw_type":"article"},{"id":"mag:2243833711","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/en/VEWSSID/J_pdf/50001620150202.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2258536317","doi":null,"is_oa":true,"landing_page_url":"https://jeffreydachmd.com/wp-content/uploads/2015/07/Riboflavin-Lowers-Blood-Pressure-Strain-2015.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210180795","display_name":"Nutrition and Food Sciences Research","issn_l":"2383-0441","issn":["2383-0441","2383-3009"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nutrition and Food Sciences Research","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","doi":null,"is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/9795daea-4acb-48d0-b0ea-7e1a0b1fa84c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strain, JJ, Hughes, CF, McNulty, H & Ward, M 2015, 'Riboflavin lowers blood pressure: a review of a novel gene-nutrient interaction', Nutrition and Food Sciences Research, vol. 2, no. 2, pp. 3-6.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W75245760","https://openalex.org/W1541429691","https://openalex.org/W1967710756","https://openalex.org/W1973562097","https://openalex.org/W1975354861","https://openalex.org/W1993561257","https://openalex.org/W2001629081","https://openalex.org/W2031773241","https://openalex.org/W2081532048","https://openalex.org/W2090897293","https://openalex.org/W2097992938","https://openalex.org/W2100997592","https://openalex.org/W2105407919","https://openalex.org/W2113709232","https://openalex.org/W2115830594","https://openalex.org/W2117238388","https://openalex.org/W2121067875","https://openalex.org/W2122029623","https://openalex.org/W2123554519","https://openalex.org/W2129254992","https://openalex.org/W2157862480","https://openalex.org/W2165715420"],"related_works":["https://openalex.org/W2266364909","https://openalex.org/W2410828267","https://openalex.org/W2006432764","https://openalex.org/W934056559","https://openalex.org/W395342570","https://openalex.org/W2396407382","https://openalex.org/W2309044926","https://openalex.org/W4389685535","https://openalex.org/W1030993071","https://openalex.org/W4249639699"],"abstract_inverted_index":{"Hypertension,":[0,245],"defined":[1],"as":[2,77],"a":[3,16,78,235],"systolic/diastolic":[4],"blood":[5,35,122,126,163,204],"pressure":[6,36,127,164,205],"of":[7,20,49,56,71,167,176],"140/90":[8],"mmHg":[9],"or":[10,116],"greater,":[11],"is":[12,86,212],"estimated":[13],"to":[14,91,99,114,131,187,190,202,239],"carry":[15],"three-fold":[17],"increased":[18,54,97],"risk":[19,55],"developing":[21],"cardiovascular":[22],"diseases":[23],"(CVDs).":[24],"Evidence":[25],"from":[26,88,101],"genome-wide":[27],"association":[28,33],"studies":[29,51,90],"has":[30],"identified":[31],"an":[32,53,96],"between":[34],"and":[37,82,124,155,159],"the":[38,41,62,69,83,141,162,170,181,197,216],"gene":[39],"encoding":[40],"folate-metabolising":[42],"enzyme,":[43],"methylenetetrahydrofolate":[44],"reductase":[45],"(MTHFR).":[46],"Recent":[47],"meta-analyses":[48],"observational":[50],"show":[52],"hypertension":[57,188],"in":[58,65,68,136,140,151,169,206],"people":[59],"homozygous":[60],"for":[61,80,94],"677C\u2192T":[63],"polymorphism":[64,186],"MTHFR.":[66],"Riboflavin":[67,249],"form":[70],"flavin":[72],"adenine":[73],"dinucleotide":[74],"(FAD)":[75],"acts":[76],"cofactor":[79],"MTHFR,":[81,246],"variant":[84,217],"enzyme":[85,219],"known":[87],"molecular":[89],"become":[92],"inactive":[93],"having":[95],"propensity":[98],"dissociate":[100],"FAD.":[102],"Our":[103],"findings":[104],"revealed":[105],"that":[106,125,161,196],"CVD":[107],"patients":[108,153],"with":[109,133,208],"MTHFR":[110,209,218],"677TT":[111,210],"genotype":[112,143,172],"(compared":[113],"CC":[115],"CT":[117],"genotype)":[118],"have":[119],"significantly":[120],"higher":[121,203],"pressure,":[123,244],"was":[128,174],"highly":[129],"responsive":[130],"intervention":[132],"riboflavin,":[134,225],"resulting":[135],"significant":[137],"lowering,":[138],"specifically":[139,227],"TT":[142,171],"group.":[144],"Further":[145],"investigations":[146],"confirmed":[147],"this":[148,185,229],"gene-nutrient":[149],"interaction":[150],"hypertensive":[152],"(with":[154],"without":[156],"overt":[157],"CVD),":[158],"showed":[160],"lowering":[165],"effect":[166],"riboflavin":[168,222],"group":[173],"independent":[175],"antihypertensive":[177],"drug":[178],"use.":[179],"Although":[180],"precise":[182],"mechanism":[183],"linking":[184],"remains":[189],"be":[191],"established,":[192],"it":[193],"would":[194],"appear":[195],"biological":[198],"perturbation,":[199],"which":[200],"leads":[201],"individuals":[207],"genotype,":[211],"modifiable":[213],"by":[214],"correcting":[215],"through":[220],"enhancing":[221],"status.":[223],"Thus":[224],"targeted":[226],"at":[228],"genetically":[230],"at-risk":[231],"group,":[232],"may":[233],"offer":[234],"personalised":[236],"non-drug":[237],"approach":[238],"managing":[240],"hypertension.":[241],"Keywords:":[242],"Blood":[243],"Personalised":[247],"medicine,":[248]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
