{"id":"https://openalex.org/W2243607044","doi":null,"title":"The possible role of oxidative stress in heart failure and the potential of antioxidant intervention.","display_name":"The possible role of oxidative stress in heart failure and the potential of antioxidant intervention.","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2243607044","mag":"2243607044","pmid":"https://pubmed.ncbi.nlm.nih.gov/12824962"},"language":"en","primary_location":{"id":"pmid:12824962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12824962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004286227","display_name":"Panagiotis G. Korantzopoulos","orcid":"https://orcid.org/0000-0002-4228-3593","observed_orcids":["https://orcid.org/0000-0002-4228-3593"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Korantzopoulos","raw_affiliation_strings":["Laboratory of Biological Chemistry, University of Ioannina, Medical School, Ioannina, Greece. pkor@oneway.gr","Laboratory of Biological Chemistry, University of Ioannina Medical School, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biological Chemistry, University of Ioannina, Medical School, Ioannina, Greece. pkor@oneway.gr","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"Laboratory of Biological Chemistry, University of Ioannina Medical School, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062517767","display_name":"Dimitrios Galaris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dimitrios Galaris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067660926","display_name":"Dimitrios Papaioannides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dimitrios Papaioannides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054852209","display_name":"Konstantinos Siogas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Siogas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2763,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85887814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"6","first_page":"RA120","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.2896000146865845,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neurohormonal-activation","display_name":"neurohormonal activation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ventricular-remodeling","display_name":"ventricular remodeling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":1.0},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.703000009059906},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":0.9890000224113464},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.9073871374130249},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6909909248352051},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5998031497001648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5893288850784302},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5853967666625977},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4918704032897949},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4688984453678131},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4317821264266968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43028271198272705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4201759696006775},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35860854387283325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26415181159973145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17303818464279175}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12824962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12824962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},{"id":"mag:2243607044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12824962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W173517793","https://openalex.org/W2123660053","https://openalex.org/W2025891650","https://openalex.org/W7100737176","https://openalex.org/W2046433820","https://openalex.org/W3004928696","https://openalex.org/W2949950605","https://openalex.org/W2896234395","https://openalex.org/W2417401935","https://openalex.org/W1971093605"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"(HF)":[2],"is":[3,23,29,107,206],"a":[4],"major":[5],"health":[6],"problem,":[7],"causing":[8],"significant":[9],"morbidity":[10],"and":[11,54,80,115,146,181,227],"mortality.":[12],"Its":[13],"complex":[14],"pathophysiology":[15],"has":[16,117,166],"not":[17],"yet":[18],"been":[19,57,84,134,167],"fully":[20],"elucidated.":[21],"There":[22],"growing":[24],"evidence":[25,205],"that":[26,125,148],"oxidative":[27,61,90,99,113,129,159,223],"stress":[28,100,114,160,224],"implicated":[30],"in":[31,161,170,193,215,225],"the":[32,64,96,102,120,128,203,219,228],"cardiac":[33],"dysfunction":[34,82],"leading":[35],"to":[36,59,86,119,217],"HF.":[37],"In":[38],"addition,":[39],"several":[40,182],"components":[41],"of":[42,70,98,105,122,158,222,231],"neurohormonal":[43,191],"activation,":[44],"such":[45,72],"as":[46,73,143,154],"catecholamines,":[47],"angiotensin,":[48],"aldosterone,":[49],"tumor":[50],"necrosis":[51],"factor-a,":[52],"endothelin,":[53],"cytokines,":[55],"have":[56,83,133,196],"demonstrated":[58],"enhance":[60],"stress.":[62,91],"On":[63],"other":[65,183],"hand,":[66],"various":[67],"pathophysiological":[68,164],"parameters":[69,104],"HF,":[71,194],"cardiomyocyte":[74],"apoptosis,":[75],"ventricular":[76],"remodeling,":[77],"mechanoelectric":[78],"uncoupling,":[79],"endothelial":[81],"shown":[85,169],"be":[87],"induced":[88],"by":[89],"Despite":[92],"substantial":[93],"experimental":[94,204],"evidence,":[95],"correlation":[97],"with":[101,163,174],"clinical":[103,175,211],"HF":[106,116,226],"unclear.":[108],"The":[109,156],"potential":[110,229],"association":[111],"between":[112],"led":[118],"study":[121],"antioxidant":[123,199,232],"interventions":[124],"may":[126,195],"attenuate":[127],"damage.":[130],"Promising":[131],"results":[132],"obtained":[135],"mainly":[136],"from":[137],"studies":[138,173],"using":[139],"water-soluble":[140],"antioxidants":[141],"(such":[142,153],"vitamin":[144],"C)":[145],"factors":[147],"inhibit":[149],"free":[150],"radical":[151],"formation":[152],"allopurinol).":[155],"amelioration":[157],"conjunction":[162],"abnormalities":[165],"clearly":[168],"humans,":[171],"but":[172],"end-points":[176],"are":[177,213],"scarce.":[178],"Furthermore,":[179],"carvedilol":[180],"cardiovascular":[184],"drugs,":[185],"besides":[186],"their":[187],"favorable":[188],"effects":[189],"on":[190],"activation":[192],"additional":[197],"intrinsic":[198],"properties.":[200],"Even":[201],"though":[202],"promising,":[207],"many":[208],"more":[209],"human":[210],"trials":[212],"needed":[214],"order":[216],"clarify":[218],"exact":[220],"role":[221],"benefits":[230],"intervention.":[233]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
