{"id":"https://openalex.org/W2243482406","doi":"https://doi.org/10.1109/icsens.2015.7370388","title":"Mathematical model for biomolecular quantification using surface-enhanced Raman spectroscopy based signal intensity distributions","display_name":"Mathematical model for biomolecular quantification using surface-enhanced Raman spectroscopy based signal intensity distributions","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2243482406","doi":"https://doi.org/10.1109/icsens.2015.7370388","mag":"2243482406"},"language":"en","primary_location":{"id":"doi:10.1109/icsens.2015.7370388","doi":"https://doi.org/10.1109/icsens.2015.7370388","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsens.2015.7370388","pdf_url":null,"source":{"id":"https://openalex.org/S4210192710","display_name":"Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ...","issn_l":"1930-0395","issn":["1930-0395","2168-9229","2168-9237"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE SENSORS","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090140398","display_name":"Mirk\u00f3 Palla","orcid":"https://orcid.org/0000-0002-4836-3690","observed_orcids":["https://orcid.org/0000-0002-4836-3690"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirko Palla","raw_affiliation_strings":["Chemical Enainecring, Columbia University, New York, NY, USA","WYSS Institute, Harvard University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Enainecring, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"WYSS Institute, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086159236","display_name":"Filippo Giacomo Bosco","orcid":"https://orcid.org/0009-0007-4033-061X","observed_orcids":["https://orcid.org/0009-0007-4033-061X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Filippo Giacomo Bosco","raw_affiliation_strings":["Chemical Enainecring, Columbia University, New York, NY, USA","Department of Micro-and Nanotechnology, DTU, Lynaby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Enainecring, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Micro-and Nanotechnology, DTU, Lynaby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101143662","display_name":"Jaeyoung Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaeyoung Yang","raw_affiliation_strings":["Chemical Enainecring, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Enainecring, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070613747","display_name":"Tomas Rindzevicius","orcid":"https://orcid.org/0000-0002-0712-1388","observed_orcids":["https://orcid.org/0000-0002-0712-1388"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomas Rindzevicius","raw_affiliation_strings":["Chemical Enainecring, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Enainecring, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064146030","display_name":"Tommy Sonne Alstr\u00f8m","orcid":"https://orcid.org/0000-0003-0941-3146","observed_orcids":["https://orcid.org/0000-0003-0941-3146"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tommy Sonne Alstrom","raw_affiliation_strings":["Department of Applied Mathematics and Computer Science, DTU, Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Computer Science, DTU, Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108547776","display_name":"Michael S. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael Stenbak Schmidt","raw_affiliation_strings":["Department of Micro-and Nanotechnology, DTU, Lynaby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Micro-and Nanotechnology, DTU, Lynaby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104929121","display_name":"Qiao Lin","orcid":"https://orcid.org/0000-0002-7487-8428","observed_orcids":["https://orcid.org/0000-0002-7487-8428"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiao Lin","raw_affiliation_strings":["WYSS Institute, Harvard University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WYSS Institute, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084552494","display_name":"Jingyue Ju","orcid":"https://orcid.org/0000-0002-4974-4241","observed_orcids":["https://orcid.org/0000-0002-4974-4241"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingyue Ju","raw_affiliation_strings":["Chemical Enainecring, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Enainecring, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053561558","display_name":"Anja Boisen","orcid":"https://orcid.org/0000-0002-9918-6567","observed_orcids":["https://orcid.org/0000-0002-9918-6567"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anja Boisen","raw_affiliation_strings":["Department of Micro-and Nanotechnology, DTU, Lynaby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Micro-and Nanotechnology, DTU, Lynaby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29744426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"103","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10295","display_name":"Plasmonic and Surface Plasmon Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surface-enhanced-raman-spectroscopy","display_name":"surface-enhanced Raman spectroscopy","score":0.996999979019165},{"id":"https://openalex.org/keywords/biomolecule-quantification","display_name":"biomolecule quantification","score":0.7620000243186951},{"id":"https://openalex.org/keywords/single-molecule-detection","display_name":"single-molecule detection","score":0.8080000281333923},{"id":"https://openalex.org/keywords/signal-intensity-distribution","display_name":"signal intensity distribution","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.8067070841789246},{"id":"https://openalex.org/C2777790068","wikidata":"https://www.wikidata.org/wiki/Q2736291","display_name":"Surface-enhanced Raman spectroscopy","level":4,"score":0.7751696109771729},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.704436182975769},{"id":"https://openalex.org/C134786449","wikidata":"https://www.wikidata.org/wiki/Q3391255","display_name":"Planar","level":2,"score":0.5534720420837402},{"id":"https://openalex.org/C75291252","wikidata":"https://www.wikidata.org/wiki/Q1315756","display_name":"TRACE (psycholinguistics)","level":2,"score":0.5046976804733276},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4883444011211395},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.47186511754989624},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.46109333634376526},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4346689283847809},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.43178680539131165},{"id":"https://openalex.org/C28843909","wikidata":"https://www.wikidata.org/wiki/Q177625","display_name":"Electromagnetic field","level":2,"score":0.42031723260879517},{"id":"https://openalex.org/C169573571","wikidata":"https://www.wikidata.org/wiki/Q466824","display_name":"Raman scattering","level":3,"score":0.37581631541252136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32706791162490845},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2606527805328369},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.24233552813529968},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/icsens.2015.7370388","doi":"https://doi.org/10.1109/icsens.2015.7370388","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsens.2015.7370388","pdf_url":null,"source":{"id":"https://openalex.org/S4210192710","display_name":"Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ...","issn_l":"1930-0395","issn":["1930-0395","2168-9229","2168-9237"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE SENSORS","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:publications/978906d6-dd2b-44d6-bc85-d732b58a1ad9","doi":null,"is_oa":false,"landing_page_url":"https://orbit.dtu.dk/en/publications/978906d6-dd2b-44d6-bc85-d732b58a1ad9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Palla , M , Bosco , F G , Yang , J , Rindzevicius , T , Alstr\u00f8m , T S , Schmidt , M S , Lin , Q , Ju , J & Boisen , A 2015 , Mathematical model for biomolecular quantification using surface-enhanced Raman spectroscopy based signal intensity distributions . in Proceedings of IEEE Sensors 2015 . IEEE , pp. 1-4 , 14th IEEE Sensors 2015 , Busan , Korea, Republic of , 01/11/2015 . https://doi.org/10.1109/ICSENS.2015.7370388","raw_type":"contributionToPeriodical"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1970592466","https://openalex.org/W1981643375","https://openalex.org/W1999173254","https://openalex.org/W2002950848","https://openalex.org/W2009658139","https://openalex.org/W2087439980","https://openalex.org/W2091779611","https://openalex.org/W2092575834","https://openalex.org/W2094325935","https://openalex.org/W2113400110","https://openalex.org/W2115797520","https://openalex.org/W2131498912","https://openalex.org/W2166215240"],"related_works":["https://openalex.org/W2105030606","https://openalex.org/W3136839103","https://openalex.org/W4401417820","https://openalex.org/W6940175473","https://openalex.org/W2743339596","https://openalex.org/W2891034484","https://openalex.org/W2358019855","https://openalex.org/W4399605647","https://openalex.org/W3190825310","https://openalex.org/W2135487480"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"the":[3,43,71],"development":[4],"of":[5,14,73],"a":[6,22,50],"novel":[7],"statistical":[8],"method":[9],"for":[10,37,58],"quantifying":[11],"trace":[12],"amounts":[13],"biomolecules":[15],"by":[16],"surface-enhanced":[17],"Raman":[18],"spectroscopy":[19],"(SERS)":[20],"using":[21],"rigorous,":[23],"single":[24],"molecule":[25],"(SM)":[26],"theory":[27],"based":[28],"mathematical":[29],"derivation.":[30],"Our":[31],"quantification":[32],"framework":[33],"could":[34],"be":[35,47],"generalized":[36],"planar":[38],"SERS":[39,74],"substrates,":[40],"in":[41,70],"which":[42,64],"nanostructured":[44],"features":[45],"can":[46],"approximated":[48],"as":[49],"closely":[51],"spaced":[52],"electromagnetic":[53],"dimer":[54],"problem.":[55],"The":[56],"potential":[57],"SM":[59],"detection":[60],"was":[61],"also":[62],"shown,":[63],"opens":[65],"up":[66],"an":[67],"exciting":[68],"opportunity":[69],"field":[72],"quantification.":[75]},"counts_by_year":[],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2016-06-24T00:00:00"}