{"id":"https://openalex.org/W22433965","doi":null,"title":"The metabolism of a new antithrombotic and vasodilating agent, cilostazol, in rat, dog and man.","display_name":"The metabolism of a new antithrombotic and vasodilating agent, cilostazol, in rat, dog and man.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W22433965","mag":"22433965","pmid":"https://pubmed.ncbi.nlm.nih.gov/4074424"},"language":"en","primary_location":{"id":"pmid:4074424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4074424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041085631","display_name":"Hitoshi Akiyama","orcid":"https://orcid.org/0000-0002-1530-2170","observed_orcids":["https://orcid.org/0000-0002-1530-2170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Akiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053680487","display_name":"S Kudo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kudo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049933848","display_name":"Tsugiko Shimizu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Shimizu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.00172018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"7A","first_page":"1133","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cilostazol","display_name":"cilostazol","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glucuronide-conjugates","display_name":"glucuronide conjugates","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.4740000069141388},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.6949999928474426},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2779820409","wikidata":"https://www.wikidata.org/wiki/Q258591","display_name":"Cilostazol","level":3,"score":0.9607901573181152},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7828925848007202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6043423414230347},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5549349784851074},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.45625054836273193},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.44385984539985657},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3219063878059387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3036729097366333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10667040944099426},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.0651833713054657}],"mesh":[{"descriptor_ui":"D000077407","descriptor_name":"Cilostazol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001393","descriptor_name":"Azoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4074424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4074424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"},{"id":"mag:22433965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4074424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2337331060","https://openalex.org/W2131451375"],"related_works":["https://openalex.org/W2149328140","https://openalex.org/W1997849419","https://openalex.org/W2066690626","https://openalex.org/W4089902","https://openalex.org/W1978906529","https://openalex.org/W2049701261","https://openalex.org/W2346358294","https://openalex.org/W2089535392","https://openalex.org/W7099130365","https://openalex.org/W2056733534"],"abstract_inverted_index":{"The":[0,155],"metabolism":[1],"of":[2,14,24,72,78,80,97,101,103,123,125,135,153,157],"cilostazol":[3,15,25],"(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-":[4],"qui":[5],"nolinone,":[6],"OPC-13013)":[7],"was":[8,74,99],"studied":[9],"after":[10],"the":[11,28,60,69,83,95,106,138,144,150,169,178,193,198,202],"oral":[12],"administration":[13],"or":[16],"14C-cilostazol":[17],"in":[18,27,59,137,143,168,177,186,190],"rats,":[19],"dogs":[20],"and":[21,31,34,43,47,53,66,68,92,94,114,116,121,129,141,147,159,165,172,174,188,201],"man.":[22],"Metabolites":[23],"identified":[26],"rat,":[29],"dog":[30,84,145,179],"human":[32,107,194],"plasma":[33,62,70],"urine":[35,140,171],"were":[36,63,89,112,119,131,161,183,204],"monohydroxycilostazol":[37],"(OPC-13213,":[38],"OPC-13217,":[39],"OPC-13366,":[40],"OPC-13371,":[41],"OPC-13215":[42],"OPC-13326),":[44],"monohydroxydehydrocilostazol":[45,130],"(OPC-13269":[46],"OPC-13388),":[48],"3,4-dihydro-6-hydroxy-2(1H)-quinolinone":[49],"(6-HQ),":[50],"their":[51,117],"conjugates":[52,156,182,203],"dehydrocilostazol":[54],"(OPC-13015).":[55],"Major":[56],"metabolites":[57,87,110],"detected":[58,88,111,132,162],"rat":[61,139,170],"OPC-13015,":[64,93],"OPC-13217":[65],"OPC-13213,":[67,90,115],"concentration":[71,152],"OPC-13015":[73,113],"53":[75],"to":[76],"79%":[77],"that":[79,102,124],"cilostazol.":[81,104],"In":[82,105,192],"plasma,":[85,108],"major":[86,109],"OPC-13366":[91],"AUC":[96,118],"OPC-13213":[98,148,196],"79.7%":[100],"11.7":[120],"9.1%":[122],"cilostazol,":[126],"respectively.":[127],"Monohydroxycilostazol":[128],"at":[133,163],"8.5%":[134],"dose":[136],"8.7%":[142],"urine,":[146,195],"showed":[149,197],"highest":[151,199],"these.":[154],"these":[158],"6-HQ":[160],"0.4":[164],"24.5%,":[166],"respectively,":[167,176],"2.4":[173],"3.7%,":[175],"urine.":[180],"These":[181],"mainly":[184,205],"sulfate":[185],"rats":[187],"glucuronide":[189],"dogs.":[191],"concentration,":[200],"glucuronide.(ABSTRACT":[206],"TRUNCATED":[207],"AT":[208],"250":[209],"WORDS)":[210]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}