{"id":"https://openalex.org/W2243344499","doi":"https://doi.org/10.1159/000362471","title":"Insights into \u03b2-Cell Biology and Type 2 Diabetes Pathogenesis from Studies of the Islet Transcriptome","display_name":"Insights into \u03b2-Cell Biology and Type 2 Diabetes Pathogenesis from Studies of the Islet Transcriptome","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2243344499","doi":"https://doi.org/10.1159/000362471","mag":"2243344499"},"language":"en","primary_location":{"id":"doi:10.1159/000362471","doi":"https://doi.org/10.1159/000362471","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000362471","pdf_url":null,"source":{"id":"https://openalex.org/S2764443867","display_name":"Frontiers in diabetes","issn_l":"0251-5342","issn":["0251-5342","1662-2995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Diabetes","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2493859915","display_name":"Genetics in Diabetes"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081052392","display_name":"Martijn van de Bunt","orcid":"https://orcid.org/0000-0002-6744-6125","observed_orcids":["https://orcid.org/0000-0002-6744-6125"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martijn van de Bunt","raw_affiliation_strings":["Oxford Centre for Diabetes, Endocrinology & Metabolism,","Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology & Metabolism,","institution_ids":["https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, and","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014654504","display_name":"Ignasi Mor\u00e1n","orcid":"https://orcid.org/0000-0002-3307-7106","observed_orcids":["https://orcid.org/0000-0002-3307-7106"]},"institutions":[{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Ignasi Mor\u00e1n","raw_affiliation_strings":["Department of Medicine, Imperial College, London, UK","Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058666146","display_name":"Jorge P. Ferrer","orcid":"https://orcid.org/0000-0002-5959-5729","observed_orcids":["https://orcid.org/0000-0002-5959-5729","https://orcid.org/0000-0002-2884-0269"]},"institutions":[{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Jorge Ferrer","raw_affiliation_strings":["Department of Medicine, Imperial College, London, UK","Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064948585","display_name":"Mark I. McCarthy","orcid":"https://orcid.org/0000-0002-4393-0510","observed_orcids":["https://orcid.org/0000-0002-4393-0510"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark I. McCarthy","raw_affiliation_strings":["Oxford Centre for Diabetes, Endocrinology & Metabolism,","Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology & Metabolism,","institution_ids":["https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, and","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17044284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"111","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.10419999808073044,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.09780000150203705,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/islet-transcriptome","display_name":"islet transcriptome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6010000109672546},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9800000190734863},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6110000014305115},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/sequence-annotation","display_name":"sequence annotation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gene-discovery","display_name":"gene discovery","score":0.6819999814033508},{"id":"https://openalex.org/keywords/pathogenesis-of-diabetes","display_name":"diabetes pathogenesis","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7121695876121521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6031320095062256},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.5030869841575623},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.48522046208381653},{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.4832078218460083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46275919675827026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4350540041923523},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.41384124755859375},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40716490149497986},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3987930417060852},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28856950998306274},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1908363699913025},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10587117075920105},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08381158113479614}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1159/000362471","doi":"https://doi.org/10.1159/000362471","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000362471","pdf_url":null,"source":{"id":"https://openalex.org/S2764443867","display_name":"Frontiers in diabetes","issn_l":"0251-5342","issn":["0251-5342","1662-2995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Diabetes","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1973194781","https://openalex.org/W1975909559","https://openalex.org/W1979892459","https://openalex.org/W1981509058","https://openalex.org/W2001295992","https://openalex.org/W2008945055","https://openalex.org/W2010173857","https://openalex.org/W2019020805","https://openalex.org/W2024108088","https://openalex.org/W2030715224","https://openalex.org/W2030845275","https://openalex.org/W2044327593","https://openalex.org/W2045017910","https://openalex.org/W2045643994","https://openalex.org/W2048335012","https://openalex.org/W2064412199","https://openalex.org/W2070457596","https://openalex.org/W2074656730","https://openalex.org/W2076618616","https://openalex.org/W2079407198","https://openalex.org/W2082793267","https://openalex.org/W2084160423","https://openalex.org/W2084825118","https://openalex.org/W2093090129","https://openalex.org/W2094586902","https://openalex.org/W2095365870","https://openalex.org/W2100779682","https://openalex.org/W2106219965","https://openalex.org/W2112001233","https://openalex.org/W2115801316","https://openalex.org/W2116429223","https://openalex.org/W2122929112","https://openalex.org/W2125987139","https://openalex.org/W2126780067","https://openalex.org/W2133009026","https://openalex.org/W2135902632","https://openalex.org/W2141642891","https://openalex.org/W2147452828","https://openalex.org/W2148201806","https://openalex.org/W2154268112","https://openalex.org/W2156431476","https://openalex.org/W2160333540","https://openalex.org/W2166810745","https://openalex.org/W2259938310"],"related_works":["https://openalex.org/W2236425703","https://openalex.org/W2220290656","https://openalex.org/W2202787541","https://openalex.org/W1491014959","https://openalex.org/W2142322476","https://openalex.org/W1999087259","https://openalex.org/W2028718946","https://openalex.org/W2537003958","https://openalex.org/W2626505967","https://openalex.org/W2808151096"],"abstract_inverted_index":{"Over":[0],"the":[1,13,38,43,48,62,72,170,174,195],"past":[2],"decade,":[3],"there":[4],"has":[5],"been":[6],"unprecedented":[7],"progress":[8,45],"in":[9,37,46,101,116,132,194],"our":[10,69,127],"understanding":[11,70,128],"of":[12,16,64,71,75,94,109,129,169,173,197],"genetic":[14,49,73,146,175],"basis":[15,50,176],"type":[17,52,76,103,178],"2":[18,53,77,104,179],"diabetes":[19,54,90,105,110,180,198],"driven":[20],"largely":[21],"by":[22,35],"technological":[23],"advances":[24],"which":[25],"have":[26],"facilitated":[27],"genome-wide":[28,65],"studies.":[29],"Bringing":[30],"together":[31],"comprehensive":[32,167],"synopses":[33],"written":[34],"leaders":[36],"field,":[39],"this":[40,137,153,184],"book":[41,185],"discusses":[42],"recent":[44],"defining":[47],"for":[51,145,177,189],"and":[55,106,111,135,160,181,199],"related":[56,182],"traits.The":[57],"opening":[58],"section":[59],"focuses":[60],"on":[61,68,97],"impact":[63,93],"association":[66,147],"studies":[67],"landscape":[74],"diabetes,":[78],"whilst":[79],"later":[80],"chapters":[81],"explore":[82],"how":[83,136],"variants":[84],"affecting":[85],"relevant":[86],"metabolic":[87],"traits":[88],"influence":[89],"susceptibility.":[91],"The":[92],"next-generation":[95],"sequencing":[96],"gene":[98],"discovery":[99],"efforts":[100,124,150],"both":[102,157],"mendelian":[107],"forms":[108],"insulin":[112],"resistance":[113],"is":[114,120,186],"covered":[115],"detail.":[117],"Particular":[118],"attention":[119],"also":[121],"given":[122],"to":[123,125,141,151],"increase":[126],"sequence":[130],"annotation":[131],"diabetes-relevant":[133],"tissues":[134],"can":[138],"be":[139],"harnessed":[140],"leverage":[142],"molecular":[143,158],"mechanisms":[144,159],"signals.":[148],"Finally,":[149],"translate":[152],"improved":[154],"knowledge":[155,172],"into":[156],"clinical":[161],"care":[162],"are":[163],"discussed.":[164],"Providing":[165],"a":[166],"overview":[168],"current":[171],"traits,":[183],"essential":[187],"reading":[188],"researchers":[190],"with":[191],"an":[192],"interest":[193],"etiology":[196],"human":[200],"genetics.":[201]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
