{"id":"https://openalex.org/W2242681069","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15008","title":"A phase I study of the addition of weekly oxaliplatin to weekly gemcitabine during radiotherapy for unresectable pancreatic or biliary malignancies","display_name":"A phase I study of the addition of weekly oxaliplatin to weekly gemcitabine during radiotherapy for unresectable pancreatic or biliary malignancies","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2242681069","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15008","mag":"2242681069"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.15008","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15008","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15008","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010925062","display_name":"Bert H. O\u2019Neil","orcid":"https://orcid.org/0000-0001-7032-7453","observed_orcids":["https://orcid.org/0000-0001-7032-7453"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. H. O\u2019Neil","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032064458","display_name":"A. William Blackstock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. W. Blackstock","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080788977","display_name":"Richard M. Goldberg","orcid":"https://orcid.org/0000-0003-0308-8223","observed_orcids":["https://orcid.org/0000-0003-0308-8223","https://orcid.org/0000-0003-3713-6895"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. M. Goldberg","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Shearer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Shearer","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085949674","display_name":"Hanna Kelly Sanoff","orcid":"https://orcid.org/0000-0001-8679-4486","observed_orcids":["https://orcid.org/0000-0001-8679-4486"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. K. Sanoff","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108640469","display_name":"Mebea Aklilu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Aklilu","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004968749","display_name":"Stephen A. Bernard","orcid":"https://orcid.org/0000-0001-7688-9852","observed_orcids":["https://orcid.org/0000-0001-7688-9852"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Bernard","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025603719","display_name":"John B. Martinie","orcid":"https://orcid.org/0000-0002-2677-9134","observed_orcids":["https://orcid.org/0000-0002-2677-9134"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Martinie","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030098591","display_name":"H. J. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. J. Kim","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018427856","display_name":"Joel E. Tepper","orcid":"https://orcid.org/0000-0002-8591-4228","observed_orcids":["https://orcid.org/0000-0002-8591-4228"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. E. Tepper","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC; Wake Forest University School of Medicine, Winston-Salem, NC; Forsyth Regional Cancer Center, Winston Salem, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"15008","last_page":"15008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locally-advanced-pancreatic-cancer","display_name":"locally advanced pancreatic cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/biliary-tract-cancer","display_name":"biliary tract cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ampullary-carcinoma","display_name":"ampullary carcinoma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/weekly-chemotherapy","display_name":"weekly chemotherapy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.3959999978542328},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8169999718666077},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.3610000014305115},{"id":"https://openalex.org/keywords/unresectable-pancreatic-cancer","display_name":"unresectable pancreatic cancer","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9371298551559448},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.8551719188690186},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.7614196538925171},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6520419120788574},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5844244956970215},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5842493772506714},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5436649918556213},{"id":"https://openalex.org/C2775908122","wikidata":"https://www.wikidata.org/wiki/Q3070621","display_name":"External beam radiotherapy","level":4,"score":0.5378540754318237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5060643553733826},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5047310590744019},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.459231972694397},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4577961564064026},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36614054441452026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3652496933937073},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34538811445236206},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.30614951252937317},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.21501091122627258},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.12320685386657715}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.15008","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15008","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15008","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998035878","https://openalex.org/W7100079306","https://openalex.org/W2244381636","https://openalex.org/W3012441846","https://openalex.org/W2162287242","https://openalex.org/W2145660562","https://openalex.org/W2169127413","https://openalex.org/W2015305721","https://openalex.org/W1966719889","https://openalex.org/W2101310161"],"abstract_inverted_index":{"15008":[0],"Purpose:":[1],"Locally":[2],"advanced":[3],"pancreatic":[4],"cancer":[5],"(LAPC)":[6],"leads":[7],"to":[8,24,70,128],"a":[9,132,281],"poor":[10],"survival,":[11],"and":[12,51,196,270,278,337],"current":[13],"therapies":[14],"are":[15],"inadequate.":[16],"External":[17],"beam":[18],"radiotherapy":[19],"(EBRT)":[20],"has":[21,47,52],"been":[22,53],"used":[23,37],"obtain":[25],"local":[26],"control,":[27],"but":[28,273,327],"the":[29,72,172,199,345],"most":[30,232],"effective":[31],"systemic":[32,60,98],"agent,":[33],"gemcitabine(gem),":[34],"can":[35,304],"be":[36,305,342],"only":[38],"at":[39,56,329,344],"low":[40],"doses":[41,57,61],"with":[42,62,81,90,109,261,308],"standard":[43],"RT.":[44],"Oxaliplatin":[45],"(ox)":[46],"activity":[48],"in":[49,79,124,148,171,180,198,221,253,320],"PC,":[50],"delivered":[54],"safely":[55,307],"near":[58],"full":[59],"EBRT":[63,121,314],"for":[64,315],"rectal":[65],"cancer.":[66],"We":[67],"set":[68],"out":[69],"define":[71],"maximum":[73],"tolerated":[74],"dose":[75,111,335],"(MTD)":[76],"of":[77,255,266,280],"ox":[78,116,318],"combination":[80,322],"gem":[82],"+":[83,104,115],"upper":[84],"abdominal":[85],"EBRT.":[86],"Methods:":[87],"Patients":[88],"(pts)":[89],"LAPC":[91],"or":[92,143],"biliary":[93],"ca":[94,263],"were":[95],"eligible.":[96],"Prior":[97],"therapy":[99,159,203],"was":[100,107,117,122,136,192,249,271],"allowed.":[101],"A":[102],"3":[103,105,145,182,186,191,216,235],"design":[106],"employed":[108],"4":[110,141,195,227],"levels":[112],"(table).":[113],"Gem":[114],"given":[118,123,306],"once":[119],"weekly.":[120,333],"1.8":[125],"Gy":[126,130],"fractions":[127],"50.4":[129],"using":[131],"multi-field":[133],"technique.":[134],"DLT":[135,184],"defined":[137],"as":[138],"any":[139],"grade":[140,144,215,226,234],"tox":[142,146,236],"resulting":[147],"treatment":[149],"delay":[150],">":[151],"1":[152,165],"wk.":[153],"Results:":[154],"11":[155,222],"pts":[156,162,170,285],"have":[157,201,219,229,286],"completed":[158,202],"(Table).":[160],"10":[161],"had":[163,166,176,183,264,274],"LAPC,":[164],"ampullary":[167,262],"ca.":[168],"No":[169,225],"first":[173],"2":[174],"cohorts":[175],"DLT.":[177],"Pt":[178],"#3":[179],"cohort":[181,200],"(grade":[185],"elevated":[187],"liver":[188],"enzymes).":[189],"Cohort":[190],"expanded;":[193],"patients":[194],"5":[197],"without":[204],"DLT;":[205],"pt":[206],"6":[207],"is":[208,293,323,328],"not":[209,324],"yet":[210,325],"evaluable.":[211],"To":[212],"date,":[213],"43":[214],"toxic":[217],"events":[218],"occurred":[220],"evaluable":[223,257],"patients.":[224],"toxicities":[228],"occurred.":[230],"The":[231,317],"common":[233],"are:":[237],"nausea":[238],"(63%),":[239],"metabolic":[240],"(54%),":[241],"hyperglycemia":[242],"(45%),":[243],"neutropenia":[244],"(36%),":[245],"vomiting":[246],"(27%).":[247],"SD":[248],"best":[250],"radiographic":[251],"response":[252],"8":[254,256],"pts.":[258],"One":[259],"patient":[260],"regression":[265],"disease":[267],"from":[268],"vessels":[269],"resected,":[272],"positive":[275],"retroperitoneal":[276],"margin":[277],"died":[279,287],"post-operative":[282],"complication.":[283],"Five":[284],"(OS":[288],"2.6\u201312.2":[289],"mos).":[290],"Median":[291],"OS":[292],"currently":[294],"9":[295],"mos":[296],"(95%":[297],"CI":[298],"4.6,":[299],"12.3).":[300],"Conclusions:":[301],"Weekly":[302],"oxaliplatin":[303],"weekly":[309],"gemcitabine":[310],"(200":[311],"mg/m2)":[312],"during":[313],"LAPC.":[316],"MTD":[319],"this":[321],"defined,":[326],"least":[330],"30":[331],"mg/m2":[332],"Final":[334],"results":[336,340],"updated":[338],"efficacy":[339],"will":[341],"presented":[343],"meeting.":[346],"[Table:":[347,350],"see":[348,351],"text]":[349,352]},"counts_by_year":[],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2016-06-24T00:00:00"}