{"id":"https://openalex.org/W2242405723","doi":null,"title":"Systemic response to local ischaemia: the evolving concept of remote ischaemic preconditioning","display_name":"Systemic response to local ischaemia: the evolving concept of remote ischaemic preconditioning","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2242405723","mag":"2242405723"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:publications/2512a039-3c6e-40c8-968e-16116c9e6f20","doi":null,"is_oa":false,"landing_page_url":"http://research-repository.uwa.edu.au/en/publications/systemic-response-to-local-ischaemia-the-evolving-concept-of-remote-ischaemic-preconditioning(2512a039-3c6e-40c8-968e-16116c9e6f20).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Saxena, P 2009, 'Systemic response to local ischaemia: the evolving concept of remote ischaemic preconditioning', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034123975","display_name":"Pankaj Saxena","orcid":"https://orcid.org/0000-0002-7772-2269","observed_orcids":["https://orcid.org/0000-0002-7772-2269"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pankaj Saxena","raw_affiliation_strings":["School of Surgery"],"raw_orcid":"https://orcid.org/0000-0002-7772-2269","affiliations":[{"raw_affiliation_string":"School of Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034123975"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remote-ischemic-preconditioning","display_name":"remote ischemic preconditioning","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9309999942779541},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.7120000123977661},{"id":"https://openalex.org/keywords/postconditioning","display_name":"postconditioning","score":0.9990000128746033},{"id":"https://openalex.org/keywords/organ-protection","display_name":"organ protection","score":0.7429999709129333},{"id":"https://openalex.org/keywords/oxygen-deprivation","display_name":"oxygen deprivation","score":0.4729999899864197},{"id":"https://openalex.org/keywords/limb-ischemia","display_name":"limb ischemia","score":0.5929999947547913},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.656000018119812},{"id":"https://openalex.org/keywords/clinical-application","display_name":"clinical application","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.49306508898735046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41783997416496277},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.29520708322525024}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:publications/2512a039-3c6e-40c8-968e-16116c9e6f20","doi":null,"is_oa":false,"landing_page_url":"http://research-repository.uwa.edu.au/en/publications/systemic-response-to-local-ischaemia-the-evolving-concept-of-remote-ischaemic-preconditioning(2512a039-3c6e-40c8-968e-16116c9e6f20).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Saxena, P 2009, 'Systemic response to local ischaemia: the evolving concept of remote ischaemic preconditioning', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2242405723","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/systemic-response-to-local-ischaemia-the-evolving-concept-of-remote-ischaemic-preconditioning(2512a039-3c6e-40c8-968e-16116c9e6f20).html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":212,"referenced_works":["https://openalex.org/W1102201","https://openalex.org/W36317781","https://openalex.org/W40869381","https://openalex.org/W112107873","https://openalex.org/W125028120","https://openalex.org/W193763600","https://openalex.org/W332095491","https://openalex.org/W1437859923","https://openalex.org/W1479937369","https://openalex.org/W1516804629","https://openalex.org/W1519825293","https://openalex.org/W1523336639","https://openalex.org/W1559221509","https://openalex.org/W1560626372","https://openalex.org/W1563659500","https://openalex.org/W1566540765","https://openalex.org/W1965480868","https://openalex.org/W1965693998","https://openalex.org/W1968110496","https://openalex.org/W1968948768","https://openalex.org/W1969421402","https://openalex.org/W1970709887","https://openalex.org/W1970948890","https://openalex.org/W1971386182","https://openalex.org/W1973226782","https://openalex.org/W1977804812","https://openalex.org/W1978221784","https://openalex.org/W1981176258","https://openalex.org/W1981940126","https://openalex.org/W1982485199","https://openalex.org/W1982557954","https://openalex.org/W1983836947","https://openalex.org/W1984305956","https://openalex.org/W1984342858","https://openalex.org/W1986905765","https://openalex.org/W1987278634","https://openalex.org/W1987664769","https://openalex.org/W1988592848","https://openalex.org/W1990989365","https://openalex.org/W1992039762","https://openalex.org/W1992799316","https://openalex.org/W1992904182","https://openalex.org/W1995552857","https://openalex.org/W1996721095","https://openalex.org/W1999220821","https://openalex.org/W2001500938","https://openalex.org/W2002651270","https://openalex.org/W2003117520","https://openalex.org/W2003467134","https://openalex.org/W2005098530","https://openalex.org/W2006469962","https://openalex.org/W2006687037","https://openalex.org/W2007308343","https://openalex.org/W2008351358","https://openalex.org/W2009171150","https://openalex.org/W2009699612","https://openalex.org/W2009812062","https://openalex.org/W2010381370","https://openalex.org/W2010996746","https://openalex.org/W2011175307","https://openalex.org/W2011205361","https://openalex.org/W2012826947","https://openalex.org/W2016278252","https://openalex.org/W2018488451","https://openalex.org/W2019272790","https://openalex.org/W2020749822","https://openalex.org/W2021311015","https://openalex.org/W2021949562","https://openalex.org/W2022318928","https://openalex.org/W2022473516","https://openalex.org/W2023574503","https://openalex.org/W2025443625","https://openalex.org/W2026180855","https://openalex.org/W2026259043","https://openalex.org/W2028599952","https://openalex.org/W2032401319","https://openalex.org/W2032715486","https://openalex.org/W2034304564","https://openalex.org/W2036829402","https://openalex.org/W2038601511","https://openalex.org/W2038707186","https://openalex.org/W2038727826","https://openalex.org/W2040721384","https://openalex.org/W2044074327","https://openalex.org/W2044202581","https://openalex.org/W2044548257","https://openalex.org/W2044615120","https://openalex.org/W2046278838","https://openalex.org/W2046874354","https://openalex.org/W2047305865","https://openalex.org/W2047763109","https://openalex.org/W2047876380","https://openalex.org/W2051130241","https://openalex.org/W2051192648","https://openalex.org/W2055063267","https://openalex.org/W2055381678","https://openalex.org/W2055545648","https://openalex.org/W2056190116","https://openalex.org/W2057141044","https://openalex.org/W2059976962","https://openalex.org/W2060699509","https://openalex.org/W2061209694","https://openalex.org/W2063339343","https://openalex.org/W2064147834","https://openalex.org/W2065715885","https://openalex.org/W2066516157","https://openalex.org/W2067038367","https://openalex.org/W2071487519","https://openalex.org/W2072457624","https://openalex.org/W2072728865","https://openalex.org/W2072796605","https://openalex.org/W2072939316","https://openalex.org/W2073196738","https://openalex.org/W2073221687","https://openalex.org/W2075215347","https://openalex.org/W2076583749","https://openalex.org/W2079585262","https://openalex.org/W2082026532","https://openalex.org/W2082738022","https://openalex.org/W2085049416","https://openalex.org/W2090109532","https://openalex.org/W2092462079","https://openalex.org/W2093932807","https://openalex.org/W2094605832","https://openalex.org/W2096459479","https://openalex.org/W2096590542","https://openalex.org/W2099675490","https://openalex.org/W2099962223","https://openalex.org/W2101971490","https://openalex.org/W2102538589","https://openalex.org/W2103992362","https://openalex.org/W2104062093","https://openalex.org/W2106922430","https://openalex.org/W2107522704","https://openalex.org/W2108306393","https://openalex.org/W2108750199","https://openalex.org/W2114205159","https://openalex.org/W2114458975","https://openalex.org/W2115565372","https://openalex.org/W2115600524","https://openalex.org/W2116672699","https://openalex.org/W2116899872","https://openalex.org/W2117344826","https://openalex.org/W2118111457","https://openalex.org/W2119333256","https://openalex.org/W2120007291","https://openalex.org/W2121057211","https://openalex.org/W2121849880","https://openalex.org/W2122018569","https://openalex.org/W2122272732","https://openalex.org/W2122501550","https://openalex.org/W2122875000","https://openalex.org/W2123048393","https://openalex.org/W2124634540","https://openalex.org/W2126066947","https://openalex.org/W2127431821","https://openalex.org/W2129978185","https://openalex.org/W2130065841","https://openalex.org/W2131015734","https://openalex.org/W2132795937","https://openalex.org/W2133319949","https://openalex.org/W2134519855","https://openalex.org/W2136272230","https://openalex.org/W2137309020","https://openalex.org/W2137320652","https://openalex.org/W2138373808","https://openalex.org/W2140233303","https://openalex.org/W2141019187","https://openalex.org/W2142313665","https://openalex.org/W2143596205","https://openalex.org/W2145307509","https://openalex.org/W2146217294","https://openalex.org/W2146800979","https://openalex.org/W2147455071","https://openalex.org/W2147819622","https://openalex.org/W2148233412","https://openalex.org/W2148390754","https://openalex.org/W2151575949","https://openalex.org/W2151589110","https://openalex.org/W2151625241","https://openalex.org/W2153919861","https://openalex.org/W2154036079","https://openalex.org/W2154138838","https://openalex.org/W2154959983","https://openalex.org/W2155967383","https://openalex.org/W2156265544","https://openalex.org/W2156495678","https://openalex.org/W2157271336","https://openalex.org/W2159200169","https://openalex.org/W2160246450","https://openalex.org/W2163815564","https://openalex.org/W2166229536","https://openalex.org/W2166660871","https://openalex.org/W2169166924","https://openalex.org/W2170347547","https://openalex.org/W2170499630","https://openalex.org/W2172221324","https://openalex.org/W2172281246","https://openalex.org/W2257844160","https://openalex.org/W2272705881","https://openalex.org/W2280214719","https://openalex.org/W2289745948","https://openalex.org/W2336925175","https://openalex.org/W2396301854","https://openalex.org/W2411198244","https://openalex.org/W2416768832","https://openalex.org/W2419589265","https://openalex.org/W2440044899","https://openalex.org/W2469984876","https://openalex.org/W2472944785","https://openalex.org/W4252433783","https://openalex.org/W4313333689"],"related_works":["https://openalex.org/W2009147223","https://openalex.org/W7095779870","https://openalex.org/W2032715486","https://openalex.org/W1970709887","https://openalex.org/W797945765","https://openalex.org/W2564682757","https://openalex.org/W2441379199","https://openalex.org/W2613980723","https://openalex.org/W2004892078","https://openalex.org/W4241235308"],"abstract_inverted_index":{"[Truncated":[0],"abstract]":[1],"Life":[2],"on":[3],"our":[4],"planet":[5],"is":[6,55,62,101,236],"possible":[7],"because":[8],"of":[9,32,41,49,71,77,96,108,118,151,177,186,196,198,215,222,240,251,268,275],"oxygen.":[10],"All":[11],"mammals,":[12],"including":[13],"humans,":[14],"evolved":[15,181],"with":[16,103],"an":[17,53],"innate":[18],"mechanism":[19],"by":[20,80,174,211,262],"which":[21],"organs":[22,216],"and":[23,39,47,85,153,167],"cells":[24],"may":[25],"protect":[26],"themselves":[27],"against":[28,126,171,243],"lack":[29,38],"or":[30,158,201,229],"excess":[31,40],"oxygen":[33,42],"to":[34,52,57,87,90],"some":[35],"extent.":[36],"This":[37,132],"that":[43,66,115,143,192,255],"occurs":[44,146],"during":[45,157],"interruption":[46],"restoration":[48],"blood":[50],"supply":[51],"organ":[54,241,277],"referred":[56],"as":[58],"ischaemia-reperfusion":[59],"(IR).":[60],"IR":[61,83,109,178],"a":[63,69,97,237],"ubiquitous":[64],"phenomenon":[65],"accounts":[67],"for":[68,224],"number":[70],"pathophysiological":[72],"conditions.":[73],"A":[74],"prolonged":[75,128,160,172,213],"period":[76],"ischaemia":[78,120,173,197,214],"followed":[79],"reperfusion":[81,154],"causes":[82],"injury":[84],"leads":[86],"significant":[88,124],"damage":[89],"the":[91,104,183,199,206,220,265,269,272],"affected":[92],"organ.":[93],"The":[94,245],"activation":[95],"systemic":[98,207],"inflammatory":[99,208],"response":[100,209],"associated":[102],"most":[105],"detrimental":[106],"effects":[107],"injury.":[110],"It":[111,190],"has":[112,179,283],"been":[113,284],"noticed":[114],"brief":[116,148,175,193],"episodes":[117,150,176,195],"intermittent":[119,149,194],"applied":[121,156],"locally":[122],"render":[123],"protection":[125,145,170,242,258],"subsequent":[127,212],"lethal":[129],"ischaemic":[130,135,233],"insult.":[131],"was":[133,141],"termed":[134,165],"pre-conditioning":[136],"(IPC).":[137],"Later,":[138],"however,":[139],"it":[140],"observed":[142],"similar":[144],"when":[147],"ischemia":[152],"were":[155,164],"after":[159],"ischaemia.":[161,244],"These":[162],"phenomena":[163],"per-conditioning":[166],"post-conditioning.":[168],"Thus,":[169],"recently":[180],"into":[182],"unified":[184],"concept":[185],"ischemic":[187],"conditioning":[188,270],"(IC).":[189],"appears":[191],"arm":[200],"leg":[202],"can":[203,259],"significantly":[204],"decrease":[205],"triggered":[210],"located":[217],"remotely":[218],"from":[219],"site":[221],"conditioning,":[223],"instance":[225],"heart,":[226],"lung,":[227],"liver":[228],"kidney.":[230],"Hence,":[231],"remote":[232],"preconditioning":[234],"(RIPC)":[235],"global":[238],"form":[239],"first":[246],"clinical":[247,281],"randomized":[248],"controlled":[249],"trial":[250],"RIPC":[252],"application":[253,274],"suggested":[254],"clinically":[256],"relevant":[257],"be":[260],"achieved":[261],"RIPC.":[263],"Despite":[264],"proven":[266],"benefits":[267],"effects,":[271],"overall":[273],"this":[276],"protective":[278],"strategy":[279],"in":[280],"practice":[282]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
