{"id":"https://openalex.org/W2242153643","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.4535","title":"Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA.","display_name":"Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA.","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2242153643","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.4535","mag":"2242153643"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.15_suppl.4535","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.4535","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.4535","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039792880","display_name":"Hubert R K\u00fcbler","orcid":"https://orcid.org/0000-0002-6677-2519","observed_orcids":["https://orcid.org/0000-0002-6677-2519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. K\u00fcbler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030908792","display_name":"Tobias Maurer","orcid":"https://orcid.org/0000-0002-5660-7691","observed_orcids":["https://orcid.org/0000-0002-5660-7691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Maurer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086583298","display_name":"Arnulf Stenzl","orcid":"https://orcid.org/0000-0003-4207-9928","observed_orcids":["https://orcid.org/0000-0003-4207-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Stenzl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053241643","display_name":"Suzan Feyerabend","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Feyerabend","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"U. Steiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Steiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079462263","display_name":"Martin Schostak","orcid":"https://orcid.org/0000-0002-8717-2096","observed_orcids":["https://orcid.org/0000-0002-8717-2096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Schostak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102382072","display_name":"Wolfgang Schultze\u2010Seemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Schultze-Seemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036610105","display_name":"F. vom Dorp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. vom Dorp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111889495","display_name":"Lorenzo Pilla","orcid":"https://orcid.org/0000-0002-1067-1356","observed_orcids":["https://orcid.org/0000-0002-1067-1356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Pilla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030021529","display_name":"G. Viatali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Viatali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076525255","display_name":"Constanze Hampel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Hampel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S. Wedel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Wedel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067050215","display_name":"Lutz Trojan","orcid":"https://orcid.org/0000-0001-9328-6965","observed_orcids":["https://orcid.org/0000-0001-9328-6965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Trojan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009500070","display_name":"KA Hiller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Hiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013257307","display_name":"Martin Sommerauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Sommerauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002400084","display_name":"D. Jocham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Jocham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112453456","display_name":"Birgit Scheel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Scheel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112158534","display_name":"T. Lander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Lander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001797354","display_name":"Karl\u2010Josef Kallen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Kallen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090742989","display_name":"Karina A. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"15_suppl","first_page":"4535","last_page":"4535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-vaccine","display_name":"prostate cancer vaccine","score":0.8130000233650208},{"id":"https://openalex.org/keywords/intradermal-vaccination","display_name":"intradermal vaccination","score":0.7749999761581421},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/psa","display_name":"PSA","score":0.5139999985694885},{"id":"https://openalex.org/keywords/prostate-stem-cell-antigen","display_name":"prostate stem cell antigen","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.996999979019165},{"id":"https://openalex.org/keywords/steap1","display_name":"STEAP1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.6959999799728394},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5950000286102295},{"id":"https://openalex.org/keywords/antigen-specific-t-cells","display_name":"antigen-specific T cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.3869999945163727},{"id":"https://openalex.org/keywords/urinary-retention","display_name":"urinary retention","score":0.546999990940094},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.3540000021457672},{"id":"https://openalex.org/keywords/tetramer-analysis","display_name":"tetramer analysis","score":0.5199999809265137},{"id":"https://openalex.org/keywords/elispot","display_name":"ELISPOT","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.889684796333313},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7027926445007324},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.6970781087875366},{"id":"https://openalex.org/C2778594517","wikidata":"https://www.wikidata.org/wiki/Q2260058","display_name":"Chills","level":2,"score":0.6588088274002075},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6515257358551025},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6085692644119263},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5611605644226074},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.544568657875061},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5023417472839355},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5002505779266357},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4396291673183441},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4356759488582611},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4335188567638397},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39717966318130493},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3318370282649994},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.08810111880302429}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2011.29.15_suppl.4535","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.4535","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.4535","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1334891","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1334891","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1833523230","https://openalex.org/W2763967548","https://openalex.org/W1992754083","https://openalex.org/W2941989751","https://openalex.org/W1973794335","https://openalex.org/W1984619541","https://openalex.org/W2070241777","https://openalex.org/W2257241232","https://openalex.org/W2012332384","https://openalex.org/W1965174902"],"abstract_inverted_index":{"4535":[0],"Background:":[1],"CV9103":[2,310],"is":[3],"a":[4,44,280,301],"prostate":[5],"cancer":[6],"(PCA)":[7],"vaccine":[8],"that":[9],"contains":[10],"the":[11,54,70,90,96,128,143,197,214,219,238],"four":[12],"antigens":[13,251],"PSA":[14,34],"(prostate":[15],"specific":[16],"antigen),":[17],"PSCA,":[18],"PSMA":[19],"and":[20,35,63,83,92,130,164,182,286,313,315],"STEAP1":[21],"as":[22,168,180,192],"self-adjuvanted":[23],"full-length":[24],"mRNAs.":[25],"Methods:":[26],"Patients":[27,73],"with":[28,32],"castrate":[29],"resistant":[30],"PCA":[31],"rising":[33],"predominantly":[36],"existing":[37],"metastases":[38],"(>":[39],"80%)":[40],"were":[41,67,74,87,103,125,162,166,173,190,225,247],"enrolled":[42,217],"into":[43],"first-in-man":[45],"phase":[46,71],"I/IIa":[47],"study.":[48],"The":[49,256],"primary":[50],"endpoint":[51],"was":[52,140,148,157,201,209,261,276,311],"safety,":[53],"secondary":[55],"immunogenicity.":[56,323],"Three":[57,122],"different":[58],"dose":[59,132,135,145,156,199,221],"levels":[60,275],"(256\u00b5g,":[61],"640\u00b5g":[62],"1280\u00b5g":[64],"total":[65],"mRNA)":[66],"tested":[68],"in":[69,77,211,227,263,306],"I.":[72],"vaccinated":[75],"intradermally":[76],"weeks":[78,94],"1,":[79],"3,":[80],"7,":[81],"15":[82],"23.":[84],"Blood":[85],"samples":[86],"taken":[88],"before":[89],"first":[91],"two":[93],"after":[95,295],"2nd":[97],"to":[98,150],"4th":[99],"vaccination.":[100],"Immune":[101,245],"responses":[102,246],"assessed":[104],"by":[105,203],"ELISPOT":[106],"(IFN-g),":[107],"intracellular":[108],"cytokine":[109],"staining":[110],"(IFN-g,":[111],"TNFa),":[112],"tetramer":[113],"analysis":[114],"(all":[115],"ex":[116],"vivo)":[117],"or":[118,176],"ELISA":[119],"(PSA).":[120],"Results:":[121],"patients":[123,205,216,230,289],"each":[124],"accrued":[126],"at":[127,142,218],"low":[129],"medium":[131],"level.":[133,222],"One":[134,298],"limiting":[136],"toxicity,":[137],"urinary":[138],"retention,":[139],"observed":[141],"high":[144,198,220,319],"level":[146,200,320],"which":[147],"expanded":[149,202],"six":[151],"patients.":[152,265],"A":[153],"maximum":[154],"tolerated":[155],"not":[158],"defined.":[159],"389":[160],"AEs":[161],"reported,":[163],"282":[165],"classified":[167,191],"related.":[169,193],"Of":[170,184],"these,":[171],"most":[172],"injection-site":[174],"reactions":[175],"flu-like":[177],"symptoms":[178],"such":[179],"chills":[181],"fever.":[183],"21":[185],"serious":[186],"adverse":[187],"events,":[188],"7":[189],"With":[194],"safety":[195],"established,":[196],"32":[204],"(phase":[206],"IIa).":[207],"Immunomonitoring":[208],"possible":[210],"33":[212],"of":[213,229,232,237,253,258,271,293,321],"38":[215],"Antigen-specific":[223],"T-cells":[224],"detected":[226,248],"79%":[228],"independent":[231],"their":[233],"HLA-background.":[234],"Importantly,":[235],"58%":[236],"immunological":[239],"responders":[240],"reacted":[241],"against":[242,249],"multiple":[243],"antigens.":[244],"all":[250],"regardless":[252],"cellular":[254,322],"localization.":[255],"frequency":[257],"antigen-unspecific":[259],"B-cells":[260],"increased":[262,283],"74%":[264],"In":[266],"3":[267],"patients,":[268],"an":[269,317],"increase":[270],"preexisting":[272],"anti-PSA":[273],"antibody":[274],"measured.":[277],"NK-cells":[278],"showed":[279],"tendency":[281],"for":[282],"activation":[284],"(CD25":[285],"CD69).":[287],"Individual":[288],"had":[290,300],"prolonged":[291],"stabilization":[292],"PSA-levels":[294],"initial":[296],"rises.":[297],"patient":[299],"greater":[302],"than":[303],"85%":[304],"drop":[305],"his":[307],"PSA-level.":[308],"Conclusions:":[309],"safe":[312],"well-tolerated":[314],"displayed":[316],"unexpectedly":[318]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}