{"id":"https://openalex.org/W22413535","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.709.3","title":"Sex bias in drug\u2010induced immune mediated hepatitis","display_name":"Sex bias in drug\u2010induced immune mediated hepatitis","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W22413535","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.709.3","mag":"22413535"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.709.3","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.709.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.709.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100380845","display_name":"Zhaoxia Li","orcid":"https://orcid.org/0000-0001-6561-1302","observed_orcids":["https://orcid.org/0000-0001-6561-1302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaoxia Li","raw_affiliation_strings":["Anesthesiology and Critical Care Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Critical Care Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114204446","display_name":"Monica Vladut Talor","orcid":"https://orcid.org/0000-0002-8275-5698","observed_orcids":["https://orcid.org/0000-0002-8275-5698"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Vladut Talor","raw_affiliation_strings":["Pathology, Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111434805","display_name":"Noel R. Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noel R. Rose","raw_affiliation_strings":["Pathology, Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070318474","display_name":"Dolores B. Njoku","orcid":"https://orcid.org/0000-0002-5458-4596","observed_orcids":["https://orcid.org/0000-0002-5458-4596"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores B. Njoku","raw_affiliation_strings":["Anesthesiology and Critical Care Medicine","Pathology, Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Critical Care Medicine","institution_ids":[]},{"raw_affiliation_string":"Pathology, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00456697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-bias","display_name":"sex bias","score":0.972000002861023},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.8080000281333923},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9330000281333923},{"id":"https://openalex.org/keywords/autoimmune-liver-disease","display_name":"autoimmune liver disease","score":0.5239999890327454},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5997875928878784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.580815315246582},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5748745203018188},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.532815158367157},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5009517669677734},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49257761240005493},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4898225963115692},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4770714044570923},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.47617214918136597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37332168221473694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3608963191509247},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.07273182272911072}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.709.3","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.709.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.709.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307138","display_name":"American Autoimmune Related Diseases Association","ror":"https://ror.org/02ch6a529"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096385817","https://openalex.org/W2001265096","https://openalex.org/W4313359477","https://openalex.org/W4313385234","https://openalex.org/W4299506633","https://openalex.org/W2167465189","https://openalex.org/W1802912856","https://openalex.org/W195916820","https://openalex.org/W63093424","https://openalex.org/W2053997785"],"abstract_inverted_index":{"Many":[0],"autoimmune":[1],"diseases":[2],"are":[3,39],"more":[4,25,107],"prevalent":[5,26],"in":[6,9,27,30,45,132,164,179,183],"women":[7,28],"than":[8,29,117],"men.":[10,31],"Drug":[11],"hapten\u2010induced":[12],"immune\u2010mediated":[13],"hepatitis":[14,109],"(DIH)":[15],"from":[16,66],"halogenated":[17],"volatile":[18],"anesthetics":[19],"or":[20,192],"other":[21],"drugs":[22],"is":[23,166],"also":[24,90],"However,":[32],"precise":[33],"mechanisms":[34],"responsible":[35],"for":[36],"sex":[37,43],"bias":[38,44,163],"unclear.":[40],"We":[41,89,101],"investigated":[42],"female":[46,104,133],"and":[47,79,82,85,110,114,128,150,174,199,208],"male":[48,139],"BALB/c":[49],"mice":[50,105,140],"by":[51,196],"immunizing":[52],"with":[53],"hepatic":[54],"S100":[55,80],"proteins":[56],"covalently":[57],"linked":[58],"to":[59,169,190],"the":[60],"trifluoroacetyl":[61],"chloride":[62],"(TFA)":[63],"hapten":[64],"formed":[65],"CYP2E1":[67],"metabolism":[68],"of":[69,144],"anesthetics.":[70],"After":[71],"three":[72],"weeks":[73,98,158],"we":[74],"measured":[75,91],"hepatitis,":[76],"serum":[77],"TFA":[78],"antibodies,":[81],"assessed":[83],"liver":[84],"spleen":[86],"supernatant":[87],"cytokines.":[88],"splenic":[92,145,152],"foxp3+CD4+CD25+":[93],"regulatory":[94,176],"T":[95,154,177],"cells":[96,155,178],"two":[97,157],"following":[99],"immunizations.":[100],"found":[102,131],"that":[103],"developed":[106],"severe":[108],"had":[111,141],"higher":[112,142],"anti\u2010TFA":[113],"\u2212S100":[115],"antibodies":[116],"males":[118],"(p":[119,135,147,159],"<":[120,136,148,160],"0.01).":[121,137],"Elevated":[122],"pro\u2010inflammatory":[123],"cytokines":[124],"IL\u20102,":[125],"IL\u20109,":[126],"IL\u201012p70,":[127],"IL\u201017":[129],"were":[130],"livers":[134],"Interestingly,":[138],"levels":[143],"IL\u201010":[146,173],"0.05)":[149],"elevated":[151,170],"foxp3+CD25+CD4+":[153],"at":[156],"0.05).":[161],"Sex":[162],"DIH":[165],"partially":[167],"due":[168],"anti\u2010inflammatory":[171],"cytokine":[172],"induced":[175],"males.":[180],"Further":[181],"investigations":[182],"these":[184],"areas":[185],"may":[186],"uncover":[187],"therapeutic":[188],"agents":[189],"treat":[191],"prevent":[193],"DIH.":[194],"Supported":[195],"AARDA,":[197],"Mr.":[198],"Mrs.":[200],"Joseph":[201],"Scoby,":[202],"The":[203],"Gail":[204],"I":[205],"Zuckerman":[206],"Foundation":[207],"NIHR21DK075828.":[209]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
