{"id":"https://openalex.org/W2240997684","doi":null,"title":"Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells.","display_name":"Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells.","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2240997684","mag":"2240997684","pmid":"https://pubmed.ncbi.nlm.nih.gov/8398897"},"language":"en","primary_location":{"id":"pmid:8398897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8398897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073362806","display_name":"Ming\u2010Sound Tsao","orcid":"https://orcid.org/0000-0002-9160-5405","observed_orcids":["https://orcid.org/0000-0002-9160-5405"]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M S Tsao","raw_affiliation_strings":["Department of Pathology, Montreal General Hospital, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Montreal General Hospital, Quebec, Canada","institution_ids":["https://openalex.org/I2800293973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061700388","display_name":"Hong\u2010Jian Zhu","orcid":"https://orcid.org/0000-0002-1478-995X","observed_orcids":["https://orcid.org/0000-0002-1478-995X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066195250","display_name":"Adel Giaid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Giaid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076058689","display_name":"Jean Viallet","orcid":"https://orcid.org/0000-0003-1137-0093","observed_orcids":["https://orcid.org/0000-0003-1137-0093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Viallet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103015927","display_name":"Takashi Nakamura","orcid":"https://orcid.org/0000-0001-9904-1037","observed_orcids":["https://orcid.org/0000-0001-9904-1037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088293962","display_name":"Morag Park","orcid":"https://orcid.org/0000-0001-5400-606X","observed_orcids":["https://orcid.org/0000-0001-5400-606X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.0548,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.97758679,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"7","first_page":"571","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autocrine-growth-factor","display_name":"autocrine growth factor","score":0.8059999942779541},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hgf-receptor","display_name":"HGF receptor","score":0.6510000228881836},{"id":"https://openalex.org/keywords/receptor-tyrosine-phosphorylation","display_name":"receptor tyrosine phosphorylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ciliated-columnar-epithelium","display_name":"ciliated columnar epithelium","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.9048234820365906},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.869900107383728},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.8196396827697754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7626343965530396},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5605951547622681},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5223082900047302},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4133619964122772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3965749144554138},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3682672679424286},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33269816637039185},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22759422659873962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07923686504364014},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:8398897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8398897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.4792","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.4792","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/4/7/571.pdf","raw_type":"text"},{"id":"mag:2240997684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8398897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W83231304","https://openalex.org/W90465349","https://openalex.org/W246102073","https://openalex.org/W248225102","https://openalex.org/W1501532961","https://openalex.org/W1583592634","https://openalex.org/W1593060795","https://openalex.org/W1605709431","https://openalex.org/W1911676479","https://openalex.org/W1968219840","https://openalex.org/W1977171839","https://openalex.org/W1978745104","https://openalex.org/W1979211697","https://openalex.org/W1981304601","https://openalex.org/W1984294894","https://openalex.org/W1987460795","https://openalex.org/W1992628345","https://openalex.org/W1995299530","https://openalex.org/W1996389318","https://openalex.org/W2002236210","https://openalex.org/W2003524810","https://openalex.org/W2005487014","https://openalex.org/W2005782838","https://openalex.org/W2007904495","https://openalex.org/W2014563731","https://openalex.org/W2027997722","https://openalex.org/W2035174231","https://openalex.org/W2037968180","https://openalex.org/W2041705218","https://openalex.org/W2048367533","https://openalex.org/W2050734291","https://openalex.org/W2054042846","https://openalex.org/W2057409901","https://openalex.org/W2058023126","https://openalex.org/W2065851961","https://openalex.org/W2071110875","https://openalex.org/W2072635469","https://openalex.org/W2077838938","https://openalex.org/W2078753736","https://openalex.org/W2079156086","https://openalex.org/W2082280408","https://openalex.org/W2087447167","https://openalex.org/W2091132474","https://openalex.org/W2099673935","https://openalex.org/W2106562547","https://openalex.org/W2113065332","https://openalex.org/W2113142255","https://openalex.org/W2149902890","https://openalex.org/W2156498737","https://openalex.org/W2164884227","https://openalex.org/W2300788244","https://openalex.org/W2315734235","https://openalex.org/W2337709939","https://openalex.org/W2340387843","https://openalex.org/W2342658017","https://openalex.org/W2417657174","https://openalex.org/W2576734941","https://openalex.org/W2585923473"],"related_works":["https://openalex.org/W7097554567","https://openalex.org/W2443196076","https://openalex.org/W7096456178","https://openalex.org/W2054164812","https://openalex.org/W2025607100","https://openalex.org/W2081055202","https://openalex.org/W2026109211","https://openalex.org/W7217398817","https://openalex.org/W4242194563","https://openalex.org/W1972780993"],"abstract_inverted_index":{"Hepatocyte":[0],"growth":[1],"factor":[2,6,147],"(HGF)":[3],"or":[4],"scatter":[5],"(SF)":[7],"has":[8],"been":[9],"considered":[10],"primarily":[11],"as":[12],"an":[13,145],"endocrine/paracrine":[14],"factor.":[15],"We":[16],"report":[17],"here":[18],"that":[19,139],"HGF/SF":[20,140],"mRNA":[21],"was":[22,41,53,94],"expressed":[23],"by":[24,55],"cultured":[25,76,92],"human":[26,59,68,85,103,152],"normal":[27,84,131,149],"bronchial":[28,132,153],"epithelial":[29,133,154],"cells":[30,93,155],"and":[31,50,78,126,150],"many":[32],"non-small":[33,119],"cell":[34,37,120,123],"lung":[35,121],"carcinoma":[36,122],"lines.":[38],"Scatter":[39],"activity":[40,52],"detected":[42],"in":[43,71,79,156],"the":[44,64,72,107,110,113,118,128,136],"culture":[45],"media":[46],"of":[47,66,74,83,90,109,115,117,130],"these":[48,75,91],"cells,":[49,77],"this":[51],"inhibited":[54,112],"a":[56],"neutralizing":[57,101],"anti-recombinant":[58,102],"HGF":[60,104],"antiserum.":[61],"Immunostaining":[62],"confirmed":[63],"presence":[65],"immunoreactive":[67],"HGF-like":[69,142],"protein":[70,143],"cytoplasm":[73],"ciliated":[80],"columnar":[81],"epithelium":[82],"bronchus/bronchioles.":[86],"The":[87],"met/HGF/SF":[88],"receptor":[89],"constitutively":[95],"phosphorylated":[96],"on":[97],"tyrosine":[98],"residues.":[99],"A":[100],"antiserum":[105],"decreased":[106],"phosphorylation":[108],"receptor,":[111],"proliferation":[114,129],"45%":[116],"lines":[124],"studied,":[125],"stimulated":[127],"cells.":[134],"Altogether,":[135],"data":[137],"demonstrate":[138],"and/or":[141],"is":[144],"autocrine":[146],"for":[148],"neoplastic":[151],"culture.":[157]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}