{"id":"https://openalex.org/W2240633929","doi":"https://doi.org/10.1177/135965350501002s11","title":"Methodological Considerations in Human Studies of Gene Expression in HIV-Associated Lipodystrophy","display_name":"Methodological Considerations in Human Studies of Gene Expression in HIV-Associated Lipodystrophy","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2240633929","doi":"https://doi.org/10.1177/135965350501002s11","mag":"2240633929","pmid":"https://pubmed.ncbi.nlm.nih.gov/16152711"},"language":"en","primary_location":{"id":"doi:10.1177/135965350501002s11","doi":"https://doi.org/10.1177/135965350501002s11","is_oa":true,"landing_page_url":"https://doi.org/10.1177/135965350501002s11","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350501002S11","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350501002S11","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021195498","display_name":"Patrick W. G. Mallon","orcid":"https://orcid.org/0000-0002-4337-6222","observed_orcids":["https://orcid.org/0000-0002-4337-6222"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Patrick WG Mallon","raw_affiliation_strings":["HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","institution_ids":[]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069657476","display_name":"Rebecca Sedwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rebecca Sedwell","raw_affiliation_strings":["HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","institution_ids":[]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018810156","display_name":"Patrick Unemori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Patrick Unemori","raw_affiliation_strings":["HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","institution_ids":[]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068421356","display_name":"Anthony Dominic Kelleher","orcid":"https://orcid.org/0000-0002-0009-3337","observed_orcids":["https://orcid.org/0000-0002-0009-3337"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony Kelleher","raw_affiliation_strings":["HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","institution_ids":[]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834622","display_name":"David A. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David A Cooper","raw_affiliation_strings":["HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","institution_ids":[]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112161317","display_name":"Andrew D Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew Carr","raw_affiliation_strings":["HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Immunovirology Research Laboratory, Centre for Immunology, St Vincent's Research Campus, Sydney, Australia","institution_ids":[]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.7349,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.79234413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"2_suppl","first_page":"101","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-lipodystrophy","display_name":"HIV-associated lipodystrophy","score":1.0},{"id":"https://openalex.org/keywords/lipoatrophy","display_name":"lipoatrophy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antiretroviral-therapy-adverse-effects","display_name":"antiretroviral therapy adverse effects","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6470000147819519},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6150000095367432},{"id":"https://openalex.org/keywords/biological-sample-collection","display_name":"biological sample collection","score":0.5920000076293945},{"id":"https://openalex.org/keywords/assay-variability","display_name":"assay variability","score":0.49000000953674316},{"id":"https://openalex.org/keywords/study-design","display_name":"research design","score":0.9049999713897705},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.652999997138977},{"id":"https://openalex.org/keywords/drug-induced-gene-expression-changes","display_name":"drug-induced gene expression changes","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.9431256651878357},{"id":"https://openalex.org/C2779546735","wikidata":"https://www.wikidata.org/wiki/Q3500973","display_name":"Lipoatrophy","level":5,"score":0.6626553535461426},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5850525498390198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5294346809387207},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4888250231742859},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48375868797302246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4598994255065918},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4564625322818756},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43261903524398804},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4315439462661743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40068319439888},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.3500882387161255},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.279779314994812},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.275406152009964},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.244266539812088},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.11879608035087585},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/135965350501002s11","doi":"https://doi.org/10.1177/135965350501002s11","is_oa":true,"landing_page_url":"https://doi.org/10.1177/135965350501002s11","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350501002S11","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:16152711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16152711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/135965350501002s11","doi":"https://doi.org/10.1177/135965350501002s11","is_oa":true,"landing_page_url":"https://doi.org/10.1177/135965350501002s11","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/135965350501002S11","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2240633929.pdf","grobid_xml":"https://content.openalex.org/works/W2240633929.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1501152217","https://openalex.org/W1577577364","https://openalex.org/W1978724449","https://openalex.org/W1978902758","https://openalex.org/W1983502319","https://openalex.org/W1990006539","https://openalex.org/W2013711685","https://openalex.org/W2019113684","https://openalex.org/W2025866303","https://openalex.org/W2035325160","https://openalex.org/W2050999867","https://openalex.org/W2056779298","https://openalex.org/W2059252951","https://openalex.org/W2069685389","https://openalex.org/W2089557992","https://openalex.org/W2107068945","https://openalex.org/W2117483311","https://openalex.org/W2122944706","https://openalex.org/W2128249506","https://openalex.org/W2133946149","https://openalex.org/W2156664292","https://openalex.org/W2164676747","https://openalex.org/W2324473093","https://openalex.org/W4205098749"],"related_works":["https://openalex.org/W2066891834","https://openalex.org/W2171937497","https://openalex.org/W1979486830","https://openalex.org/W2413139163","https://openalex.org/W152471773","https://openalex.org/W2146401731","https://openalex.org/W2993051231","https://openalex.org/W2466050633","https://openalex.org/W7097022652","https://openalex.org/W2156246696"],"abstract_inverted_index":{"In":[0],"the":[1,49,74,129,137],"majority":[2],"of":[3,18,35,48,140,147,164],"cases,":[4],"HIV-associated":[5,53],"lipodystrophy,":[6],"lipoatrophy":[7],"in":[8,42,69,84,87,103,110,136],"particular,":[9],"becomes":[10],"clinically":[11],"apparent":[12],"only":[13],"after":[14],"months":[15],"or":[16,95],"years":[17],"continuous":[19],"exposure":[20],"to":[21,29,59,62,71,92,123],"antiretroviral":[22,36,77],"medications":[23,37],"and,":[24],"once":[25],"developed,":[26],"is":[27,57],"difficult":[28],"reverse.":[30],"Many":[31],"lipid-related":[32],"side":[33],"effects":[34],"result":[38],"from":[39],"drug-induced":[40],"changes":[41,64,83,102,109],"gene":[43,85,111],"expression.":[44],"As":[45],"our":[46],"understanding":[47],"pathogenic":[50],"mechanisms":[51,75],"underlying":[52],"lipodystrophy":[54],"improves,":[55],"it":[56],"important":[58],"be":[60,124],"able":[61],"explore":[63],"at":[65,113],"a":[66,114],"molecular":[67],"level":[68,116],"order":[70],"fully":[72],"elucidate":[73],"whereby":[76],"drugs":[78],"exert":[79],"their":[80],"toxicities.":[81],"Monitoring":[82],"expression":[86,112,139],"vivo":[88],"may":[89],"enable":[90],"physicians":[91],"identify,":[93],"predict":[94],"prevent":[96],"drug":[97],"toxicities":[98],"early,":[99],"before":[100],"irreversible":[101],"body":[104],"composition":[105],"occur.":[106],"However,":[107],"monitoring":[108],"population":[115],"presents":[117],"many":[118,163],"methodological":[119],"challenges":[120],"that":[121],"need":[122],"addressed,":[125],"over":[126],"and":[127,132,145,154,156],"above":[128],"considerable":[130],"intra-":[131],"inter-individual":[133],"variability":[134],"inherent":[135],"cellular":[138],"any":[141],"gene.":[142],"Careful":[143],"collection":[144],"processing":[146],"adequate":[148],"biological":[149],"samples,":[150],"robust":[151],"laboratory":[152],"processes":[153],"assays,":[155],"appropriate":[157],"study":[158],"design":[159],"can":[160],"help":[161],"overcome":[162],"these":[165],"difficulties.":[166]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}