{"id":"https://openalex.org/W2240632115","doi":"https://doi.org/10.1007/978-1-4612-4508-7_49","title":"Epstein-Barr Virus Replication and Gene Expression in Oral \u201cHairy\u201d Leukoplakia","display_name":"Epstein-Barr Virus Replication and Gene Expression in Oral \u201cHairy\u201d Leukoplakia","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2240632115","doi":"https://doi.org/10.1007/978-1-4612-4508-7_49","mag":"2240632115"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4612-4508-7_49","doi":"https://doi.org/10.1007/978-1-4612-4508-7_49","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-4508-7_49","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epstein-Barr Virus and Human Disease \u2022 1988","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1567685376","display_name":"Epstein-Barr Virus and Human Disease \u2022 1988"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075561849","display_name":"Lawrence S. Young","orcid":"https://orcid.org/0000-0003-3919-4298","observed_orcids":["https://orcid.org/0000-0003-3919-4298"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. S. Young","raw_affiliation_strings":["Dept. Cancer Studies, Univ. of Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Cancer Studies, Univ. of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011313939","display_name":"L. Brooks","orcid":"https://orcid.org/0009-0007-6442-870X","observed_orcids":["https://orcid.org/0009-0007-6442-870X"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Brooks","raw_affiliation_strings":["Dept. Cancer Studies, Univ. of Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Cancer Studies, Univ. of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003040563","display_name":"Kevin J. Gilligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Gilligan","raw_affiliation_strings":["Lineberger Cancer Research Center, Univ. of North Carolina, N.C., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Cancer Research Center, Univ. of North Carolina, N.C., USA","institution_ids":["https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014777458","display_name":"William O. Dawson","orcid":"https://orcid.org/0000-0003-0050-6717","observed_orcids":["https://orcid.org/0000-0003-0050-6717"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. W. Dawson","raw_affiliation_strings":["Dept. Cancer Studies, Univ. of Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Cancer Studies, Univ. of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045564855","display_name":"Lionel Resnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095266","display_name":"Mount Sinai Medical Center","ror":"https://ror.org/00wgjpw02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095266"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Resnick","raw_affiliation_strings":["Mount Sinai Medical Center, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Medical Center, Miami, FL, USA","institution_ids":["https://openalex.org/I4210095266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022059483","display_name":"Nancy Raab\u2010Traub","orcid":"https://orcid.org/0000-0002-7709-1014","observed_orcids":["https://orcid.org/0000-0002-7709-1014"]},"institutions":[{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Raab-Traub","raw_affiliation_strings":["Lineberger Cancer Research Center, Univ. of North Carolina, N.C., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Cancer Research Center, Univ. of North Carolina, N.C., USA","institution_ids":["https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039856726","display_name":"Alan B. Rickinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. B. Rickinson","raw_affiliation_strings":["Dept. Cancer Studies, Univ. of Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Cancer Studies, Univ. of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0769,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.89543726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"329","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13761","display_name":"HIV/AIDS oral health manifestations","score":0.1256999969482422,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oral-hairy-leukoplakia","display_name":"oral hairy leukoplakia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.8339999914169312},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.6370000243186951},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.746999979019165},{"id":"https://openalex.org/keywords/viral-capsid-antigen","display_name":"viral capsid antigen","score":0.8980000019073486},{"id":"https://openalex.org/keywords/early-antigen","display_name":"early antigen","score":0.9570000171661377},{"id":"https://openalex.org/keywords/koilocytosis","display_name":"koilocytosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tongue-lesions","display_name":"tongue lesions","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6662870645523071},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6543724536895752},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6094451546669006},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5968735814094543},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.567710280418396},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.5369678735733032},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.44419604539871216},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.42010441422462463},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19434452056884766},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4612-4508-7_49","doi":"https://doi.org/10.1007/978-1-4612-4508-7_49","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-4508-7_49","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epstein-Barr Virus and Human Disease \u2022 1988","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1996168666","https://openalex.org/W2033666772","https://openalex.org/W2063175140","https://openalex.org/W2076665646","https://openalex.org/W2086932055","https://openalex.org/W2090498101"],"related_works":["https://openalex.org/W2128206643","https://openalex.org/W2076665646","https://openalex.org/W4235787397","https://openalex.org/W2125247146","https://openalex.org/W2328545151","https://openalex.org/W2010078398","https://openalex.org/W1992428824","https://openalex.org/W2415742245","https://openalex.org/W2145675421","https://openalex.org/W2055431682"],"abstract_inverted_index":{"Oral":[0],"\u201chairy\u201d":[1],"leukoplakia":[2],"(OHL)":[3],"is":[4,32,167],"a":[5,80],"recently":[6],"described":[7],"lesion":[8],"occurring":[9],"in":[10,52,66,145],"association":[11],"with":[12,99,124],"AIDS":[13],"(1).":[14],"OHL":[15,71,133],"presents":[16],"as":[17,88,141,175],"raised":[18],"white":[19],"areas":[20],"usually":[21],"on":[22],"the":[23,27,42,73,77,106,129,146,163,170,176],"lateral":[24],"border":[25],"of":[26,41,62,70,79,105,128,148],"tongue.":[28],"The":[29],"histological":[30],"appearance":[31],"characterised":[33],"by":[34,90,96,158,162],"very":[35],"fine":[36],"keratin":[37],"projections":[38],"and":[39,95,115,119,160,169],"koilo-cytosis":[40],"prickle":[43],"cell":[44],"layer.":[45],"While":[46],"this":[47,149],"histology":[48],"resembles":[49],"that":[50],"observed":[51],"papillomavirus-associated":[53],"infec":[54],"tions,":[55],"there":[56],"has":[57],"been":[58],"no":[59],"reliable":[60],"demonstration":[61],"such":[63],"an":[64,126,142],"infection":[65],"OHL.":[67],"Initial":[68],"examination":[69],"under":[72],"electron":[74],"microscope":[75],"showed":[76],"presence":[78],"herpes-type":[81],"virus":[82,107],"particle":[83],"which":[84],"was":[85,134],"later":[86],"confirmed":[87],"EBV":[89,103,140],"both":[91],"DNA":[92,131],"hybridisation":[93],"studies":[94],"immunohistochemical":[97],"analysis":[98],"antibodies":[100],"directed":[101],"against":[102],"antigens":[104],"lytic":[108],"cycle":[109],"e.g.":[110],"viral":[111],"capsid":[112],"antigen":[113,117],"(VCA)":[114],"early":[116],"(EA-D":[118],"EA-R)":[120],"(2).":[121],"On":[122],"treatment":[123],"acyclovir,":[125],"inhibitor":[127],"herpesvirus":[130],"polymerase,":[132],"found":[135],"to":[136],"regress":[137],"further":[138],"implicating":[139],"aetiological":[143],"agent":[144],"development":[147],"non-malignant":[150],"epithelial":[151],"proliferation":[152],"(3).":[153],"These":[154],"keywords":[155,171],"were":[156],"added":[157],"machine":[159],"not":[161],"authors.":[164],"This":[165],"process":[166],"experimental":[168],"may":[172],"be":[173],"updated":[174],"learning":[177],"algorithm":[178],"improves.":[179]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}