{"id":"https://openalex.org/W2240600229","doi":null,"title":"Putting regeneration into regenerative medicine.","display_name":"Putting regeneration into regenerative medicine.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2240600229","mag":"2240600229","pmid":"https://pubmed.ncbi.nlm.nih.gov/24982746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074488"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4074488","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Ophthalmic Vis Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064254636","display_name":"Reyna I. Martinez\u2010De Luna","orcid":"https://orcid.org/0009-0007-8830-7507","observed_orcids":["https://orcid.org/0009-0007-8830-7507"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reyna I Martinez-De Luna","raw_affiliation_strings":["Departments of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068899631","display_name":"Zuber Me","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E Zuber","raw_affiliation_strings":["Departments of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20388574"],"apc_list":null,"apc_paid":null,"fwci":0.8627,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7219969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"1","first_page":"126","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-regeneration","display_name":"retinal regeneration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.949999988079071},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/stem-cell-reprogramming","display_name":"stem cell reprogramming","score":0.7480000257492065},{"id":"https://openalex.org/keywords/in-vivo-regeneration","display_name":"in vivo regeneration","score":0.5690000057220459},{"id":"https://openalex.org/keywords/frog-retina","display_name":"frog retina","score":0.6100000143051147},{"id":"https://openalex.org/keywords/vertebrate-regeneration","display_name":"vertebrate regeneration","score":0.5180000066757202},{"id":"https://openalex.org/keywords/vision-restoration","display_name":"vision restoration","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2771230","wikidata":"https://www.wikidata.org/wiki/Q4926699","display_name":"Blinding","level":3,"score":0.7710018157958984},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7630742788314819},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.7546572685241699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7200136780738831},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.691038966178894},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.634863018989563},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.619091272354126},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.5935680866241455},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.5278729796409607},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.5278311371803284},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5140751600265503},{"id":"https://openalex.org/C177275483","wikidata":"https://www.wikidata.org/wiki/Q7316769","display_name":"Retinal regeneration","level":3,"score":0.48089078068733215},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.45604732632637024},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.45399460196495056},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3845096528530121},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33899691700935364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21467339992523193},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19088098406791687},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.10822656750679016},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08738753199577332},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07278093695640564},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4074488","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Ophthalmic Vis Res","raw_type":"Text"},{"id":"pmid:24982746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ophthalmic & vision research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.801.3853","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.801.3853","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/58/46/JOVR-09-126.PMC4074488.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d4abad08d55444b6a78651bd98feb39d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d4abad08d55444b6a78651bd98feb39d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Ophthalmic & Vision Research, Vol 9, Iss 1, Pp 126-133 (2014)","raw_type":"article"},{"id":"mag:2240600229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4074488","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074488/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Ophthalmic Vis Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4533446040","display_name":"Retinal stem cell culture and characterization","funder_award_id":"R01EY015748","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8878346150","display_name":"Genetic Regulatory Network Controlling Vertebrate Eye Formation","funder_award_id":"R01EY017964","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2240600229.pdf","grobid_xml":"https://content.openalex.org/works/W2240600229.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W183701603","https://openalex.org/W1507611099","https://openalex.org/W1516362092","https://openalex.org/W1707989573","https://openalex.org/W1836194650","https://openalex.org/W1895565798","https://openalex.org/W1966476278","https://openalex.org/W1967448020","https://openalex.org/W1968076268","https://openalex.org/W1971649501","https://openalex.org/W1974765744","https://openalex.org/W1978371504","https://openalex.org/W1978928843","https://openalex.org/W1984567642","https://openalex.org/W1986119451","https://openalex.org/W1997734040","https://openalex.org/W2007014682","https://openalex.org/W2007773129","https://openalex.org/W2011634069","https://openalex.org/W2013617404","https://openalex.org/W2013744830","https://openalex.org/W2016552437","https://openalex.org/W2021724765","https://openalex.org/W2024196970","https://openalex.org/W2031166546","https://openalex.org/W2033829746","https://openalex.org/W2034016343","https://openalex.org/W2034036860","https://openalex.org/W2041387096","https://openalex.org/W2046497474","https://openalex.org/W2049126107","https://openalex.org/W2053536783","https://openalex.org/W2053928527","https://openalex.org/W2058607314","https://openalex.org/W2058963589","https://openalex.org/W2059699224","https://openalex.org/W2062112670","https://openalex.org/W2064214766","https://openalex.org/W2067118342","https://openalex.org/W2070628315","https://openalex.org/W2073097612","https://openalex.org/W2074314696","https://openalex.org/W2082353342","https://openalex.org/W2087357183","https://openalex.org/W2088886159","https://openalex.org/W2089779087","https://openalex.org/W2091864167","https://openalex.org/W2092927664","https://openalex.org/W2097832718","https://openalex.org/W2105161755","https://openalex.org/W2109583860","https://openalex.org/W2111195609","https://openalex.org/W2112694631","https://openalex.org/W2114268866","https://openalex.org/W2114967857","https://openalex.org/W2115612876","https://openalex.org/W2116718309","https://openalex.org/W2116869556","https://openalex.org/W2117547777","https://openalex.org/W2125987139","https://openalex.org/W2127251089","https://openalex.org/W2128803651","https://openalex.org/W2138427488","https://openalex.org/W2142432925","https://openalex.org/W2146078700","https://openalex.org/W2146819974","https://openalex.org/W2150461206","https://openalex.org/W2151890531","https://openalex.org/W2152344341","https://openalex.org/W2152874382","https://openalex.org/W2153411657","https://openalex.org/W2161264600","https://openalex.org/W2166621376"],"related_works":["https://openalex.org/W1983159993","https://openalex.org/W4323348793","https://openalex.org/W1994869619","https://openalex.org/W3202629875","https://openalex.org/W1986301987","https://openalex.org/W4236791646","https://openalex.org/W4289450218","https://openalex.org/W4379382931","https://openalex.org/W2411707190","https://openalex.org/W2995851959"],"abstract_inverted_index":{"The":[0,108],"prevalence":[1],"of":[2,32,41,46,55,136],"blinding":[3],"diseases":[4],"such":[5],"as":[6],"age-related":[7],"macular":[8],"degeneration":[9],"(AMD),":[10],"glaucoma":[11],"and":[12,58,64,140],"diabetic":[13],"retinopathy":[14],"have":[15],"significantly":[16],"increased":[17],"in":[18,61,104,112,117,138,151],"the":[19,23,29,36,42,52,62,115,152],"United":[20],"States":[21],"over":[22],"last":[24],"decade.1":[25],"In":[26,126],"response":[27],"to":[28,72,80,91,148],"higher":[30],"incidence":[31],"retinal":[33,85],"degenerative":[34],"diseases,":[35],"National":[37,44],"Eye":[38],"Institute":[39],"(NEI)":[40],"US":[43],"Institutes":[45],"Health":[47],"(NIH)":[48],"has":[49,71],"recently":[50],"proposed":[51],"audacious":[53],"goal":[54],"regenerating":[56],"neurons":[57,86],"neural":[59],"connections":[60],"eye":[63],"visual":[65],"system.2":[66],"To":[67],"date,":[68],"regenerative":[69,106],"medicine":[70],"a":[73],"large":[74],"extent":[75],"focused":[76],"on":[77,133],"determining":[78],"how":[79,141],"reprogram":[81],"stem":[82],"cells":[83],"into":[84],"that":[87,99],"can":[88],"be":[89],"used":[90],"restore":[92],"vision.":[93],"Recent":[94],"surprising":[95],"findings,":[96],"however,":[97],"suggest":[98],"mammals":[100,122],"may":[101],"possess":[102],"limited":[103],"vivo":[105],"potential.":[107],"challenge":[109],"now":[110],"lies":[111],"understanding":[113],"why":[114],"retina":[116],"other":[118],"vertebrates":[119],"regenerates,":[120],"while":[121],"lack":[123],"this":[124,127],"ability.":[125],"review,":[128],"we":[129],"summarize":[130],"current":[131],"knowledge":[132],"endogenous":[134],"mechanisms":[135],"regeneration":[137,150],"frogs":[139],"these":[142],"findings":[143],"might":[144],"provide":[145],"essential":[146],"information":[147],"stimulate":[149],"human":[153],"retina.":[154]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}