{"id":"https://openalex.org/W2240454946","doi":null,"title":"Role and regulation of homologous recombination in response to DNA double strand breaks and replication stress in Saccharomyces cerevisiae","display_name":"Role and regulation of homologous recombination in response to DNA double strand breaks and replication stress in Saccharomyces cerevisiae","publication_year":2014,"publication_date":"2014-02-06","ids":{"openalex":"https://openalex.org/W2240454946","mag":"2240454946"},"language":"en","primary_location":{"id":"pmh:oai:boa.unimib.it:10281/50242","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/50242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10281/50242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031494591","display_name":"Marco Falcettoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marco Falcettoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031494591"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9409999847412109},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.9729999899864197},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/single-strand-annealing","display_name":"single-strand annealing","score":0.7649999856948853},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9789999723434448},{"id":"https://openalex.org/keywords/replication-fork-recovery","display_name":"replication fork recovery","score":0.4869999885559082},{"id":"https://openalex.org/keywords/rpa","display_name":"RPA","score":0.48399999737739563},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.9470000267028809},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.4390000104904175},{"id":"https://openalex.org/keywords/meiosis","display_name":"meiosis","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.7618299722671509},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7384344935417175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5512769818305969},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5024011135101318},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.45514798164367676},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4436034858226776},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.41563478112220764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40872082114219666},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35316652059555054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.258279412984848},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.10962995886802673}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:boa.unimib.it:10281/50242","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/50242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2240454946","doi":null,"is_oa":false,"landing_page_url":"https://boa.unimib.it/handle/10281/50242","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:boa.unimib.it:10281/50242","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/50242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W176465738","https://openalex.org/W1006224826","https://openalex.org/W1501659119","https://openalex.org/W1506492200","https://openalex.org/W1595838029","https://openalex.org/W1597133026","https://openalex.org/W1752089945","https://openalex.org/W1815850336","https://openalex.org/W1888032283","https://openalex.org/W1905978644","https://openalex.org/W1929569478","https://openalex.org/W1934183749","https://openalex.org/W1936192069","https://openalex.org/W1965546838","https://openalex.org/W1965675005","https://openalex.org/W1967830103","https://openalex.org/W1971349099","https://openalex.org/W1971419576","https://openalex.org/W1973252845","https://openalex.org/W1973495504","https://openalex.org/W1974706661","https://openalex.org/W1977552539","https://openalex.org/W1978029697","https://openalex.org/W1978054036","https://openalex.org/W1978794333","https://openalex.org/W1979015046","https://openalex.org/W1981844581","https://openalex.org/W1984290310","https://openalex.org/W1984843095","https://openalex.org/W1985018899","https://openalex.org/W1986121915","https://openalex.org/W1989136612","https://openalex.org/W1990441769","https://openalex.org/W1995431542","https://openalex.org/W1995831273","https://openalex.org/W2000950365","https://openalex.org/W2003411878","https://openalex.org/W2005353346","https://openalex.org/W2006268714","https://openalex.org/W2006294958","https://openalex.org/W2007889926","https://openalex.org/W2008491373","https://openalex.org/W2009167909","https://openalex.org/W2012948497","https://openalex.org/W2015096425","https://openalex.org/W2031292590","https://openalex.org/W2033651349","https://openalex.org/W2037211079","https://openalex.org/W2039216958","https://openalex.org/W2043988341","https://openalex.org/W2048839078","https://openalex.org/W2050189514","https://openalex.org/W2052547134","https://openalex.org/W2060632849","https://openalex.org/W2062739292","https://openalex.org/W2069757035","https://openalex.org/W2070887305","https://openalex.org/W2074126694","https://openalex.org/W2082447947","https://openalex.org/W2084934035","https://openalex.org/W2085866527","https://openalex.org/W2086445948","https://openalex.org/W2086707417","https://openalex.org/W2086932102","https://openalex.org/W2087249338","https://openalex.org/W2090119499","https://openalex.org/W2090358554","https://openalex.org/W2093814864","https://openalex.org/W2094020226","https://openalex.org/W2095769358","https://openalex.org/W2102433010","https://openalex.org/W2103972950","https://openalex.org/W2107991933","https://openalex.org/W2109470020","https://openalex.org/W2110223248","https://openalex.org/W2110806607","https://openalex.org/W2113305379","https://openalex.org/W2113439921","https://openalex.org/W2113912029","https://openalex.org/W2119628884","https://openalex.org/W2126492332","https://openalex.org/W2126552646","https://openalex.org/W2126916325","https://openalex.org/W2128715992","https://openalex.org/W2131081117","https://openalex.org/W2134179374","https://openalex.org/W2134807701","https://openalex.org/W2135902783","https://openalex.org/W2137530487","https://openalex.org/W2137682724","https://openalex.org/W2143064529","https://openalex.org/W2144550200","https://openalex.org/W2145719044","https://openalex.org/W2158692018","https://openalex.org/W2159656070","https://openalex.org/W2160998060","https://openalex.org/W2162561014","https://openalex.org/W2163029215","https://openalex.org/W2403306193"],"related_works":["https://openalex.org/W7099614911","https://openalex.org/W2022648619","https://openalex.org/W2228001583","https://openalex.org/W2620322469","https://openalex.org/W2139229198","https://openalex.org/W2957992451","https://openalex.org/W2015918838","https://openalex.org/W4249819421","https://openalex.org/W4236883489","https://openalex.org/W7098381153"],"abstract_inverted_index":{"Homologous":[0,616],"recombination":[1,48,304,340,503,518,533,617,1067,1098,1161,1208],"(HR)":[2,305],"is":[3,28,49,230,254,323,448,522,570,660,683,701,708,1057],"a":[4,22,140,158,169,266,320,326,435,739,781,794,823,885],"key":[5,782],"pathway":[6,172,1038],"to":[7,14,57,114,142,153,200,206,214,235,309,388,433,452,549,589,597,643,685,717,734,765,792,896,905,917,1027,1102,1117,1212],"maintain":[8],"genomic":[9],"integrity":[10,625],"from":[11,862,1164],"one":[12,186,821],"generation":[13],"another":[15,586],"(meiosis)":[16],"and":[17,38,61,89,188,244,251,272,288,319,462,486,508,531,638,656,688,691,712,790,803,817,835,839,852,959,990,1041,1050,1133],"during":[18,257,555,600,627,647,703,920,1059,1141,1176],"ontogenic":[19],"development":[20],"in":[21,96,179,344,376,383,439,471,484,515,547,581,621,641,653,667,671,678,710,723,760,797,804,837,846,859,888,903,963,977,984,997,1036,1062,1091,1109,1112,1138,1179],"single":[23,824],"organism":[24],"(DNA":[25],"repair).":[26],"Recombination":[27],"required":[29,949],"for":[30,393,499,562,743,776,872,938,1003,1021],"the":[31,39,76,87,106,130,190,211,258,277,291,356,373,377,390,402,424,440,467,538,560,567,661,718,749,768,830,847,898,928,931,939,964,985,1029,1063,1131,1154,1180,1198,1204],"repair":[32,97,181,301,327,337,434,528,574],"or":[33,43,149,1196],"tolerance":[34],"of":[35,41,91,98,110,185,189,210,268,280,290,355,379,412,428,469,579,607,623,752,771,799,814,820,874,877,890,900,911,933,946,974,987,1005,1032,1046,1065,1072,1080,1097,1124,1126,1135,1149,1151,1156,1160,1182,1200,1207],"DNA":[36,99,111,132,137,163,218,300,315,336,598,601,608,611,648,679,687,704],"damage":[37,599,609],"recovery":[40],"stalled":[42],"broken":[44,131,212],"replication":[45,602,612,614,628,719,735,1060,1118,1177,1213],"forks.":[46],"However,":[47,992],"also":[50,120,498,626],"potentially":[51,62],"dangerous":[52,108,1108,1175],"as":[53,84,86,139,207,325,409,573,681],"it":[54,682,707],"can":[55,117,165,240,584],"lead":[56],"gross":[58],"chromosomal":[59,82],"rearrangements":[60,565],"lethal":[63],"intermediates.":[64],"For":[65],"this":[66,307,369,576,699,843],"reason,":[67],"recombinational":[68],"events":[69,543,1159],"must":[70,632],"be":[71,118,166,633,915],"strictly":[72],"regulated":[73,256],"depending":[74],"on":[75,276,456],"organism,":[77],"cell":[78,259,262,311,442,557,921],"type,":[79],"cell-cycle":[80],"stage,":[81],"region,":[83],"well":[85],"type":[88],"level":[90],"genotoxic":[92],"stress.":[93,615,629,1214],"HR":[94,134,171,194,252,349,363,381,630,655,1037,1113,1139,1193,1201],"participates":[95],"double-strand":[100],"breaks":[101],"(DSBs),":[102],"which":[103,177,221,284,406,420,785,828,1115,1210],"are":[104,146,222,407,431,464,482,512,594,732,845,856,1174],"among":[105],"most":[107,945],"kinds":[109],"lesions.":[112],"Alternatively":[113],"HR,":[115],"DSBs":[116],"repaired":[119,167],"by":[121,161,168,224,233,302,338,350,437,466,529,534,1078],"non-homologous":[122],"end":[123],"joining":[124],"(NHEJ).":[125],"While":[126],"NHEJ":[127,250],"directly":[128],"relegates":[129],"ends,":[133],"uses":[135],"homologous":[136,242,303,339],"sequences":[138],"template":[141],"form":[143,236],"recombinants":[144,481],"that":[145,239,297,333,417,478,492,698,747,757,855,867,926,972,995,1012,1045,1054,1085,1122,1147,1170,1186],"either":[147],"crossover":[148,517,551],"noncrossover":[150,480,532],"with":[151,182,197,635,787,822],"regard":[152],"flanking":[154],"parental":[155],"sequences.":[156],"Furthermore,":[157,475],"DSB":[159,180,357,413,425,436,457,493,527,1136],"flanked":[160],"direct":[162],"repeats":[164],"particular":[170],"called":[173],"single-strand":[174],"annealing":[175],"(SSA),":[176],"results":[178],"concomitant":[183],"deletion":[184],"repeat":[187],"intervening":[191],"sequence.":[192],"All":[193],"processes":[195,382],"initiate":[196],"extensive":[198],"5\u2019":[199],"3\u2019":[201],"end-processing":[202],"(a":[203],"process":[204,308],"referred":[205],"5\u2019-3\u2019":[208],"resection)":[209],"ends":[213,426],"yield":[215],"3\u2019-ended":[216],"single-stranded":[217],"(ssDNA)":[219],"tails,":[220],"bound":[223],"Replication":[225],"Protein":[226],"A":[227],"(RPA).":[228],"RPA":[229],"then":[231],"displaced":[232],"Rad51":[234],"nucleoprotein":[237],"filaments":[238],"catalyse":[241],"pairing":[243],"strand":[245],"invasion.":[246],"The":[247],"choice":[248],"between":[249],"pathways":[253],"tightly":[255],"cycle.":[260],"Eukaryotic":[261],"division":[263,1158,1206],"cycle":[264,312,443,922],"comprises":[265],"series":[267],"events,":[269],"whose":[270],"ordering":[271],"correct":[273],"progression":[274,640],"depends":[275,455],"oscillating":[278],"activity":[279,347,447,521,1056],"cyclin-dependent":[281],"kinases":[282],"(Cdks),":[283],"safeguard":[285],"timely":[286],"duplication":[287],"segregation":[289],"genome.":[292],"It":[293,329,694],"has":[294,316,330,618,675,695,884],"been":[295,317,331,696],"demonstrated":[296,332,697,866,971,1053,1121],"Cdks":[298,334],"promotes":[299,335,526],"restricting":[306],"S/G2":[310],"phases,":[313],"when":[314,445,519,566],"replicated":[318],"sister":[321,568],"chromatid":[322,569],"available":[324],"template.":[328],"(HR).":[341],"Cdk":[342],"(Cdk1":[343],"Saccharomyces":[345],"cerevisiae)":[346],"initiates":[348],"promoting":[351,582],"5\u2032\u20133\u2032":[352],"nucleolytic":[353],"degradation":[354],"ends.":[358],"Whether":[359],"Cdk1":[360,374,391,429,446,496,520,525,580],"regulates":[361],"other":[362],"steps":[364],"was":[365,763,1018,1025,1075,1088],"unknown.":[366],"To":[367,725],"address":[368],"question,":[370],"we":[371,395,476,737,894,952,993,1010,1083,1120,1145,1168],"explored":[372],"requirement":[375,392,497],"execution":[378],"different":[380,676,863],"S.":[384,955],"cerevisiae.":[385],"In":[386,1100],"order":[387,548,642,904,1101],"bypass":[389],"resection":[394,461,494,539],"analyzed":[396],"cells":[397,511,731,913,966,1023,1110],"lacking":[398],"Yku":[399],"heterodimer":[400],"and/or":[401],"checkpoint":[403,637,1047,1073,1087],"protein":[404],"Rad9,":[405],"known":[408],"negative":[410],"regulators":[411],"resection.":[414],"We":[415,755,809,865,924,970,1184],"showed":[416,925,994,1084,1146],"yku70\u0394":[418,472,485,487,507,509],"cells,":[419,490],"accumulate":[421],"ssDNA":[422],"at":[423,537],"independently":[427],"activity,":[430],"able":[432,684,764,1026],"SSA":[438,454,463,530],"G1":[441,473,489],"phase,":[444],"low.":[449,523],"This":[450,673,1052],"ability":[451],"perform":[453],"resection,":[458],"because":[459,603],"both":[460,654,988,1130],"enhanced":[465],"lack":[468],"Rad9":[470],"cells.":[474,754],"found":[477,810,1011],"interchromosomal":[479,516],"generated":[483],"rad9\u0394":[488,510],"indicating":[491],"bypasses":[495],"carrying":[500],"out":[501],"these":[502,868],"events.":[504],"By":[505],"contrast,":[506],"specifically":[513],"defective":[514,1035,1111],"Thus,":[524,1167],"acting":[535],"mostly":[536],"level,":[540],"whereas":[541],"additional":[542,577],"require":[544],"Cdk1-dependent":[545],"regulation":[546,798,889],"generate":[550],"outcomes.":[552],"As":[553,944],"crossovers":[554,583],"mitotic":[556],"growth":[558],"have":[559],"potential":[561],"deleterious":[563,1058],"genome":[564,591,624],"not":[571,1001,1019,1044,1076,1089],"used":[572],"template,":[575],"function":[578,875,975,1082],"provide":[585],"safety":[587],"mechanism":[588],"ensure":[590,644],"stability.":[592],"Cells":[593],"particularly":[595],"vulnerable":[596],"virtually":[604],"all":[605],"forms":[606],"block":[610],"causing":[613],"pivotal":[619],"roles":[620,677],"maintenance":[622],"machinery":[631,1114],"coordinated":[634],"S-phase":[636,1086],"replisome":[639,657],"its":[645,713],"stability":[646,658],"synthesis.":[649],"Among":[650],"factors":[651],"involved":[652,796,962,1090],"there":[659],"conserved":[662,858],"eterotrimeric":[663],"complex":[664,674,700],"MRX":[665,729],"(Mre11\u2013Rad50\u2013Xrs2)":[666],"yeast,":[668],"MRN":[669],"(Mre11\u2013Rad50\u2013Nbs1)":[670],"mammals.":[672],"metabolism,":[680],"bind":[686],"exerts":[689],"architectural":[690],"catalytic":[692],"functions.":[693],"important":[702],"synthesis":[705],"since":[706],"essential":[709],"vertebrate":[711],"disruption":[714],"causes":[715],"sensitivity":[716,751,770,909,942,968,1016,1031,1071,1095],"inhibitor":[720],"hydroxyurea":[721],"(HU)":[722],"yeast.":[724],"better":[726],"understand":[727,906],"why":[728],"deficient":[730],"sensitive":[733],"stress":[736,1061,1119,1178],"performed":[738],"genetic":[740],"screening":[741],"searching":[742],"spontaneous":[744],"extragenic":[745],"mutations":[746,976],"suppress":[748,767,1028],"HU":[750,769,908,941,967,1007,1015,1030,1070,1094,1142,1165],"mre11\u0394":[753,912,940,965,1006,1022],"discovered":[756],"recessive":[758],"mutation":[759,844],"TRR1":[761,774,815,978],"gene":[762,979],"partially":[766,1128],"mre11\uf044":[772],"strain.":[773],"encode":[775,871],"cytoplasmic":[777],"thioredoxin":[778,860,878,882,1171,1187],"reductase":[779,801,879,892,1172,1188],"(Trr1),":[780],"regulatory":[783],"enzyme":[784,802,893],"cooperate":[786],"thioredoxins":[788,950,957,998],"(Trx1":[789,958],"Trx2)":[791,960],"forming":[793],"system":[795,883],"ribonucleotide":[800,891],"cellular":[805],"response":[806],"against":[807],"oxidative.":[808],"two":[811],"mutated":[812,869],"alleles":[813,870],"(trr1-2":[816],"trr1-6)":[818],"each":[819],"base":[825],"pair":[826],"substitution":[827],"caused":[829,981],"amino":[831],"acid":[832],"substitutions":[833],"A18D":[834],"I116S":[836],"trr1-2":[838],"trr1-6":[840],"respectively.":[841],"Both":[842],"Trr1":[848,947,1055,1081,1105,1127,1152],"FAD":[849],"binding":[850],"domain":[851],"involve":[853],"residues":[854],"highly":[857],"reductases":[861],"organisms.":[864],"loss":[873,973,1079,1123,1148],"variants":[876],"enzyme.":[880],"Since":[881],"fundamental":[886],"role":[887],"tried":[895],"modulate":[897],"amounts":[899,935,986],"deoxyribonucleotide":[901],"(dNTP)":[902],"if":[907,954,1104],"suppression":[910,1004,1017,1096],"could":[914,1190],"linked":[916],"dNTPs":[918,934],"levels":[919,999],"progression.":[923],"nor":[927],"increase":[929,983],"neither":[930],"reduction":[932],"were":[936,961,1000,1107],"responsible":[937,1002],"suppression.":[943,969],"functions":[948,1125,1150],"activities":[951,1106,1173],"tested":[953],"cerevisiae":[956],"allele":[980],"an":[982],"Trx1":[989],"Trx2.":[991],"variation":[996],"sensitivity.":[1008],"Then,":[1009],"trr1":[1013,1092],"mediated":[1014,1093],"specific":[1020],"but":[1024,1043],"several":[1033],"mutants":[1034,1048,1074,1140,1162,1209],"(rad51\u0394,":[1039],"rad52\u0394":[1040],"sae2\u0394)":[1042],"(mec1\u0394":[1049],"mrc1\u0394).":[1051],"absence":[1064,1181],"functional":[1066],"machinery.":[1068],"Although":[1069],"suppressed":[1077],"mutants.":[1099],"test":[1103],"undergoes":[1116,1211],"prevented":[1129],"formation":[1132],"accumulation":[1134,1199],"lesions":[1137],"treatment.":[1143,1166],"Finally,":[1144],"increased":[1153],"frequency":[1155],"nuclear":[1157,1205],"released":[1163],"concluded":[1169],"recombination.":[1183],"proposed":[1185],"inactivation":[1189],"promote":[1191],"some":[1192],"alternative":[1194],"mechanisms":[1195],"prevents":[1197],"substrates":[1202],"improving":[1203]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}