{"id":"https://openalex.org/W2240397985","doi":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","title":"Design of a Microfluidic Chip for Enrichment of Circulating Tumor Cells","display_name":"Design of a Microfluidic Chip for Enrichment of Circulating Tumor Cells","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2240397985","doi":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","mag":"2240397985"},"language":"en","primary_location":{"id":"doi:10.4028/www.scientific.net/kem.645-646.1320","doi":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","is_oa":true,"landing_page_url":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","pdf_url":null,"source":{"id":"https://openalex.org/S75411654","display_name":"Key engineering materials","issn_l":"1013-9826","issn":["1013-9826","1662-9795","1662-9809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317839","host_organization_name":"Trans Tech Publications","host_organization_lineage":["https://openalex.org/P4310317839"],"host_organization_lineage_names":["Trans Tech Publications"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Key Engineering Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046068218","display_name":"Xixin Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Xin Ling","raw_affiliation_strings":["Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111858500","display_name":"Da Hai Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Da Hai Ren","raw_affiliation_strings":["Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041300353","display_name":"Zheng You","orcid":"https://orcid.org/0000-0002-3941-1371","observed_orcids":["https://orcid.org/0000-0002-3941-1371"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng You","raw_affiliation_strings":["Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111858500"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"645-646","issue":null,"first_page":"1320","last_page":"1325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ctc-enrichment","display_name":"CTC enrichment","score":0.9079999923706055},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dielectrophoresis","display_name":"dielectrophoresis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ctc-isolation","display_name":"CTC isolation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/wave-structure","display_name":"wave structure","score":0.7080000042915344},{"id":"https://openalex.org/keywords/herringbone-structure","display_name":"herringbone structure","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.9291121959686279},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7628237009048462},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.7542620897293091},{"id":"https://openalex.org/C46435376","wikidata":"https://www.wikidata.org/wiki/Q1829750","display_name":"Multiphysics","level":3,"score":0.6296696662902832},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.5966461300849915},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5727115869522095},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4872516691684723},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4534558951854706},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4267902374267578},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3590081036090851},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29821208119392395},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15817496180534363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11987489461898804},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.06339657306671143},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4028/www.scientific.net/kem.645-646.1320","doi":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","is_oa":true,"landing_page_url":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","pdf_url":null,"source":{"id":"https://openalex.org/S75411654","display_name":"Key engineering materials","issn_l":"1013-9826","issn":["1013-9826","1662-9795","1662-9809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317839","host_organization_name":"Trans Tech Publications","host_organization_lineage":["https://openalex.org/P4310317839"],"host_organization_lineage_names":["Trans Tech Publications"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Key Engineering Materials","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4028/www.scientific.net/kem.645-646.1320","doi":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","is_oa":true,"landing_page_url":"https://doi.org/10.4028/www.scientific.net/kem.645-646.1320","pdf_url":null,"source":{"id":"https://openalex.org/S75411654","display_name":"Key engineering materials","issn_l":"1013-9826","issn":["1013-9826","1662-9795","1662-9809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317839","host_organization_name":"Trans Tech Publications","host_organization_lineage":["https://openalex.org/P4310317839"],"host_organization_lineage_names":["Trans Tech Publications"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Key Engineering Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1966365049","https://openalex.org/W1975214851","https://openalex.org/W1986688132","https://openalex.org/W1995249314","https://openalex.org/W2030593367","https://openalex.org/W2041695600","https://openalex.org/W2050547995","https://openalex.org/W2050827942","https://openalex.org/W2057992135","https://openalex.org/W2061527904","https://openalex.org/W2066126707","https://openalex.org/W2073311421","https://openalex.org/W2108668545","https://openalex.org/W2115158793","https://openalex.org/W2117851496","https://openalex.org/W2123453785","https://openalex.org/W2170157144","https://openalex.org/W2187232168"],"related_works":["https://openalex.org/W4404953696","https://openalex.org/W4407364368","https://openalex.org/W2349759736","https://openalex.org/W3097089541","https://openalex.org/W2919946606","https://openalex.org/W4224233046","https://openalex.org/W4387781406","https://openalex.org/W2979427410","https://openalex.org/W7167270953","https://openalex.org/W2564865439"],"abstract_inverted_index":{"Identification":[0],"and":[1,40,50,69,100,120],"characterization":[2],"of":[3,14,20,26,37,81,125],"CTCs":[4,64],"can":[5],"be":[6],"used":[7,23,61,75],"as":[8],"a":[9,114],"tool":[10],"for":[11,24,122],"the":[12,48,70,123],"study":[13],"cancer":[15],"metastases.":[16],"A":[17],"novel":[18],"design":[19],"microfluidic":[21],"chip":[22,112],"enrichment":[25,42,72,124],"circulating":[27],"tumor":[28],"cells":[29,67],"is":[30,60,74],"presented":[31],"in":[32,97],"this":[33],"paper.":[34],"An":[35],"integration":[36],"DLD":[38,58,98],"method":[39,43],"negative":[41,71],"were":[44,83],"designed":[45],"to":[46,62,76],"improve":[47],"throughput":[49,119],"recovery":[51],"rate":[52],"while":[53],"getting":[54],"intact":[55],"CTCs.":[56,79,126],"The":[57],"stage":[59,73],"separate":[63],"from":[65],"blood":[66],"preliminarily,":[68],"acquire":[77],"purified":[78],"Both":[80],"them":[82],"simulated":[84],"with":[85,117],"COMSOL":[86],"Multiphysics.":[87],"Simulation":[88],"results":[89],"showed":[90],"that":[91],"triangular":[92],"micro-posts":[93],"have":[94],"better":[95,105],"performance":[96],"stage,":[99],"wave":[101],"structures":[102],"could":[103],"generate":[104],"disturbance":[106],"effect":[107],"than":[108],"herringbone":[109],"structures.":[110],"This":[111],"provides":[113],"potential":[115],"approach":[116],"high":[118],"purity":[121]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
