{"id":"https://openalex.org/W2240337678","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.847.3","title":"Evidence for B cell antigen receptor (BCR)\u2010driven, BAFF\u2010facilitated positive selection within a unique population of late transitional B cells","display_name":"Evidence for B cell antigen receptor (BCR)\u2010driven, BAFF\u2010facilitated positive selection within a unique population of late transitional B cells","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2240337678","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.847.3","mag":"2240337678"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.847.3","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.847.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.847.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011116502","display_name":"Almut Meyer\u2010Bahlburg","orcid":"https://orcid.org/0000-0001-8640-8282","observed_orcids":["https://orcid.org/0000-0001-8640-8282"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Almut Meyer\u2010Bahlburg","raw_affiliation_strings":["Pediatric Immunology, Seattle Childrens Hospital Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Immunology, Seattle Childrens Hospital Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045226464","display_name":"Sarah F. Andrews","orcid":"https://orcid.org/0000-0002-2583-1949","observed_orcids":["https://orcid.org/0000-0002-2583-1949"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah F Andrews","raw_affiliation_strings":["Immunology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026874968","display_name":"Karl O. A. Yu","orcid":"https://orcid.org/0000-0002-3418-7614","observed_orcids":["https://orcid.org/0000-0002-3418-7614"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl OA Yu","raw_affiliation_strings":["Microbiology and Immunolgoy, Albert Einstein Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunolgoy, Albert Einstein Institute, New York, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016158429","display_name":"Steven Anthony Porcelli","orcid":"https://orcid.org/0000-0002-4441-9888","observed_orcids":["https://orcid.org/0000-0002-4441-9888"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Porcelli","raw_affiliation_strings":["Microbiology and Immunolgoy, Albert Einstein Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunolgoy, Albert Einstein Institute, New York, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027470095","display_name":"David J. Rawlings","orcid":"https://orcid.org/0000-0002-0810-1776","observed_orcids":["https://orcid.org/0000-0002-0810-1776","https://orcid.org/0000-0003-4370-4772"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J Rawlings","raw_affiliation_strings":["Pediatric Immunology, Seattle Childrens Hospital Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Immunology, Seattle Childrens Hospital Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20896923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.8270000219345093},{"id":"https://openalex.org/keywords/baff","display_name":"BAFF","score":0.9580000042915344},{"id":"https://openalex.org/keywords/baff-receptor","display_name":"BAFF receptor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/follicular-b-cells","display_name":"follicular B cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/b-cell-homeostasis","display_name":"B cell homeostasis","score":0.753000020980835},{"id":"https://openalex.org/keywords/kappa-deleting-recombination-excision-circles","display_name":"kappa-deleting recombination excision circles","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.7378917932510376},{"id":"https://openalex.org/C170286685","wikidata":"https://www.wikidata.org/wiki/Q409346","display_name":"B-cell activating factor","level":4,"score":0.655031144618988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6267400979995728},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6088221073150635},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5889098644256592},{"id":"https://openalex.org/C2779921676","wikidata":"https://www.wikidata.org/wiki/Q6760434","display_name":"Marginal zone","level":4,"score":0.5838170647621155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5135843753814697},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4907918870449066},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.49076327681541443},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.4357043206691742},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34177127480506897},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3322107493877411},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31537100672721863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2292328178882599},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.847.3","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.847.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.847.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6840800033","display_name":"Regulation of B Cell Development and Signaling by Btk","funder_award_id":"R01HD037091","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000111555","https://openalex.org/W1543903698","https://openalex.org/W2069939743","https://openalex.org/W7097913505","https://openalex.org/W2090324342","https://openalex.org/W2138483765","https://openalex.org/W2037463072","https://openalex.org/W1499054844","https://openalex.org/W1968108602","https://openalex.org/W2046696423"],"abstract_inverted_index":{"In":[0,151],"addition":[1],"to":[2,70,144],"negative":[3],"selection,":[4],"several":[5],"lines":[6],"of":[7,56,84,98,110,120,189,202],"evidence":[8],"suggest":[9,184],"that":[10,156,185],"positive":[11],"selection":[12,197],"may":[13,191],"also":[14],"play":[15],"an":[16,53],"important":[17,199],"role":[18],"in":[19,68,105],"shaping":[20],"the":[21,71,117,148,203],"na\u00efve":[22],"mature":[23,59,166,204],"B":[24,34,65,79,86,126,132,159,168,205],"cell":[25,35,94],"repertoire.":[26,206],"We":[27],"have":[28],"characterized":[29],"a":[30,38,81,162,174,194],"late":[31,157],"transitional":[32,75,158],"(T2)":[33],"subset":[36,51,112,141],"with":[37,116],"distinct":[39],"phenotypic,":[40],"functional,":[41],"and":[42,61,77,104,170],"gene":[43],"expression":[44,122],"profile.":[45],"Adoptive":[46],"transfer":[47],"experiments":[48],"identify":[49],"this":[50,111,140,186],"as":[52,91,173],"immediate":[54],"precursor":[55,164],"both":[57],"follicular":[58],"(FM)":[60],"marginal":[62],"zone":[63],"(MZ)":[64],"cells.":[66,127],"Intriguingly,":[67],"contrast":[69],"largely":[72],"quiescent":[73],"early":[74],"(T1)":[76],"FM":[78],"cells,":[80],"high":[82],"percentage":[83],"T2":[85],"cells":[87,133,160,190],"are":[88,134],"actively":[89],"cycling":[90],"demonstrated":[92],"by":[93,137,208],"cycle":[95],"analysis,":[96],"measurement":[97],"kappa\u2010deleting":[99],"recombination":[100],"excision":[101],"circles":[102],"(KRECS)":[103],"vivo":[106],"BrdU":[107],"labeling.":[108],"Proliferation":[109],"is":[113],"BAFF\u2010dependent,":[114],"consistent":[115],"highest":[118],"levels":[119],"BAFF\u2010R":[121],"among":[123],"all":[124],"splenic":[125,167],"Finally,":[128],"M167":[129],"BCR":[130],"idiotypic\u2010specific":[131],"first":[135],"selected":[136],"self\u2010antigen":[138],"within":[139,147],"leading,":[142],"ultimately,":[143],"preferential":[145],"enrichment":[146],"MZ":[149],"compartment.":[150],"summary,":[152],"our":[153],"data":[154],"indicate":[155],"represent":[161],"bipotent":[163],"for":[165,176,200],"cells;":[169],"can":[171],"function":[172],"target":[175],"BCR\u2010driven,":[177],"BAFF\u2010facilitated":[178],"homeostatic":[179],"signaling.":[180],"These":[181],"combined":[182],"findings":[183],"small":[187],"pool":[188],"operate":[192],"at":[193],"previously":[195],"unknown":[196],"point":[198],"establishment":[201],"Funded":[207],"NIH":[209],"5RO1HD37091":[210]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
