{"id":"https://openalex.org/W2239984751","doi":null,"title":"mRNA expression of the angiogenesis markers VEGF and CD105 (endoglin) in human breast cancer.","display_name":"mRNA expression of the angiogenesis markers VEGF and CD105 (endoglin) in human breast cancer.","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2239984751","mag":"2239984751","pmid":"https://pubmed.ncbi.nlm.nih.gov/15274325"},"language":"en","primary_location":{"id":"pmid:15274325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082091364","display_name":"Francisco G\u00f3mez\u2010Esquer","orcid":"https://orcid.org/0000-0002-5426-4349","observed_orcids":["https://orcid.org/0000-0002-5426-4349"]},"institutions":[{"id":"https://openalex.org/I182083151","display_name":"Universidad Rey Juan Carlos","ror":"https://ror.org/01v5cv687","country_code":"ES","type":"education","lineage":["https://openalex.org/I182083151"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco G\u00f3mez-Esquer","raw_affiliation_strings":["Universidad Rey Juan Carlos, Facultad de Ciencias de la Salud, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Rey Juan Carlos, Facultad de Ciencias de la Salud, Madrid, Spain","institution_ids":["https://openalex.org/I182083151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025652691","display_name":"David Agudo","orcid":"https://orcid.org/0000-0002-8917-5071","observed_orcids":["https://orcid.org/0000-0002-8917-5071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Agudo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008044041","display_name":"Fernando Mart\u00ednez\u2010Arribas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Mart\u00ednez-Arribas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111983598","display_name":"Mar\u00eda-Jos\u00e9 N\u00fa\u00f1ez-Villar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda-Jos\u00e9 Nu\u00f1ez-Villar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076986738","display_name":"Jos\u00e9 Schneider","orcid":"https://orcid.org/0000-0003-4503-9956","observed_orcids":["https://orcid.org/0000-0003-4503-9956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Schneider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7102,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.66526218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"3a","first_page":"1581","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.9240000247955322},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nuclear-grade","display_name":"nuclear grade","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mammaglobin","display_name":"mammaglobin","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.954032301902771},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6633601784706116},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6304616332054138},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4578678607940674},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4387821555137634},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4309009313583374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42672306299209595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42078205943107605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41850799322128296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29652273654937744},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.10867387056350708},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071063","descriptor_name":"Endoglin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15274325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2239984751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1538804386","https://openalex.org/W1693302173","https://openalex.org/W1865024184","https://openalex.org/W2016105691","https://openalex.org/W2023949193","https://openalex.org/W2031548299","https://openalex.org/W2033759107","https://openalex.org/W2044346544","https://openalex.org/W2065022006","https://openalex.org/W2080233763","https://openalex.org/W2125618279","https://openalex.org/W2131399163","https://openalex.org/W2135924006","https://openalex.org/W2159895250","https://openalex.org/W2170361716","https://openalex.org/W2409564652"],"related_works":["https://openalex.org/W2375152378","https://openalex.org/W2548320150","https://openalex.org/W2371879832","https://openalex.org/W2383663113","https://openalex.org/W2371903414","https://openalex.org/W2363488074","https://openalex.org/W2985070832","https://openalex.org/W2354993800","https://openalex.org/W2369928946","https://openalex.org/W2164069313"],"abstract_inverted_index":{"BACKGROUND:":[0],"Both":[1],"VEGF":[2,48,94,163,220,230],"and":[3,14,49,62,72,95,123,130,147,179,184],"CD105":[4,50,96,191,245],"(endoglin)":[5,51,97,192,246],"have":[6,20],"been":[7,22],"identified":[8],"as":[9,145],"markers":[10],"of":[11,27,31,39,47,59,75,113,128,136,141,181,210],"tumor":[12,28,82],"angiogenesis":[13],"prognosis":[15],"in":[16,24,56,106],"breast":[17,60,88],"cancer.":[18],"They":[19],"always":[21],"studied":[23,92],"this":[25,237],"kind":[26],"by":[29,37,111,126,134],"means":[30,38,112,127,135],"immunological":[32],"methods.":[33],"OBJECTIVE:":[34],"To":[35],"study,":[36],"reverse-transcription":[40],"polymerase":[41],"chain":[42],"reaction":[43],"(RT-PCR),":[44],"the":[45,53,65,76,101,142,159,168,182,197,233,242],"expression":[46,125,133,165,189,194,209,222],"at":[52,232],"mRNA":[54,164,193,221,247],"level":[55],"a":[57],"series":[58],"cancers":[61],"to":[63,225,240],"correlate":[64,215],"results":[66],"obtained":[67],"with":[68,175,186,203,216,229],"all":[69,107],"available":[70],"clinical":[71],"biological":[73],"features":[74],"tumors.":[77],"MATERIALS":[78],"AND":[79],"METHODS:":[80],"Fresh":[81],"tissue":[83],"from":[84],"103":[85],"previously":[86],"untreated":[87],"cancer":[89],"patients":[90],"was":[91],"for":[93,244],"expression.":[98],"In":[99],"addition,":[100],"following":[102],"parameters":[103,140],"were":[104,155,171],"determined":[105],"tumors:":[108],"DNA":[109],"ploidy":[110],"flow":[114],"cytometry;":[115],"hormone":[116],"receptor":[117,188],"(ER":[118],"&":[119],"PR),":[120],"Ki67,":[121],"c-erb-B2":[122],"p53":[124],"immunohistochemistry;":[129],"h-MAM":[131],"(mammaglobin)":[132],"RT-PCR.":[137],"Classical":[138],"prognostic":[139],"tumors,":[143],"such":[144],"histological":[146],"nuclear":[148,204],"grade":[149,205],"or":[150],"axillary":[151],"lymph":[152],"node":[153],"invasion,":[154],"also":[156],"included":[157],"into":[158],"statistical":[160],"analysis.":[161],"RESULTS:":[162],"levels":[166,195,223],"above":[167,196],"25th":[169,198],"percentile":[170,199],"significantly":[172,202],"(p<0.05)":[173],"associated":[174,228],"high":[176],"proliferation":[177],"(Ki67>10%)":[178],"aneuploidy":[180],"tumors":[183],"inversely":[185],"estrogen":[187],"(p<0.01).":[190],"only":[200],"correlated":[201],"3":[206],"(p<0.05).":[207],"The":[208],"both":[211],"genes":[212],"did":[213],"not":[214,239],"each":[217],"other.":[218],"CONCLUSION:":[219],"seem":[224],"be":[226,241],"directly":[227],"functions":[231],"protein":[234],"level,":[235],"whereas":[236],"seems":[238],"case":[243],"levels.":[248]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}