{"id":"https://openalex.org/W22398218","doi":null,"title":"A two-dimensional scanning ocular fluorophotometer.","display_name":"A two-dimensional scanning ocular fluorophotometer.","publication_year":1985,"publication_date":"1985-02-01","ids":{"openalex":"https://openalex.org/W22398218","mag":"22398218","pmid":"https://pubmed.ncbi.nlm.nih.gov/3972497"},"language":"en","primary_location":{"id":"pmid:3972497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3972497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023436559","display_name":"Jay W. McLaren","orcid":"https://orcid.org/0000-0002-2573-425X","observed_orcids":["https://orcid.org/0000-0002-2573-425X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W McLaren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110377289","display_name":"Richard F. Brubaker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F Brubaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6314,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.97656138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"26","issue":"2","first_page":"144","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.3582000136375427,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.3582000136375427,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cornea","display_name":"cornea","score":0.7929999828338623},{"id":"https://openalex.org/keywords/anterior-chamber","display_name":"anterior chamber","score":0.9010000228881836},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.8489699959754944},{"id":"https://openalex.org/C2778015030","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Fluorescein","level":3,"score":0.7560725808143616},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.4767138361930847},{"id":"https://openalex.org/C2779503344","wikidata":"https://www.wikidata.org/wiki/Q5973514","display_name":"IRIS (biosensor)","level":3,"score":0.45804259181022644},{"id":"https://openalex.org/C2778113962","wikidata":"https://www.wikidata.org/wiki/Q965041","display_name":"Slit lamp","level":2,"score":0.45639508962631226},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4194275736808777},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39350268244743347},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3799918293952942},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.33945417404174805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24164679646492004},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09622988104820251},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C184297639","wikidata":"https://www.wikidata.org/wiki/Q177765","display_name":"Biometrics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009885","descriptor_name":"Ophthalmology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D019793","descriptor_name":"Fluorescein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3972497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3972497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:22398218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3972497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W24495058","https://openalex.org/W29035045","https://openalex.org/W41888130","https://openalex.org/W110864682","https://openalex.org/W126396083","https://openalex.org/W131560491","https://openalex.org/W139562766","https://openalex.org/W168348532","https://openalex.org/W364346673","https://openalex.org/W644245134","https://openalex.org/W1025272345","https://openalex.org/W1493880347","https://openalex.org/W1559128470","https://openalex.org/W1582038792","https://openalex.org/W1833633739","https://openalex.org/W1968251820","https://openalex.org/W1969566712","https://openalex.org/W1970645558","https://openalex.org/W1974267026","https://openalex.org/W1977400775","https://openalex.org/W1980815549","https://openalex.org/W1981629041","https://openalex.org/W1983987984","https://openalex.org/W1984219155","https://openalex.org/W1986026520","https://openalex.org/W1986160938","https://openalex.org/W1987565779","https://openalex.org/W1988451651","https://openalex.org/W1989893780","https://openalex.org/W1990034515","https://openalex.org/W1993918561","https://openalex.org/W1994995252","https://openalex.org/W1999269766","https://openalex.org/W2000726781","https://openalex.org/W2000978761","https://openalex.org/W2003674452","https://openalex.org/W2003969772","https://openalex.org/W2004702150","https://openalex.org/W2004950145","https://openalex.org/W2012965883","https://openalex.org/W2013792539","https://openalex.org/W2021848355","https://openalex.org/W2024288031","https://openalex.org/W2033073182","https://openalex.org/W2033160691","https://openalex.org/W2036595618","https://openalex.org/W2042549084","https://openalex.org/W2043969220","https://openalex.org/W2048585336","https://openalex.org/W2051650406","https://openalex.org/W2053395707","https://openalex.org/W2053522132","https://openalex.org/W2054132358","https://openalex.org/W2055545054","https://openalex.org/W2060100643","https://openalex.org/W2062433007","https://openalex.org/W2067810471","https://openalex.org/W2068145264","https://openalex.org/W2074736197","https://openalex.org/W2079737911","https://openalex.org/W2087121252","https://openalex.org/W2094298397","https://openalex.org/W2095141456","https://openalex.org/W2099015358","https://openalex.org/W2100036957","https://openalex.org/W2100794308","https://openalex.org/W2110499439","https://openalex.org/W2119946832","https://openalex.org/W2123509863","https://openalex.org/W2125120811","https://openalex.org/W2127063113","https://openalex.org/W2127720008","https://openalex.org/W2130804040","https://openalex.org/W2132142558","https://openalex.org/W2134248390","https://openalex.org/W2139206998","https://openalex.org/W2144440695","https://openalex.org/W2146329417","https://openalex.org/W2149739510","https://openalex.org/W2149835511","https://openalex.org/W2150321849","https://openalex.org/W2151857151","https://openalex.org/W2151877638","https://openalex.org/W2159158593","https://openalex.org/W2162468415","https://openalex.org/W2164212829","https://openalex.org/W2166895048","https://openalex.org/W2172299998","https://openalex.org/W2184526621","https://openalex.org/W2267125167","https://openalex.org/W2405159068","https://openalex.org/W2406270921","https://openalex.org/W2419519065","https://openalex.org/W2615198785","https://openalex.org/W4252239275","https://openalex.org/W4300179236","https://openalex.org/W4300917589"],"related_works":["https://openalex.org/W56685678","https://openalex.org/W2146509443","https://openalex.org/W2463136842","https://openalex.org/W1977935080","https://openalex.org/W1990034515","https://openalex.org/W2049639787","https://openalex.org/W2420874756","https://openalex.org/W2100467796","https://openalex.org/W1980107272","https://openalex.org/W2125139368"],"abstract_inverted_index":{"For":[0],"certain":[1],"studies":[2],"of":[3,6,12,27,76,119,134,161,174,191],"the":[4,9,13,28,39,67,84,92,140,164,197,205,210],"dynamics":[5],"fluorescein":[7,60,135,175,195],"in":[8,35,62,156,194,209],"anterior":[10,31,70,165],"segment":[11],"eye":[14],"it":[15],"would":[16],"be":[17,185],"advantageous":[18],"to":[19,58,149,187],"measure":[20,59,188],"fluorescent":[21,95],"intensity":[22],"from":[23,139,144],"several":[24],"anatomic":[25],"regions":[26],"cornea":[29,68,168,211],"and":[30,56,69,94,111,167,171,204],"chamber":[32,166],"simultaneously":[33],"or":[34],"rapid":[36],"succession.":[37],"In":[38],"present":[40],"paper":[41],"we":[42,53],"describe":[43],"a":[44,47,63,100,157],"device":[45],"called":[46],"two-dimensional":[48,132],"scanning":[49],"ocular":[50],"fluorophotometer":[51],"that":[52],"have":[54],"designed":[55],"built":[57],"concentration":[61,136,207],"horizontal":[64],"section":[65],"through":[66,83,163],"chamber.":[71],"The":[72],"488-nm":[73],"wavelength":[74],"beam":[75],"an":[77],"argon":[78],"laser":[79],"is":[80,97,112,137],"mechanically":[81],"scanned":[82],"target":[85],"area":[86],"(70":[87],"microW":[88],"total":[89],"power":[90],"at":[91],"eye)":[93],"light":[96],"measured":[98,155],"with":[99],"photon-counting":[101],"photomultiplier":[102],"tube.":[103],"A":[104,131],"single":[105,158],"anterior-posterior":[106,124],"scan":[107],"requires":[108],"100":[109],"msec":[110,121],"divided":[113],"into":[114],"33":[115],"sample":[116],"time":[117],"periods":[118],"3":[120,129,145,150],"each.":[122],"Thirty":[123],"scans":[125,162,179],"are":[126,154,176],"made":[127],"within":[128],"sec.":[130],"array":[133],"reconstructed":[138],"data.":[141],"Concentrations":[142],"ranging":[143],"X":[146,151],"10(-10)":[147],"gm/ml":[148],"10(-6)":[152],"g/ml":[153],"scan.":[159],"Examples":[160],"after":[169],"topical":[170,202],"systemic":[172,213],"administration":[173,203],"presented.":[177],"These":[178],"illustrate":[180],"how":[181],"this":[182],"instrument":[183],"can":[184],"used":[186],"two":[189],"types":[190],"regional":[192],"differences":[193],"concentration,":[196],"\"pupillary":[198],"aqueous":[199],"bubble\"":[200],"following":[201,212],"radial":[206],"gradient":[208],"administration.":[214]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}