{"id":"https://openalex.org/W2238790889","doi":null,"title":"Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production.","display_name":"Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2238790889","mag":"2238790889","pmid":"https://pubmed.ncbi.nlm.nih.gov/26722597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4680542"},"language":"en","primary_location":{"id":"pmid:26722597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26722597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4680542/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064554209","display_name":"Jia Li","orcid":"https://orcid.org/0000-0002-3606-3949","observed_orcids":["https://orcid.org/0000-0002-3606-3949"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102272097","display_name":"Chongru He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongru He","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035679060","display_name":"Wenwen Tong","orcid":"https://orcid.org/0000-0003-0176-9834","observed_orcids":["https://orcid.org/0000-0003-0176-9834"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Tong","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030608378","display_name":"Yuming Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuming Zou","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dahe Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dahe Li","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374156","display_name":"Chen Zhang","orcid":"https://orcid.org/0000-0003-0494-1994","observed_orcids":["https://orcid.org/0000-0003-0494-1994"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Zhang","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100729627","display_name":"Weidong Xu","orcid":"https://orcid.org/0000-0001-8805-2371","observed_orcids":["https://orcid.org/0000-0001-8805-2371"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Xu","raw_affiliation_strings":["Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8449,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.85129162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"10","first_page":"13695","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tanshinone-iia","display_name":"tanshinone IIA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9800000190734863},{"id":"https://openalex.org/keywords/osteoblast-apoptosis","display_name":"osteoblast apoptosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.8939999938011169},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteoporosis","display_name":"glucocorticoid-induced osteoporosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9449999928474426},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9950000047683716},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.9083617925643921},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7657723426818848},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6835096478462219},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.537519097328186},{"id":"https://openalex.org/C2776332195","wikidata":"https://www.wikidata.org/wiki/Q1000854","display_name":"Salvia miltiorrhiza","level":4,"score":0.5027689933776855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4672054648399353},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4431047737598419},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.43410491943359375},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4102792739868164},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.3962399661540985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3258271813392639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2844111919403076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21897897124290466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17072731256484985},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.048187434673309326},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:26722597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26722597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4680542","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4680542/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:2238790889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26722597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4680542","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4680542/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W18924068","https://openalex.org/W1509864609","https://openalex.org/W1739125925","https://openalex.org/W1972923988","https://openalex.org/W1981922352","https://openalex.org/W1984741878","https://openalex.org/W1989454963","https://openalex.org/W1990028531","https://openalex.org/W1991322109","https://openalex.org/W1991583073","https://openalex.org/W1992001223","https://openalex.org/W1996142620","https://openalex.org/W1997371194","https://openalex.org/W2001728897","https://openalex.org/W2011203192","https://openalex.org/W2012195535","https://openalex.org/W2015351957","https://openalex.org/W2016531954","https://openalex.org/W2029391324","https://openalex.org/W2037333519","https://openalex.org/W2038942359","https://openalex.org/W2042219837","https://openalex.org/W2053516334","https://openalex.org/W2062650207","https://openalex.org/W2069811152","https://openalex.org/W2080089180","https://openalex.org/W2081373408","https://openalex.org/W2083248385","https://openalex.org/W2098915805","https://openalex.org/W2099327883","https://openalex.org/W2114344041","https://openalex.org/W2116703462","https://openalex.org/W2116751183","https://openalex.org/W2118264464","https://openalex.org/W2132673369","https://openalex.org/W2154277972","https://openalex.org/W2169198657","https://openalex.org/W4247598681"],"related_works":["https://openalex.org/W3084220568","https://openalex.org/W2925324269","https://openalex.org/W2015341058","https://openalex.org/W2001728897","https://openalex.org/W3032134867","https://openalex.org/W2006806414","https://openalex.org/W4295086731","https://openalex.org/W3085470662","https://openalex.org/W2788029357","https://openalex.org/W1163071911"],"abstract_inverted_index":{"Apoptosis":[0],"of":[1,16,28,68,81,144,151,165,178,192,200,208],"osteoblasts":[2,214],"caused":[3,90],"by":[4,55,119,130],"glucocorticoids":[5],"has":[6,34],"been":[7,35],"identified":[8],"as":[9,60],"an":[10,21],"important":[11],"contributor":[12],"to":[13,37,174,210],"the":[14,26,29,44,65,148,168],"development":[15],"osteoporosis.":[17,42,217],"Tanshinone":[18],"IIA":[19],"(Tan),":[20],"active":[22],"ingredient":[23],"extracted":[24],"from":[25],"rhizome":[27],"Salvia":[30],"miltiorrhiza":[31],"Bunge":[32],"(Danshen),":[33],"reported":[36],"cast":[38],"positive":[39],"effects":[40,67],"on":[41,153],"However,":[43],"precise":[45],"mechanisms":[46],"accounting":[47],"this":[48,53],"action":[49],"remain":[50],"elusive.":[51],"In":[52],"study,":[54],"using":[56],"osteoblastic":[57],"MC3T3-E1":[58],"cells":[59],"a":[61,204],"model,":[62],"we":[63,183],"confirmed":[64],"protective":[66],"Tan":[69,113,152,186,209],"against":[70,212],"dexamethasone":[71],"(Dex)-induced":[72],"cell":[73,91,126,155],"apoptosis":[74,102,175,189,215],"and":[75,98,106,125,137,157,216],"further":[76],"clarified":[77],"its":[78],"molecular":[79],"mechanism":[80],"action.":[82],"Our":[83],"results":[84,160],"showed":[85],"that":[86,185,198],"treatment":[87],"with":[88],"Dex":[89],"injury,":[92],"increased":[93],"cytosol":[94],"cytochrome":[95],"c":[96],"level":[97],"Nox":[99],"expression,":[100],"induced":[101],"in":[103,167],"caspase-9-dependent":[104],"manner,":[105],"enhanced":[107],"reactive":[108],"oxygen":[109],"species":[110],"(ROS)":[111],"production.":[112],"attenuated":[114],"these":[115],"deleterious":[116],"consequence":[117],"triggered":[118],"Dex.":[120],"Moreover,":[121],"Dex-induced":[122,154,169,188],"ROS":[123,172],"production":[124],"injury":[127,156],"were":[128],"inhibited":[129],"antioxidant,":[131],"NADPH":[132],"oxidases":[133],"inhibitors,":[134],"Nox4":[135,138,145,166,201],"inhibitor,":[136],"small":[139],"interfering":[140],"RNA":[141],"(siRNA).":[142],"Overexpression":[143],"almost":[146],"abolished":[147],"inhibitory":[149],"effect":[150],"apoptosis.":[158,170],"The":[159,194],"also":[161],"demonstrated":[162],"significant":[163],"involvement":[164],"Nox4-derived":[171],"led":[173],"through":[176],"activation":[177],"intrinsic":[179],"mitochondrial":[180],"pathway.":[181],"Additionally,":[182],"evidenced":[184],"reversed":[187],"via":[190],"inactivation":[191],"Nox4.":[193],"present":[195],"findings":[196],"suggest":[197],"inhibition":[199],"may":[202],"be":[203],"novel":[205],"therapeutic":[206],"approach":[207],"prevent":[211],"glucocorticoids-induced":[213]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
