{"id":"https://openalex.org/W2238358981","doi":null,"title":"Mediadores inflamat\u00f3rios no transtorno bipolar","display_name":"Mediadores inflamat\u00f3rios no transtorno bipolar","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2238358981","mag":"2238358981"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3176188","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/24601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/24601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076331964","display_name":"Elisa Macedo Brietzke","orcid":"https://orcid.org/0000-0003-2697-1342","observed_orcids":["https://orcid.org/0000-0003-2697-1342"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elisa Macedo Brietzke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076331964"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-i-disorder","display_name":"bipolar I disorder","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.8740000128746033},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mania","display_name":"mania","score":0.8149999976158142},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9629999995231628},{"id":"https://openalex.org/keywords/euthymia","display_name":"euthymia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8880000114440918},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9290000200271606},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ccl24","display_name":"CCL24","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.972000002861023},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.29648396372795105}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:3176188","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/24601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/24601","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/24601","pdf_url":"https://lume.ufrgs.br/bitstream/10183/24601/1/000747552.pdf","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tese"},{"id":"mag:2238358981","doi":null,"is_oa":false,"landing_page_url":"https://livros01.livrosgratis.com.br/cp133578.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3176188","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/24601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2238358981.pdf","grobid_xml":"https://content.openalex.org/works/W2238358981.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W37637289","https://openalex.org/W267005988","https://openalex.org/W1501778305","https://openalex.org/W1580706769","https://openalex.org/W1607819524","https://openalex.org/W1933656616","https://openalex.org/W1963739260","https://openalex.org/W1969405886","https://openalex.org/W1971295949","https://openalex.org/W1971618316","https://openalex.org/W1974800864","https://openalex.org/W1976870407","https://openalex.org/W1978762354","https://openalex.org/W1979000113","https://openalex.org/W1979173012","https://openalex.org/W1981748148","https://openalex.org/W1989190407","https://openalex.org/W1996554590","https://openalex.org/W1996558108","https://openalex.org/W1997363702","https://openalex.org/W1998520631","https://openalex.org/W2003038736","https://openalex.org/W2016209226","https://openalex.org/W2024486446","https://openalex.org/W2026728307","https://openalex.org/W2028285408","https://openalex.org/W2028738698","https://openalex.org/W2031329056","https://openalex.org/W2032618901","https://openalex.org/W2033726432","https://openalex.org/W2036288913","https://openalex.org/W2037929058","https://openalex.org/W2041912691","https://openalex.org/W2044445029","https://openalex.org/W2048866565","https://openalex.org/W2053730308","https://openalex.org/W2055211617","https://openalex.org/W2056305549","https://openalex.org/W2056873227","https://openalex.org/W2058339095","https://openalex.org/W2059790137","https://openalex.org/W2061442310","https://openalex.org/W2061631515","https://openalex.org/W2063620427","https://openalex.org/W2067466132","https://openalex.org/W2070948781","https://openalex.org/W2078865976","https://openalex.org/W2080350725","https://openalex.org/W2084464987","https://openalex.org/W2087184916","https://openalex.org/W2087898128","https://openalex.org/W2095156987","https://openalex.org/W2117804236","https://openalex.org/W2119507401","https://openalex.org/W2121211009","https://openalex.org/W2123593542","https://openalex.org/W2131201065","https://openalex.org/W2131942594","https://openalex.org/W2135649193","https://openalex.org/W2144357933","https://openalex.org/W2144468748","https://openalex.org/W2149069297","https://openalex.org/W2158143414","https://openalex.org/W2165781717","https://openalex.org/W2168911501"],"related_works":["https://openalex.org/W3007003792","https://openalex.org/W1927866700","https://openalex.org/W187505977","https://openalex.org/W2334618892","https://openalex.org/W7047749434","https://openalex.org/W210609365","https://openalex.org/W2096853514","https://openalex.org/W2029560485","https://openalex.org/W2569277856","https://openalex.org/W32256297"],"abstract_inverted_index":{"Objetivos:":[0],"Comparar":[1,21],"os":[2,22,97,117,163,192,202],"n\u00edveis":[3,23,49,118,177,193,203],"s\u00e9ricos":[4,24,50,119,194],"de":[5,25,51,84,86,112,134,159,178,195,204],"citocinas":[6,80,142,179],"entre":[7,27,96],"volunt\u00e1rios":[8,28,76,113,160],"saud\u00e1veis":[9,29,114],"e":[10,19,30,39,57,59,64,94,130,146],"em":[11,16,35,62,154,165],"pacientes":[12,31,41,103,151,164,181,200],"bipolares":[13,32,42,104],"tipo":[14,33,105],"1":[15,34,106],"mania,":[17,140],"depress\u00e3o":[18],"eutimia.":[20,36],"quimiocinas":[26],"Metodologia:":[37],"Sessenta":[38],"um":[40],"foram":[43,81,107],"recrutados":[44],"para":[45,115],"a":[46,71,109,139],"avalia\u00e7\u00e3o":[47],"dos":[48,176],"citocinas.":[52],"Desses,":[53],"24":[54,60],"estavam":[55,61,148,197,206],"eut\u00edmicos,":[56,182],"23":[58],"mania":[63],"depress\u00e3o,":[65],"respectivamente.":[66],"Este":[67],"grupo":[68,158],"foi":[69],"comparado":[70],"outro,":[72],"composto":[73],"por":[74],"25":[75],"saud\u00e1veis.":[77,161],"As":[78],"seguintes":[79,121],"exainadas":[82],"atrav\u00e9s":[83,133],"citometria":[85],"fluxo:":[87],"TNF-alfa,":[88],"IL-2,":[89,144],"IL-4,":[90],"IL-6,":[91],"IL-10,":[92],"IFN-gama":[93],"comparadas":[95],"grupos.":[98],"Al\u00e9m":[99],"dessa":[100],"an\u00e1lise,":[101],"30":[102],"comparados":[108],"igual":[110],"n\u00famero":[111],"estudar":[116],"das":[120],"quimiocinas:":[122],"CCL2,":[123],"CCL3,":[124],"CCL8,":[125],"CCL":[126],"9,":[127],"CCL10,":[128],"CCL11":[129],"CCL24,":[131],"dosadas":[132],"ELISA":[135],"sandwich.":[136],"Resultados:":[137],"Duarnte":[138],"as":[141,189],"pr\u00f3-inflamat\u00f3rias":[143],"IL-4":[145],"IL-6":[147],"elevadas":[149],"nos":[150,180,199],"com":[152,156],"TB":[153],"compara\u00e7\u00e3o":[155],"o":[157],"J\u00e1":[162],"epis\u00f3dio":[166],"depressivo,":[167],"apresentavam":[168],"somente":[169],"eleva\u00e7\u00e3o":[170],"da":[171,186],"IL-6.":[172],"N\u00e3o":[173],"houve":[174],"modifica\u00e7\u00e3o":[175],"exceto":[183],"pelo":[184],"aumento":[185],"IL-4.":[187],"Quanto":[188],"quimiocinas,":[190],"enquanto":[191],"CXCL10":[196],"elevados":[198],"bipolares,":[201],"CCL24":[205],"diminu\u00eddos.":[207]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}