{"id":"https://openalex.org/W2238344282","doi":"https://doi.org/10.15690/vramn.v70i2.1310","title":"Autoimmune Rheumatic Diseases \u2014 Problems of Immunopathology and Personalized Treatment","display_name":"Autoimmune Rheumatic Diseases \u2014 Problems of Immunopathology and Personalized Treatment","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2238344282","doi":"https://doi.org/10.15690/vramn.v70i2.1310","mag":"2238344282","pmid":"https://pubmed.ncbi.nlm.nih.gov/26234089"},"language":"ru","primary_location":{"id":"doi:10.15690/vramn.v70i2.1310","doi":"https://doi.org/10.15690/vramn.v70i2.1310","is_oa":true,"landing_page_url":"https://doi.org/10.15690/vramn.v70i2.1310","pdf_url":"https://vestnikramn.spr-journal.ru/jour/article/download/53/444","source":{"id":"https://openalex.org/S2755404556","display_name":"Annals of the Russian academy of medical sciences","issn_l":"0869-6047","issn":["0869-6047","2414-3545"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312655","host_organization_name":"Paediatrician Publishers, LLC","host_organization_lineage":["https://openalex.org/P4310312655"],"host_organization_lineage_names":["Paediatrician Publishers, LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Russian academy of medical sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://vestnikramn.spr-journal.ru/jour/article/download/53/444","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015242242","display_name":"Evgeny Lvovich Nasonov","orcid":"https://orcid.org/0000-0002-7177-2409","observed_orcids":["https://orcid.org/0000-0002-7177-2409"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.L. Nasonov","raw_affiliation_strings":["V.A. Nasonova Research Institute for Rheumatology, Moscow, Russian Federation","\u041d\u0418\u0418\u0420 \u0438\u043c. \u0412.\u0410. \u041d\u0430\u0441\u043e\u043d\u043e\u0432\u043e\u0439, \u041c\u043e\u0441\u043a\u0432\u0430, \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0430\u044f \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u044f"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute for Rheumatology, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210121474"]},{"raw_affiliation_string":"\u041d\u0418\u0418\u0420 \u0438\u043c. \u0412.\u0410. \u041d\u0430\u0441\u043e\u043d\u043e\u0432\u043e\u0439, \u041c\u043e\u0441\u043a\u0432\u0430, \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0430\u044f \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u044f","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074646458","display_name":"\u0415 \u041d \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-4074-5907","observed_orcids":["https://orcid.org/0000-0003-4074-5907"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.N. Aleksandrova","raw_affiliation_strings":["V.A. Nasonova Research Institute for Rheumatology, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute for Rheumatology, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020275031","display_name":"Alexander A. Novikov","orcid":"https://orcid.org/0000-0002-2738-2956","observed_orcids":["https://orcid.org/0000-0002-2738-2956"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.A. Novikov","raw_affiliation_strings":["V.A. Nasonova Research Institute for Rheumatology, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute for Rheumatology, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210121474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210121474"],"apc_list":null,"apc_paid":null,"fwci":0.3784,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.31406844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"70","issue":"2","first_page":"169","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.17820000648498535,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-rheumatic-diseases","display_name":"autoimmune rheumatic diseases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.859000027179718},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.8550000190734863},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.8190000057220459},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/autoinflammatory-disease","display_name":"autoinflammatory disease","score":0.8259999752044678},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.6010000109672546},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8659999966621399},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.921999990940094},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9649999737739563},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6819999814033508},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.6890000104904175},{"id":"https://openalex.org/keywords/transcriptomic-markers","display_name":"transcriptomic markers","score":0.9570000171661377},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7471036911010742},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7356775999069214},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6259967088699341},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5932719707489014},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5323880910873413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4842917323112488},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.47594213485717773},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4290623068809509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3455127477645874},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18398961424827576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1444568932056427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0994335412979126}],"mesh":[{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001691","descriptor_name":"Biological Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.15690/vramn.v70i2.1310","doi":"https://doi.org/10.15690/vramn.v70i2.1310","is_oa":true,"landing_page_url":"https://doi.org/10.15690/vramn.v70i2.1310","pdf_url":"https://vestnikramn.spr-journal.ru/jour/article/download/53/444","source":{"id":"https://openalex.org/S2755404556","display_name":"Annals of the Russian academy of medical sciences","issn_l":"0869-6047","issn":["0869-6047","2414-3545"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312655","host_organization_name":"Paediatrician Publishers, LLC","host_organization_lineage":["https://openalex.org/P4310312655"],"host_organization_lineage_names":["Paediatrician Publishers, LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Russian academy of medical sciences","raw_type":"journal-article"},{"id":"pmid:26234089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26234089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik Rossiiskoi akademii meditsinskikh nauk","raw_type":"English Abstract"},{"id":"mag:2442709001","doi":null,"is_oa":false,"landing_page_url":"https://vestnikramn.spr-journal.ru/jour/article/download/53/444","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.15690/vramn.v70i2.1310","doi":"https://doi.org/10.15690/vramn.v70i2.1310","is_oa":true,"landing_page_url":"https://doi.org/10.15690/vramn.v70i2.1310","pdf_url":"https://vestnikramn.spr-journal.ru/jour/article/download/53/444","source":{"id":"https://openalex.org/S2755404556","display_name":"Annals of the Russian academy of medical sciences","issn_l":"0869-6047","issn":["0869-6047","2414-3545"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312655","host_organization_name":"Paediatrician Publishers, LLC","host_organization_lineage":["https://openalex.org/P4310312655"],"host_organization_lineage_names":["Paediatrician Publishers, LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Russian academy of medical sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2238344282.pdf","grobid_xml":"https://content.openalex.org/works/W2238344282.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964095605","https://openalex.org/W1996460626","https://openalex.org/W2007815737","https://openalex.org/W2010417263","https://openalex.org/W2034100892","https://openalex.org/W2040213563","https://openalex.org/W2041084308","https://openalex.org/W2043606648","https://openalex.org/W2052368532","https://openalex.org/W2063485775","https://openalex.org/W2067693090","https://openalex.org/W2081819242","https://openalex.org/W2090057959","https://openalex.org/W2099100132","https://openalex.org/W2109845269","https://openalex.org/W2110826367","https://openalex.org/W2114909821","https://openalex.org/W2125497658","https://openalex.org/W2132302212","https://openalex.org/W2132841358","https://openalex.org/W2137071075","https://openalex.org/W2148512105","https://openalex.org/W2149145393","https://openalex.org/W2155109530","https://openalex.org/W2156593826","https://openalex.org/W2161016955","https://openalex.org/W4210768724","https://openalex.org/W4308769923","https://openalex.org/W4311675917"],"related_works":["https://openalex.org/W3047642739","https://openalex.org/W2111689304","https://openalex.org/W4390329510","https://openalex.org/W1965911896","https://openalex.org/W4386301507","https://openalex.org/W4323056589","https://openalex.org/W7098793285","https://openalex.org/W3126682693","https://openalex.org/W2793536432","https://openalex.org/W3188371230"],"abstract_inverted_index":{"By":[0],"current":[1],"standards":[2],"autoimmunity":[3],"is":[4,109,116],"a":[5,11,32,111,156],"complex":[6],"pathological":[7,18],"process":[8],"based":[9,147],"on":[10,126,138,148],"violation":[12],"of":[13,31,35,54,89,100,113,123,129,145,155,159,172,174,180,187,189,203],"tolerance":[14],"and,":[15],"consequently,":[16],"the":[17,29,67,98,121,127,139,175,178,181],"immune":[19,44,58,76],"response":[20],"against":[21],"its":[22],"own":[23],"tissues":[24],"components":[25,88,179],"(autoantigens)":[26],"leading":[27],"to":[28,200],"development":[30,99],"wide":[33,157],"range":[34,158],"autoimmune":[36,101],"diseases":[37,106,115],"in":[38],"humans.":[39],"In":[40],"recent":[41],"years,":[42],"multiple":[43],"disorders":[45,64],"both":[46],"acquired":[47],"and/":[48],"or":[49],"congenital":[50],"(associated":[51],"with":[52],"polymorphisms":[53],"genes":[55],"that":[56],"regulate":[57],"response)":[59],"have":[60],"been":[61],"transcribed.":[62],"These":[63],"occur":[65],"at":[66],"cellular":[68,162],"and":[69,80,93,104,107,137,143,150,161,191],"humoral":[70],"levels:":[71],"thymus,":[72],"intestines,":[73],"peripheral":[74],"blood":[75],"cells,":[77,85],"including":[78],"T":[79],"B":[81],"lymphocytes,":[82],"macrophages,":[83],"dendritic":[84],"Treg-cells":[86],"(Treg),":[87],"complement":[90,182],"system,":[91,183],"cytokines":[92],"others.":[94],"The":[95,118,198],"interaction":[96],"between":[97],"rheumatic":[102],"(ARD)":[103],"autoinflammatory":[105],"syndromes":[108],"detected;":[110],"classification":[112],"immune-inflammatory":[114],"designed.":[117],"article":[119],"describes":[120],"results":[122],"our":[124],"studies":[125],"treatment":[128,202],"ARD":[130,146,204],"using":[131],"innovative":[132],"genetically":[133],"engineered":[134],"biological":[135,152],"agents":[136],"research":[140],"ofpathogenetic":[141],"mechanisms":[142],"diagnostics":[144],"immunological":[149],"molecular":[151,160],"diagnostic":[153],"techniques":[154],"biomarkers":[163],"(autoantibodies,":[164],"inflammatory":[165],"acute":[166],"phase":[167],"proteins,":[168],"cytokines,":[169],"chemokines,":[170],"markers":[171],"activation":[173],"vascular":[176],"endothelium,":[177],"lymphocyte":[184],"subpopulations,":[185],"products":[186],"metabolism":[188],"bone":[190],"cartilage":[192],"tissue,":[193],"genetic,":[194],"epigenetic,":[195],"transcriptomic":[196],"markers).":[197],"approaches":[199],"personalized":[201],"are":[205],"presented.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}