{"id":"https://openalex.org/W2237614735","doi":"https://doi.org/10.1152/ajpheart.00746.2014","title":"Effects of incremental beta-blocker dosing on myocardial mechanics of the human left ventricle: MRI 3D-tagging insight into pharmacodynamics supports theory of inner antagonism","display_name":"Effects of incremental beta-blocker dosing on myocardial mechanics of the human left ventricle: MRI 3D-tagging insight into pharmacodynamics supports theory of inner antagonism","publication_year":2015,"publication_date":"2015-04-17","ids":{"openalex":"https://openalex.org/W2237614735","doi":"https://doi.org/10.1152/ajpheart.00746.2014","mag":"2237614735","pmid":"https://pubmed.ncbi.nlm.nih.gov/25888512"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00746.2014","doi":"https://doi.org/10.1152/ajpheart.00746.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00746.2014","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34253400","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074652924","display_name":"Boris Schmitt","orcid":"https://orcid.org/0000-0002-6987-1264","observed_orcids":["https://orcid.org/0000-0002-6987-1264"]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Boris Schmitt","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tieyan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tieyan Li","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006021560","display_name":"Shelby Kutty","orcid":"https://orcid.org/0000-0001-9428-0979","observed_orcids":["https://orcid.org/0000-0001-9428-0979"]},"institutions":[{"id":"https://openalex.org/I4210150184","display_name":"Children's Hospital & Medical Center","ror":"https://ror.org/04j36h363","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150184"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelby Kutty","raw_affiliation_strings":["Department of Pediatric Cardiology, University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, Nebraska;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, Nebraska;","institution_ids":["https://openalex.org/I4210150184","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015428277","display_name":"Alireza Khasheei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alireza Khasheei","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058135387","display_name":"Katharina R. L. Schmitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina R. L. Schmitt","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057285218","display_name":"Robert Henry Anderson","orcid":"https://orcid.org/0000-0001-5163-9021","observed_orcids":["https://orcid.org/0000-0001-5163-9021"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert H. Anderson","raw_affiliation_strings":["Institute of Medical Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom; and","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075793188","display_name":"Paul P. Lunkenheimer","orcid":"https://orcid.org/0000-0002-3881-622X","observed_orcids":["https://orcid.org/0000-0002-3881-622X"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul P. Lunkenheimer","raw_affiliation_strings":["Department of Experimental Thoracic and Cardiovascular Surgery, University Hospital M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Thoracic and Cardiovascular Surgery, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083550145","display_name":"Felix F. Berger","orcid":"https://orcid.org/0000-0001-7881-1557","observed_orcids":["https://orcid.org/0000-0001-7881-1557"]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix Berger","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027026850","display_name":"Titus K\u00fchne","orcid":"https://orcid.org/0009-0002-1849-4013","observed_orcids":["https://orcid.org/0009-0002-1849-4013"]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Titus K\u00fchne","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103037833","display_name":"Bj\u00f6rn Peters","orcid":"https://orcid.org/0000-0003-1474-2876","observed_orcids":["https://orcid.org/0000-0003-1474-2876"]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Peters","raw_affiliation_strings":["Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I4210105663"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074652924"],"corresponding_institution_ids":["https://openalex.org/I4210105663"],"apc_list":null,"apc_paid":null,"fwci":1.2104,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.8286841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"309","issue":"1","first_page":"H45","last_page":"H52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9729999899864197},{"id":"https://openalex.org/keywords/esmolol","display_name":"esmolol","score":0.9779999852180481},{"id":"https://openalex.org/keywords/myocardial-mechanics","display_name":"myocardial mechanics","score":0.7379999756813049},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.7699999809265137},{"id":"https://openalex.org/keywords/myocardial-shortening","display_name":"myocardial shortening","score":0.8270000219345093},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ventricular-hypertrophy","display_name":"ventricular hypertrophy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.6549999713897705},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7823620438575745},{"id":"https://openalex.org/C2780996683","wikidata":"https://www.wikidata.org/wiki/Q418139","display_name":"Esmolol","level":4,"score":0.7241966724395752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6552086472511292},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6208652257919312},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5435036420822144},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5368103981018066},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5081546306610107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5028983950614929},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.46817177534103394},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4195692241191864},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.41008105874061584},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2644839286804199},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.239622563123703},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10448715090751648},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0980047881603241},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0979650616645813},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpheart.00746.2014","doi":"https://doi.org/10.1152/ajpheart.00746.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00746.2014","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:25888512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25888512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34253400","doi":"https://doi.org/10.25405/ncl.34253400","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34253400","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34253400.v1","doi":"https://doi.org/10.25405/ncl.34253400.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34253400.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34253400","doi":"https://doi.org/10.25405/ncl.34253400","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34253400","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W40175792","https://openalex.org/W1978292647","https://openalex.org/W1995546178","https://openalex.org/W2003670255","https://openalex.org/W2009292356","https://openalex.org/W2017410839","https://openalex.org/W2024303796","https://openalex.org/W2030553750","https://openalex.org/W2036730723","https://openalex.org/W2042845128","https://openalex.org/W2045584927","https://openalex.org/W2112894095","https://openalex.org/W2113278431","https://openalex.org/W2155214618","https://openalex.org/W2165562521","https://openalex.org/W2170980186","https://openalex.org/W2274103408"],"related_works":["https://openalex.org/W2170980186","https://openalex.org/W2605333007","https://openalex.org/W7018639517","https://openalex.org/W2328842956","https://openalex.org/W1915238334","https://openalex.org/W2013444053","https://openalex.org/W1998412248","https://openalex.org/W2028506186","https://openalex.org/W2416157577","https://openalex.org/W1968308007"],"abstract_inverted_index":{"Beta-blockers":[0],"contribute":[1],"to":[2,101,136,187],"treatment":[3],"of":[4,9,19,36,55,71,121,134,160,170],"heart":[5],"failure.":[6],"Their":[7],"mechanism":[8],"action,":[10],"however,":[11],"is":[12],"incompletely":[13],"understood.":[14],"Gradients":[15],"in":[16],"beta-blocker":[17,191],"sensitivity":[18],"helically":[20],"aligned":[21],"cardiomyocytes":[22,28,39,173],"compared":[23,127,156],"with":[24,128,142,157,164],"counteracting":[25],"transversely":[26,37,171],"intruding":[27,38,172],"seem":[29],"crucial.":[30],"We":[31,58],"hypothesize":[32],"that":[33],"selective":[34,174],"blockade":[35],"by":[40,63],"low-dose":[41,175],"beta-blockade":[42,176],"unloads":[43],"ventricular":[44,165],"performance.":[45,57],"Cardiac":[46],"magnetic":[47],"resonance":[48],"imaging":[49],"(MRI)":[50],"3D":[51,65,183],"tagging":[52,66,184],"delivers":[53],"parameters":[54],"myocardial":[56,78,152],"studied":[59],"13":[60],"healthy":[61,146],"volunteers":[62,147],"MRI":[64,182],"during":[67],"escalated":[68],"intravenous":[69],"administration":[70],"esmolol.":[72,131],"The":[73,85],"circumferential,":[74],"longitudinal,":[75],"and":[76,94,167],"radial":[77],"shortening":[79,153],"was":[80],"determined":[81],"for":[82,89],"each":[83],"dose.":[84],"curves":[86,123],"were":[87],"analyzed":[88],"peak":[90,104],"value,":[91],"time-to-peak,":[92],"upslope,":[93],"area-under-the-curve.":[95],"At":[96,132],"low":[97,125,155],"doses,":[98],"from":[99],"5":[100],"25":[102],"\u03bcg\u00b7kg(-1)\u00b7min(-1),":[103,138],"contraction":[105],"increased":[106],"while":[107],"time-to-peak":[108],"decreased":[109],"yielding":[110],"a":[111,118,139],"steeper":[112],"upslope.":[113],"Combining":[114],"the":[115,122],"values":[116],"revealed":[117],"left":[119],"shift":[120,141],"at":[124,154],"doses":[126,133],"baseline":[129],"without":[130],"50":[135],"150":[137],"right":[140],"flattening":[143],"occurred.":[144],"In":[145,162],"we":[148],"found":[149],"more":[150,180],"pronounced":[151],"clinical":[158],"dosage":[159],"beta-blockers.":[161],"patients":[163],"hypertrophy":[166],"higher":[168],"prevalence":[169],"could":[177,185],"be":[178],"even":[179],"effective.":[181],"help":[186],"determine":[188],"optimal":[189],"individual":[190],"dosing":[192],"avoiding":[193],"undesirable":[194],"side":[195],"effects.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
