{"id":"https://openalex.org/W2235889356","doi":"https://doi.org/10.1007/s10337-015-3019-3","title":"Development of an HPLC-FLD Method for Determination of Rhodamine-123 in Caco-2 Cell-Based Permeability Studies","display_name":"Development of an HPLC-FLD Method for Determination of Rhodamine-123 in Caco-2 Cell-Based Permeability Studies","publication_year":2016,"publication_date":"2016-01-09","ids":{"openalex":"https://openalex.org/W2235889356","doi":"https://doi.org/10.1007/s10337-015-3019-3","mag":"2235889356"},"language":"en","primary_location":{"id":"doi:10.1007/s10337-015-3019-3","doi":"https://doi.org/10.1007/s10337-015-3019-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10337-015-3019-3","pdf_url":null,"source":{"id":"https://openalex.org/S6712347","display_name":"Chromatographia","issn_l":"0009-5893","issn":["0009-5893","1612-1112"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chromatographia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100941253","display_name":"Zhonglian Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhonglian Cao","raw_affiliation_strings":["School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Pudong, 201203, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Pudong, 201203, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":["Children\u2019s Hospital of Fudan University, Minhang, 201102, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Fudan University, Minhang, 201102, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087587395","display_name":"Xueling Liao","orcid":"https://orcid.org/0000-0001-5986-0054","observed_orcids":["https://orcid.org/0000-0001-5986-0054"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueling Liao","raw_affiliation_strings":["School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Pudong, 201203, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Pudong, 201203, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100681639","display_name":"Ping Yang","orcid":"https://orcid.org/0000-0003-2904-8916","observed_orcids":["https://orcid.org/0000-0003-2904-8916"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Yang","raw_affiliation_strings":["School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Pudong, 201203, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Pudong, 201203, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100681639"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.1801,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61293259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"79","issue":"3-4","first_page":"261","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.20669999718666077,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodamine-123","display_name":"rhodamine 123","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hplc-with-fluorescence-detection","display_name":"HPLC-fluorescence detection","score":0.8270000219345093},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.7829999923706055},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibitors","display_name":"P-glycoprotein inhibitors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tetrandrine","display_name":"tetrandrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.7059999704360962},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.4490000009536743},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8353770971298218},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.7100551128387451},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6900292038917542},{"id":"https://openalex.org/C2778589691","wikidata":"https://www.wikidata.org/wiki/Q3429577","display_name":"Rhodamine 123","level":4,"score":0.6717618703842163},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.6620302200317383},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6196762323379517},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6086360812187195},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.5666698813438416},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.469054251909256},{"id":"https://openalex.org/C2779916640","wikidata":"https://www.wikidata.org/wiki/Q420410","display_name":"Rhodamine","level":3,"score":0.43433335423469543},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2276458740234375},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22595107555389404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1777454912662506},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.144801527261734},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s10337-015-3019-3","doi":"https://doi.org/10.1007/s10337-015-3019-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10337-015-3019-3","pdf_url":null,"source":{"id":"https://openalex.org/S6712347","display_name":"Chromatographia","issn_l":"0009-5893","issn":["0009-5893","1612-1112"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chromatographia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1574019439","https://openalex.org/W1603239479","https://openalex.org/W1904678284","https://openalex.org/W1966255834","https://openalex.org/W1975566374","https://openalex.org/W1979196526","https://openalex.org/W2003143984","https://openalex.org/W2028273867","https://openalex.org/W2035803268","https://openalex.org/W2044148793","https://openalex.org/W2046827775","https://openalex.org/W2049135632","https://openalex.org/W2083206079","https://openalex.org/W2103278059","https://openalex.org/W2119203526","https://openalex.org/W2123002505","https://openalex.org/W2132542476","https://openalex.org/W2165711991","https://openalex.org/W2512454832"],"related_works":["https://openalex.org/W1244355934","https://openalex.org/W2086013018","https://openalex.org/W2041700999","https://openalex.org/W2219017300","https://openalex.org/W3046846159","https://openalex.org/W2103278059","https://openalex.org/W2039278445","https://openalex.org/W2067688780","https://openalex.org/W2014008305","https://openalex.org/W2055683699"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}