{"id":"https://openalex.org/W2235566368","doi":null,"title":"Acute otitis media in young children : randomized controlled trials of antimicrobial treatment, prevention and quality of life","display_name":"Acute otitis media in young children : randomized controlled trials of antimicrobial treatment, prevention and quality of life","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2235566368","mag":"2235566368"},"language":"en","primary_location":{"id":"mag:2235566368","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9789526208909.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002410601","display_name":"Tiia Kujala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tiia Kujala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002410601"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2675,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77648404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-otitis-media","display_name":"acute otitis media","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recurrent-otitis-media","display_name":"recurrent otitis media","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/middle-ear-effusion","display_name":"middle ear effusion","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tympanostomy-tubes","display_name":"tympanostomy tubes","score":0.8519999980926514},{"id":"https://openalex.org/keywords/adenoidectomy","display_name":"adenoidectomy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.734000027179718},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5379999876022339},{"id":"https://openalex.org/keywords/tympanometry","display_name":"tympanometry","score":0.7300000190734863},{"id":"https://openalex.org/keywords/parental-quality-of-life","display_name":"parental quality of life","score":0.550000011920929},{"id":"https://openalex.org/keywords/tympanoplasty","display_name":"tympanoplasty","score":0.5239999890327454},{"id":"https://openalex.org/keywords/mastoidectomy","display_name":"mastoidectomy","score":0.5360000133514404},{"id":"https://openalex.org/keywords/tympanoplasty-outcomes","display_name":"tympanoplasty outcomes","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.946434497833252},{"id":"https://openalex.org/C2780283655","wikidata":"https://www.wikidata.org/wiki/Q1671504","display_name":"Tympanometry","level":4,"score":0.8455823063850403},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6971532106399536},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6032541394233704},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.596244215965271},{"id":"https://openalex.org/C2776439223","wikidata":"https://www.wikidata.org/wiki/Q480700","display_name":"Otitis","level":2,"score":0.595801055431366},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5821556448936462},{"id":"https://openalex.org/C163430725","wikidata":"https://www.wikidata.org/wiki/Q424532","display_name":"Effusion","level":2,"score":0.5673477053642273},{"id":"https://openalex.org/C2777346780","wikidata":"https://www.wikidata.org/wiki/Q356194","display_name":"Adenoidectomy","level":3,"score":0.4571648836135864},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45102518796920776},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4363844394683838},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3761756718158722},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25468507409095764},{"id":"https://openalex.org/C2779073326","wikidata":"https://www.wikidata.org/wiki/Q170381","display_name":"Tonsillectomy","level":2,"score":0.19959136843681335},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.15689095854759216},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.15455934405326843},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.06461051106452942},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2235566368","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9789526208909.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":225,"referenced_works":["https://openalex.org/W79463187","https://openalex.org/W94718963","https://openalex.org/W129762789","https://openalex.org/W159607295","https://openalex.org/W180230778","https://openalex.org/W198805990","https://openalex.org/W1482787702","https://openalex.org/W1498584195","https://openalex.org/W1528745862","https://openalex.org/W1551409957","https://openalex.org/W1563624628","https://openalex.org/W1581023115","https://openalex.org/W1593100288","https://openalex.org/W1600438245","https://openalex.org/W1604318881","https://openalex.org/W1826610031","https://openalex.org/W1845923557","https://openalex.org/W1853791642","https://openalex.org/W1912804674","https://openalex.org/W1932972313","https://openalex.org/W1958252340","https://openalex.org/W1962683771","https://openalex.org/W1965558315","https://openalex.org/W1966710383","https://openalex.org/W1967813898","https://openalex.org/W1969074108","https://openalex.org/W1970701302","https://openalex.org/W1971788582","https://openalex.org/W1973726186","https://openalex.org/W1974210311","https://openalex.org/W1975722696","https://openalex.org/W1975930329","https://openalex.org/W1977084891","https://openalex.org/W1978758220","https://openalex.org/W1978978834","https://openalex.org/W1979727882","https://openalex.org/W1979782902","https://openalex.org/W1979856180","https://openalex.org/W1980949414","https://openalex.org/W1982245642","https://openalex.org/W1982912848","https://openalex.org/W1982931044","https://openalex.org/W1984566099","https://openalex.org/W1985080501","https://openalex.org/W1988078823","https://openalex.org/W1988434387","https://openalex.org/W1990017677","https://openalex.org/W1990945560","https://openalex.org/W1991373559","https://openalex.org/W1992659048","https://openalex.org/W1993427425","https://openalex.org/W1995613822","https://openalex.org/W1996140932","https://openalex.org/W1996465498","https://openalex.org/W1996774484","https://openalex.org/W1996887025","https://openalex.org/W1996913920","https://openalex.org/W1997511481","https://openalex.org/W2002274677","https://openalex.org/W2003157535","https://openalex.org/W2004345624","https://openalex.org/W2007084225","https://openalex.org/W2007851903","https://openalex.org/W2008556541","https://openalex.org/W2008601728","https://openalex.org/W2009613022","https://openalex.org/W2010334392","https://openalex.org/W2010676240","https://openalex.org/W2011157158","https://openalex.org/W2012150652","https://openalex.org/W2012968801","https://openalex.org/W2013168997","https://openalex.org/W2013452417","https://openalex.org/W2014104046","https://openalex.org/W2017098827","https://openalex.org/W2017206704","https://openalex.org/W2018508067","https://openalex.org/W2019602591","https://openalex.org/W2021230298","https://openalex.org/W2021796563","https://openalex.org/W2022966386","https://openalex.org/W2023625570","https://openalex.org/W2024466692","https://openalex.org/W2026818875","https://openalex.org/W2027298079","https://openalex.org/W2027865237","https://openalex.org/W2030185838","https://openalex.org/W2030503980","https://openalex.org/W2031319641","https://openalex.org/W2032201324","https://openalex.org/W2034153524","https://openalex.org/W2034745373","https://openalex.org/W2035423366","https://openalex.org/W2035431567","https://openalex.org/W2035459955","https://openalex.org/W2036151753","https://openalex.org/W2037752261","https://openalex.org/W2039230725","https://openalex.org/W2040175992","https://openalex.org/W2040737980","https://openalex.org/W2041147541","https://openalex.org/W2044323817","https://openalex.org/W2046703544","https://openalex.org/W2051862350","https://openalex.org/W2052509225","https://openalex.org/W2054172607","https://openalex.org/W2055409587","https://openalex.org/W2057456741","https://openalex.org/W2057809421","https://openalex.org/W2059512533","https://openalex.org/W2059875807","https://openalex.org/W2061486920","https://openalex.org/W2063469440","https://openalex.org/W2064295915","https://openalex.org/W2065673455","https://openalex.org/W2066895487","https://openalex.org/W2067713246","https://openalex.org/W2068240651","https://openalex.org/W2069097723","https://openalex.org/W2070409252","https://openalex.org/W2072363856","https://openalex.org/W2073532367","https://openalex.org/W2074767095","https://openalex.org/W2075275158","https://openalex.org/W2076907320","https://openalex.org/W2078558628","https://openalex.org/W2079172396","https://openalex.org/W2081627469","https://openalex.org/W2081819577","https://openalex.org/W2084191728","https://openalex.org/W2085895329","https://openalex.org/W2088244608","https://openalex.org/W2089114810","https://openalex.org/W2089467774","https://openalex.org/W2090859065","https://openalex.org/W2090865013","https://openalex.org/W2090968165","https://openalex.org/W2092601695","https://openalex.org/W2093326054","https://openalex.org/W2093625209","https://openalex.org/W2095074862","https://openalex.org/W2097166599","https://openalex.org/W2099164514","https://openalex.org/W2099409015","https://openalex.org/W2100097059","https://openalex.org/W2101615652","https://openalex.org/W2105173090","https://openalex.org/W2105436171","https://openalex.org/W2105675648","https://openalex.org/W2107155132","https://openalex.org/W2109934495","https://openalex.org/W2110148332","https://openalex.org/W2110275928","https://openalex.org/W2110539907","https://openalex.org/W2110624979","https://openalex.org/W2110661096","https://openalex.org/W2111556556","https://openalex.org/W2111828634","https://openalex.org/W2112078228","https://openalex.org/W2112101284","https://openalex.org/W2115200058","https://openalex.org/W2116355732","https://openalex.org/W2117450257","https://openalex.org/W2118710869","https://openalex.org/W2119561943","https://openalex.org/W2120031697","https://openalex.org/W2121269352","https://openalex.org/W2122040197","https://openalex.org/W2122816801","https://openalex.org/W2122858334","https://openalex.org/W2122894476","https://openalex.org/W2123177155","https://openalex.org/W2123233957","https://openalex.org/W2125640600","https://openalex.org/W2126990616","https://openalex.org/W2127172447","https://openalex.org/W2128161956","https://openalex.org/W2133319648","https://openalex.org/W2134027088","https://openalex.org/W2134766294","https://openalex.org/W2135901532","https://openalex.org/W2139664065","https://openalex.org/W2140187573","https://openalex.org/W2144210627","https://openalex.org/W2145181045","https://openalex.org/W2145654322","https://openalex.org/W2149240402","https://openalex.org/W2149579741","https://openalex.org/W2150500774","https://openalex.org/W2152522593","https://openalex.org/W2154213597","https://openalex.org/W2157673810","https://openalex.org/W2158289146","https://openalex.org/W2159189010","https://openalex.org/W2161213320","https://openalex.org/W2163130233","https://openalex.org/W2163468581","https://openalex.org/W2165515055","https://openalex.org/W2169729911","https://openalex.org/W2169928094","https://openalex.org/W2222610549","https://openalex.org/W2223290064","https://openalex.org/W2223789614","https://openalex.org/W2224422624","https://openalex.org/W2227283879","https://openalex.org/W2233229877","https://openalex.org/W2233531630","https://openalex.org/W2235655171","https://openalex.org/W2237451584","https://openalex.org/W2238843201","https://openalex.org/W2238847304","https://openalex.org/W2245169090","https://openalex.org/W2317705821","https://openalex.org/W2319166635","https://openalex.org/W2328198785","https://openalex.org/W2337235121","https://openalex.org/W2340010939","https://openalex.org/W2397878654","https://openalex.org/W2407970072","https://openalex.org/W2408822287","https://openalex.org/W2408834558","https://openalex.org/W2480993318","https://openalex.org/W2605667004","https://openalex.org/W4229741621","https://openalex.org/W4246147341"],"related_works":["https://openalex.org/W4250385459","https://openalex.org/W1982245642","https://openalex.org/W921304037","https://openalex.org/W7064334591","https://openalex.org/W1965558315","https://openalex.org/W2164936674","https://openalex.org/W2028467589","https://openalex.org/W7052044111","https://openalex.org/W2062279680","https://openalex.org/W2022966386"],"abstract_inverted_index":{"The":[0,57,172],"purpose":[1],"of":[2,10,24,38,42,59,108,133,154,174,211,277,318,349],"this":[3,237],"study":[4,314],"was":[5,63,75,176,248,306],"to":[6,21,99,189,196,202,242,290,303,336],"evaluate":[7,22,35],"the":[8,36,112,136,142,157,163,280,285,295,313,316,347,378],"effect":[9,173,317,348],"antibiotic":[11,50,137,158],"treatment":[12,53],"and":[13,20,31,90,139,160,205,207,292,299,330,343,346,356],"surgery":[14,175,319,350],"on":[15,315,351,391],"acute":[16],"otitis":[17],"media":[18],"(AOM),":[19],"quality":[23],"life":[25],"(QoL)":[26],"among":[27,124,308,339],"children":[28,44,134,155,182,212,225,278,310,321,340],"with":[29,45,183,297,322,341,354],"AOM":[30,46,235,256,342,355],"their":[32,232,344,357],"parents.":[33],"To":[34],"effectiveness":[37],"antibiotics,":[39,115],"a":[40,106,221,252,360],"total":[41],"82":[43],"were":[47,96,240],"randomized":[48],"for":[49,54,105,220,270],"or":[51,102,104,231,266],"placebo":[52,127,143,164],"7":[55,88],"days.":[56],"duration":[58],"middle":[60,116,168],"ear":[61,117,169],"effusion":[62,118,170,268],"measured":[64,77],"by":[65,178],"daily":[66],"tympanometry":[67,147],"screenings":[68],"at":[69,78,82,214,370],"home":[70],"over":[71],"2":[72,109,190,255,259,271],"weeks.":[73],"Duration":[74],"also":[76],"clinical":[79,215],"visits,":[80],"including":[81],"entry,":[83],"after":[84,87],"3":[85,193,261],"days,":[86,89],"then":[91],"weekly":[92],"until":[93],"both":[94],"ears":[95],"healthy":[97,365,382],"according":[98],"pneumatic":[100],"otoscopy":[101],"otomicroscopy,":[103],"maximum":[107],"months.":[110,272],"Among":[111],"group":[113,138,144,159,165,287,296],"receiving":[114,126],"disappeared":[119],"2.0":[120],"weeks":[121],"earlier":[122],"than":[123,364],"those":[125],"(P<0.02).":[128],"On":[129,150],"day":[130,151],"14,":[131],"69%":[132],"in":[135,141,156,162,258,263,275,279,284,294,312,320,381],"38%":[140],"had":[145,166,254,359],"normal":[146],"findings":[148],"(P=0.02).":[149],"60,":[152],"5%":[153],"24%":[161],"persistent":[167,267],"(P=0.01).":[171],"assessed":[177,307],"randomly":[179],"assigning":[180],"300":[181],"recurrent":[184,323],"AOM,":[185],"aged":[186],"10":[187],"months":[188,219,265],"years,":[191],"into":[192],"groups:":[194],"1.":[195],"receive":[197,203,243],"ventilation":[198],"tubes":[199],"(VTs),":[200],"2.":[201],"VTs":[204],"adenoidectomy":[206,300],"3.":[208],"non-surgery.":[209],"Follow-up":[210],"occurred":[213],"visits":[216],"every":[217],"4":[218],"1-year":[222,371],"period.":[223],"If":[224],"suffered":[226],"from":[227],"upper":[228],"respiratory":[229],"symptoms":[230],"parents":[233,358],"suspected":[234],"during":[236],"period":[238],"they":[239],"encouraged":[241],"additional":[244,389],"follow-up":[245],"care.":[246],"Intervention":[247,273],"considered":[249],"unsuccessful":[250],"if":[251],"child":[253],"episodes":[257,262],"months,":[260],"6":[264],"lasting":[269],"failed":[274],"34%":[276],"non-surgery":[281],"group,":[282],"21%":[283],"VT":[286,298],"(P=0.04":[288],"compared":[289,302],"non-surgery)":[291],"16%":[293],"(P=0.004":[301],"non-surgery).":[304],"QoL":[305,338,363,367],"159":[309],"participating":[311],"AOM.":[324],"We":[325],"used":[326],"disease-specific":[327],"(Otitis":[328],"Media-6)":[329],"generic":[331],"instruments":[332],"(Child":[333],"Health":[334],"Questionnaire-50)":[335],"measure":[337],"parents,":[345],"QoL.":[352,392],"Children":[353],"significantly":[361,369],"poorer":[362],"children.":[366,383],"improved":[368],"follow-up,":[372],"but":[373],"it":[374],"did":[375,385],"not":[376,386],"reach":[377],"level":[379],"observed":[380],"Surgery":[384],"have":[387],"any":[388],"impact":[390]},"counts_by_year":[{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}