{"id":"https://openalex.org/W2235524659","doi":null,"title":"Altered dopamine D1 and D2 receptor mRNA expression in mesencephalon from mice exposed to repeated treatments with methamphetamine and cannabinoid CB1 agonist methanandamide.","display_name":"Altered dopamine D1 and D2 receptor mRNA expression in mesencephalon from mice exposed to repeated treatments with methamphetamine and cannabinoid CB1 agonist methanandamide.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2235524659","mag":"2235524659","pmid":"https://pubmed.ncbi.nlm.nih.gov/22936253"},"language":"en","primary_location":{"id":"pmid:22936253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22936253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090584570","display_name":"Leo\u0161 Landa","orcid":"https://orcid.org/0000-0002-5551-8734","observed_orcids":["https://orcid.org/0000-0002-5551-8734"]},"institutions":[{"id":"https://openalex.org/I113254221","display_name":"University of Veterinary Sciences Brno","ror":"https://ror.org/04rk6w354","country_code":"CZ","type":"education","lineage":["https://openalex.org/I113254221"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Leos Landa","raw_affiliation_strings":["Department of Pharmacology and Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic","institution_ids":["https://openalex.org/I113254221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038951792","display_name":"Michal Jurajda","orcid":"https://orcid.org/0000-0003-1017-4357","observed_orcids":["https://orcid.org/0000-0003-1017-4357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Jurajda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048587359","display_name":"Alexandra \u0160ulcov\u00e1","orcid":"https://orcid.org/0000-0001-8854-558X","observed_orcids":["https://orcid.org/0000-0001-8854-558X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Sulcova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0776,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74182044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"4","first_page":"446","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":1.0},{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.6809999942779541},{"id":"https://openalex.org/keywords/methanandamide","display_name":"methanandamide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/receptor-crosstalk","display_name":"receptor cross-talk","score":0.5709999799728394},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.781000018119812},{"id":"https://openalex.org/keywords/behavioral-sensitization","display_name":"behavioral sensitization","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cross-sensitization","display_name":"cross-sensitization","score":0.9829999804496765},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/receptor-mrna-expression","display_name":"receptor mRNA expression","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.8433348536491394},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.8017880916595459},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.7594242691993713},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7367251515388489},{"id":"https://openalex.org/C2778296116","wikidata":"https://www.wikidata.org/wiki/Q253187","display_name":"Quinpirole","level":4,"score":0.6027155518531799},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5768499970436096},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.4684130549430847},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.45556238293647766},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.4451267123222351},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.44122034311294556},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.436953067779541},{"id":"https://openalex.org/C2778258207","wikidata":"https://www.wikidata.org/wiki/Q600203","display_name":"Dopamine agonist","level":4,"score":0.43339449167251587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3783615231513977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36111700534820557},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34712547063827515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3270530104637146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30654633045196533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2216271162033081},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.145843505859375}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017447","descriptor_name":"Receptors, Dopamine D1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017447","descriptor_name":"Receptors, Dopamine D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017447","descriptor_name":"Receptors, Dopamine D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059333","descriptor_name":"Central Nervous System Sensitization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22936253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22936253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:2235524659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22936253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1613719983","https://openalex.org/W1654795077","https://openalex.org/W1671111160","https://openalex.org/W1968889342","https://openalex.org/W1985417344","https://openalex.org/W1986626488","https://openalex.org/W1990225937","https://openalex.org/W1999771095","https://openalex.org/W2010467963","https://openalex.org/W2012449993","https://openalex.org/W2024078494","https://openalex.org/W2028476505","https://openalex.org/W2041739013","https://openalex.org/W2049244494","https://openalex.org/W2049796382","https://openalex.org/W2053430303","https://openalex.org/W2055954675","https://openalex.org/W2059410203","https://openalex.org/W2067745857","https://openalex.org/W2067873567","https://openalex.org/W2071330075","https://openalex.org/W2075429497","https://openalex.org/W2087754468","https://openalex.org/W2088522292","https://openalex.org/W2089172972","https://openalex.org/W2090481799","https://openalex.org/W2098730433","https://openalex.org/W2106862702","https://openalex.org/W2109807784","https://openalex.org/W2125364966","https://openalex.org/W2127946577","https://openalex.org/W2130332398","https://openalex.org/W2131667348","https://openalex.org/W2135773579","https://openalex.org/W2153060278","https://openalex.org/W2156217052","https://openalex.org/W2166224717","https://openalex.org/W2168882723","https://openalex.org/W2170938765","https://openalex.org/W2315122190","https://openalex.org/W2400322879","https://openalex.org/W2404024030","https://openalex.org/W2429658157","https://openalex.org/W2624946009"],"related_works":["https://openalex.org/W2429658157","https://openalex.org/W2067609167","https://openalex.org/W2624946009","https://openalex.org/W2010467963","https://openalex.org/W2626751110","https://openalex.org/W2622229847","https://openalex.org/W281154781","https://openalex.org/W4226182301","https://openalex.org/W2095428224","https://openalex.org/W2084058724"],"abstract_inverted_index":{"OBJECTIVES:":[0],"In":[1,244],"our":[2,166,274],"previous":[3],"studies":[4,168],"we":[5,57,104,174],"found":[6,175],"that":[7,50,277],"both":[8,180,254,278],"acute":[9],"administration":[10],"of":[11,64,98,131,135,165,182,218,227,234,259],"CB1":[12,29,46,89,200],"receptor":[13,30,69,90,199,211,251,288,301],"agonist":[14,91,201],"methanandamide":[15,18,92,235,262,281],"and":[16,47,67,83,139,150,155,191,229,261,280,297],"repeated":[17,77,124,189],"pre-treatment":[19,125,196],"prior":[20],"to":[21,79,85,184,193],"methamphetamine":[22,80,86,120,122,185,219,241,260,268],"challenge":[23,242,269],"dose":[24,217,226,233,258],"elicited":[25],"increase":[26,208,294],"in":[27,33,61,71,73,107,163,176,209,249,286,290,295,299],"the":[28,34,44,110,140,148,170,177,215,224,231,240,256,267,293],"mRNA":[31,70,212,252],"expression":[32,63,213,253],"mouse":[35,291],"mesencephalon.":[36],"As":[37,162],"a":[38,246],"reciprocal":[39],"cross-talk":[40],"is":[41],"reported":[42],"between":[43],"cannabinoid":[45,88,198],"dopamine":[48,65,287],"receptors,":[49],"are":[51],"highly":[52],"co-localized":[53],"on":[54],"brain":[55,141],"neurones,":[56],"targeted":[58],"possible":[59],"changes":[60,106,285],"relative":[62],"D1":[66,210,296],"D2":[68,250,300],"mesencephalon":[72],"mice":[74],"sensitized":[75],"by":[76,87,195],"treatments":[78],"stimulatory":[81,186],"effects":[82,187],"cross-sensitized":[84],"pre-treatment.":[93],"METHODS:":[94],"To":[95],"confirm":[96],"development":[97,181],"behavioural":[99,178],"sensitization":[100,183],"or":[101,121],"cross-sensitization,":[102],"respectively,":[103],"observed":[105],"locomotion":[108,132],"using":[109],"open":[111],"field":[112],"test.":[113],"Mice":[114],"were":[115,137],"treated":[116],"repeatedly":[117],"with":[118,126,169,197],"either":[119],"after":[123,188,214,223,230,239,255,266],"methanandamide.":[127,202],"After":[128],"each":[129],"measurement":[130],"one":[133],"third":[134],"animals":[136],"sacrificed":[138],"was":[142,145,271],"stored.":[143],"RNA":[144],"isolated":[146],"from":[147],"midbrain":[149],"used":[151],"for":[152],"reverse":[153],"transcription":[154],"subsequent":[156],"real-time":[157],"PCR.":[158],"RESULTS":[159],"AND":[160],"CONCLUSION:":[161],"many":[164],"earlier":[167],"same":[171],"dosage":[172],"regimen":[173],"part":[179],"treatment":[190,282],"cross-sensitization":[192],"them":[194],"Real-time":[203],"PCR":[204],"analyses":[205],"showed":[206],"an":[207],"first":[216,232,257],"(that":[220,263],"persisted":[221,238,264],"also":[222,237,265],"last":[225],"methamphetamine)":[228],"(which":[236],"dose).":[243],"opposite":[245],"significant":[247],"decrease":[248,298],"doses)":[270],"registered.":[272],"Thus,":[273],"results":[275],"suggest":[276],"methamphetmine":[279],"can":[283],"provoke":[284],"density":[289],"mesenpcephalon,":[292],"subtypes.":[302]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}