{"id":"https://openalex.org/W2235218503","doi":"https://doi.org/10.1016/j.ymben.2016.01.004","title":"Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli","display_name":"Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli","publication_year":2016,"publication_date":"2016-01-15","ids":{"openalex":"https://openalex.org/W2235218503","doi":"https://doi.org/10.1016/j.ymben.2016.01.004","mag":"2235218503","pmid":"https://pubmed.ncbi.nlm.nih.gov/26778413"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymben.2016.01.004","doi":"https://doi.org/10.1016/j.ymben.2016.01.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymben.2016.01.004","pdf_url":null,"source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101648624","display_name":"Zhengjun Li","orcid":"https://orcid.org/0000-0001-6249-637X","observed_orcids":["https://orcid.org/0000-0001-6249-637X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zheng-Jun Li","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":"https://orcid.org/0000-0001-6249-637X","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I75390827"]},{"raw_affiliation_string":"Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I75390827"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033912004","display_name":"Kangjian Qiao","orcid":"https://orcid.org/0000-0002-9897-1707","observed_orcids":["https://orcid.org/0000-0002-9897-1707"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kangjian Qiao","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609790","display_name":"Weichao Shi","orcid":"https://orcid.org/0000-0002-3587-6729","observed_orcids":["https://orcid.org/0000-0002-3587-6729","https://orcid.org/0000-0003-4625-4797"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weichao Shi","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Pereira","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haoran Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoran Zhang","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063934419","display_name":"Bradley D. Olsen","orcid":"https://orcid.org/0000-0002-7272-7140","observed_orcids":["https://orcid.org/0000-0002-7272-7140"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley D. Olsen","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: gregstep@mit.edu","Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: gregstep@mit.edu","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009763658"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.6868,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.88782472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"35","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14285","display_name":"Biopolymer Synthesis and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyhydroxyalkanoates","display_name":"polyhydroxyalkanoates","score":0.746999979019165},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.671999990940094},{"id":"https://openalex.org/keywords/glucose-conversion","display_name":"glucose conversion","score":0.39399999380111694},{"id":"https://openalex.org/keywords/glyoxylate-reductase","display_name":"glyoxylate reductase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/3-hydroxybutyryl-coa","display_name":"3-hydroxybutyryl-CoA","score":0.9620000123977661},{"id":"https://openalex.org/keywords/polyhydroxyalkanoate-synthase","display_name":"polyhydroxyalkanoate synthase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cupriavidus-necator","display_name":"Cupriavidus necator","score":0.8349999785423279},{"id":"https://openalex.org/keywords/crystallinity","display_name":"crystallinity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.6420000195503235},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7620300054550171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6389358043670654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6204943060874939},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5943595170974731},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5346915125846863},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11080935597419739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06090930104255676}],"mesh":[{"descriptor_ui":"D000070101","descriptor_name":"Megasphaera elsdenii","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000070101","descriptor_name":"Megasphaera elsdenii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020118","descriptor_name":"Cupriavidus necator","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020118","descriptor_name":"Cupriavidus necator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ymben.2016.01.004","doi":"https://doi.org/10.1016/j.ymben.2016.01.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymben.2016.01.004","pdf_url":null,"source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},{"id":"pmid:26778413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26778413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G116326153","display_name":null,"funder_award_id":"DE-SC0012377","funder_id":"https://openalex.org/F4320310419","funder_display_name":"Pennsylvania State University"},{"id":"https://openalex.org/G2565181513","display_name":"\u5927\u80a0\u6746\u83cc\u6728\u7cd6\u751f\u7269\u5408\u6210\u4e59\u9187\u9178\u548c\u4e59\u9187\u9178\u57fa\u805a\u5408\u7269\u7684\u4ee3\u8c22\u5de5\u7a0b\u7814\u7a76","funder_award_id":"21476014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3519002784","display_name":null,"funder_award_id":"02/MI/MI/CP/11/ 07633/GEN/G/00","funder_id":"https://openalex.org/F4320309369","funder_display_name":"Massachusetts Institute of Technology"},{"id":"https://openalex.org/G8886465312","display_name":"NAD\u6fc0\u9176\u7684\u57fa\u56e0\u7ec4\u8fc7\u8868\u8fbe\u53ca\u5176\u8c03\u63a7PHB\u5408\u6210\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"31100025","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320310419","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322420","display_name":"Masdar Institute of Science and Technology","ror":"https://ror.org/05hffr360"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1524508146","https://openalex.org/W1591010486","https://openalex.org/W1964833768","https://openalex.org/W1982334966","https://openalex.org/W1985241293","https://openalex.org/W1988777459","https://openalex.org/W1992753818","https://openalex.org/W1995873602","https://openalex.org/W2009381454","https://openalex.org/W2015639818","https://openalex.org/W2020398834","https://openalex.org/W2020866548","https://openalex.org/W2023188336","https://openalex.org/W2024763584","https://openalex.org/W2028548623","https://openalex.org/W2033051381","https://openalex.org/W2034636366","https://openalex.org/W2035081785","https://openalex.org/W2036917159","https://openalex.org/W2045264900","https://openalex.org/W2048784314","https://openalex.org/W2056778275","https://openalex.org/W2061045095","https://openalex.org/W2076925826","https://openalex.org/W2088914103","https://openalex.org/W2090118779","https://openalex.org/W2091646456","https://openalex.org/W2093230215","https://openalex.org/W2102668223","https://openalex.org/W2115522644","https://openalex.org/W2116137883","https://openalex.org/W2119815359","https://openalex.org/W2123794239","https://openalex.org/W2126123875","https://openalex.org/W2142198651","https://openalex.org/W2152211203","https://openalex.org/W2166879168","https://openalex.org/W2167149191","https://openalex.org/W2323757040","https://openalex.org/W2334850571","https://openalex.org/W4211245217"],"related_works":["https://openalex.org/W2754424078","https://openalex.org/W2940380860","https://openalex.org/W2035081785","https://openalex.org/W2091222369","https://openalex.org/W2296914528","https://openalex.org/W7163021835","https://openalex.org/W3015480064","https://openalex.org/W2069874154","https://openalex.org/W2019611830","https://openalex.org/W2077066088"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
