{"id":"https://openalex.org/W2235201945","doi":null,"title":"Der protektive Einfluss des TNF-alpha-Antik\u00f6rpers auf die Pathogenese der nekrotisierenden Enterocolitis","display_name":"Der protektive Einfluss des TNF-alpha-Antik\u00f6rpers auf die Pathogenese der nekrotisierenden Enterocolitis","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2235201945","mag":"2235201945"},"language":"de","primary_location":{"id":"mag:2235201945","doi":null,"is_oa":false,"landing_page_url":"https://publikationen.uni-tuebingen.de/xmlui/bitstream/10900/45080/1/pdf/Doktorarbeit_weng.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011216660","display_name":"Monika Maria Weng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monika Maria Weng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011216660"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13206","display_name":"Neonatal skin health care","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tnf-alpha-antibodies","display_name":"TNF-alpha antibodies","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tnf-alpha-blockade","display_name":"TNF-alpha blockade","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neonatal-inflammation","display_name":"neonatal inflammation","score":0.49399998784065247},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.5320000052452087},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bottle-feeding","display_name":"bottle feeding","score":0.625},{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.5720000267028809},{"id":"https://openalex.org/keywords/neonatal-rat-model","display_name":"neonatal rat model","score":0.5109999775886536},{"id":"https://openalex.org/keywords/nec-pathogenesis","display_name":"NEC pathogenesis","score":0.48500001430511475},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7925840616226196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5059129595756531},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41262054443359375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16482198238372803}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2235201945","doi":null,"is_oa":false,"landing_page_url":"https://publikationen.uni-tuebingen.de/xmlui/bitstream/10900/45080/1/pdf/Doktorarbeit_weng.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W49407949","https://openalex.org/W71639122","https://openalex.org/W336804536","https://openalex.org/W619670566","https://openalex.org/W1480326397","https://openalex.org/W1523012725","https://openalex.org/W1543006452","https://openalex.org/W1589415602","https://openalex.org/W1600123260","https://openalex.org/W1856132450","https://openalex.org/W1935587632","https://openalex.org/W1965732972","https://openalex.org/W1968057232","https://openalex.org/W1968713831","https://openalex.org/W1976390544","https://openalex.org/W1978031368","https://openalex.org/W1979722576","https://openalex.org/W1985194981","https://openalex.org/W1986569120","https://openalex.org/W1989647615","https://openalex.org/W1989825777","https://openalex.org/W1999797629","https://openalex.org/W2002483968","https://openalex.org/W2005629510","https://openalex.org/W2011292542","https://openalex.org/W2013204608","https://openalex.org/W2013482119","https://openalex.org/W2016283686","https://openalex.org/W2019549525","https://openalex.org/W2022916027","https://openalex.org/W2023741423","https://openalex.org/W2024248310","https://openalex.org/W2024633528","https://openalex.org/W2025738510","https://openalex.org/W2027887689","https://openalex.org/W2031046717","https://openalex.org/W2033894014","https://openalex.org/W2034096812","https://openalex.org/W2035018358","https://openalex.org/W2038434279","https://openalex.org/W2039842091","https://openalex.org/W2040692501","https://openalex.org/W2041306926","https://openalex.org/W2042504178","https://openalex.org/W2047449586","https://openalex.org/W2049103294","https://openalex.org/W2054623702","https://openalex.org/W2055005615","https://openalex.org/W2058789249","https://openalex.org/W2059289753","https://openalex.org/W2060193765","https://openalex.org/W2063775447","https://openalex.org/W2063884517","https://openalex.org/W2064120562","https://openalex.org/W2065992586","https://openalex.org/W2066087962","https://openalex.org/W2072079441","https://openalex.org/W2075960404","https://openalex.org/W2077358600","https://openalex.org/W2079812171","https://openalex.org/W2082062648","https://openalex.org/W2085335784","https://openalex.org/W2085429049","https://openalex.org/W2085491999","https://openalex.org/W2088543913","https://openalex.org/W2093707803","https://openalex.org/W2096428903","https://openalex.org/W2097900300","https://openalex.org/W2101698988","https://openalex.org/W2103890250","https://openalex.org/W2107396956","https://openalex.org/W2109015418","https://openalex.org/W2110174748","https://openalex.org/W2110706037","https://openalex.org/W2111282166","https://openalex.org/W2116519404","https://openalex.org/W2118223033","https://openalex.org/W2118872783","https://openalex.org/W2120800817","https://openalex.org/W2122593055","https://openalex.org/W2124312551","https://openalex.org/W2125792276","https://openalex.org/W2127693350","https://openalex.org/W2133567506","https://openalex.org/W2138302361","https://openalex.org/W2138794424","https://openalex.org/W2140654447","https://openalex.org/W2152550452","https://openalex.org/W2157745003","https://openalex.org/W2159719279","https://openalex.org/W2162385486","https://openalex.org/W2163655541","https://openalex.org/W2165655699","https://openalex.org/W2171341132","https://openalex.org/W2177322388","https://openalex.org/W2214683865","https://openalex.org/W2242239927","https://openalex.org/W2283851324","https://openalex.org/W2287454957","https://openalex.org/W2342029315","https://openalex.org/W2401226286"],"related_works":["https://openalex.org/W2055385223","https://openalex.org/W2161858872","https://openalex.org/W2189582859","https://openalex.org/W2026016571","https://openalex.org/W2278352093","https://openalex.org/W2056075184","https://openalex.org/W2056868267","https://openalex.org/W4385460816","https://openalex.org/W3213038499","https://openalex.org/W1988761945"],"abstract_inverted_index":{"Ziel:":[0],"Die":[1,71,103,140,224],"NEC":[2,69,95,149,181,208,241],"ist":[3],"die":[4,18,36,42,78,98,136,183],"haufigste":[5],"erworbene":[6],"lebensbedrohliche":[7],"Erkrankung":[8,29],"des":[9,44],"Gastrointestinaltraktes":[10],"bei":[11,56,106,242],"Fruhund":[12],"Neugeborenen.":[13],"Es":[14],"wird":[15],"angenommen,":[16],"dass":[17,229],"vermehrte":[19],"Produktion":[20],"proinflammatorischer":[21],"Zytokine,":[22],"insbesondere":[23],"TNF-\u03b1,":[24],"an":[25],"der":[26,28,59,73,90,133,142,174,204,230,239],"Pathogenese":[27],"beteiligt":[30],"ist.":[31],"In":[32,173],"dieser":[33],"Studie":[34],"wurde":[35,62,93,135,206],"Auswirkung":[37],"einer":[38,179],"selektiven":[39],"TNF-\u03b1-Blockade":[40],"auf":[41,77,236],"Entzundungsreaktion":[43],"Darmes":[45],"untersucht.":[46],"Methodik:":[47],"Neugeborene":[48],"Sprague-Dawley-Ratten":[49],"wurden":[50,76,105,119],"in":[51],"3":[52],"verschiedene":[53],"Gruppen":[54],"aufgeteilt:":[55],"den":[57,88,202,237],"Tieren":[58,89,203],"Gruppe":[60,74,91,143,175],"I":[61,144],"durch":[63],"Hypoxie,":[64],"Hypothermie":[65],"sowie":[66,126,163],"Ersatznahrung":[67],"eine":[68,147,164,233],"induziert.":[70],"Tiere":[72,104,141],"II":[75,176],"gleiche":[79],"Weise":[80],"behandelt,":[81],"zusatzlich":[82],"erhielten":[83],"sie":[84],"einen":[85],"TNF-\u03b1Antikorper.":[86],"Bei":[87,201],"III":[92],"keine":[94,207],"induziert":[96],"(Kontrollgruppe),":[97],"Ernahrung":[99],"erfolgte":[100],"mit":[101],"Muttermilch.":[102],"drohendem":[107],"Tod":[108],"sofort,":[109],"sonst":[110],"spatestens":[111],"nach":[112],"96":[113],"Stunden":[114],"dekaptiert.":[115],"Jejunum":[116],"und":[117,122],"Colon":[118],"getrennt":[120],"entnommen":[121],"fur":[123],"histologische":[124],"(HE-Farbung)":[125],"immunhistochemische":[127],"(MPO-Farbung)":[128],"Untersuchungen":[129],"weiterverarbeitet.":[130],"Mit":[131],"Hilfe":[132],"TUNEL-Farbung":[134],"Apoptose":[137],"dargestellt.":[138],"Ergebnis:":[139],"zeigten":[145],"morphologisch":[146],"ausgepragte":[148],"(MW":[150,168,188,215],"NEC-Score:":[151],"3,33":[152],"\u00b1":[153,161,171,191,199,221],"0,24,":[154],"MW":[155,193,218],"MPO:":[156,194,219],"65,58":[157],"/":[158,196],"20":[159,197],"Gesichtsfelder":[160,198],"8,02)":[162],"massiv":[165],"erhohte":[166],"Apoptoserate":[167,184],"TUNEL-Score":[169],"3,22":[170],"0,36).":[172],"waren":[177],"Anzeichen":[178],"milden":[180],"vorhanden,":[182],"war":[185],"masig":[186],"gesteigert":[187],"NEC-Score":[189,216],"1,66":[190],"0,47,":[192],"33,16":[195],"5,92).":[200],"Kontrollgruppe":[205],"induziert,":[209],"vereinzelt":[210],"fanden":[211],"sich":[212],"apoptotische":[213],"Zellen":[214],"0.0\u00b10,":[217],"14,27":[220],"3,89).":[222],"Schlussfolgerung:":[223],"Ergebnisse":[225],"weisen":[226],"darauf":[227],"hin,":[228],"TNF-\u03b1Antikorper":[231],"wahrscheinlich":[232],"hemmende":[234],"Wirkung":[235],"Entzundungsverlauf":[238],"experimentellen":[240],"neugeborenen":[243],"Ratten":[244],"hat.":[245]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}