{"id":"https://openalex.org/W2234999929","doi":null,"title":"Prescription de Trastuzumab IV dans le carcinome mammaire m\u00e9tastatique HER2+ : donn\u00e9es \u00e9pid\u00e9miologiques, modalit\u00e9s de prescription, \u00e9valuation de l\u2019efficacit\u00e9 au sein d\u2019un CLCC et proposition d\u2019une dose IV standardis\u00e9e","display_name":"Prescription de Trastuzumab IV dans le carcinome mammaire m\u00e9tastatique HER2+ : donn\u00e9es \u00e9pid\u00e9miologiques, modalit\u00e9s de prescription, \u00e9valuation de l\u2019efficacit\u00e9 au sein d\u2019un CLCC et proposition d\u2019une dose IV standardis\u00e9e","publication_year":2014,"publication_date":"2014-10-21","ids":{"openalex":"https://openalex.org/W2234999929","mag":"2234999929"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:dumas-01109531v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01109531","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sciences pharmaceutiques. 2014","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dumas.ccsd.cnrs.fr/dumas-01109531","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064293228","display_name":"Thomas Genev\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Thomas Genev\u00e9e","raw_affiliation_strings":["Universite De Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite De Bordeaux","institution_ids":["https://openalex.org/I15057530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064293228"],"corresponding_institution_ids":["https://openalex.org/I15057530"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"96","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prescribing-patterns","display_name":"prescribing patterns","score":0.5709999799728394},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.902999997138977},{"id":"https://openalex.org/keywords/drug-stock-management","display_name":"drug stock management","score":0.4860000014305115},{"id":"https://openalex.org/keywords/oncology-drug-reimbursement","display_name":"oncology drug reimbursement","score":0.33799999952316284},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.4480000138282776},{"id":"https://openalex.org/keywords/trastuzumab-biosimilar","display_name":"trastuzumab biosimilar","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7554023265838623},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7108610272407532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6950247883796692},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.17563626170158386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0750190019607544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05565601587295532}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:dumas-01109531v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01109531","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sciences pharmaceutiques. 2014","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2234999929","doi":null,"is_oa":false,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01109531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:dumas-01109531v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01109531","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sciences pharmaceutiques. 2014","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W134944081","https://openalex.org/W135096470","https://openalex.org/W173833309","https://openalex.org/W1498713448","https://openalex.org/W1516107827","https://openalex.org/W1531524380","https://openalex.org/W1766065308","https://openalex.org/W1884767706","https://openalex.org/W1970875728","https://openalex.org/W1971267920","https://openalex.org/W1974024530","https://openalex.org/W1999946604","https://openalex.org/W2001596868","https://openalex.org/W2003761478","https://openalex.org/W2015186160","https://openalex.org/W2020321814","https://openalex.org/W2034801324","https://openalex.org/W2035484878","https://openalex.org/W2040173909","https://openalex.org/W2041715804","https://openalex.org/W2047259303","https://openalex.org/W2059050919","https://openalex.org/W2070264012","https://openalex.org/W2070842899","https://openalex.org/W2093729570","https://openalex.org/W2107103026","https://openalex.org/W2113670583","https://openalex.org/W2116356654","https://openalex.org/W2127457632","https://openalex.org/W2131082981","https://openalex.org/W2132434084","https://openalex.org/W2132756648","https://openalex.org/W2137853125","https://openalex.org/W2143738177","https://openalex.org/W2147349643","https://openalex.org/W2148527073","https://openalex.org/W2159305151","https://openalex.org/W2167766783","https://openalex.org/W2220500259","https://openalex.org/W2318605753","https://openalex.org/W2411113765","https://openalex.org/W2524322792","https://openalex.org/W4393328312"],"related_works":["https://openalex.org/W2745907565","https://openalex.org/W2282777725","https://openalex.org/W2921370679","https://openalex.org/W3034744371","https://openalex.org/W1578140595","https://openalex.org/W4310804865","https://openalex.org/W2782215920","https://openalex.org/W2998101594","https://openalex.org/W1859048196","https://openalex.org/W2230586567"],"abstract_inverted_index":{"Apr\u00e8s":[0],"plus":[1],"de":[2,6,46,58,80,82,87,91,94,105,132,152,154,173,191,197,213,219,221,246,254,256,298,301,311],"10":[3],"ans":[4],"d\u2019administration":[5],"trastuzumab":[7,49,83,95,135,155,174,206,257,312],"par":[8,24,31],"voie":[9,25,280],"intraveineuse":[10],"(IV)":[11,84],"\u00e0":[12,76,108,193,229,275,292],"une":[13,64,103,169,308,315],"dose":[14,22,170,251,295,309,316],"normalis\u00e9e":[15,317],"au":[16,67,181,318],"poids":[17,319],"du":[18,48,134,320],"patient,":[19],"l\u2019utilisation":[20,47],"d\u2019une":[21,294],"fixe":[23,171,252,296,310],"sous-cutan\u00e9e":[26],"(SC)":[27],"a":[28,110,176,262],"\u00e9t\u00e9":[29,111,122,143,165,177,263],"autoris\u00e9e":[30],"les":[32,128,138,233],"autorit\u00e9s":[33],"comp\u00e9tentes":[34],"en":[35,85,239,304],"septembre":[36],"2013.":[37],"Nous":[38,185],"avons":[39,74,186],"souhait\u00e9":[40],"r\u00e9aliser":[41],"un":[42,100,125,288],"\u00e9tat":[43],"des":[44,55,119,266,284],"lieux":[45],"et":[50,97,117,131,314],"\u00e9valuer":[51],"son":[52],"efficacit\u00e9":[53],"chez":[54],"patientes":[56,120,192],"atteintes":[57],"carcinome":[59],"mammaire":[60],"m\u00e9tastatique":[61],"HER2+":[62],"via":[63],"analyse":[65],"r\u00e9trospective":[66],"sein":[68],"d\u2019un":[69],"CLCC.":[70],"Par":[71,282],"ailleurs":[72],"nous":[73],"recherch\u00e9":[75],"optimiser":[77],"la":[78,88,160,201,279],"consommation":[79],"flacons":[81,260],"raison":[86],"gestion":[89],"prochaine":[90],"2":[92],"stocks":[93],"(SC":[96],"IV).":[98],"Dans":[99,124],"1er":[101],"temps,":[102,127],"photographie":[104],"notre":[106,189],"population":[107,190],"l\u2019\u00e9tude":[109,194],"r\u00e9alis\u00e9e.":[112],"Les":[113],"caract\u00e9ristiques":[114],"\u00e9pid\u00e9miologiques,":[115],"tumorales":[116],"m\u00e9tastatiques":[118],"ont":[121,142,163],"recherch\u00e9es.":[123],"2\u00e8me":[126],"modalit\u00e9s":[129],"d\u2019utilisation":[130,141],"prescription":[133],"IV":[136,156,175,258,313],"dans":[137,200,210,216,232,270],"conditions":[139],"r\u00e9elles":[140],"\u00e9tudi\u00e9es.":[144],"Des":[145],"crit\u00e8res":[146],"d\u2019efficacit\u00e9":[147],"tels":[148],"que":[149,188],"le":[150,183,205,211,217,244,271],"nombre":[151],"cycles":[153],"cumul\u00e9":[157],"ou":[158],"encore":[159],"Survie":[161,224],"globale":[162,225],"\u00e9galement":[164],"recherch\u00e9s.":[166],"Pour":[167],"finir,":[168],"standardis\u00e9e":[172,253],"propos\u00e9e":[178],"afin":[179,297],"d\u2019optimiser":[180],"mieux":[182],"stock.":[184],"observ\u00e9":[187],"\u00e9tait":[195],"proche":[196],"celle":[198,230],"d\u00e9crite":[199],"litt\u00e9rature.":[202],"D\u2019autre":[203],"part,":[204],"est":[207,227],"prescrit":[208],"soit":[209,215],"cadre":[212],"l\u2019AMM,":[214],"respect":[218],"th\u00e9saurus":[220],"canc\u00e9rologie.":[222],"La":[223],"observ\u00e9e":[226],"sup\u00e9rieure":[228],"annonc\u00e9e":[231],"\u00e9tudes":[234,285],"\u00ab":[235],"pivot":[236],"\u00bb":[237],"probablement":[238],"lien":[240],"avec":[241,278],"l\u2019arriv\u00e9e":[242],"sur":[243],"march\u00e9":[245],"nouveaux":[247],"traitements":[248],"efficaces.":[249],"Une":[250],"375mg":[255],"(2.5":[259],"d\u2019Herceptin\u00ae)":[261],"propos\u00e9e.":[264],"L\u2019ensemble":[265],"donn\u00e9es":[267],"collect\u00e9es":[268],"pourront":[269],"futur":[272],"\u00eatre":[273],"compar\u00e9es":[274],"celles":[276],"obtenues":[277],"SC.":[281],"ailleurs,":[283],"PK":[286],"sont":[287],"pr\u00e9":[289],"requis":[290],"indispensable":[291],"l\u2019administration":[293],"v\u00e9rifier":[299],"l\u2019absence":[300],"diff\u00e9rences":[302],"significatives":[303],"termes":[305],"d\u2019exposition":[306],"entre":[307],"patient.":[321]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}