{"id":"https://openalex.org/W2234809362","doi":"https://doi.org/10.1097/mlr.0000000000000486","title":"Estimating the Population Benefits and Costs of Rituximab Therapy in the United States from 1998 to 2013 Using Real-World Data","display_name":"Estimating the Population Benefits and Costs of Rituximab Therapy in the United States from 1998 to 2013 Using Real-World Data","publication_year":2016,"publication_date":"2016-01-14","ids":{"openalex":"https://openalex.org/W2234809362","doi":"https://doi.org/10.1097/mlr.0000000000000486","mag":"2234809362","pmid":"https://pubmed.ncbi.nlm.nih.gov/26759977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4795096"},"language":"en","primary_location":{"id":"doi:10.1097/mlr.0000000000000486","doi":"https://doi.org/10.1097/mlr.0000000000000486","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mlr.0000000000000486","pdf_url":null,"source":{"id":"https://openalex.org/S79233773","display_name":"Medical Care","issn_l":"0025-7079","issn":["0025-7079","1537-1948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","fnege-3","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/mlr.0000000000000486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018773741","display_name":"Mark D. Danese","orcid":"https://orcid.org/0000-0002-7068-9603","observed_orcids":["https://orcid.org/0000-0002-7068-9603"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark D. Danese","raw_affiliation_strings":["*Outcomes Insights Inc., Westlake Village \u2020Genentech Inc., South San Francisco, CA \u2021Mayo Clinic Arizona, Scottsdale, AZ","*Outcomes Insights Inc., Westlake Village","M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","\u2020Genentech Inc., South San Francisco, CA","\u2021Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village \u2020Genentech Inc., South San Francisco, CA \u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I183934855","https://openalex.org/I4210125099"]},{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village","institution_ids":[]},{"raw_affiliation_string":"M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","institution_ids":[]},{"raw_affiliation_string":"Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","institution_ids":[]},{"raw_affiliation_string":"Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","institution_ids":[]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","institution_ids":[]},{"raw_affiliation_string":"\u2020Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057312624","display_name":"Carolina M. Reyes","orcid":"https://orcid.org/0000-0002-6358-3464","observed_orcids":["https://orcid.org/0000-0002-6358-3464"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolina M. Reyes","raw_affiliation_strings":["Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","*Outcomes Insights Inc., Westlake Village","M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","\u2020Genentech Inc., South San Francisco, CA","\u2021Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","institution_ids":[]},{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village","institution_ids":[]},{"raw_affiliation_string":"M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","institution_ids":[]},{"raw_affiliation_string":"Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","institution_ids":[]},{"raw_affiliation_string":"\u2020Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108546587","display_name":"Michelle L. Gleeson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L. Gleeson","raw_affiliation_strings":["Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","*Outcomes Insights Inc., Westlake Village","M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","\u2020Genentech Inc., South San Francisco, CA","\u2021Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","institution_ids":[]},{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village","institution_ids":[]},{"raw_affiliation_string":"M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","institution_ids":[]},{"raw_affiliation_string":"Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","institution_ids":[]},{"raw_affiliation_string":"\u2020Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109225785","display_name":"Marc Halperin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Halperin","raw_affiliation_strings":["Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","*Outcomes Insights Inc., Westlake Village","M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","\u2020Genentech Inc., South San Francisco, CA","\u2021Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","institution_ids":[]},{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village","institution_ids":[]},{"raw_affiliation_string":"M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","institution_ids":[]},{"raw_affiliation_string":"Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","institution_ids":[]},{"raw_affiliation_string":"\u2020Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008049586","display_name":"Sandra L. Skettino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra L. Skettino","raw_affiliation_strings":["Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","*Outcomes Insights Inc., Westlake Village","M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","\u2020Genentech Inc., South San Francisco, CA","\u2021Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","institution_ids":[]},{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village","institution_ids":[]},{"raw_affiliation_string":"M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","institution_ids":[]},{"raw_affiliation_string":"Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","institution_ids":[]},{"raw_affiliation_string":"\u2020Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058598134","display_name":"Joseph R Mikhael","orcid":"https://orcid.org/0000-0001-9670-2864","observed_orcids":["https://orcid.org/0000-0001-9670-2864"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Mikhael","raw_affiliation_strings":["Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","*Outcomes Insights Inc., Westlake Village","M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","\u2020Genentech Inc., South San Francisco, CA","\u2021Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Outcomes Insights Inc. received research funding for this study from Genentech. Outcomes Insights Inc. also receives research and consulting services in the area of hematology from Amgen and Genentech","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.lww-medicalcare.com","institution_ids":[]},{"raw_affiliation_string":"*Outcomes Insights Inc., Westlake Village","institution_ids":[]},{"raw_affiliation_string":"M.D.D., M.L.G., and M.H. were employed by Outcomes Insights Inc. at the time this work was completed. C.M.R. and S.L.S. were employed by Genentech at the time this study was completed. J.M. received no compensation for his participation in this research. J.M. receives research funding from Celgene, Onyx, Sanofi, and Novartis, unrelated to this project","institution_ids":[]},{"raw_affiliation_string":"Reprints: Mark D. Danese, MHS, PhD, Outcomes Insights Inc., 2801 Townsgate Blvd, Suite 330, Westlake Village, CA 91361. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/","institution_ids":[]},{"raw_affiliation_string":"\u2020Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018773741"],"corresponding_institution_ids":["https://openalex.org/I183934855","https://openalex.org/I4210125099"],"apc_list":null,"apc_paid":null,"fwci":7.446,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.96674363,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"54","issue":"4","first_page":"343","last_page":"349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":1.0},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":1.0},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/life-years-saved","display_name":"life-years saved","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.699999988079071},{"id":"https://openalex.org/keywords/incremental-cost","display_name":"incremental cost","score":0.47099998593330383},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.6309999823570251},{"id":"https://openalex.org/keywords/seer-medicare-linkage","display_name":"SEER-Medicare linkage","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.840681791305542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7627456188201904},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6232302188873291},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5574331283569336},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.453920841217041},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.4287570118904114},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2979520857334137},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.23495545983314514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.189640074968338},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.14072442054748535},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006278","descriptor_name":"Medicare","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008224","descriptor_name":"Lymphoma, Follicular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016527","descriptor_name":"Drug Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D018803","descriptor_name":"Models, Economic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/mlr.0000000000000486","doi":"https://doi.org/10.1097/mlr.0000000000000486","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mlr.0000000000000486","pdf_url":null,"source":{"id":"https://openalex.org/S79233773","display_name":"Medical Care","issn_l":"0025-7079","issn":["0025-7079","1537-1948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","fnege-3","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4795096","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4795096/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4795096/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Care","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3789608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4795096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26759977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26759977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical care","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/mlr.0000000000000486","doi":"https://doi.org/10.1097/mlr.0000000000000486","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mlr.0000000000000486","pdf_url":null,"source":{"id":"https://openalex.org/S79233773","display_name":"Medical Care","issn_l":"0025-7079","issn":["0025-7079","1537-1948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","fnege-3","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2234809362.pdf","grobid_xml":"https://content.openalex.org/works/W2234809362.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1536569285","https://openalex.org/W1543389126","https://openalex.org/W1961762341","https://openalex.org/W1974855794","https://openalex.org/W1982654262","https://openalex.org/W1982967337","https://openalex.org/W2018071905","https://openalex.org/W2050056063","https://openalex.org/W2051648120","https://openalex.org/W2052053078","https://openalex.org/W2058015212","https://openalex.org/W2058056848","https://openalex.org/W2078492238","https://openalex.org/W2094905849","https://openalex.org/W2100868098","https://openalex.org/W2111970267","https://openalex.org/W2113346537","https://openalex.org/W2116643602","https://openalex.org/W2129550879","https://openalex.org/W2132047269","https://openalex.org/W2136544104","https://openalex.org/W2145583742","https://openalex.org/W2151981428","https://openalex.org/W2159861616","https://openalex.org/W2161866812","https://openalex.org/W2164821482","https://openalex.org/W4248559216","https://openalex.org/W4250849363","https://openalex.org/W6680146708"],"related_works":["https://openalex.org/W2907417295","https://openalex.org/W1536569285","https://openalex.org/W2113346537","https://openalex.org/W2418200842","https://openalex.org/W31572822","https://openalex.org/W6939506524","https://openalex.org/W1978914151","https://openalex.org/W2171202266","https://openalex.org/W2031046511","https://openalex.org/W2048937093"],"abstract_inverted_index":{"BACKGROUND:":[0],"Rituximab":[1],"was":[2,182],"approved":[3,44],"in":[4,133,189],"1997":[5],"and":[6,20,36,63,68],"is":[7],"regularly":[8],"one":[9],"of":[10,40,90,144,180,194,208,218,225,234],"the":[11,34,37,48,60,91,124,134,141,206,222,226,231],"largest":[12],"drug":[13],"expenditures":[14],"for":[15,42],"Medicare;":[16],"however,":[17],"its":[18,43],"benefits":[19],"costs":[21,233],"have":[22],"not":[23],"been":[24],"estimated":[25,123,140,183],"from":[26,59,71,102],"a":[27,215],"population":[28,49,92],"perspective.":[29],"OBJECTIVES:":[30],"To":[31],"estimate":[32],"both":[33],"clinical":[35,211],"economic":[38,131,150,192,223],"outcomes":[39,69],"rituximab":[41,146,181,209],"hematological":[45],"uses":[46],"at":[47,172],"level.":[50],"RESEARCH":[51],"DESIGN:":[52],"Analyses":[53],"using":[54],"cancer":[55],"registry":[56],"incidence":[57],"data":[58,70,73],"Surveillance,":[61],"Epidemiology,":[62],"End":[64],"Results":[65],"(SEER)":[66],"program,":[67],"SEER":[72],"linked":[74],"with":[75,107],"Medicare":[76,155],"administrative":[77],"claims":[78],"(SEER-Medicare":[79],"data).":[80],"These":[81,198],"results":[82],"were":[83,152,164,170],"incorporated":[84],"into":[85,210],"an":[86,190],"epidemiological":[87],"simulation":[88],"model":[89],"over":[93],"time.":[94],"SUBJECTS:":[95],"We":[96,138],"modeled":[97],"all":[98],"United":[99,135],"States":[100,136],"patients":[101],"1998":[103],"to":[104,147,159,184],"2013":[105,160],"diagnosed":[106],"diffuse":[108],"large":[109],"B-cell":[110],"lymphoma,":[111,113],"follicular":[112],"or":[114],"chronic":[115],"lymphocytic":[116],"leukemia.":[117],"MEASURES:":[118],"Using":[119],"this":[120],"model,":[121],"we":[122],"life-years":[125,167,227],"saved,":[126],"as":[127,129],"well":[128],"their":[130],"benefit,":[132],"population.":[137],"also":[139],"incremental":[142,176,191,219],"cost":[143,179],"adding":[145],"chemotherapy.":[148],"All":[149],"inputs":[151],"based":[153,200],"on":[154,201],"reimbursed":[156],"amounts":[157],"inflated":[158],"dollars.":[161],"RESULTS:":[162],"There":[163],"279,704":[165],"cumulative":[166],"saved":[168],"which":[169],"valued":[171],"$25.44":[173],"billion.":[174,196],"The":[175],"direct":[177],"medical":[178],"be":[185],"$8.92":[186],"billion,":[187],"resulting":[188],"gain":[193],"$16.52":[195],"CONCLUSIONS:":[197],"analyses,":[199],"real-world":[202],"evidence,":[203],"show":[204],"that":[205],"introduction":[207],"practice":[212],"has":[213],"produced":[214],"substantial":[216],"number":[217],"life-years.":[220],"Importantly,":[221],"benefit":[224],"gained":[228],"greatly":[229],"exceeds":[230],"added":[232],"treatment.":[235]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
